TLR10 (toll like receptor 10)

Gene

• Entrez ID: 81793
• Gene name: Toll like receptor 10
• Gene symbol: TLR10
• Synonyms: CD290
• Chromosome: 4
• Chromosome location: 4p14
• Summary: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and func

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT049221	hsa-miR-92a-3p	CLASH	23622248
MIRT1426877	hsa-miR-1193	CLIP-seq
MIRT1426878	hsa-miR-122	CLIP-seq
MIRT1426879	hsa-miR-1226	CLIP-seq
MIRT1426880	hsa-miR-1273f	CLIP-seq
MIRT1426881	hsa-miR-1289	CLIP-seq
MIRT1426882	hsa-miR-143	CLIP-seq
MIRT1426883	hsa-miR-197	CLIP-seq
MIRT1426884	hsa-miR-2392	CLIP-seq
MIRT1426885	hsa-miR-3135b	CLIP-seq
MIRT1426886	hsa-miR-3149	CLIP-seq
MIRT1426887	hsa-miR-3163	CLIP-seq
MIRT1426888	hsa-miR-3187-3p	CLIP-seq
MIRT1426889	hsa-miR-3198	CLIP-seq
MIRT1426890	hsa-miR-340	CLIP-seq
MIRT1426891	hsa-miR-3652	CLIP-seq
MIRT1426892	hsa-miR-411	CLIP-seq
MIRT1426893	hsa-miR-4294	CLIP-seq
MIRT1426894	hsa-miR-4307	CLIP-seq
MIRT1426895	hsa-miR-4309	CLIP-seq
MIRT1426896	hsa-miR-4430	CLIP-seq
MIRT1426897	hsa-miR-4435	CLIP-seq
MIRT1426898	hsa-miR-4470	CLIP-seq
MIRT1426899	hsa-miR-450b-5p	CLIP-seq
MIRT1426900	hsa-miR-4534	CLIP-seq
MIRT1426901	hsa-miR-4695-3p	CLIP-seq
MIRT1426902	hsa-miR-4701-5p	CLIP-seq
MIRT1426903	hsa-miR-4708-5p	CLIP-seq
MIRT1426904	hsa-miR-4715-3p	CLIP-seq
MIRT1426905	hsa-miR-4716-5p	CLIP-seq
MIRT1426906	hsa-miR-4733-3p	CLIP-seq
MIRT1426907	hsa-miR-4770	CLIP-seq
MIRT1426908	hsa-miR-4772-3p	CLIP-seq
MIRT1426909	hsa-miR-4781-3p	CLIP-seq
MIRT1426910	hsa-miR-507	CLIP-seq
MIRT1426911	hsa-miR-5096	CLIP-seq
MIRT1426912	hsa-miR-548aa	CLIP-seq
MIRT1426913	hsa-miR-548ac	CLIP-seq
MIRT1426914	hsa-miR-548d-3p	CLIP-seq
MIRT1426915	hsa-miR-548s	CLIP-seq
MIRT1426916	hsa-miR-548z	CLIP-seq
MIRT1426917	hsa-miR-557	CLIP-seq
MIRT1426918	hsa-miR-587	CLIP-seq
MIRT1426919	hsa-miR-588	CLIP-seq
MIRT1426920	hsa-miR-720	CLIP-seq
MIRT1426921	hsa-miR-767-5p	CLIP-seq
MIRT1426922	hsa-miR-891b	CLIP-seq
MIRT1426923	hsa-miR-1185	CLIP-seq
MIRT1426878	hsa-miR-122	CLIP-seq
MIRT1426879	hsa-miR-1226	CLIP-seq
MIRT1426924	hsa-miR-1265	CLIP-seq
MIRT1426925	hsa-miR-2113	CLIP-seq
MIRT1426885	hsa-miR-3135b	CLIP-seq
MIRT1426888	hsa-miR-3187-3p	CLIP-seq
MIRT1426926	hsa-miR-3605-5p	CLIP-seq
MIRT1426891	hsa-miR-3652	CLIP-seq
MIRT1426927	hsa-miR-3679-5p	CLIP-seq
MIRT1426894	hsa-miR-4307	CLIP-seq
MIRT1426896	hsa-miR-4430	CLIP-seq
MIRT1426898	hsa-miR-4470	CLIP-seq
MIRT1426928	hsa-miR-4474-3p	CLIP-seq
MIRT1426899	hsa-miR-450b-5p	CLIP-seq
MIRT1426929	hsa-miR-4529-5p	CLIP-seq
MIRT1426901	hsa-miR-4695-3p	CLIP-seq
MIRT1426906	hsa-miR-4733-3p	CLIP-seq
MIRT1426910	hsa-miR-507	CLIP-seq
MIRT1426912	hsa-miR-548aa	CLIP-seq
MIRT1426913	hsa-miR-548ac	CLIP-seq
MIRT1426914	hsa-miR-548d-3p	CLIP-seq
MIRT1426916	hsa-miR-548z	CLIP-seq
MIRT1426917	hsa-miR-557	CLIP-seq
MIRT1426930	hsa-miR-663b	CLIP-seq
MIRT1426921	hsa-miR-767-5p	CLIP-seq
MIRT1426883	hsa-miR-197	CLIP-seq
MIRT1426884	hsa-miR-2392	CLIP-seq
MIRT1426886	hsa-miR-3149	CLIP-seq
MIRT1426888	hsa-miR-3187-3p	CLIP-seq
MIRT1426892	hsa-miR-411	CLIP-seq
MIRT1426897	hsa-miR-4435	CLIP-seq
MIRT1426898	hsa-miR-4470	CLIP-seq
MIRT1426899	hsa-miR-450b-5p	CLIP-seq
MIRT1426902	hsa-miR-4701-5p	CLIP-seq
MIRT1426905	hsa-miR-4716-5p	CLIP-seq
MIRT1426931	hsa-miR-4735-5p	CLIP-seq
MIRT1426932	hsa-miR-4775	CLIP-seq
MIRT1426909	hsa-miR-4781-3p	CLIP-seq
MIRT1426910	hsa-miR-507	CLIP-seq
MIRT1426911	hsa-miR-5096	CLIP-seq
MIRT1426912	hsa-miR-548aa	CLIP-seq
MIRT1426913	hsa-miR-548ac	CLIP-seq
MIRT1426914	hsa-miR-548d-3p	CLIP-seq
MIRT1426915	hsa-miR-548s	CLIP-seq
MIRT1426916	hsa-miR-548z	CLIP-seq
MIRT1426917	hsa-miR-557	CLIP-seq
MIRT1426919	hsa-miR-588	CLIP-seq
MIRT1426933	hsa-miR-590-3p	CLIP-seq
MIRT1426921	hsa-miR-767-5p	CLIP-seq
MIRT1920979	hsa-miR-150	CLIP-seq
MIRT1920980	hsa-miR-498	CLIP-seq
MIRT1426921	hsa-miR-767-5p	CLIP-seq
MIRT1920979	hsa-miR-150	CLIP-seq
MIRT1920980	hsa-miR-498	CLIP-seq
MIRT1426921	hsa-miR-767-5p	CLIP-seq
MIRT1920979	hsa-miR-150	CLIP-seq
MIRT1920980	hsa-miR-498	CLIP-seq
MIRT1426921	hsa-miR-767-5p	CLIP-seq
MIRT1920979	hsa-miR-150	CLIP-seq
MIRT1426883	hsa-miR-197	CLIP-seq
MIRT1426886	hsa-miR-3149	CLIP-seq
MIRT1426892	hsa-miR-411	CLIP-seq
MIRT1426905	hsa-miR-4716-5p	CLIP-seq
MIRT1426931	hsa-miR-4735-5p	CLIP-seq
MIRT1426932	hsa-miR-4775	CLIP-seq
MIRT1426909	hsa-miR-4781-3p	CLIP-seq
MIRT1920980	hsa-miR-498	CLIP-seq
MIRT1426911	hsa-miR-5096	CLIP-seq
MIRT1426933	hsa-miR-590-3p	CLIP-seq
MIRT1920979	hsa-miR-150	CLIP-seq
MIRT1426899	hsa-miR-450b-5p	CLIP-seq
MIRT1920980	hsa-miR-498	CLIP-seq
MIRT1426910	hsa-miR-507	CLIP-seq
MIRT1426912	hsa-miR-548aa	CLIP-seq
MIRT1426913	hsa-miR-548ac	CLIP-seq
MIRT1426914	hsa-miR-548d-3p	CLIP-seq
MIRT1426916	hsa-miR-548z	CLIP-seq
MIRT1426917	hsa-miR-557	CLIP-seq
MIRT1426921	hsa-miR-767-5p	CLIP-seq
MIRT1426878	hsa-miR-122	CLIP-seq
MIRT1426879	hsa-miR-1226	CLIP-seq
MIRT1426885	hsa-miR-3135b	CLIP-seq
MIRT1426891	hsa-miR-3652	CLIP-seq
MIRT1426896	hsa-miR-4430	CLIP-seq
MIRT1426901	hsa-miR-4695-3p	CLIP-seq
MIRT1426906	hsa-miR-4733-3p	CLIP-seq
MIRT1426883	hsa-miR-197	CLIP-seq
MIRT1426886	hsa-miR-3149	CLIP-seq
MIRT1426888	hsa-miR-3187-3p	CLIP-seq
MIRT1426892	hsa-miR-411	CLIP-seq
MIRT1426897	hsa-miR-4435	CLIP-seq
MIRT1426902	hsa-miR-4701-5p	CLIP-seq
MIRT1426905	hsa-miR-4716-5p	CLIP-seq
MIRT1426931	hsa-miR-4735-5p	CLIP-seq
MIRT1426932	hsa-miR-4775	CLIP-seq
MIRT1426909	hsa-miR-4781-3p	CLIP-seq
MIRT1426911	hsa-miR-5096	CLIP-seq
MIRT1426915	hsa-miR-548s	CLIP-seq
MIRT1426919	hsa-miR-588	CLIP-seq
MIRT1426933	hsa-miR-590-3p	CLIP-seq
MIRT1426921	hsa-miR-767-5p	CLIP-seq
MIRT1426886	hsa-miR-3149	CLIP-seq
MIRT1426892	hsa-miR-411	CLIP-seq
MIRT1426931	hsa-miR-4735-5p	CLIP-seq
MIRT1426932	hsa-miR-4775	CLIP-seq
MIRT1426933	hsa-miR-590-3p	CLIP-seq
MIRT1426921	hsa-miR-767-5p	CLIP-seq
MIRT1426877	hsa-miR-1193	CLIP-seq
MIRT1426883	hsa-miR-197	CLIP-seq
MIRT1426884	hsa-miR-2392	CLIP-seq
MIRT1426886	hsa-miR-3149	CLIP-seq
MIRT1426888	hsa-miR-3187-3p	CLIP-seq
MIRT1426892	hsa-miR-411	CLIP-seq
MIRT1426897	hsa-miR-4435	CLIP-seq
MIRT1426902	hsa-miR-4701-5p	CLIP-seq
MIRT1426905	hsa-miR-4716-5p	CLIP-seq
MIRT1426931	hsa-miR-4735-5p	CLIP-seq
MIRT1426932	hsa-miR-4775	CLIP-seq
MIRT1426909	hsa-miR-4781-3p	CLIP-seq
MIRT1426911	hsa-miR-5096	CLIP-seq
MIRT1426915	hsa-miR-548s	CLIP-seq
MIRT1426919	hsa-miR-588	CLIP-seq
MIRT1426933	hsa-miR-590-3p	CLIP-seq
MIRT1426921	hsa-miR-767-5p	CLIP-seq
MIRT1426877	hsa-miR-1193	CLIP-seq
MIRT1426883	hsa-miR-197	CLIP-seq
MIRT1426884	hsa-miR-2392	CLIP-seq
MIRT1426886	hsa-miR-3149	CLIP-seq
MIRT1426888	hsa-miR-3187-3p	CLIP-seq
MIRT1426892	hsa-miR-411	CLIP-seq
MIRT1426897	hsa-miR-4435	CLIP-seq
MIRT1426902	hsa-miR-4701-5p	CLIP-seq
MIRT1426905	hsa-miR-4716-5p	CLIP-seq
MIRT1426931	hsa-miR-4735-5p	CLIP-seq
MIRT1426932	hsa-miR-4775	CLIP-seq
MIRT1426909	hsa-miR-4781-3p	CLIP-seq
MIRT1426911	hsa-miR-5096	CLIP-seq
MIRT1426915	hsa-miR-548s	CLIP-seq
MIRT1426919	hsa-miR-588	CLIP-seq
MIRT1426933	hsa-miR-590-3p	CLIP-seq
MIRT1426921	hsa-miR-767-5p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
FOXP3	Unknown	17641056
RXRA	Unknown	24373795
VDR	Unknown	24373795

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002224	Process	Toll-like receptor signaling pathway	IBA	21873635
GO:0002755	Process	MyD88-dependent toll-like receptor signaling pathway	TAS
GO:0004888	Function	Transmembrane signaling receptor activity	TAS	11267672
GO:0005515	Function	Protein binding	IPI	15728506, 23155421, 32814053
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0006954	Process	Inflammatory response	IBA	21873635
GO:0006955	Process	Immune response	NAS	11267672
GO:0016020	Component	Membrane	TAS	11267672
GO:0034166	Process	Toll-like receptor 10 signaling pathway	TAS
GO:0038023	Function	Signaling receptor activity	IBA	21873635
GO:0042802	Function	Identical protein binding	IPI	15728506, 23155421
GO:0045087	Process	Innate immune response	IEA
GO:0050135	Function	NAD(P)+ nucleosidase activity	IEA
GO:0050729	Process	Positive regulation of inflammatory response	IEA
GO:0061809	Function	NAD+ nucleotidase, cyclic ADP-ribose generating	IEA

Other IDs

• MIM: 606270
• HGNC: 15634
• e!Ensembl: ENSG00000174123

Protein

• UniProt ID: Q9BXR5
• Protein name: Toll-like receptor 10 (CD antigen CD290)
• Protein function: Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
• PDB: 2J67
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00560	LRR_1	50 → 71	Leucine Rich Repeat	Repeat
  PF13855	LRR_8	72 → 129	Leucine rich repeat	Repeat
  PF01582	TIR	633 → 802	TIR domain	Family

• Sequence:

  MRLIRNIYIFCSIVMTAEGDAPELPEERELMTNCSNMSLRKVPADLTPATTTLDLSYNLL
  FQLQSSDFHSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNRLKSVTWYLLAGLR
  YLDLSFNDFDTMPICEEAGNMSHLEILGLSGAKIQKSDFQKIAHLHLNTVFLGFRTLPHY
  EEGSLPILNTTKLHIVLPMDTNFWVLLRDGIKTSKILEMTNIDGKSQFVSYEMQRNLSLE
  NAKTSVLLLNKVDLLWDDLFLILQFVWHTSVEHFQIRNVTFGGKAYLDHNSFDYSNTVMR
  TIKLEHVHFRVFYIQQDKIYLLLTKMDIENLTISNAQMPHMLFPNYPTKFQYLNFANNIL
  TDELFKRTIQLPHLKTLILNGNKLETLSLVSCFANNTPLEHLDLSQNLLQHKNDENCSWP
  ETVVNMNLSYNKLSDSVFRCLPKSIQILDLNNNQIQTVPKETIHLMALRELNIAFNFLTD
  LPGCSHFSRLSVLNIEMNFILSPSLDFVQSCQEVKTLNAGRNPFRCTCELKNFIQLETYS
  EVMMVGWSDSYTCEYPLNLRGTRLKDVHLHELSCNTALLIVTIVVIMLVLGLAVAFCCLH
  FDLPWYLRMLGQCTQTWHRVRKTTQEQLKRNVRFHAFISYSEHDSLWVKNELIPNLEKED
  GSILICLYESYFDPGKSISENIVSFIEKSYKSIFVLSPNFVQNEWCHYEFYFAHHNLFHE
  NSDHIILILLEPIPFYCIPTRYHKLKALLEKKAYLEWPKDRRKCGLFWANLRAAINVNVL
  ATREMYELQTFTELNEESRGSTISLMRTDCL

• Sequence length: 811

Pathways

Reactome:

Toll Like Receptor 10 (TLR10) Cascade
IRAK4 deficiency (TLR5)
MyD88 cascade initiated on plasma membrane

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Asthma	Asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	29785011

Unknown
Disease name	Disease term	dbSNP ID	References
Vascular diseases	Peripheral Arterial Diseases		27082954