L3MBTL2 (L3MBTL histone methyl-lysine binding protein 2)

Gene

• Entrez ID: 83746
• Gene name: L3MBTL histone methyl-lysine binding protein 2
• Gene symbol: L3MBTL2
• Synonyms: H-l(3)mbt-l, L3MBT
• Chromosome: 22
• Chromosome location: 22q13.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT042333	hsa-miR-484	CLASH	23622248
MIRT037598	hsa-miR-744-5p	CLASH	23622248
MIRT532639	hsa-miR-4668-3p	PAR-CLIP	22012620
MIRT532638	hsa-miR-8063	PAR-CLIP	22012620
MIRT532637	hsa-miR-6890-3p	PAR-CLIP	22012620
MIRT532636	hsa-miR-4793-5p	PAR-CLIP	22012620
MIRT532635	hsa-miR-5587-5p	PAR-CLIP	22012620
MIRT532639	hsa-miR-4668-3p	PAR-CLIP	22012620
MIRT532638	hsa-miR-8063	PAR-CLIP	22012620
MIRT532637	hsa-miR-6890-3p	PAR-CLIP	22012620
MIRT532636	hsa-miR-4793-5p	PAR-CLIP	22012620
MIRT532635	hsa-miR-5587-5p	PAR-CLIP	22012620
MIRT1102935	hsa-miR-1913	CLIP-seq
MIRT1102936	hsa-miR-298	CLIP-seq
MIRT1102937	hsa-miR-324-3p	CLIP-seq
MIRT1102938	hsa-miR-3616-3p	CLIP-seq
MIRT1102939	hsa-miR-3621	CLIP-seq
MIRT1102940	hsa-miR-3684	CLIP-seq
MIRT1102941	hsa-miR-3692	CLIP-seq
MIRT1102942	hsa-miR-3922-5p	CLIP-seq
MIRT1102943	hsa-miR-3937	CLIP-seq
MIRT1102944	hsa-miR-4313	CLIP-seq
MIRT1102945	hsa-miR-4436b-3p	CLIP-seq
MIRT1102946	hsa-miR-4660	CLIP-seq
MIRT1102947	hsa-miR-4717-5p	CLIP-seq
MIRT1102948	hsa-miR-4728-5p	CLIP-seq
MIRT1102949	hsa-miR-4753-5p	CLIP-seq
MIRT1102950	hsa-miR-485-5p	CLIP-seq
MIRT1102951	hsa-miR-646	CLIP-seq
MIRT2028156	hsa-miR-1208	CLIP-seq
MIRT2028157	hsa-miR-2278	CLIP-seq
MIRT738686	hsa-miR-27a	CLIP-seq
MIRT738687	hsa-miR-27b	CLIP-seq
MIRT738684	hsa-miR-3065-3p	CLIP-seq
MIRT738688	hsa-miR-3614-3p	CLIP-seq
MIRT2028158	hsa-miR-431	CLIP-seq
MIRT2028159	hsa-miR-4420	CLIP-seq
MIRT2028160	hsa-miR-4477b	CLIP-seq
MIRT2028161	hsa-miR-4496	CLIP-seq
MIRT2028162	hsa-miR-4514	CLIP-seq
MIRT2028163	hsa-miR-4532	CLIP-seq
MIRT2028164	hsa-miR-4690-5p	CLIP-seq
MIRT2028165	hsa-miR-4692	CLIP-seq
MIRT2028166	hsa-miR-4768-3p	CLIP-seq
MIRT2028167	hsa-miR-4797-5p	CLIP-seq
MIRT2028168	hsa-miR-510	CLIP-seq
MIRT738685	hsa-miR-513a-5p	CLIP-seq
MIRT2028169	hsa-miR-630	CLIP-seq
MIRT2028170	hsa-miR-643	CLIP-seq
MIRT2028171	hsa-miR-651	CLIP-seq
MIRT2259286	hsa-miR-106a	CLIP-seq
MIRT2259287	hsa-miR-106b	CLIP-seq
MIRT2259288	hsa-miR-1292	CLIP-seq
MIRT2259289	hsa-miR-149	CLIP-seq
MIRT2259290	hsa-miR-17	CLIP-seq
MIRT2259291	hsa-miR-20a	CLIP-seq
MIRT2259292	hsa-miR-20b	CLIP-seq
MIRT2259293	hsa-miR-214	CLIP-seq
MIRT2028157	hsa-miR-2278	CLIP-seq
MIRT738686	hsa-miR-27a	CLIP-seq
MIRT738687	hsa-miR-27b	CLIP-seq
MIRT2259294	hsa-miR-3064-5p	CLIP-seq
MIRT2259295	hsa-miR-3122	CLIP-seq
MIRT2259296	hsa-miR-3148	CLIP-seq
MIRT2259297	hsa-miR-3612	CLIP-seq
MIRT2259298	hsa-miR-3619-5p	CLIP-seq
MIRT2259299	hsa-miR-3622b-5p	CLIP-seq
MIRT2259300	hsa-miR-3652	CLIP-seq
MIRT2259301	hsa-miR-3913-5p	CLIP-seq
MIRT2259302	hsa-miR-4267	CLIP-seq
MIRT2259303	hsa-miR-4321	CLIP-seq
MIRT2259304	hsa-miR-4430	CLIP-seq
MIRT2259305	hsa-miR-4433	CLIP-seq
MIRT2259306	hsa-miR-4443	CLIP-seq
MIRT2259307	hsa-miR-4459	CLIP-seq
MIRT2259308	hsa-miR-4471	CLIP-seq
MIRT2259309	hsa-miR-4505	CLIP-seq
MIRT2259310	hsa-miR-4508	CLIP-seq
MIRT2028162	hsa-miR-4514	CLIP-seq
MIRT2259311	hsa-miR-4530	CLIP-seq
MIRT2259312	hsa-miR-4667-5p	CLIP-seq
MIRT2259313	hsa-miR-4680-5p	CLIP-seq
MIRT2028164	hsa-miR-4690-5p	CLIP-seq
MIRT2259314	hsa-miR-4691-5p	CLIP-seq
MIRT2028165	hsa-miR-4692	CLIP-seq
MIRT2259315	hsa-miR-4700-5p	CLIP-seq
MIRT2028166	hsa-miR-4768-3p	CLIP-seq
MIRT2259316	hsa-miR-4781-5p	CLIP-seq
MIRT2259317	hsa-miR-4794	CLIP-seq
MIRT738685	hsa-miR-513a-5p	CLIP-seq
MIRT2259318	hsa-miR-519a	CLIP-seq
MIRT2259319	hsa-miR-519b-3p	CLIP-seq
MIRT2259320	hsa-miR-519c-3p	CLIP-seq
MIRT2259321	hsa-miR-519d	CLIP-seq
MIRT2259322	hsa-miR-520g	CLIP-seq
MIRT2259323	hsa-miR-520h	CLIP-seq
MIRT2259324	hsa-miR-622	CLIP-seq
MIRT2259325	hsa-miR-637	CLIP-seq
MIRT2259326	hsa-miR-650	CLIP-seq
MIRT2259327	hsa-miR-744	CLIP-seq
MIRT2259328	hsa-miR-761	CLIP-seq
MIRT2259329	hsa-miR-875-3p	CLIP-seq
MIRT2259330	hsa-miR-876-3p	CLIP-seq
MIRT2259331	hsa-miR-93	CLIP-seq
MIRT2259332	hsa-miR-944	CLIP-seq
MIRT2390063	hsa-miR-4775	CLIP-seq
MIRT2452840	hsa-miR-1910	CLIP-seq
MIRT2452841	hsa-miR-455-3p	CLIP-seq
MIRT2452842	hsa-miR-4719	CLIP-seq
MIRT2559586	hsa-miR-1294	CLIP-seq
MIRT2559587	hsa-miR-1304	CLIP-seq
MIRT2559588	hsa-miR-1827	CLIP-seq
MIRT2559589	hsa-miR-2467-3p	CLIP-seq
MIRT2559590	hsa-miR-2467-5p	CLIP-seq
MIRT2559591	hsa-miR-3150a-3p	CLIP-seq
MIRT2559592	hsa-miR-3175	CLIP-seq
MIRT2559593	hsa-miR-3188	CLIP-seq
MIRT2259299	hsa-miR-3622b-5p	CLIP-seq
MIRT2559594	hsa-miR-362-5p	CLIP-seq
MIRT2559595	hsa-miR-3657	CLIP-seq
MIRT2559596	hsa-miR-377	CLIP-seq
MIRT2559597	hsa-miR-3909	CLIP-seq
MIRT2559598	hsa-miR-3929	CLIP-seq
MIRT2559599	hsa-miR-3975	CLIP-seq
MIRT2259302	hsa-miR-4267	CLIP-seq
MIRT2028158	hsa-miR-431	CLIP-seq
MIRT2559600	hsa-miR-4419b	CLIP-seq
MIRT2559601	hsa-miR-4478	CLIP-seq
MIRT2559602	hsa-miR-4643	CLIP-seq
MIRT2559603	hsa-miR-4645-5p	CLIP-seq
MIRT2559604	hsa-miR-4659a-3p	CLIP-seq
MIRT2559605	hsa-miR-4659b-3p	CLIP-seq
MIRT2259312	hsa-miR-4667-5p	CLIP-seq
MIRT2559606	hsa-miR-4669	CLIP-seq
MIRT2559607	hsa-miR-4673	CLIP-seq
MIRT2559608	hsa-miR-4684-3p	CLIP-seq
MIRT2259314	hsa-miR-4691-5p	CLIP-seq
MIRT2259315	hsa-miR-4700-5p	CLIP-seq
MIRT2559609	hsa-miR-4749-3p	CLIP-seq
MIRT2028167	hsa-miR-4797-5p	CLIP-seq
MIRT1102950	hsa-miR-485-5p	CLIP-seq
MIRT2559610	hsa-miR-500b	CLIP-seq
MIRT2559611	hsa-miR-511	CLIP-seq
MIRT2559612	hsa-miR-526b	CLIP-seq
MIRT2559613	hsa-miR-576-3p	CLIP-seq
MIRT2259325	hsa-miR-637	CLIP-seq
MIRT2559614	hsa-miR-766	CLIP-seq
MIRT2559615	hsa-miR-885-3p	CLIP-seq
MIRT2559616	hsa-miR-939	CLIP-seq
MIRT2559586	hsa-miR-1294	CLIP-seq
MIRT2559591	hsa-miR-3150a-3p	CLIP-seq
MIRT2559592	hsa-miR-3175	CLIP-seq
MIRT2559594	hsa-miR-362-5p	CLIP-seq
MIRT2559595	hsa-miR-3657	CLIP-seq
MIRT2559596	hsa-miR-377	CLIP-seq
MIRT2559597	hsa-miR-3909	CLIP-seq
MIRT2259302	hsa-miR-4267	CLIP-seq
MIRT2028158	hsa-miR-431	CLIP-seq
MIRT2559603	hsa-miR-4645-5p	CLIP-seq
MIRT2259312	hsa-miR-4667-5p	CLIP-seq
MIRT2559606	hsa-miR-4669	CLIP-seq
MIRT2559607	hsa-miR-4673	CLIP-seq
MIRT2559608	hsa-miR-4684-3p	CLIP-seq
MIRT2259314	hsa-miR-4691-5p	CLIP-seq
MIRT2259315	hsa-miR-4700-5p	CLIP-seq
MIRT2559609	hsa-miR-4749-3p	CLIP-seq
MIRT2028167	hsa-miR-4797-5p	CLIP-seq
MIRT2559610	hsa-miR-500b	CLIP-seq
MIRT2559611	hsa-miR-511	CLIP-seq
MIRT2559612	hsa-miR-526b	CLIP-seq
MIRT2559613	hsa-miR-576-3p	CLIP-seq
MIRT2259325	hsa-miR-637	CLIP-seq
MIRT2559614	hsa-miR-766	CLIP-seq
MIRT2559615	hsa-miR-885-3p	CLIP-seq
MIRT2559616	hsa-miR-939	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003682	Function	Chromatin binding	IBA	21873635
GO:0005515	Function	Protein binding	IPI	16189514, 20385135, 24981860, 25416956, 25609649, 26871637, 27705803, 32296183
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006325	Process	Chromatin organization	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0035064	Function	Methylated histone binding	IBA	21873635
GO:0035064	Function	Methylated histone binding	IDA	19233876
GO:0042393	Function	Histone binding	IBA	21873635
GO:0042393	Function	Histone binding	IPI	17540172
GO:0045892	Process	Negative regulation of transcription, DNA-templated	IBA	21873635
GO:0070317	Process	Negative regulation of G0 to G1 transition	TAS

Other IDs

• MIM: 611865
• HGNC: 18594
• e!Ensembl: ENSG00000100395

Protein

• UniProt ID: Q969R5
• Protein name: Lethal(3)malignant brain tumor-like protein 2 (H-l(3)mbt-like protein 2) (L(3)mbt-like protein 2)
• Protein function: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remode
• PDB: 2W0T, 3CEY, 3F70
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02820	MBT	214 → 287	mbt repeat	Domain
  PF02820	MBT	327 → 393	mbt repeat	Domain
  PF02820	MBT	432 → 504	mbt repeat	Domain
  PF02820	MBT	540 → 608	mbt repeat	Domain

• Sequence:

  MEKPRSIEETPSSEPMEEEEDDDLELFGGYDSFRSYNSSVGSESSSYLEESSEAENEDRE
  AGELPTSPLHLLSPGTPRSLDGSGSEPAVCEMCGIVGTREAFFSKTKRFCSVSCSRSYSS
  NSKKASILARLQGKPPTKKAKVLHKAAWSAKIGAFLHSQGTGQLADGTPTGQDALVLGFD
  WGKFLKDHSYKAAPVSCFKHVPLYDQWEDVMKGMKVEVLNSDAVLPSRVYWIASVIQTAG
  YRVLLRYEGFENDASHDFWCNLGTVDVHPIGWCAINSKILVPPRTIHAKFTDWKGYLMKR
  LVGSRTLPVDFHIKMVESMKYPFRQGMRLEVVDKSQVSRTRMAVVDTVIGGRLRLLYEDG
  DSDDDFWCHMWSPLIHPVGWSRRVGHGIKMSERRSDMAHHPTFRKIYCDAVPYLFKKVRA
  VYTEGGWFEEGMKLEAIDPLNLGNICVATVCKVLLDGYLMICVDGGPSTDGLDWFCYHAS
  SHAIFPATFCQKNDIELTPPKGYEAQTFNWENYLEKTKSKAAPSRLFNMDCPNHGFKVGM
  KLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDSEYDQWVDCESPDIYPVGWCELTGYQ
  LQPPVAAEPATPLKAKEATKKKKKQFGKKRKRIPPTKTRPLRQGSKKPLLEDDPQGARKI
  SSEPVPGEIIAVRVKEEHLDVASPDKASSPELPVSVENIKQETDD

• Sequence length: 705

Pathways

KEGG:

Polycomb repressive complex

Reactome:

SUMOylation of chromatin organization proteins
Transcriptional Regulation by E2F6

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451, rs397507859, rs80359709, rs80359742, rs80359205, rs80357627, rs80357004, rs80357571, rs80357767, rs80357653, rs80358086, rs80357608, rs28897696, rs41293465, rs146650273, rs63751017, rs63750617, rs63750726, rs63750199, rs63749848, rs398122618, rs398122653, rs397509211, rs80357791, rs121912666, rs587778541, rs121908698, rs536907995, rs587781302, rs140342925, rs587781506, rs587782652, rs587782849, rs587783057, rs10520699, rs11852999, rs139770721, rs374950566, rs786202800, rs863224451, rs377153250, rs747727055, rs876658804, rs780001540, rs760815829, rs878854926, rs775248597, rs886040658, rs886040192, rs786203523, rs886040319, rs397508006, rs587782011, rs1060502772, rs1555461727, rs1553333072, rs1114167702, rs1257401983, rs886040950, rs1060502759, rs774684620, rs142947311, rs1555580883, rs748513310, rs376170600, rs863224499, rs1593909229, rs748453607, rs1294578913, rs1574737047, rs1593909960, rs2081922847, rs2082559544, rs2053694038	29059683
Medulloblastoma	Medulloblastoma, Childhood Medulloblastoma, Adult Medulloblastoma, Desmoplastic Medulloblastoma, Melanotic medulloblastoma	rs1589970134, rs587776578, rs587776579, rs17847577, rs111033171, rs80359604, rs80358785, rs80358814, rs863224925, rs1555950011, rs1554231278, rs926177767, rs759412460, rs1564032829, rs761911009	19270706

Unknown
Disease name	Disease term	dbSNP ID	References
Medullomyoblastoma	Medullomyoblastoma		19270706
Mental depression	Major Depressive Disorder	rs587778876, rs587778877	27479909, 29700475