FCRL5 (Fc receptor like 5)

Gene

• Entrez ID: 83416
• Gene name: Fc receptor like 5
• Gene symbol: FCRL5
• Synonyms: BXMAS1, CD307, CD307e, FCRH5, IRTA2, PRO820
• Chromosome: 1
• Chromosome location: 1q23.1
• Summary: This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I mem

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT994168	hsa-miR-1243	CLIP-seq
MIRT994169	hsa-miR-1290	CLIP-seq
MIRT994170	hsa-miR-2115	CLIP-seq
MIRT994171	hsa-miR-3167	CLIP-seq
MIRT994172	hsa-miR-3202	CLIP-seq
MIRT994173	hsa-miR-3529	CLIP-seq
MIRT994174	hsa-miR-365	CLIP-seq
MIRT994175	hsa-miR-379	CLIP-seq
MIRT994176	hsa-miR-3927	CLIP-seq
MIRT994177	hsa-miR-4330	CLIP-seq
MIRT994178	hsa-miR-4438	CLIP-seq
MIRT994179	hsa-miR-4533	CLIP-seq
MIRT994180	hsa-miR-4633-5p	CLIP-seq
MIRT994181	hsa-miR-4643	CLIP-seq
MIRT994182	hsa-miR-4736	CLIP-seq
MIRT994183	hsa-miR-4766-5p	CLIP-seq
MIRT994184	hsa-miR-491-3p	CLIP-seq
MIRT994185	hsa-miR-548ae	CLIP-seq
MIRT994186	hsa-miR-548aj	CLIP-seq
MIRT994187	hsa-miR-548am	CLIP-seq
MIRT994188	hsa-miR-548q	CLIP-seq
MIRT994189	hsa-miR-548x	CLIP-seq
MIRT994190	hsa-miR-642b	CLIP-seq
MIRT994191	hsa-miR-876-5p	CLIP-seq
MIRT994192	hsa-miR-938	CLIP-seq
MIRT1994820	hsa-miR-1208	CLIP-seq
MIRT1994821	hsa-miR-1915	CLIP-seq
MIRT1994822	hsa-miR-3918	CLIP-seq
MIRT1994823	hsa-miR-4640-5p	CLIP-seq
MIRT1994824	hsa-miR-4685-5p	CLIP-seq
MIRT1994825	hsa-miR-4726-3p	CLIP-seq
MIRT1994826	hsa-miR-4726-5p	CLIP-seq
MIRT1994827	hsa-miR-548n	CLIP-seq
MIRT1994828	hsa-miR-548t	CLIP-seq
MIRT1994829	hsa-miR-595	CLIP-seq
MIRT2228944	hsa-miR-1184	CLIP-seq
MIRT2228945	hsa-miR-1205	CLIP-seq
MIRT2228946	hsa-miR-1245b-5p	CLIP-seq
MIRT2228947	hsa-miR-181a	CLIP-seq
MIRT2228948	hsa-miR-181b	CLIP-seq
MIRT2228949	hsa-miR-181c	CLIP-seq
MIRT2228950	hsa-miR-181d	CLIP-seq
MIRT2228951	hsa-miR-1972	CLIP-seq
MIRT2228952	hsa-miR-3142	CLIP-seq
MIRT2228953	hsa-miR-3156-5p	CLIP-seq
MIRT2228954	hsa-miR-3158-5p	CLIP-seq
MIRT2228955	hsa-miR-421	CLIP-seq
MIRT2228956	hsa-miR-4262	CLIP-seq
MIRT2228957	hsa-miR-4650-5p	CLIP-seq
MIRT2228958	hsa-miR-4709-5p	CLIP-seq
MIRT2228959	hsa-miR-545	CLIP-seq
MIRT2428861	hsa-miR-103a	CLIP-seq
MIRT2428862	hsa-miR-107	CLIP-seq
MIRT2428863	hsa-miR-15a	CLIP-seq
MIRT2428864	hsa-miR-15b	CLIP-seq
MIRT2428865	hsa-miR-16	CLIP-seq
MIRT1994821	hsa-miR-1915	CLIP-seq
MIRT2428866	hsa-miR-195	CLIP-seq
MIRT2428867	hsa-miR-324-5p	CLIP-seq
MIRT1994822	hsa-miR-3918	CLIP-seq
MIRT2428868	hsa-miR-424	CLIP-seq
MIRT2428869	hsa-miR-4310	CLIP-seq
MIRT2428870	hsa-miR-4530	CLIP-seq
MIRT1994823	hsa-miR-4640-5p	CLIP-seq
MIRT1994824	hsa-miR-4685-5p	CLIP-seq
MIRT2428871	hsa-miR-4711-5p	CLIP-seq
MIRT1994825	hsa-miR-4726-3p	CLIP-seq
MIRT1994826	hsa-miR-4726-5p	CLIP-seq
MIRT2428872	hsa-miR-497	CLIP-seq
MIRT2442163	hsa-miR-146b-3p	CLIP-seq
MIRT2442164	hsa-miR-3194-5p	CLIP-seq
MIRT2442165	hsa-miR-4260	CLIP-seq
MIRT2442166	hsa-miR-486-3p	CLIP-seq
MIRT2442167	hsa-miR-922	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004888	Function	Transmembrane signaling receptor activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0007166	Process	Cell surface receptor signaling pathway	IBA	21873635
GO:0009986	Component	Cell surface	IDA	16849395
GO:0043235	Component	Receptor complex	IDA	23382219

Other IDs

• MIM: 605877
• HGNC: 18508
• e!Ensembl: ENSG00000143297

Protein

• UniProt ID: Q96RD9
• Protein name: Fc receptor-like protein 5 (FcR-like protein 5) (FcRL5) (BXMAS1) (Fc receptor homolog 5) (FcRH5) (Immune receptor translocation-associated protein 2) (CD antigen CD307e)
• Protein function: Plays an important role in B-cell response to antigen that acts both as a negative or positive coreceptor. Inhibits B-cell receptor (BCR) signaling in the absence of CR2 stimulation but engagement with CR2 and the BCR lead to a superior calcium
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13895	Ig_2	22 → 100	Immunoglobulin domain	Domain
  PF13895	Ig_2	104 → 185	Immunoglobulin domain	Domain
  PF13895	Ig_2	286 → 373	Immunoglobulin domain	Domain
  PF13895	Ig_2	379 → 466	Immunoglobulin domain	Domain
  PF13895	Ig_2	472 → 559	Immunoglobulin domain	Domain
  PF13895	Ig_2	565 → 652	Immunoglobulin domain	Domain
  PF13895	Ig_2	751 → 837	Immunoglobulin domain	Domain

• Sequence:

  MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHR
  YLGKEILRETPDNILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSVFEGDSVV
  LRCRAKAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNT
  VKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWS
  LSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFE
  GTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLTTENSGNYYCTADNG
  LGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAA
  LERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSA
  EALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYY
  CTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWF
  YHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPI
  LTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTE
  HSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSP
  LILYRFFHEDVTLGNRSSPSGGASLNLSLTAEHSGNYSCEADNGLGAQRSETVTLYITGL
  TANRSGPFATGVAGGLLSIAGLAAGALLLYCWLSRKAGRKPASDPARSPSDSDSQEPTYH
  NVPAWEELQPVYTNANPRGENVVYSEVRIIQEKKKHAVASDPRHLRNKGSPIIYSEVKVA
  STPVSGSLFLASSAPHR

• Sequence length: 977

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243