PIP5K1B (phosphatidylinositol-4-phosphate 5-kinase type 1 beta)

Gene

• Entrez ID: 8395
• Gene name: Phosphatidylinositol-4-phosphate 5-kinase type 1 beta
• Gene symbol: PIP5K1B
• Synonyms: MSS4, STM7
• Chromosome: 9
• Chromosome location: 9q21.11

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT2069424	hsa-miR-1206	CLIP-seq
MIRT2069425	hsa-miR-128	CLIP-seq
MIRT2069426	hsa-miR-27a	CLIP-seq
MIRT2069427	hsa-miR-27b	CLIP-seq
MIRT2069428	hsa-miR-412	CLIP-seq
MIRT2069429	hsa-miR-4277	CLIP-seq
MIRT2069430	hsa-miR-4291	CLIP-seq
MIRT2069431	hsa-miR-513a-5p	CLIP-seq
MIRT2069432	hsa-miR-545	CLIP-seq
MIRT2069424	hsa-miR-1206	CLIP-seq
MIRT2069425	hsa-miR-128	CLIP-seq
MIRT2069426	hsa-miR-27a	CLIP-seq
MIRT2069427	hsa-miR-27b	CLIP-seq
MIRT2069428	hsa-miR-412	CLIP-seq
MIRT2069429	hsa-miR-4277	CLIP-seq
MIRT2069431	hsa-miR-513a-5p	CLIP-seq
MIRT2594237	hsa-miR-24	CLIP-seq
MIRT2594238	hsa-miR-3151	CLIP-seq
MIRT2594239	hsa-miR-3157-5p	CLIP-seq
MIRT2594240	hsa-miR-3691-5p	CLIP-seq
MIRT2594241	hsa-miR-4283	CLIP-seq
MIRT2594242	hsa-miR-4437	CLIP-seq
MIRT2594243	hsa-miR-4480	CLIP-seq
MIRT2594244	hsa-miR-4489	CLIP-seq
MIRT2594245	hsa-miR-4691-3p	CLIP-seq
MIRT2594246	hsa-miR-4752	CLIP-seq
MIRT2594237	hsa-miR-24	CLIP-seq
MIRT2594238	hsa-miR-3151	CLIP-seq
MIRT2594239	hsa-miR-3157-5p	CLIP-seq
MIRT2594240	hsa-miR-3691-5p	CLIP-seq
MIRT2594241	hsa-miR-4283	CLIP-seq
MIRT2594242	hsa-miR-4437	CLIP-seq
MIRT2594243	hsa-miR-4480	CLIP-seq
MIRT2594244	hsa-miR-4489	CLIP-seq
MIRT2594245	hsa-miR-4691-3p	CLIP-seq
MIRT2594246	hsa-miR-4752	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001931	Component	Uropod	IDA	20442317
GO:0005515	Function	Protein binding	IPI	20442317
GO:0005524	Function	ATP binding	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IEA
GO:0006661	Process	Phosphatidylinositol biosynthetic process	TAS
GO:0012505	Component	Endomembrane system	IEA
GO:0014066	Process	Regulation of phosphatidylinositol 3-kinase signaling	TAS
GO:0016308	Function	1-phosphatidylinositol-4-phosphate 5-kinase activity	ISS
GO:0016308	Function	1-phosphatidylinositol-4-phosphate 5-kinase activity	NAS	8955136
GO:0046854	Process	Phosphatidylinositol phosphorylation	IEA

Other IDs

• MIM: 602745
• HGNC: 8995
• e!Ensembl: ENSG00000107242

Protein

• UniProt ID: O14986
• Protein name: Phosphatidylinositol 4-phosphate 5-kinase type-1 beta (PIP5K1-beta) (PtdIns(4)P-5-kinase 1 beta) (EC 2.7.1.68) (Phosphatidylinositol 4-phosphate 5-kinase type I beta) (PIP5KIbeta) (Protein STM-7) (Type I phosphatidylinositol 4-phosphate 5-kinase beta)
• Protein function: Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transductio
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01504	PIP5K	110 → 394	Phosphatidylinositol-4-phosphate 5-Kinase	Family

• Sequence:

  MSSAAENGEAAPGKQNEEKTYKKTASSAIKGAIQLGIGYTVGNLTSKPERDVLMQDFYVV
  ESVFLPSEGSNLTPAHHYPDFRFKTYAPLAFRYFRELFGIKPDDYLYSICSEPLIELSNP
  GASGSLFFVTSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCMQSGG
  INIRIVVMNNVLPRSMRMHFTYDLKGSTYKRRASRKEREKSNPTFKDLDFLQDMHEGLYF
  DTETYNALMKTLQRDCRVLESFKIMDYSLLLGIHFLDHSLKEKEEETPQNVPDAKRTGMQ
  KVLYSTAMESIQGPGKSGDGIITENPDTMGGIPAKSHRGEKLLLFMGIIDILQSYRLMKK
  LEHSWKALVYDGDTVSVHRPSFYADRFLKFMNSRVFKKIQALKASPSKKRCNSIAALKAT
  SQEIVSSISQEWKDEKRDLLTEGQSFSSLDEEALGSRHRPDLVPSTPSLFEAASLATTIS
  SSSLYVNEHYPHDRPTLYSNSKGLPSSSTFTLEEGTIYLTAEPNTLEVQDDNASVLDVYL
  

• Sequence length: 540

Pathways

KEGG:

Inositol phosphate metabolism
Metabolic pathways
Phosphatidylinositol signaling system
Phospholipase D signaling pathway
Endocytosis
Focal adhesion
Fc gamma R-mediated phagocytosis
Regulation of actin cytoskeleton
Yersinia infection
Choline metabolism in cancer

Reactome:

Synthesis of PIPs at the plasma membrane
WNT mediated activation of DVL
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Diabetes	Diabetes	rs80356611	31451708
Diabetes mellitus	Diabetes Mellitus	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	31451708
Kidney disease	Chronic Kidney Diseases	rs74315342, rs749740335, rs757649673, rs112417755, rs35138315	22479191, 20383146

Unknown
Disease name	Disease term	dbSNP ID	References
Dental caries	Dental caries pit and fissure		23470693
Kidney failure	Kidney Failure, Chronic		20383146, 31152163
Malignant neoplasm	Malignant Neoplasms		29299148