Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
821 |
Gene nameGene Name - the full gene name approved by the HGNC.
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Calnexin |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
CANX |
SynonymsGene synonyms aliases
|
CNX, IP90, P90 |
ChromosomeChromosome number
|
5 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
5q35.3 |
SummarySummary of gene provided in NCBI Entrez Gene.
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This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating prote |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0002474 |
Process |
Antigen processing and presentation of peptide antigen via MHC class I |
TAS |
|
GO:0003723 |
Function |
RNA binding |
HDA |
22658674, 22681889 |
GO:0005509 |
Function |
Calcium ion binding |
IBA |
21873635 |
GO:0005515 |
Function |
Protein binding |
IPI |
16361248, 16546175, 17110338, 17220478, 17380188, 20528919, 21205830, 22190034, 22314232, 22872700, 23826168, 24764305, 25170080, 26496610, 28514442, 29568061, 29765154, 29924966, 31735293 |
GO:0005783 |
Component |
Endoplasmic reticulum |
IDA |
14966132, 18458083, 21190736, 22572157, 23826168, 24263861, 24454821, 30188326 |
GO:0005788 |
Component |
Endoplasmic reticulum lumen |
TAS |
|
GO:0005789 |
Component |
Endoplasmic reticulum membrane |
IBA |
21873635 |
GO:0005789 |
Component |
Endoplasmic reticulum membrane |
IDA |
19723497, 20531390, 23814182 |
GO:0006457 |
Process |
Protein folding |
IBA |
21873635 |
GO:0006457 |
Process |
Protein folding |
TAS |
|
GO:0009306 |
Process |
Protein secretion |
TAS |
8055875 |
GO:0016020 |
Component |
Membrane |
HDA |
19946888 |
GO:0016032 |
Process |
Viral process |
IEA |
|
GO:0019886 |
Process |
Antigen processing and presentation of exogenous peptide antigen via MHC class II |
TAS |
|
GO:0030246 |
Function |
Carbohydrate binding |
IEA |
|
GO:0030968 |
Process |
Endoplasmic reticulum unfolded protein response |
IBA |
21873635 |
GO:0034975 |
Process |
Protein folding in endoplasmic reticulum |
TAS |
22013210 |
GO:0042470 |
Component |
Melanosome |
IEA |
|
GO:0044233 |
Component |
Mitochondria-associated endoplasmic reticulum membrane |
IDA |
23455425 |
GO:0048488 |
Process |
Synaptic vesicle endocytosis |
ISS |
|
GO:0051082 |
Function |
Unfolded protein binding |
IEA |
|
GO:0070062 |
Component |
Extracellular exosome |
HDA |
23533145 |
GO:0070062 |
Component |
Extracellular exosome |
IDA |
21235781 |
GO:0070106 |
Process |
Interleukin-27-mediated signaling pathway |
TAS |
|
GO:0070757 |
Process |
Interleukin-35-mediated signaling pathway |
TAS |
|
GO:0071556 |
Component |
Integral component of lumenal side of endoplasmic reticulum membrane |
TAS |
|
GO:0072583 |
Process |
Clathrin-dependent endocytosis |
ISS |
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GO:0098793 |
Component |
Presynapse |
IEA |
|
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
P27824 |
Protein name |
Calnexin (IP90) (Major histocompatibility complex class I antigen-binding protein p88) (p90) |
Protein function |
Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems t |
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00262 |
Calreticulin |
71 → 440 |
Calreticulin family |
Family |
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Sequence |
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Sequence length |
592 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Myocardial ischemia |
Myocardial Ischemia |
|
16214533 |
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