NUF2 (NUF2 component of NDC80 kinetochore complex)

Gene

• Entrez ID: 83540
• Gene name: NUF2 component of NDC80 kinetochore complex
• Gene symbol: NUF2
• Synonyms: CDCA1, CT106, NUF2R
• Chromosome: 1
• Chromosome location: 1q23.3
• Summary: This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the sp

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024606	hsa-miR-215-5p	Microarray	19074876
MIRT026247	hsa-miR-192-5p	Microarray	19074876
MIRT046921	hsa-miR-221-3p	CLASH	23622248
MIRT1198401	hsa-miR-22	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000775	Component	Chromosome, centromeric region	NAS	11266451
GO:0000776	Component	Kinetochore	IDA
GO:0000778	Component	Condensed nuclear chromosome kinetochore	IBA	21873635
GO:0003674	Function	Molecular_function	ND
GO:0005515	Function	Protein binding	IPI	14699129, 15961401, 17129783, 17535814, 20360068, 22581055, 24981860, 25416956, 26068854, 26496610
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0007052	Process	Mitotic spindle organization	IBA	21873635
GO:0007059	Process	Chromosome segregation	NAS	11266451
GO:0016020	Component	Membrane	HDA	19946888
GO:0031262	Component	Ndc80 complex	IBA	21873635
GO:0031262	Component	Ndc80 complex	IDA	14699129
GO:0044877	Function	Protein-containing complex binding	IBA	21873635
GO:0045132	Process	Meiotic chromosome segregation	IBA	21873635
GO:0051301	Process	Cell division	IEA
GO:0051315	Process	Attachment of mitotic spindle microtubules to kinetochore	IBA	21873635
GO:0051383	Process	Kinetochore organization	IBA	21873635

Other IDs

• MIM: 611772
• HGNC: 14621
• e!Ensembl: ENSG00000143228

Protein

• UniProt ID: Q9BZD4
• Protein name: Kinetochore protein Nuf2 (hNuf2) (hNuf2R) (hsNuf2) (Cell division cycle-associated protein 1)
• Protein function: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12438418, PubMed:14654001, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:
• PDB: 2VE7, 3IZ0, 8G0P
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03800	Nuf2	3 → 146	Nuf2 family	Family

• Sequence:

  METLSFPRYNVAEIVIHIRNKILTGADGKNLTKNDLYPNPKPEVLHMIYMRALQIVYGIR
  LEHFYMMPVNSEVMYPHLMEGFLPFSNLVTHLDSFLPICRVNDFETADILCPKAKRTSRF
  LSGIINFIHFREACRETYMEFLWQYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEF
  KQLSDGIQELQQSLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESL
  KTKIVDSPEKLKNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKI
  QDLSDNREKLASILKESLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKIN
  KKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQ
  EIFLNLKTALEKYHDGIEKAAEDSYAKIDEKTAELKRKMFKMST

• Sequence length: 464

Pathways

Reactome:

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation

Associated diseases

Unknown
Disease name	Disease term	dbSNP ID	References
Liver carcinoma	Liver carcinoma		28284560