CHD6 (chromodomain helicase DNA binding protein 6)

Gene

• Entrez ID: 84181
• Gene name: Chromodomain helicase DNA binding protein 6
• Gene symbol: CHD6
• Synonyms: CHD-6, CHD5, RIGB
• Chromosome: 20
• Chromosome location: 20q12
• Summary: This gene encodes a member of the SNF2/RAD54 helicase protein family. The encoded protein contains two chromodomains, a helicase domain, and an ATPase domain. Several multi-subunit protein complexes remodel chromatin to allow patterns of cell type-specifi

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016929	hsa-miR-335-5p	Microarray	18185580
MIRT889230	hsa-miR-1265	CLIP-seq
MIRT889231	hsa-miR-1287	CLIP-seq
MIRT889232	hsa-miR-1296	CLIP-seq
MIRT889233	hsa-miR-1324	CLIP-seq
MIRT889234	hsa-miR-141	CLIP-seq
MIRT889235	hsa-miR-200a	CLIP-seq
MIRT889236	hsa-miR-200b	CLIP-seq
MIRT889237	hsa-miR-200c	CLIP-seq
MIRT889238	hsa-miR-221	CLIP-seq
MIRT889239	hsa-miR-222	CLIP-seq
MIRT889240	hsa-miR-2277-3p	CLIP-seq
MIRT889241	hsa-miR-2909	CLIP-seq
MIRT889242	hsa-miR-3065-5p	CLIP-seq
MIRT889243	hsa-miR-3135b	CLIP-seq
MIRT889244	hsa-miR-3143	CLIP-seq
MIRT889245	hsa-miR-3146	CLIP-seq
MIRT889246	hsa-miR-3154	CLIP-seq
MIRT889247	hsa-miR-3161	CLIP-seq
MIRT889248	hsa-miR-3609	CLIP-seq
MIRT889249	hsa-miR-3647-3p	CLIP-seq
MIRT889250	hsa-miR-369-3p	CLIP-seq
MIRT889251	hsa-miR-374a	CLIP-seq
MIRT889252	hsa-miR-374b	CLIP-seq
MIRT889253	hsa-miR-3920	CLIP-seq
MIRT889254	hsa-miR-3923	CLIP-seq
MIRT889255	hsa-miR-429	CLIP-seq
MIRT889256	hsa-miR-4310	CLIP-seq
MIRT889257	hsa-miR-4434	CLIP-seq
MIRT889258	hsa-miR-4436b-3p	CLIP-seq
MIRT889259	hsa-miR-4436b-5p	CLIP-seq
MIRT889260	hsa-miR-4475	CLIP-seq
MIRT889261	hsa-miR-4504	CLIP-seq
MIRT889262	hsa-miR-4516	CLIP-seq
MIRT889263	hsa-miR-451b	CLIP-seq
MIRT889264	hsa-miR-4522	CLIP-seq
MIRT889265	hsa-miR-4528	CLIP-seq
MIRT889266	hsa-miR-4531	CLIP-seq
MIRT889267	hsa-miR-4661-5p	CLIP-seq
MIRT889268	hsa-miR-4699-5p	CLIP-seq
MIRT889269	hsa-miR-4709-3p	CLIP-seq
MIRT889270	hsa-miR-4716-3p	CLIP-seq
MIRT889271	hsa-miR-4738-3p	CLIP-seq
MIRT889272	hsa-miR-4761-3p	CLIP-seq
MIRT889273	hsa-miR-4764-5p	CLIP-seq
MIRT889274	hsa-miR-4786-5p	CLIP-seq
MIRT889275	hsa-miR-4796-5p	CLIP-seq
MIRT889276	hsa-miR-493	CLIP-seq
MIRT889277	hsa-miR-498	CLIP-seq
MIRT889278	hsa-miR-514	CLIP-seq
MIRT889279	hsa-miR-514b-3p	CLIP-seq
MIRT889280	hsa-miR-539	CLIP-seq
MIRT889281	hsa-miR-542-3p	CLIP-seq
MIRT889282	hsa-miR-548aa	CLIP-seq
MIRT889283	hsa-miR-548ac	CLIP-seq
MIRT889284	hsa-miR-548ah	CLIP-seq
MIRT889285	hsa-miR-548d-3p	CLIP-seq
MIRT889286	hsa-miR-548t	CLIP-seq
MIRT889287	hsa-miR-548v	CLIP-seq
MIRT889288	hsa-miR-548z	CLIP-seq
MIRT889289	hsa-miR-549	CLIP-seq
MIRT889290	hsa-miR-579	CLIP-seq
MIRT889291	hsa-miR-582-3p	CLIP-seq
MIRT889292	hsa-miR-624	CLIP-seq
MIRT889293	hsa-miR-625	CLIP-seq
MIRT889294	hsa-miR-628-3p	CLIP-seq
MIRT889295	hsa-miR-769-5p	CLIP-seq
MIRT889296	hsa-miR-802	CLIP-seq
MIRT1963543	hsa-miR-103a	CLIP-seq
MIRT1963544	hsa-miR-103b	CLIP-seq
MIRT1963545	hsa-miR-107	CLIP-seq
MIRT1963546	hsa-miR-1278	CLIP-seq
MIRT889233	hsa-miR-1324	CLIP-seq
MIRT1963547	hsa-miR-1539	CLIP-seq
MIRT1963548	hsa-miR-15a	CLIP-seq
MIRT1963549	hsa-miR-15b	CLIP-seq
MIRT1963550	hsa-miR-16	CLIP-seq
MIRT1963551	hsa-miR-195	CLIP-seq
MIRT889240	hsa-miR-2277-3p	CLIP-seq
MIRT1963552	hsa-miR-2278	CLIP-seq
MIRT1963553	hsa-miR-3121-3p	CLIP-seq
MIRT1963554	hsa-miR-3133	CLIP-seq
MIRT889244	hsa-miR-3143	CLIP-seq
MIRT1963555	hsa-miR-3173-5p	CLIP-seq
MIRT1963556	hsa-miR-3193	CLIP-seq
MIRT1963557	hsa-miR-339-5p	CLIP-seq
MIRT1963558	hsa-miR-361-3p	CLIP-seq
MIRT1963559	hsa-miR-376a	CLIP-seq
MIRT1963560	hsa-miR-376b	CLIP-seq
MIRT889253	hsa-miR-3920	CLIP-seq
MIRT1963561	hsa-miR-3976	CLIP-seq
MIRT1963562	hsa-miR-424	CLIP-seq
MIRT889256	hsa-miR-4310	CLIP-seq
MIRT889257	hsa-miR-4434	CLIP-seq
MIRT889259	hsa-miR-4436b-5p	CLIP-seq
MIRT889261	hsa-miR-4504	CLIP-seq
MIRT889262	hsa-miR-4516	CLIP-seq
MIRT889263	hsa-miR-451b	CLIP-seq
MIRT889266	hsa-miR-4531	CLIP-seq
MIRT889267	hsa-miR-4661-5p	CLIP-seq
MIRT1963563	hsa-miR-4698	CLIP-seq
MIRT889268	hsa-miR-4699-5p	CLIP-seq
MIRT889269	hsa-miR-4709-3p	CLIP-seq
MIRT1963564	hsa-miR-4724-5p	CLIP-seq
MIRT1963565	hsa-miR-4742-3p	CLIP-seq
MIRT1963566	hsa-miR-4778-3p	CLIP-seq
MIRT1963567	hsa-miR-4802-3p	CLIP-seq
MIRT1963568	hsa-miR-497	CLIP-seq
MIRT889277	hsa-miR-498	CLIP-seq
MIRT1963569	hsa-miR-499a-5p	CLIP-seq
MIRT889278	hsa-miR-514	CLIP-seq
MIRT889279	hsa-miR-514b-3p	CLIP-seq
MIRT889281	hsa-miR-542-3p	CLIP-seq
MIRT1963570	hsa-miR-548a-3p	CLIP-seq
MIRT1963571	hsa-miR-548e	CLIP-seq
MIRT1963572	hsa-miR-548f	CLIP-seq
MIRT889290	hsa-miR-579	CLIP-seq
MIRT1963546	hsa-miR-1278	CLIP-seq
MIRT889233	hsa-miR-1324	CLIP-seq
MIRT2199956	hsa-miR-3682-5p	CLIP-seq
MIRT2199957	hsa-miR-3688-3p	CLIP-seq
MIRT889253	hsa-miR-3920	CLIP-seq
MIRT2199958	hsa-miR-4261	CLIP-seq
MIRT889256	hsa-miR-4310	CLIP-seq
MIRT2199959	hsa-miR-4330	CLIP-seq
MIRT889259	hsa-miR-4436b-5p	CLIP-seq
MIRT889261	hsa-miR-4504	CLIP-seq
MIRT889265	hsa-miR-4528	CLIP-seq
MIRT889268	hsa-miR-4699-5p	CLIP-seq
MIRT889269	hsa-miR-4709-3p	CLIP-seq
MIRT1963564	hsa-miR-4724-5p	CLIP-seq
MIRT1963569	hsa-miR-499a-5p	CLIP-seq
MIRT889281	hsa-miR-542-3p	CLIP-seq
MIRT1963570	hsa-miR-548a-3p	CLIP-seq
MIRT1963571	hsa-miR-548e	CLIP-seq
MIRT1963572	hsa-miR-548f	CLIP-seq
MIRT2199960	hsa-miR-550b	CLIP-seq
MIRT2199961	hsa-miR-7	CLIP-seq
MIRT2199962	hsa-miR-890	CLIP-seq
MIRT889259	hsa-miR-4436b-5p	CLIP-seq
MIRT2446996	hsa-miR-3185	CLIP-seq
MIRT2446997	hsa-miR-3915	CLIP-seq
MIRT2446998	hsa-miR-3928	CLIP-seq
MIRT2502669	hsa-miR-2110	CLIP-seq
MIRT2502670	hsa-miR-2682	CLIP-seq
MIRT2502671	hsa-miR-302a	CLIP-seq
MIRT2502672	hsa-miR-302b	CLIP-seq
MIRT2502673	hsa-miR-302c	CLIP-seq
MIRT2502674	hsa-miR-302d	CLIP-seq
MIRT2502675	hsa-miR-302e	CLIP-seq
MIRT889244	hsa-miR-3143	CLIP-seq
MIRT889246	hsa-miR-3154	CLIP-seq
MIRT2446996	hsa-miR-3185	CLIP-seq
MIRT2502676	hsa-miR-3673	CLIP-seq
MIRT2502677	hsa-miR-372	CLIP-seq
MIRT2502678	hsa-miR-373	CLIP-seq
MIRT2446997	hsa-miR-3915	CLIP-seq
MIRT2446998	hsa-miR-3928	CLIP-seq
MIRT2502679	hsa-miR-409-3p	CLIP-seq
MIRT2502680	hsa-miR-4264	CLIP-seq
MIRT2502681	hsa-miR-4271	CLIP-seq
MIRT2502682	hsa-miR-4277	CLIP-seq
MIRT2502683	hsa-miR-4423-3p	CLIP-seq
MIRT889257	hsa-miR-4434	CLIP-seq
MIRT889259	hsa-miR-4436b-5p	CLIP-seq
MIRT889260	hsa-miR-4475	CLIP-seq
MIRT2502684	hsa-miR-449c	CLIP-seq
MIRT889262	hsa-miR-4516	CLIP-seq
MIRT889266	hsa-miR-4531	CLIP-seq
MIRT2502685	hsa-miR-4662a-3p	CLIP-seq
MIRT889268	hsa-miR-4699-5p	CLIP-seq
MIRT889269	hsa-miR-4709-3p	CLIP-seq
MIRT2502686	hsa-miR-4725-3p	CLIP-seq
MIRT889274	hsa-miR-4786-5p	CLIP-seq
MIRT2502687	hsa-miR-4797-3p	CLIP-seq
MIRT1963567	hsa-miR-4802-3p	CLIP-seq
MIRT2502688	hsa-miR-488	CLIP-seq
MIRT889276	hsa-miR-493	CLIP-seq
MIRT2502689	hsa-miR-512-3p	CLIP-seq
MIRT2502690	hsa-miR-520a-3p	CLIP-seq
MIRT2502691	hsa-miR-520b	CLIP-seq
MIRT2502692	hsa-miR-520c-3p	CLIP-seq
MIRT2502693	hsa-miR-520d-3p	CLIP-seq
MIRT2502694	hsa-miR-520e	CLIP-seq
MIRT889295	hsa-miR-769-5p	CLIP-seq
MIRT2502695	hsa-miR-940	CLIP-seq
MIRT2502669	hsa-miR-2110	CLIP-seq
MIRT2502670	hsa-miR-2682	CLIP-seq
MIRT2502671	hsa-miR-302a	CLIP-seq
MIRT2502672	hsa-miR-302b	CLIP-seq
MIRT2502673	hsa-miR-302c	CLIP-seq
MIRT2502674	hsa-miR-302d	CLIP-seq
MIRT2502675	hsa-miR-302e	CLIP-seq
MIRT889244	hsa-miR-3143	CLIP-seq
MIRT889246	hsa-miR-3154	CLIP-seq
MIRT2446996	hsa-miR-3185	CLIP-seq
MIRT2502677	hsa-miR-372	CLIP-seq
MIRT2502678	hsa-miR-373	CLIP-seq
MIRT2446997	hsa-miR-3915	CLIP-seq
MIRT2446998	hsa-miR-3928	CLIP-seq
MIRT2502680	hsa-miR-4264	CLIP-seq
MIRT2502681	hsa-miR-4271	CLIP-seq
MIRT2502682	hsa-miR-4277	CLIP-seq
MIRT2502683	hsa-miR-4423-3p	CLIP-seq
MIRT889257	hsa-miR-4434	CLIP-seq
MIRT889260	hsa-miR-4475	CLIP-seq
MIRT2502684	hsa-miR-449c	CLIP-seq
MIRT889262	hsa-miR-4516	CLIP-seq
MIRT889266	hsa-miR-4531	CLIP-seq
MIRT2502686	hsa-miR-4725-3p	CLIP-seq
MIRT889274	hsa-miR-4786-5p	CLIP-seq
MIRT2502687	hsa-miR-4797-3p	CLIP-seq
MIRT1963567	hsa-miR-4802-3p	CLIP-seq
MIRT2502688	hsa-miR-488	CLIP-seq
MIRT889276	hsa-miR-493	CLIP-seq
MIRT2502689	hsa-miR-512-3p	CLIP-seq
MIRT2502690	hsa-miR-520a-3p	CLIP-seq
MIRT2502691	hsa-miR-520b	CLIP-seq
MIRT2502692	hsa-miR-520c-3p	CLIP-seq
MIRT2502693	hsa-miR-520d-3p	CLIP-seq
MIRT2502694	hsa-miR-520e	CLIP-seq
MIRT889295	hsa-miR-769-5p	CLIP-seq
MIRT2502695	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001221	Function	Transcription coregulator binding	IPI	16314513
GO:0003677	Function	DNA binding	IEA
GO:0003678	Function	DNA helicase activity	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005654	Component	Nucleoplasm	IDA	17027977
GO:0006325	Process	Chromatin organization	IEA
GO:0008094	Function	DNA-dependent ATPase activity	IDA	17027977
GO:0016032	Process	Viral process	IEA
GO:0032508	Process	DNA duplex unwinding	IEA
GO:0036091	Process	Positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress	IMP	16314513

Other IDs

• MIM: 616114
• HGNC: 19057
• e!Ensembl: ENSG00000124177

Protein

• UniProt ID: Q8TD26
• Protein name: Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.-) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein)
• Protein function: ATP-dependent chromatin-remodeling factor (PubMed:17027977, PubMed:28533432). Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin; nucleosome disruption requir
• PDB: 2EPB
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00385	Chromo	292 → 354	Chromo (CHRromatin Organisation MOdifier) domain	Domain
  PF00385	Chromo	375 → 429	Chromo (CHRromatin Organisation MOdifier) domain	Domain
  PF00176	SNF2_N	436 → 751	SNF2 family N-terminal domain	Family
  PF00271	Helicase_C	783 → 897	Helicase conserved C-terminal domain	Family

• Sequence:

  MKMKIQKKEKQLSNLKVLNHSPMSDASVNFDYKSPSPFDCSTDQEEKIEDVASHCLPQKD
  LYTAEEEAATLFPRKMTSHNGMEDSGGGGTGVKKKRKKKEPGDQEGAAKGSKDREPKPKR
  KREPKEPKEPRKAKEPKKAKEHKEPKQKDGAKKARKPREASGTKEAKEKRSCTDSAARTK
  SRKASKEQGPTPVEKKKKGKRKSETTVESLELDQGLTNPSLRSPEESTESTDSQKRRSGR
  QVKRRKYNEDLDFKVVDDDGETIAVLGAGRTSALSASTLAWQAEEPPEDDANIIEKILAS
  KTVQEVHPGEPPFDLELFYVKYRNFSYLHCKWATMEELEKDPRIAQKIKRFRNKQAQMKH
  IFTEPDEDLFNPDYVEVDRILEVAHTKDAETGEEVTHYLVKWCSLPYEESTWELEEDVDP
  AKVKEFESLQVLPEIKHVERPASDSWQKLEKSREYKNSNQLREYQLEGMNWLLFNWYNRK
  NCILADEMGLGKTIQSITFLSEIFLRGIHGPFLIIAPLSTITNWEREFRTWTEMNAIVYH
  GSQISRQMIQQYEMVYRDAQGNPLSGVFKFHVVITTFEMILADCPELKKIHWSCVIIDEA
  HRLKNRNCKLLEGLKLMALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETAFLEEFG
  DLKTEEQVKKLQSILKPMMLRRLKDDVEKNLAPKQETIIEVELTNIQKKYYRAILEKNFS
  FLTKGANQHNMPNLINTMMELRKCCNHPYLINGAEEKILEDFRKTHSPDAPDFQLQAMIQ
  AAGKLVLIDKLLPKLIAGGHKVLIFSQMVRCLDILEDYLIQRRYTYERIDGRVRGNLRQA
  AIDRFCKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSK
  AVKVYRLITRNSYEREMFDKASLKLGLDKAVLQDINRKGGTNGVQQLSKMEVEDLLRKGA
  YGALMDEEDEGSKFCEEDIDQILQRRTHTITIQSEGKGSTFAKASFVASGNRTDISLDDP
  NFWQKWAKIAELDTEAKNEKESLVIDRPRVRKQTKHYNSFEEDELMEFSELDSDSDERPT
  RSRRLNDKARRYLRAECFRVEKNLLIFGWGRWKDILTHGRFKWHLNEKDMEMICRALLVY
  CVKHYKGDEKIKSFIWELITPTKDGQAQTLQNHSGLSAPVPRGRKGKKTKNQLLIPELKD
  ADWLATCNPEVVLHDDGYKKHLKQHCNKVLLRVRMLYYLKAEILGEAAEKAFEGSPAREL
  DVPLPDIDYMEIPVDWWDAEADKSLLIGVFKHGYERYNAMRADPALCFLEKVGMPDEKSL
  SAEQGVTDGTSDIPERGNTDKEDNAEDKVDGLQKQTESSSDGGDGVFSEKKDDSRAAQDG
  SDPDKSPWPVSSALTARLRRLVTVYQRCNRKELCRPEILGPGNQGYWVQEEMFRRTSEMD
  LINKEAQKRWTRREQADFYRTVSSFGVVYDQEKKTFDWTQFRIISRLDKKSDESLEQYFY
  SFVAMCRNVCRLPTWKDGGPPDTTIYVEPITEERAARTLYRIELLRKVREQVLKCPQLHE
  RLQLCRPSLYLPVWWECGKHDRDLLIGTAKHGLNRTDCYIMNDPQLSFLDAYRNYAQHKR
  SGTQAPGNLCCLYQTNSKLYESLTYSQMSRTSESLENEPENLVRVESRDDHLSLPDVTCE
  NFISKVQDVISINHDESLLPESLESMMYGKKVLSQEPSSFQESPSTNTESRKDVITISIS
  KDGNCQSGGPEAEIASGPTFMGSLEAGGVAQANIKNGKHLLMSISKEGELCCSEAGQRPE
  NIGQLEAKCLASPSLNPGNESGFVDMCSLSVCDSKRNLSSDQQLIDLLENKSLESKLILS
  QNHSDEEEEEEENEEENLAMAVGMGERPEVLHLTEPTTNISREKNQGFQDETKKGSLEVA
  NQTPGLQRAFPAPAACQCHCKHMERWMHGLENDEFEIEKPKAYIPDLFKSKTNTIAMEGE
  PTAIPSQPFKVKHELLKEPWKESAEGQNVFPTYPLEGSELKSEDMDFENKDDYDRDGNCH
  SQDYPGKYSEEESKSSTSGITGDIGDELQEARAPTIAQLLQEKTLYSFSEWPKDRVIINR
  LDNICHVVLKGKWPSSQQYEPSGTLPTPVLTSSAGSRTSLSEPEAAEHSFSNGAALAAQI
  HKESFLAPVFTKDEQKHRRPYEFEVERDAKARGLEQFSATHGHTPIILNGWHGESAMDLS
  CSSEGSPGATSPFPVSASTPKIGAISSLQGALGMDLSGILQAGLIHPVTGQIVNGSLRRD
  DAATRRRRGRRKHVEGGMDLIFLKEQTLQAGILEVHEDPGQATLSTTHPEGPGPATSAPE
  PATAASSQAEKSIPSKSLLDWLRQQADYSLEVPGFGANFSDKPKQRRPRCKEPGKLDVSS
  LSGEERVPAIPKEPGLRGFLPENKFNHTLAEPILRDTGPRRRGRRPRSELLKAPSIVADS
  PSGMGPLFMNGLIAGMDLVGLQNMRNMPGIPLTGLVGFPAGFATMPTGEEVKSTLSMLPM
  MLPGMAAVPQMFGVGGLLSPPMATTCTSTAPASLSSTTKSGTAVTEKTAEDKPSSHDVKT
  DTLAEDKPGPGPFSDQSEPAITTSSPVAFNPFLIPGVSPGLIYPSMFLSPGMGMALPAMQ
  QARHSEIVGLESQKRKKKKTKGDNPNSHPEPAPSCEREPSGDENCAEPSAPLPAEREHGA
  QAGEGALKDSNNDTN

• Sequence length: 2715

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Neuroblastoma	Neuroblastoma	rs121908161, rs113994087, rs113994089, rs281864719, rs863225285, rs863225284, rs863225283, rs281864720, rs863225282, rs863225281, rs1057519698, rs915983602, rs1469271544	18577749
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	29610475

Unknown
Disease name	Disease term	dbSNP ID	References
Astigmatism	Astigmatism		30306274
Urinary bladder cancer	Malignant neoplasm of urinary bladder		21822268
Bladder neoplasm	Bladder Neoplasm		21822268
Prostatic neoplasms	Prostatic Neoplasms		29610475