INHBE (inhibin subunit beta E)

Gene

• Entrez ID: 83729
• Gene name: Inhibin subunit beta E
• Gene symbol: INHBE
• Synonyms: -
• Chromosome: 12
• Chromosome location: 12q13.3
• Summary: This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate an inhibin beta subunit. Inhibins have been implicated in regulating numerous cellular

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016770	hsa-miR-335-5p	Microarray	18185580
MIRT027405	hsa-miR-98-5p	Microarray	19088304
MIRT739666	hsa-miR-1470	CLIP-seq
MIRT1066651	hsa-miR-1827	CLIP-seq
MIRT1066652	hsa-miR-3148	CLIP-seq
MIRT1066653	hsa-miR-3153	CLIP-seq
MIRT1066654	hsa-miR-3178	CLIP-seq
MIRT1066655	hsa-miR-331-3p	CLIP-seq
MIRT1066656	hsa-miR-335	CLIP-seq
MIRT1066657	hsa-miR-3647-3p	CLIP-seq
MIRT1066658	hsa-miR-3672	CLIP-seq
MIRT1066659	hsa-miR-3926	CLIP-seq
MIRT1066660	hsa-miR-3929	CLIP-seq
MIRT1066661	hsa-miR-423-3p	CLIP-seq
MIRT1066662	hsa-miR-4292	CLIP-seq
MIRT739670	hsa-miR-4297	CLIP-seq
MIRT1066663	hsa-miR-4299	CLIP-seq
MIRT1066664	hsa-miR-4419b	CLIP-seq
MIRT1066665	hsa-miR-4421	CLIP-seq
MIRT1066666	hsa-miR-4461	CLIP-seq
MIRT739667	hsa-miR-4469	CLIP-seq
MIRT1066667	hsa-miR-4478	CLIP-seq
MIRT1066668	hsa-miR-4646-5p	CLIP-seq
MIRT1066669	hsa-miR-4649-3p	CLIP-seq
MIRT739665	hsa-miR-4667-3p	CLIP-seq
MIRT1066670	hsa-miR-4668-5p	CLIP-seq
MIRT739668	hsa-miR-4768-5p	CLIP-seq
MIRT1066671	hsa-miR-4775	CLIP-seq
MIRT1066672	hsa-miR-4786-5p	CLIP-seq
MIRT1066673	hsa-miR-4793-5p	CLIP-seq
MIRT1066674	hsa-miR-4795-3p	CLIP-seq
MIRT1066675	hsa-miR-485-5p	CLIP-seq
MIRT1066676	hsa-miR-508-5p	CLIP-seq
MIRT1066677	hsa-miR-542-3p	CLIP-seq
MIRT1066678	hsa-miR-548aa	CLIP-seq
MIRT1066679	hsa-miR-548ac	CLIP-seq
MIRT1066680	hsa-miR-548d-3p	CLIP-seq
MIRT1066681	hsa-miR-548s	CLIP-seq
MIRT1066682	hsa-miR-548z	CLIP-seq
MIRT1066683	hsa-miR-566	CLIP-seq
MIRT1066684	hsa-miR-590-3p	CLIP-seq
MIRT739669	hsa-miR-642a	CLIP-seq
MIRT1066685	hsa-miR-653	CLIP-seq
MIRT1066686	hsa-miR-766	CLIP-seq
MIRT1066687	hsa-miR-769-5p	CLIP-seq
MIRT2015990	hsa-miR-187	CLIP-seq
MIRT2015991	hsa-miR-298	CLIP-seq
MIRT1066653	hsa-miR-3153	CLIP-seq
MIRT2015992	hsa-miR-34b	CLIP-seq
MIRT2015993	hsa-miR-3614-5p	CLIP-seq
MIRT1066660	hsa-miR-3929	CLIP-seq
MIRT1066661	hsa-miR-423-3p	CLIP-seq
MIRT1066664	hsa-miR-4419b	CLIP-seq
MIRT1066667	hsa-miR-4478	CLIP-seq
MIRT1066668	hsa-miR-4646-5p	CLIP-seq
MIRT1066670	hsa-miR-4668-5p	CLIP-seq
MIRT2015994	hsa-miR-4768-3p	CLIP-seq
MIRT1066675	hsa-miR-485-5p	CLIP-seq
MIRT2015995	hsa-miR-597	CLIP-seq
MIRT2015996	hsa-miR-665	CLIP-seq
MIRT2248467	hsa-miR-106a	CLIP-seq
MIRT2248468	hsa-miR-106b	CLIP-seq
MIRT2248469	hsa-miR-1324	CLIP-seq
MIRT2248470	hsa-miR-17	CLIP-seq
MIRT1066651	hsa-miR-1827	CLIP-seq
MIRT2248471	hsa-miR-20a	CLIP-seq
MIRT2248472	hsa-miR-20b	CLIP-seq
MIRT2248473	hsa-miR-24	CLIP-seq
MIRT2015991	hsa-miR-298	CLIP-seq
MIRT1066654	hsa-miR-3178	CLIP-seq
MIRT2015992	hsa-miR-34b	CLIP-seq
MIRT2015993	hsa-miR-3614-5p	CLIP-seq
MIRT2248474	hsa-miR-371b-3p	CLIP-seq
MIRT1066660	hsa-miR-3929	CLIP-seq
MIRT2248475	hsa-miR-4284	CLIP-seq
MIRT2248476	hsa-miR-4330	CLIP-seq
MIRT1066664	hsa-miR-4419b	CLIP-seq
MIRT1066667	hsa-miR-4478	CLIP-seq
MIRT2248477	hsa-miR-4641	CLIP-seq
MIRT1066669	hsa-miR-4649-3p	CLIP-seq
MIRT2248478	hsa-miR-4755-3p	CLIP-seq
MIRT2015994	hsa-miR-4768-3p	CLIP-seq
MIRT1066675	hsa-miR-485-5p	CLIP-seq
MIRT2248479	hsa-miR-519d	CLIP-seq
MIRT2248480	hsa-miR-548l	CLIP-seq
MIRT1066683	hsa-miR-566	CLIP-seq
MIRT2015996	hsa-miR-665	CLIP-seq
MIRT2248481	hsa-miR-93	CLIP-seq
MIRT2451865	hsa-miR-2115	CLIP-seq
MIRT2451866	hsa-miR-4686	CLIP-seq
MIRT2451867	hsa-miR-4691-5p	CLIP-seq
MIRT2451868	hsa-miR-516a-3p	CLIP-seq
MIRT1066651	hsa-miR-1827	CLIP-seq
MIRT2015991	hsa-miR-298	CLIP-seq
MIRT2552003	hsa-miR-3150a-5p	CLIP-seq
MIRT2552004	hsa-miR-3150b-5p	CLIP-seq
MIRT1066654	hsa-miR-3178	CLIP-seq
MIRT1066659	hsa-miR-3926	CLIP-seq
MIRT1066660	hsa-miR-3929	CLIP-seq
MIRT1066661	hsa-miR-423-3p	CLIP-seq
MIRT1066664	hsa-miR-4419b	CLIP-seq
MIRT2552005	hsa-miR-4460	CLIP-seq
MIRT1066667	hsa-miR-4478	CLIP-seq
MIRT1066669	hsa-miR-4649-3p	CLIP-seq
MIRT2552006	hsa-miR-4727-3p	CLIP-seq
MIRT1066672	hsa-miR-4786-5p	CLIP-seq
MIRT1066673	hsa-miR-4793-5p	CLIP-seq
MIRT1066675	hsa-miR-485-5p	CLIP-seq
MIRT1066681	hsa-miR-548s	CLIP-seq
MIRT1066683	hsa-miR-566	CLIP-seq
MIRT1066685	hsa-miR-653	CLIP-seq
MIRT1066687	hsa-miR-769-5p	CLIP-seq
MIRT1066651	hsa-miR-1827	CLIP-seq
MIRT2552003	hsa-miR-3150a-5p	CLIP-seq
MIRT2552004	hsa-miR-3150b-5p	CLIP-seq
MIRT1066654	hsa-miR-3178	CLIP-seq
MIRT1066660	hsa-miR-3929	CLIP-seq
MIRT1066661	hsa-miR-423-3p	CLIP-seq
MIRT1066664	hsa-miR-4419b	CLIP-seq
MIRT1066667	hsa-miR-4478	CLIP-seq
MIRT1066669	hsa-miR-4649-3p	CLIP-seq
MIRT2552006	hsa-miR-4727-3p	CLIP-seq
MIRT1066675	hsa-miR-485-5p	CLIP-seq
MIRT1066683	hsa-miR-566	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005125	Function	Cytokine activity	IBA	21873635
GO:0005179	Function	Hormone activity	IEA
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0008083	Function	Growth factor activity	IEA
GO:0010862	Process	Positive regulation of pathway-restricted SMAD protein phosphorylation	IBA	21873635
GO:0060395	Process	SMAD protein signal transduction	IBA	21873635
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	25037231

Other IDs

• MIM: 612031
• HGNC: 24029
• e!Ensembl: ENSG00000139269

Protein

• UniProt ID: P58166
• Protein name: Inhibin beta E chain (Activin beta-E chain)
• Protein function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonad
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00019	TGF_beta	246 → 349	Transforming growth factor beta like domain	Domain

• Sequence:

  MRLPDVQLWLVLLWALVRAQGTGSVCPSCGGSKLAPQAERALVLELAKQQILDGLHLTSR
  PRITHPPPQAALTRALRRLQPGSVAPGNGEEVISFATVTDSTSAYSSLLTFHLSTPRSHH
  LYHARLWLHVLPTLPGTLCLRIFRWGPRRRRQGSRTLLAEHHITNLGWHTLTLPSSGLRG
  EKSGVLKLQLDCRPLEGNSTVTGQPRRLLDTAGHQQPFLELKIRANEPGAGRARRRTPTC
  EPATPLCCRRDHYVDFQELGWRDWILQPEGYQLNYCSGQCPPHLAGSPGIAASFHSAVFS
  LLKANNPWPASTSCCVPTARRPLSLLYLDHNGNVVKTDVPDMVVEACGCS

• Sequence length: 350

Pathways

KEGG:

Cytokine-cytokine receptor interaction
TGF-beta signaling pathway
Signaling pathways regulating pluripotency of stem cells

Reactome:

Glycoprotein hormones

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243

Unknown
Disease name	Disease term	dbSNP ID	References
Gout	Gout		23263486
Gouty arthritis	Arthritis, Gouty		23263486
Lipoidosis	Lipoidosis		17175557