BCO2 (beta-carotene oxygenase 2)

Gene

• Entrez ID: 83875
• Gene name: Beta-carotene oxygenase 2
• Gene symbol: BCO2
• Synonyms: B-DIOX-II, BCDO2
• Chromosome: 11
• Chromosome location: 11q23.1
• Summary: This gene encodes an enzyme which oxidizes carotenoids such as beta-carotene during the biosynthesis of vitamin A. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT820204	hsa-miR-1236	CLIP-seq
MIRT820205	hsa-miR-376c	CLIP-seq
MIRT820206	hsa-miR-3944-5p	CLIP-seq
MIRT820207	hsa-miR-4313	CLIP-seq
MIRT820208	hsa-miR-4314	CLIP-seq
MIRT820209	hsa-miR-4666-5p	CLIP-seq
MIRT820210	hsa-miR-4667-5p	CLIP-seq
MIRT820211	hsa-miR-4691-5p	CLIP-seq
MIRT820212	hsa-miR-4700-5p	CLIP-seq
MIRT820213	hsa-miR-489	CLIP-seq
MIRT820214	hsa-miR-502-5p	CLIP-seq
MIRT820215	hsa-miR-637	CLIP-seq
MIRT1942391	hsa-miR-1206	CLIP-seq
MIRT1942392	hsa-miR-203	CLIP-seq
MIRT1942393	hsa-miR-579	CLIP-seq
MIRT1942394	hsa-miR-600	CLIP-seq
MIRT2181081	hsa-miR-136	CLIP-seq
MIRT2181082	hsa-miR-15a	CLIP-seq
MIRT2181083	hsa-miR-15b	CLIP-seq
MIRT2181084	hsa-miR-16	CLIP-seq
MIRT2181085	hsa-miR-192	CLIP-seq
MIRT2181086	hsa-miR-195	CLIP-seq
MIRT2181087	hsa-miR-215	CLIP-seq
MIRT2181088	hsa-miR-217	CLIP-seq
MIRT2181089	hsa-miR-3199	CLIP-seq
MIRT2181090	hsa-miR-338-3p	CLIP-seq
MIRT2181091	hsa-miR-3908	CLIP-seq
MIRT2181092	hsa-miR-424	CLIP-seq
MIRT2181093	hsa-miR-4418	CLIP-seq
MIRT2181094	hsa-miR-4530	CLIP-seq
MIRT2181095	hsa-miR-4540	CLIP-seq
MIRT820213	hsa-miR-489	CLIP-seq
MIRT2181096	hsa-miR-497	CLIP-seq
MIRT2181097	hsa-miR-509-3-5p	CLIP-seq
MIRT2181098	hsa-miR-509-5p	CLIP-seq
MIRT2181099	hsa-miR-554	CLIP-seq
MIRT2181100	hsa-miR-606	CLIP-seq
MIRT2181101	hsa-miR-766	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001523	Process	Retinoid metabolic process	TAS
GO:0003834	Function	Beta-carotene 15,15'-monooxygenase activity	IBA	21873635
GO:0005739	Component	Mitochondrion	IBA	21873635
GO:0005739	Component	Mitochondrion	ISS	21106934
GO:0005739	Component	Mitochondrion	TAS	21106934
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0010436	Function	Carotenoid dioxygenase activity	IBA	21873635
GO:0016116	Process	Carotenoid metabolic process	ISS	21106934
GO:0016119	Process	Carotene metabolic process	IDA	11278918
GO:0016121	Process	Carotene catabolic process	IBA	21873635
GO:0016121	Process	Carotene catabolic process	IDA	21302131
GO:0016122	Process	Xanthophyll metabolic process	IEA
GO:0016702	Function	Oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IDA	11278918, 21302131
GO:0042573	Process	Retinoic acid metabolic process	NAS	11278918
GO:0042574	Process	Retinal metabolic process	IBA	21873635
GO:0042574	Process	Retinal metabolic process	NAS	11278918
GO:0046872	Function	Metal ion binding	IEA
GO:0051881	Process	Regulation of mitochondrial membrane potential	ISS	21106934
GO:0102076	Function	Beta,beta-carotene-9',10'-cleaving oxygenase activity	IEA
GO:2000377	Process	Regulation of reactive oxygen species metabolic process	ISS	21106934

Other IDs

• MIM: 611740
• HGNC: 18503
• e!Ensembl: ENSG00000197580

Protein

• UniProt ID: Q9BYV7
• Protein name: Carotenoid-cleaving dioxygenase, mitochondrial (EC 1.13.11.-) (EC 1.13.11.71) (B-diox-II) (Beta,beta-carotene 9',10'-oxygenase) (Beta-carotene dioxygenase 2)
• Protein function: Broad specificity mitochondrial dioxygenase that mediates the asymmetric oxidative cleavage of carotenoids. Cleaves carotenes (pure hydrocarbon carotenoids) such as all-trans-beta-carotene and lycopene as well as xanthophylls (oxygenated caroten
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03055	RPE65	58 → 578	Retinal pigment epithelial membrane protein	Family

• Sequence:

  MFFRVFLHFIRSHSATAVDFLPVMVHRLPVFKRYMGNTPQKKAVFGQCRGLPCVAPLLTT
  VEEAPRGISARVWGHFPKWLNGSLLRIGPGKFEFGKDKYNHWFDGMALLHQFRMAKGTVT
  YRSKFLQSDTYKANSAKNRIVISEFGTLALPDPCKNVFERFMSRFELPGKAAAMTDNTNV
  NYVRYKGDYYLCTETNFMNKVDIETLEKTEKVDWSKFIAVNGATAHPHYDLDGTAYNMGN
  SFGPYGFSYKVIRVPPEKVDLGETIHGVQVICSIASTEKGKPSYYHSFGMTRNYIIFIEQ
  PLKMNLWKIATSKIRGKAFSDGISWEPQCNTRFHVVEKRTGQLLPGRYYSKPFVTFHQIN
  AFEDQGCVIIDLCCQDNGRTLEVYQLQNLRKAGEGLDQVHNSAAKSFPRRFVLPLNVSLN
  APEGDNLSPLSYTSASAVKQADGTIWCSHENLHQEDLEKEGGIEFPQIYYDRFSGKKYHF
  FYGCGFRHLVGDSLIKVDVVNKTLKVWREDGFYPSEPVFVPAPGTNEEDGGVILSVVITP
  NQNESNFILVLDAKNFEELGRAEVPVQMPYGFHGTFIPI

• Sequence length: 579

Pathways

Reactome:

Retinoid metabolism and transport

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Epilepsy	Epilepsy	rs113994140, rs119454947, rs28937874, rs1589762127, rs104894166, rs28939075, rs2134001459, rs104894167, rs119488099, rs119488100, rs1805032, rs387906420, rs121917752, rs121918622, rs121434579, rs1581220270, rs281865564, rs387907313, rs397514564, rs397514670, rs768241563, rs587776973, rs587776974, rs587776975, rs879255234, rs587776976, rs587776977, rs121917993, rs398123588, rs13306758, rs587777363, rs587777364, rs587777458, rs587777459, rs541024038, rs797044545, rs730882240, rs786205703, rs794726859, rs796053126, rs796053035, rs796053216, rs796052839, rs869025201, rs797044999, rs797044998, rs797045045, rs794726762, rs869312971, rs869312972, rs879255652, rs886037938, rs886037958, rs886037959, rs886037960, rs886037961, rs886037962, rs886037965, rs886037966, rs886039245, rs886039246, rs886039251, rs886039252, rs772872014, rs886039253, rs886039256, rs757511744, rs886039261, rs886039263, rs578185749, rs886039266, rs886039268, rs886039269, rs886039273, rs368820286, rs1057518801, rs1057518688, rs1057519107, rs1057519273, rs752753379, rs767795673, rs1057519424, rs755946598, rs760609867, rs1057521066, rs1057524233, rs1060501488, rs1060501487, rs755127868, rs751533302, rs771373457, rs1475605360, rs1555401942, rs1553567864, rs200661329, rs766667249, rs1556607762, rs1555882921, rs1555882867, rs1555900914, rs1553546836, rs77216276, rs755595256, rs1554169267, rs747661902, rs2105890565, rs1021001959, rs1555441032, rs1555439541, rs1556526609, rs1315483224, rs759952667, rs1555885023, rs1553456695, rs1555942720, rs1569083500, rs1559127505, rs1206309859, rs1567139896, rs1567134495, rs1431914212, rs1569166925, rs1569255443, rs1568955379, rs1567152003, rs374158137, rs1567129567, rs1569523728, rs1568991466, rs1569186093, rs1569254004, rs1372605067, rs1569067939, rs1568963062, rs1563959514, rs1569012755, rs1559118914, rs1602338615, rs1596522356, rs1364913665, rs1596522300, rs1596526976, rs1229740428, rs1596385588, rs1596500172, rs1596505517, rs1601925213, rs1601970168, rs1602010382, rs1602903591, rs1603014297, rs1603014708, rs1601875057, rs1601970824, rs1601755632, rs1587393982, rs1592977444, rs1575562076, rs1570998206, rs1588057922, rs1596528731, rs1602349641, rs1587401875, rs2065899210, rs1596526915, rs2093486364, rs2056165149, rs2056100951, rs781482552, rs1899868619, rs1900088045, rs1898675878, rs1898686157, rs1898837245, rs1898844513, rs2082841677, rs2085727988, rs2092933941, rs2091657024, rs1899864955, rs1898844907, rs2083056830, rs2084070588, rs1899713412, rs2082695884, rs1977106116, rs1977105425, rs1443687532	30868120

Unknown
Disease name	Disease term	dbSNP ID	References
Liver carcinoma	Liver carcinoma		28284560