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ZIC4 (Zic family zinc finger 4)

Gene

Zic family zinc finger 4

ZIC4

3q24

This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development, and have been associated with X-linked visceral heterotaxy and holoprosencephaly type 5. This gene is closely linked t

Show/Hide all(111)

miRTarBase ID	miRNA	Experiments	Reference
MIRT627179	hsa-miR-892a	HITS-CLIP	23824327
MIRT627178	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT640634	hsa-miR-1208	HITS-CLIP	23824327
MIRT627177	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT627176	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT627175	hsa-miR-4420	HITS-CLIP	23824327
MIRT627174	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT627173	hsa-miR-5096	HITS-CLIP	23824327
MIRT627172	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT627179	hsa-miR-892a	HITS-CLIP	23824327
MIRT627178	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT627177	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT627176	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT627175	hsa-miR-4420	HITS-CLIP	23824327
MIRT627174	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT627173	hsa-miR-5096	HITS-CLIP	23824327
MIRT627172	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT441707	hsa-miR-105-5p	PAR-CLIP	22100165
MIRT441704	hsa-miR-7853-5p	PAR-CLIP	22100165
MIRT441705	hsa-miR-4662a-5p	PAR-CLIP	22100165
MIRT627179	hsa-miR-892a	HITS-CLIP	23824327
MIRT627178	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT640634	hsa-miR-1208	HITS-CLIP	23824327
MIRT627177	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT627176	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT627175	hsa-miR-4420	HITS-CLIP	23824327
MIRT627174	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT627173	hsa-miR-5096	HITS-CLIP	23824327
MIRT627172	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT627179	hsa-miR-892a	HITS-CLIP	23824327
MIRT627178	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT627177	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT627176	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT627175	hsa-miR-4420	HITS-CLIP	23824327
MIRT627174	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT627173	hsa-miR-5096	HITS-CLIP	23824327
MIRT627172	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT441707	hsa-miR-105-5p	PAR-CLIP	22100165
MIRT441704	hsa-miR-7853-5p	PAR-CLIP	22100165
MIRT441705	hsa-miR-4662a-5p	PAR-CLIP	22100165
MIRT1513468	hsa-miR-103a	CLIP-seq
MIRT1513469	hsa-miR-107	CLIP-seq
MIRT1513470	hsa-miR-1301	CLIP-seq
MIRT1513471	hsa-miR-2278	CLIP-seq
MIRT1513472	hsa-miR-369-3p	CLIP-seq
MIRT1513473	hsa-miR-374a	CLIP-seq
MIRT1513474	hsa-miR-374b	CLIP-seq
MIRT1513475	hsa-miR-4468	CLIP-seq
MIRT1513476	hsa-miR-450b-5p	CLIP-seq
MIRT1513477	hsa-miR-5047	CLIP-seq
MIRT1513478	hsa-miR-507	CLIP-seq
MIRT1513479	hsa-miR-557	CLIP-seq
MIRT1513480	hsa-miR-140-3p	CLIP-seq
MIRT1513481	hsa-miR-1587	CLIP-seq
MIRT1513482	hsa-miR-205	CLIP-seq
MIRT1513483	hsa-miR-2467-3p	CLIP-seq
MIRT1513484	hsa-miR-3119	CLIP-seq
MIRT1513485	hsa-miR-3163	CLIP-seq
MIRT1513486	hsa-miR-329	CLIP-seq
MIRT1513487	hsa-miR-3620	CLIP-seq
MIRT1513488	hsa-miR-362-3p	CLIP-seq
MIRT1513489	hsa-miR-3675-3p	CLIP-seq
MIRT1513490	hsa-miR-4257	CLIP-seq
MIRT1513491	hsa-miR-4492	CLIP-seq
MIRT1513492	hsa-miR-4498	CLIP-seq
MIRT1513493	hsa-miR-4524	CLIP-seq
MIRT1513494	hsa-miR-4656	CLIP-seq
MIRT1513495	hsa-miR-4674	CLIP-seq
MIRT1513496	hsa-miR-4675	CLIP-seq
MIRT1513497	hsa-miR-4741	CLIP-seq
MIRT1513498	hsa-miR-635	CLIP-seq
MIRT1513499	hsa-miR-762	CLIP-seq
MIRT1513500	hsa-miR-1243	CLIP-seq
MIRT1513501	hsa-miR-144	CLIP-seq
MIRT1513502	hsa-miR-185	CLIP-seq
MIRT1513503	hsa-miR-3654	CLIP-seq
MIRT1513504	hsa-miR-4306	CLIP-seq
MIRT1513505	hsa-miR-4644	CLIP-seq
MIRT1513506	hsa-miR-4645-3p	CLIP-seq
MIRT1513507	hsa-miR-542-3p	CLIP-seq
MIRT2154751	hsa-miR-4260	CLIP-seq
MIRT2154752	hsa-miR-4744	CLIP-seq
MIRT2441794	hsa-miR-296-5p	CLIP-seq
MIRT2441795	hsa-miR-544	CLIP-seq
MIRT2667364	hsa-miR-1245b-3p	CLIP-seq
MIRT2667365	hsa-miR-1276	CLIP-seq
MIRT2667366	hsa-miR-1305	CLIP-seq
MIRT2667367	hsa-miR-147	CLIP-seq
MIRT2667368	hsa-miR-3133	CLIP-seq
MIRT2667369	hsa-miR-3201	CLIP-seq
MIRT2667370	hsa-miR-3682-3p	CLIP-seq
MIRT2667371	hsa-miR-3684	CLIP-seq
MIRT2667372	hsa-miR-3691-5p	CLIP-seq
MIRT2667373	hsa-miR-3911	CLIP-seq
MIRT2667374	hsa-miR-3924	CLIP-seq
MIRT2667375	hsa-miR-4302	CLIP-seq
MIRT2667376	hsa-miR-4311	CLIP-seq
MIRT2667377	hsa-miR-4431	CLIP-seq
MIRT2667378	hsa-miR-4432	CLIP-seq
MIRT2667379	hsa-miR-452	CLIP-seq
MIRT2667380	hsa-miR-4676-3p	CLIP-seq
MIRT2154752	hsa-miR-4744	CLIP-seq
MIRT2667381	hsa-miR-4752	CLIP-seq
MIRT2667382	hsa-miR-4791	CLIP-seq
MIRT2667383	hsa-miR-548b-3p	CLIP-seq
MIRT2667384	hsa-miR-561	CLIP-seq
MIRT2667385	hsa-miR-583	CLIP-seq
MIRT2667386	hsa-miR-644	CLIP-seq
MIRT2667378	hsa-miR-4432	CLIP-seq
MIRT2667379	hsa-miR-452	CLIP-seq
MIRT2667380	hsa-miR-4676-3p	CLIP-seq

Show/Hide all(9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0003677	Function	DNA binding	ISS
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	ISS
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0007417	Process	Central nervous system development	IBA	21873635
GO:0046872	Function	Metal ion binding	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
608948	20393	ENSG00000174963

Protein

UniProt ID

Q8N9L1

Protein name

Zinc finger protein ZIC 4 (Zinc finger protein of the cerebellum 4)

Protein function

Binds to DNA.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF18366	zf_ZIC	121 → 166	Zic proteins zinc finger domain	Domain
PF00096	zf-C2H2	204 → 228	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	264 → 288	Zinc finger, C2H2 type	Domain

Sequence

MRYKTSLVMRKRLRLYRNTLKESSSSSGHHGPQLTAASSPSVFPGLHEEPPQASPSRPLN
GLLRLGLPGDMYARPEPFPPGPAARSDALAAAAALHGYGGMNLTVNLAAPHGPGAFFRYM
RQPIKQELICKWLAADGTATPSLCSKTFSTMHELVTHVTVEHVGGPEQANHICFWEECPR
QGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFRCEFEG
CERRFANSSDRKKHSHVHTSDKPYTCKVRGCDKCYTHPSSLRKHMKVHGRSPPPSSGYDS
ATPSALVSPSSDCGHKSQVASSAAVAARTADLSE

Sequence length

334

Interactions

View interactions

Associated diseases

Show/Hide Unknown Diseases (3)

Unknown
Disease name	Disease term	dbSNP ID	References
Isolated dandy-walker malformation with hydrocephalus	Isolated Dandy-Walker malformation with hydrocephalus
Isolated dandy-walker malformation without hydrocephalus	Isolated Dandy-Walker malformation without hydrocephalus
Liver carcinoma	Liver carcinoma		28284560

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