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CAPNS1 (calpain small subunit 1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
826
Gene nameGene Name - the full gene name approved by the HGNC.
Calpain small subunit 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
CAPNS1
SynonymsGene synonyms aliases
CALPAIN4, CANP, CANPS, CAPN4, CDPS, CSS1, PPH6
ChromosomeChromosome number
19
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19q13.12
SummarySummary of gene provided in NCBI Entrez Gene.
This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subun
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT023039 hsa-miR-124-3p Microarray 18668037
MIRT048635 hsa-miR-99a-5p CLASH 23622248
MIRT048473 hsa-miR-100-5p CLASH 23622248
MIRT047067 hsa-miR-183-5p CLASH 23622248
MIRT047067 hsa-miR-183-5p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
NRF1 Activation 18234454
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004198 Function Calcium-dependent cysteine-type endopeptidase activity IDA 17646163
GO:0005509 Function Calcium ion binding IEA
GO:0005515 Function Protein binding IPI 10639123, 18519038, 18761085, 25416956, 27173435, 28319173
GO:0005829 Component Cytosol IDA 14559243
GO:0005829 Component Cytosol TAS
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P04632
Protein name Calpain small subunit 1 (CSS1) (Calcium-activated neutral proteinase small subunit) (CANP small subunit) (Calcium-dependent protease small subunit) (CDPS) (Calcium-dependent protease small subunit 1) (Calpain regulatory subunit)
Protein function Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Essential for embryonic development (By similarity). {ECO:000
PDB 1KFU , 1KFX , 4PHJ , 4PHK , 4PHM , 4WQ2 , 4WQ3 , 5D69 , 6QLB
Family and domains
Sequence
MFLVNSFLKGGGGGGGGGGGLGGGLGNVLGGLISGAGGGGGGGGGGGGGGGGGGGGTAMR
ILGGVISAISEAAAQYNPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATEL
MNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQ
FDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMF
RAFKSLDKDGTGQIQVNIQEWLQLTMYS
Sequence length 268
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Shigellosis   Degradation of the extracellular matrix
Formation of the cornified envelope
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 17013881
Unknown
Disease name Disease term dbSNP ID References
Prostatic neoplasms Prostatic Neoplasms 17013881

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