KATNAL2 (katanin catalytic subunit A1 like 2)

Gene

• Entrez ID: 83473
• Gene name: Katanin catalytic subunit A1 like 2
• Gene symbol: KATNAL2
• Synonyms: -
• Chromosome: 18
• Chromosome location: 18q21.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1079191	hsa-miR-1206	CLIP-seq
MIRT1079192	hsa-miR-1207-3p	CLIP-seq
MIRT1079193	hsa-miR-1276	CLIP-seq
MIRT1079194	hsa-miR-1285	CLIP-seq
MIRT1079195	hsa-miR-1289	CLIP-seq
MIRT1079196	hsa-miR-203	CLIP-seq
MIRT1079197	hsa-miR-3154	CLIP-seq
MIRT1079198	hsa-miR-3187-5p	CLIP-seq
MIRT1079199	hsa-miR-3198	CLIP-seq
MIRT1079200	hsa-miR-34a	CLIP-seq
MIRT1079201	hsa-miR-34c-5p	CLIP-seq
MIRT1079202	hsa-miR-3647-3p	CLIP-seq
MIRT1079203	hsa-miR-3688-3p	CLIP-seq
MIRT1079204	hsa-miR-3978	CLIP-seq
MIRT1079205	hsa-miR-4282	CLIP-seq
MIRT1079206	hsa-miR-4294	CLIP-seq
MIRT1079207	hsa-miR-4309	CLIP-seq
MIRT1079208	hsa-miR-4311	CLIP-seq
MIRT1079209	hsa-miR-4435	CLIP-seq
MIRT1079210	hsa-miR-4436b-3p	CLIP-seq
MIRT1079211	hsa-miR-4474-3p	CLIP-seq
MIRT1079212	hsa-miR-449a	CLIP-seq
MIRT1079213	hsa-miR-449b	CLIP-seq
MIRT1079214	hsa-miR-4735-5p	CLIP-seq
MIRT1079215	hsa-miR-4802-5p	CLIP-seq
MIRT1079216	hsa-miR-515-3p	CLIP-seq
MIRT1079217	hsa-miR-519e	CLIP-seq
MIRT1079218	hsa-miR-548c-3p	CLIP-seq
MIRT1079219	hsa-miR-550a	CLIP-seq
MIRT1079220	hsa-miR-583	CLIP-seq
MIRT1079221	hsa-miR-587	CLIP-seq
MIRT1079222	hsa-miR-590-3p	CLIP-seq
MIRT1079223	hsa-miR-612	CLIP-seq
MIRT1079224	hsa-miR-663b	CLIP-seq
MIRT2251638	hsa-miR-4775	CLIP-seq
MIRT1079222	hsa-miR-590-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000922	Component	Spindle pole	IDA	26929214
GO:0005515	Function	Protein binding	IPI	25910212, 32296183
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	26929214
GO:0005819	Component	Spindle	IDA	26929214
GO:0005874	Component	Microtubule	IDA	26929214
GO:0008017	Function	Microtubule binding	IEA
GO:0008568	Function	Microtubule-severing ATPase activity	IBA	21873635
GO:0016853	Function	Isomerase activity	IEA
GO:0016887	Function	ATPase activity	IBA	21873635
GO:0031122	Process	Cytoplasmic microtubule organization	IBA	21873635
GO:0051013	Process	Microtubule severing	IEA

Other IDs

• MIM: 614697
• HGNC: 25387
• e!Ensembl: ENSG00000167216

Protein

• UniProt ID: Q8IYT4
• Protein name: Katanin p60 ATPase-containing subunit A-like 2 (Katanin p60 subunit A-like 2) (EC 5.6.1.1) (p60 katanin-like 2)
• Protein function: Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08513	LisH	27 → 53	LisH	Domain
  PF00004	AAA	290 → 422	ATPase family associated with various cellular activities (AAA)	Domain
  PF17862	AAA_lid_3	450 → 497	AAA+ lid domain	Domain

• Sequence:

  MELSYQTLKFTHQAREACEMRTEARRKNLLILISHYLTQEGYIDTANALEQETKLGLRRF
  EVCDNIDLETILMEYESYYFVKFQKYPKIVKKSSDTAENNLPQRSRGKTRRMMNDSCQNL
  PKINQQRPRSKTTAGKTGDTKSLNKEHPNQEVVDNTRLESANFGLHISRIRKDSGEENAH
  PRRGQIIDFQGLLTDAIKGATSELALNTFDHNPDPSERLLKPLSAFIGMNSEMRELAAVV
  SRDIYLHNPNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGILSPWKGLLLYGPPGTGK
  TLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMS
  QRGTASGGEHEGSLRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLRRLEKRILV
  DLPSREARQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKLVCREAAMRPV
  RKIFDALENHQSESSDLPRIQLDIVTTADFLDVLTHTKPSAKNLAQRYSDWQREFESV

• Sequence length: 538

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Neurodevelopmental disorders	Neurodevelopmental Disorders	rs869312846, rs869312840, rs869312848, rs869312849, rs869312845, rs886041956, rs1064795110, rs1555762734, rs1555764992, rs1568512728, rs1568532361, rs1595472741, rs1595472764, rs1595476797, rs1016320330, rs1595127294, rs1600392059	28191889
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	31374203