RASSF5 (Ras association domain family member 5)

Gene

• Entrez ID: 83593
• Gene name: Ras association domain family member 5
• Gene symbol: RASSF5
• Synonyms: Maxp1, NORE1, NORE1A, NORE1B, RAPL, RASSF3
• Chromosome: 1
• Chromosome location: 1q32.1
• Summary: This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras,

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT002619	hsa-miR-124-3p	Microarray	15685193
MIRT017885	hsa-miR-335-5p	Microarray	18185580
MIRT002619	hsa-miR-124-3p	Microarray	15685193
MIRT002619	hsa-miR-124-3p	Microarray	18668037
MIRT023792	hsa-miR-1-3p	Microarray	18668037
MIRT041417	hsa-miR-193b-3p	CLASH	23622248
MIRT036802	hsa-miR-374b-5p	CLASH	23622248
MIRT132734	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT132744	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT132735	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT132746	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT132676	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT132677	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT1292927	hsa-miR-103a	CLIP-seq
MIRT1292928	hsa-miR-107	CLIP-seq
MIRT1292929	hsa-miR-1179	CLIP-seq
MIRT1292930	hsa-miR-1321	CLIP-seq
MIRT1292931	hsa-miR-15a	CLIP-seq
MIRT1292932	hsa-miR-15b	CLIP-seq
MIRT1292933	hsa-miR-16	CLIP-seq
MIRT1292934	hsa-miR-195	CLIP-seq
MIRT1292935	hsa-miR-1976	CLIP-seq
MIRT1292936	hsa-miR-214	CLIP-seq
MIRT1292937	hsa-miR-27a	CLIP-seq
MIRT1292938	hsa-miR-27b	CLIP-seq
MIRT1292939	hsa-miR-3163	CLIP-seq
MIRT1292940	hsa-miR-3176	CLIP-seq
MIRT1292941	hsa-miR-3613-3p	CLIP-seq
MIRT1292942	hsa-miR-3619-5p	CLIP-seq
MIRT1292943	hsa-miR-371-5p	CLIP-seq
MIRT1292944	hsa-miR-371b-5p	CLIP-seq
MIRT1292945	hsa-miR-3922-3p	CLIP-seq
MIRT1292946	hsa-miR-424	CLIP-seq
MIRT1292947	hsa-miR-4291	CLIP-seq
MIRT1292948	hsa-miR-4310	CLIP-seq
MIRT1292949	hsa-miR-4312	CLIP-seq
MIRT1292950	hsa-miR-4419a	CLIP-seq
MIRT1292951	hsa-miR-4453	CLIP-seq
MIRT1292952	hsa-miR-4510	CLIP-seq
MIRT1292953	hsa-miR-4520a-3p	CLIP-seq
MIRT1292954	hsa-miR-4520b-3p	CLIP-seq
MIRT1292955	hsa-miR-4538	CLIP-seq
MIRT1292956	hsa-miR-4724-5p	CLIP-seq
MIRT1292957	hsa-miR-4739	CLIP-seq
MIRT1292958	hsa-miR-4756-5p	CLIP-seq
MIRT1292959	hsa-miR-4768-5p	CLIP-seq
MIRT1292960	hsa-miR-497	CLIP-seq
MIRT1292961	hsa-miR-513a-5p	CLIP-seq
MIRT1292962	hsa-miR-513c	CLIP-seq
MIRT1292963	hsa-miR-514b-5p	CLIP-seq
MIRT1292964	hsa-miR-761	CLIP-seq
MIRT1292965	hsa-miR-922	CLIP-seq
MIRT1292966	hsa-miR-122	CLIP-seq
MIRT1292967	hsa-miR-1237	CLIP-seq
MIRT1292968	hsa-miR-1248	CLIP-seq
MIRT1292969	hsa-miR-3130-3p	CLIP-seq
MIRT1292970	hsa-miR-4287	CLIP-seq
MIRT1292971	hsa-miR-4469	CLIP-seq
MIRT1292972	hsa-miR-4685-3p	CLIP-seq
MIRT1292973	hsa-miR-4713-5p	CLIP-seq
MIRT1292974	hsa-miR-4793-3p	CLIP-seq
MIRT1292975	hsa-miR-642a	CLIP-seq
MIRT2311896	hsa-miR-185	CLIP-seq
MIRT1292936	hsa-miR-214	CLIP-seq
MIRT2311897	hsa-miR-3120-3p	CLIP-seq
MIRT1292942	hsa-miR-3619-5p	CLIP-seq
MIRT2311898	hsa-miR-4269	CLIP-seq
MIRT2311899	hsa-miR-4270	CLIP-seq
MIRT2311900	hsa-miR-4306	CLIP-seq
MIRT2311901	hsa-miR-4441	CLIP-seq
MIRT2311902	hsa-miR-4644	CLIP-seq
MIRT2311903	hsa-miR-532-5p	CLIP-seq
MIRT1292964	hsa-miR-761	CLIP-seq
MIRT2393512	hsa-miR-326	CLIP-seq
MIRT2393513	hsa-miR-330-5p	CLIP-seq
MIRT2311896	hsa-miR-185	CLIP-seq
MIRT1292936	hsa-miR-214	CLIP-seq
MIRT2311897	hsa-miR-3120-3p	CLIP-seq
MIRT1292942	hsa-miR-3619-5p	CLIP-seq
MIRT2442548	hsa-miR-4263	CLIP-seq
MIRT2311899	hsa-miR-4270	CLIP-seq
MIRT2311900	hsa-miR-4306	CLIP-seq
MIRT2311901	hsa-miR-4441	CLIP-seq
MIRT2442549	hsa-miR-4509	CLIP-seq
MIRT2311902	hsa-miR-4644	CLIP-seq
MIRT2442550	hsa-miR-4744	CLIP-seq
MIRT2442551	hsa-miR-4799-5p	CLIP-seq
MIRT2442552	hsa-miR-576-5p	CLIP-seq
MIRT1292964	hsa-miR-761	CLIP-seq
MIRT2457802	hsa-miR-129-5p	CLIP-seq
MIRT2457803	hsa-miR-3119	CLIP-seq
MIRT2457804	hsa-miR-4438	CLIP-seq
MIRT2457805	hsa-miR-450b-5p	CLIP-seq
MIRT2457806	hsa-miR-507	CLIP-seq
MIRT2457807	hsa-miR-512-5p	CLIP-seq
MIRT2457808	hsa-miR-557	CLIP-seq
MIRT2457809	hsa-miR-661	CLIP-seq
MIRT2457807	hsa-miR-512-5p	CLIP-seq
MIRT2457809	hsa-miR-661	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	9488663, 15109305, 18596699, 20562859, 21988832, 23455922, 24255178, 24366813, 24981860, 25416956, 25502805, 31515488
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005737	Component	Cytoplasm	IEA
GO:0005874	Component	Microtubule	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0007165	Process	Signal transduction	IBA	21873635
GO:0008285	Process	Negative regulation of cell population proliferation	IEA
GO:0031398	Process	Positive regulation of protein ubiquitination	IEA
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0042981	Process	Regulation of apoptotic process	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:1900180	Process	Regulation of protein localization to nucleus	IEA

Other IDs

• MIM: 607020
• HGNC: 17609
• e!Ensembl: ENSG00000266094

Protein

• UniProt ID: Q8WWW0
• Protein name: Ras association domain-containing protein 5 (New ras effector 1) (Regulator for cell adhesion and polarization enriched in lymphoid tissues) (RAPL)
• Protein function: Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distributio
• PDB: 4LGD, 4OH8
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00130	C1_1	123 → 173	Phorbol esters/diacylglycerol binding domain (C1 domain)	Domain
  PF00788	RA	274 → 364	Ras association (RalGDS/AF-6) domain	Domain
  PF16517	Nore1-SARAH	371 → 410	Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain	Domain

• Sequence:

  MAMASPAIGQRPYPLLLDPEPPRYLQSLSGPELPPPPPDRSSRLCVPAPLSTAPGAREGR
  SARRAARGNLEPPPRASRPARPLRPGLQQRLRRRPGAPRPRDVRSIFEQPQDPRVPAERG
  EGHCFAELVLPGGPGWCDLCGREVLRQALRCTNCKFTCHPECRSLIQLDCSQQEGLSRDR
  PSPESTLTVTFSQNVCKPVEETQRPPTLQEIKQKIDSYNTREKNCLGMKLSEDGTYTGFI
  KVHLKLRRPVTVPAGIRPQSIYDAIKEVNLAATTDKRTSFYLPLDAIKQLHISSTTTVSE
  VIQGLLKKFMVVDNPQKFALFKRIHKDGQVLFQKLSIADRPLYLRLLAGPDTEVLSFVLK
  ENETGEVEWDAFSIPELQNFLTILEKEEQDKIQQVQKKYDKFRQKLEEALRESQGKPG

• Sequence length: 418

Pathways

KEGG:

Ras signaling pathway
Rap1 signaling pathway
Cellular senescence
Leukocyte transendothelial migration
Pathways in cancer
Non-small cell lung cancer

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Autism	Autistic Disorder	rs121964908, rs121912597, rs2710102, rs7794745, rs142990298, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699, rs1553510219, rs1684182454, rs1559060428, rs1553510677, rs1576352885, rs1574152522, rs1574152672, rs1696658542, rs1751123722, rs1750373491, rs1751075634	22843504
Neuroblastoma	Neuroblastoma	rs121908161, rs113994087, rs113994089, rs281864719, rs863225285, rs863225284, rs863225283, rs281864720, rs863225282, rs863225281, rs1057519698, rs915983602, rs1469271544	18452173

Unknown
Disease name	Disease term	dbSNP ID	References
Kidney neoplasm	Kidney Neoplasm		25217643
Kidney cancer	Malignant neoplasm of kidney		25217643