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CANX (calnexin)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
821
Gene nameGene Name - the full gene name approved by the HGNC.
Calnexin
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
CANX
SynonymsGene synonyms aliases
CNX, IP90, P90
ChromosomeChromosome number
5
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q35.3
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating prote
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT050869 hsa-miR-17-5p CLASH 23622248
MIRT050692 hsa-miR-18a-5p CLASH 23622248
MIRT048231 hsa-miR-196a-5p CLASH 23622248
MIRT046689 hsa-miR-222-3p CLASH 23622248
MIRT045334 hsa-miR-185-5p CLASH 23622248
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002474 Process Antigen processing and presentation of peptide antigen via MHC class I TAS
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0005509 Function Calcium ion binding IBA 21873635
GO:0005515 Function Protein binding IPI 16361248, 16546175, 17110338, 17220478, 17380188, 20528919, 21205830, 22190034, 22314232, 22872700, 23826168, 24764305, 25170080, 26496610, 28514442, 29568061, 29765154, 29924966, 31735293
GO:0005783 Component Endoplasmic reticulum IDA 14966132, 18458083, 21190736, 22572157, 23826168, 24263861, 24454821, 30188326
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P27824
Protein name Calnexin (IP90) (Major histocompatibility complex class I antigen-binding protein p88) (p90)
Protein function Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems t
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00262 Calreticulin
71 440
Calreticulin family
Family
Sequence
Sequence length 592
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Protein processing in endoplasmic reticulum
Phagosome
Antigen processing and presentation
Thyroid hormone synthesis
Human T-cell leukemia virus 1 infection
  Assembly of Viral Components at the Budding Site
MHC class II antigen presentation
Interleukin-35 Signalling
Calnexin/calreticulin cycle
Interleukin-27 signaling
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Associated diseases
Unknown
Disease name Disease term dbSNP ID References
Myocardial ischemia Myocardial Ischemia 16214533

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