SLC14A2 (solute carrier family 14 member 2)

Gene

• Entrez ID: 8170
• Gene name: Solute carrier family 14 member 2
• Gene symbol: SLC14A2
• Synonyms: HUT2, UT-A2, UT2, UTA, UTR, hUT-A6
• Chromosome: 18
• Chromosome location: 18q12.3
• Summary: The protein encoded by this gene belongs to the urea transporter family. In mammalian cells, urea is the chief end product of nitrogen catabolism, and plays an important role in the urinary concentration mechanism. This protein is expressed in the inner m

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1352598	hsa-miR-106a	CLIP-seq
MIRT1352599	hsa-miR-106b	CLIP-seq
MIRT1352600	hsa-miR-1193	CLIP-seq
MIRT1352601	hsa-miR-1234	CLIP-seq
MIRT1352602	hsa-miR-1254	CLIP-seq
MIRT1352603	hsa-miR-150	CLIP-seq
MIRT1352604	hsa-miR-17	CLIP-seq
MIRT1352605	hsa-miR-185	CLIP-seq
MIRT1352606	hsa-miR-1976	CLIP-seq
MIRT1352607	hsa-miR-20a	CLIP-seq
MIRT1352608	hsa-miR-20b	CLIP-seq
MIRT1352609	hsa-miR-2110	CLIP-seq
MIRT1352610	hsa-miR-2392	CLIP-seq
MIRT1352611	hsa-miR-302a	CLIP-seq
MIRT1352612	hsa-miR-302b	CLIP-seq
MIRT1352613	hsa-miR-302c	CLIP-seq
MIRT1352614	hsa-miR-302d	CLIP-seq
MIRT1352615	hsa-miR-302e	CLIP-seq
MIRT1352616	hsa-miR-3116	CLIP-seq
MIRT1352617	hsa-miR-3150a-3p	CLIP-seq
MIRT1352618	hsa-miR-3175	CLIP-seq
MIRT1352619	hsa-miR-3199	CLIP-seq
MIRT1352620	hsa-miR-372	CLIP-seq
MIRT1352621	hsa-miR-373	CLIP-seq
MIRT1352622	hsa-miR-4258	CLIP-seq
MIRT1352623	hsa-miR-4260	CLIP-seq
MIRT1352624	hsa-miR-4306	CLIP-seq
MIRT1352625	hsa-miR-4644	CLIP-seq
MIRT1352626	hsa-miR-4707-3p	CLIP-seq
MIRT1352627	hsa-miR-4731-5p	CLIP-seq
MIRT1352628	hsa-miR-4735-5p	CLIP-seq
MIRT1352629	hsa-miR-4775	CLIP-seq
MIRT1352630	hsa-miR-4794	CLIP-seq
MIRT1352631	hsa-miR-512-3p	CLIP-seq
MIRT1352632	hsa-miR-519d	CLIP-seq
MIRT1352633	hsa-miR-520a-3p	CLIP-seq
MIRT1352634	hsa-miR-520b	CLIP-seq
MIRT1352635	hsa-miR-520c-3p	CLIP-seq
MIRT1352636	hsa-miR-520d-3p	CLIP-seq
MIRT1352637	hsa-miR-520e	CLIP-seq
MIRT1352638	hsa-miR-520g	CLIP-seq
MIRT1352639	hsa-miR-520h	CLIP-seq
MIRT1352640	hsa-miR-552	CLIP-seq
MIRT1352641	hsa-miR-562	CLIP-seq
MIRT1352642	hsa-miR-590-3p	CLIP-seq
MIRT1352643	hsa-miR-599	CLIP-seq
MIRT1352644	hsa-miR-640	CLIP-seq
MIRT1352645	hsa-miR-661	CLIP-seq
MIRT1352646	hsa-miR-764	CLIP-seq
MIRT1352647	hsa-miR-93	CLIP-seq
MIRT1352648	hsa-miR-939	CLIP-seq
MIRT1352602	hsa-miR-1254	CLIP-seq
MIRT2104395	hsa-miR-129-5p	CLIP-seq
MIRT1352606	hsa-miR-1976	CLIP-seq
MIRT2104396	hsa-miR-2276	CLIP-seq
MIRT1352616	hsa-miR-3116	CLIP-seq
MIRT1352622	hsa-miR-4258	CLIP-seq
MIRT2104397	hsa-miR-4279	CLIP-seq
MIRT2104398	hsa-miR-4532	CLIP-seq
MIRT1352626	hsa-miR-4707-3p	CLIP-seq
MIRT2104399	hsa-miR-4722-3p	CLIP-seq
MIRT1352628	hsa-miR-4735-5p	CLIP-seq
MIRT1352629	hsa-miR-4775	CLIP-seq
MIRT1352630	hsa-miR-4794	CLIP-seq
MIRT1352642	hsa-miR-590-3p	CLIP-seq
MIRT1352645	hsa-miR-661	CLIP-seq
MIRT1352598	hsa-miR-106a	CLIP-seq
MIRT1352599	hsa-miR-106b	CLIP-seq
MIRT2328837	hsa-miR-122	CLIP-seq
MIRT1352601	hsa-miR-1234	CLIP-seq
MIRT1352603	hsa-miR-150	CLIP-seq
MIRT1352604	hsa-miR-17	CLIP-seq
MIRT1352606	hsa-miR-1976	CLIP-seq
MIRT1352607	hsa-miR-20a	CLIP-seq
MIRT1352608	hsa-miR-20b	CLIP-seq
MIRT2104396	hsa-miR-2276	CLIP-seq
MIRT2328838	hsa-miR-24	CLIP-seq
MIRT1352611	hsa-miR-302a	CLIP-seq
MIRT1352612	hsa-miR-302b	CLIP-seq
MIRT1352613	hsa-miR-302c	CLIP-seq
MIRT1352614	hsa-miR-302d	CLIP-seq
MIRT1352615	hsa-miR-302e	CLIP-seq
MIRT2328839	hsa-miR-3135b	CLIP-seq
MIRT2328840	hsa-miR-3164	CLIP-seq
MIRT1352619	hsa-miR-3199	CLIP-seq
MIRT2328841	hsa-miR-3652	CLIP-seq
MIRT1352620	hsa-miR-372	CLIP-seq
MIRT1352621	hsa-miR-373	CLIP-seq
MIRT1352622	hsa-miR-4258	CLIP-seq
MIRT2104397	hsa-miR-4279	CLIP-seq
MIRT2328842	hsa-miR-4284	CLIP-seq
MIRT2328843	hsa-miR-4430	CLIP-seq
MIRT2104398	hsa-miR-4532	CLIP-seq
MIRT1352626	hsa-miR-4707-3p	CLIP-seq
MIRT2104399	hsa-miR-4722-3p	CLIP-seq
MIRT2328844	hsa-miR-4773	CLIP-seq
MIRT1352631	hsa-miR-512-3p	CLIP-seq
MIRT1352632	hsa-miR-519d	CLIP-seq
MIRT1352633	hsa-miR-520a-3p	CLIP-seq
MIRT1352634	hsa-miR-520b	CLIP-seq
MIRT1352635	hsa-miR-520c-3p	CLIP-seq
MIRT1352636	hsa-miR-520d-3p	CLIP-seq
MIRT1352637	hsa-miR-520e	CLIP-seq
MIRT1352638	hsa-miR-520g	CLIP-seq
MIRT1352639	hsa-miR-520h	CLIP-seq
MIRT1352640	hsa-miR-552	CLIP-seq
MIRT1352641	hsa-miR-562	CLIP-seq
MIRT2328845	hsa-miR-617	CLIP-seq
MIRT1352644	hsa-miR-640	CLIP-seq
MIRT1352646	hsa-miR-764	CLIP-seq
MIRT1352647	hsa-miR-93	CLIP-seq
MIRT2328837	hsa-miR-122	CLIP-seq
MIRT1352602	hsa-miR-1254	CLIP-seq
MIRT2459488	hsa-miR-1273f	CLIP-seq
MIRT2104395	hsa-miR-129-5p	CLIP-seq
MIRT1352606	hsa-miR-1976	CLIP-seq
MIRT2104396	hsa-miR-2276	CLIP-seq
MIRT2328838	hsa-miR-24	CLIP-seq
MIRT1352616	hsa-miR-3116	CLIP-seq
MIRT2328839	hsa-miR-3135b	CLIP-seq
MIRT2459489	hsa-miR-3149	CLIP-seq
MIRT2328841	hsa-miR-3652	CLIP-seq
MIRT2459490	hsa-miR-411	CLIP-seq
MIRT1352622	hsa-miR-4258	CLIP-seq
MIRT2104397	hsa-miR-4279	CLIP-seq
MIRT2328842	hsa-miR-4284	CLIP-seq
MIRT2328843	hsa-miR-4430	CLIP-seq
MIRT2104398	hsa-miR-4532	CLIP-seq
MIRT1352626	hsa-miR-4707-3p	CLIP-seq
MIRT2104399	hsa-miR-4722-3p	CLIP-seq
MIRT1352628	hsa-miR-4735-5p	CLIP-seq
MIRT1352629	hsa-miR-4775	CLIP-seq
MIRT1352630	hsa-miR-4794	CLIP-seq
MIRT1352642	hsa-miR-590-3p	CLIP-seq
MIRT2459491	hsa-miR-615-5p	CLIP-seq
MIRT1352645	hsa-miR-661	CLIP-seq
MIRT1352602	hsa-miR-1254	CLIP-seq
MIRT2459488	hsa-miR-1273f	CLIP-seq
MIRT2104395	hsa-miR-129-5p	CLIP-seq
MIRT1352616	hsa-miR-3116	CLIP-seq
MIRT2459489	hsa-miR-3149	CLIP-seq
MIRT2459490	hsa-miR-411	CLIP-seq
MIRT1352628	hsa-miR-4735-5p	CLIP-seq
MIRT1352629	hsa-miR-4775	CLIP-seq
MIRT1352630	hsa-miR-4794	CLIP-seq
MIRT1352642	hsa-miR-590-3p	CLIP-seq
MIRT2459491	hsa-miR-615-5p	CLIP-seq
MIRT1352645	hsa-miR-661	CLIP-seq
MIRT2328837	hsa-miR-122	CLIP-seq
MIRT1352602	hsa-miR-1254	CLIP-seq
MIRT2459488	hsa-miR-1273f	CLIP-seq
MIRT2104395	hsa-miR-129-5p	CLIP-seq
MIRT2104396	hsa-miR-2276	CLIP-seq
MIRT2328838	hsa-miR-24	CLIP-seq
MIRT1352616	hsa-miR-3116	CLIP-seq
MIRT2328839	hsa-miR-3135b	CLIP-seq
MIRT2459489	hsa-miR-3149	CLIP-seq
MIRT2328841	hsa-miR-3652	CLIP-seq
MIRT2459490	hsa-miR-411	CLIP-seq
MIRT1352622	hsa-miR-4258	CLIP-seq
MIRT2328842	hsa-miR-4284	CLIP-seq
MIRT2328843	hsa-miR-4430	CLIP-seq
MIRT2104398	hsa-miR-4532	CLIP-seq
MIRT1352626	hsa-miR-4707-3p	CLIP-seq
MIRT1352628	hsa-miR-4735-5p	CLIP-seq
MIRT1352629	hsa-miR-4775	CLIP-seq
MIRT1352630	hsa-miR-4794	CLIP-seq
MIRT1352642	hsa-miR-590-3p	CLIP-seq
MIRT2459491	hsa-miR-615-5p	CLIP-seq
MIRT1352645	hsa-miR-661	CLIP-seq
MIRT2328837	hsa-miR-122	CLIP-seq
MIRT1352602	hsa-miR-1254	CLIP-seq
MIRT2459488	hsa-miR-1273f	CLIP-seq
MIRT2104395	hsa-miR-129-5p	CLIP-seq
MIRT2104396	hsa-miR-2276	CLIP-seq
MIRT2328838	hsa-miR-24	CLIP-seq
MIRT1352616	hsa-miR-3116	CLIP-seq
MIRT2328839	hsa-miR-3135b	CLIP-seq
MIRT2459489	hsa-miR-3149	CLIP-seq
MIRT2328841	hsa-miR-3652	CLIP-seq
MIRT2459490	hsa-miR-411	CLIP-seq
MIRT1352622	hsa-miR-4258	CLIP-seq
MIRT2328842	hsa-miR-4284	CLIP-seq
MIRT2328843	hsa-miR-4430	CLIP-seq
MIRT2104398	hsa-miR-4532	CLIP-seq
MIRT1352626	hsa-miR-4707-3p	CLIP-seq
MIRT1352628	hsa-miR-4735-5p	CLIP-seq
MIRT1352629	hsa-miR-4775	CLIP-seq
MIRT1352630	hsa-miR-4794	CLIP-seq
MIRT1352642	hsa-miR-590-3p	CLIP-seq
MIRT1352645	hsa-miR-661	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	TAS
GO:0015204	Function	Urea transmembrane transporter activity	IEA
GO:0015840	Process	Urea transport	TAS	8647271
GO:0016020	Component	Membrane	TAS	8647271
GO:0016021	Component	Integral component of membrane	IEA
GO:0016324	Component	Apical plasma membrane	IEA
GO:0050839	Function	Cell adhesion molecule binding	IDA	23620790
GO:0055085	Process	Transmembrane transport	TAS
GO:0071918	Process	Urea transmembrane transport	IBA	21873635

Other IDs

• MIM: 601611
• HGNC: 10919
• e!Ensembl: ENSG00000132874

Protein

• UniProt ID: Q15849
• Protein name: Urea transporter 2 (Solute carrier family 14 member 2) (Urea transporter, kidney)
• Protein function: [Isoform 1]: Mediates the transport of urea driven by a concentration gradient across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism. {ECO:0000269|PubMed:11502588, ECO:0000
• PDB: 8BLO, 8XD7, 8XD9, 8XDA, 8XDB, 8XDC, 8XDD, 8XDE
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03253	UT	119 → 414	Urea transporter	Family
  PF03253	UT	581 → 876	Urea transporter	Family

• Sequence:

  MSDPHSSPLLPEPLSSRYKLYEAEFTSPSWPSTSPDTHPALPLLEMPEEKDLRSSNEDSH
  IVKIEKLNERSKRKDDGVAHRDSAGQRCICLSKAVGYLTGDMKEYRIWLKDKHLALQFID
  WVLRGTAQVMFINNPLSGLIIFIGLLIQNPWWTITGGLGTVVSTLTALALGQDRSAIASG
  LHGYNGMLVGLLMAVFSEKLDYYWWLLFPVTFTAMSCPVLSSALNSIFSKWDLPVFTLPF
  NIAVTLYLAATGHYNLFFPTTLVEPVSSVPNITWTEMEMPLLLQAIPVGVGQVYGCDNPW
  TGGVFLVALFISSPLICLHAAIGSIVGLLAALSVATPFETIYTGLWSYNCVLSCIAIGGM
  FYALTWQTHLLALICALFCAYMEAAISNIMSVVGVPPGTWAFCLATIIFLLLTTNNPAIF
  RLPLSKVTYPEANRIYYLTVKSGEEEKAPSGGGGEHPPTAGPKVEEGSEAVLSKHRSVFH
  IEWSSIRRRSKVFGKGEHQERQNKDPFPYRYRKPTVELLDLDTMEESSEIKVETNISKTS
  WIRSSMAASGKRVSKALSYITGEMKECGEGLKDKSPVFQFFDWVLRGTSQVMFVNNPLSG
  ILIILGLFIQNPWWAISGCLGTIMSTLTALILSQDKSAIAAGFHGYNGVLVGLLMAVFSD
  KGDYYWWLLLPVIIMSMSCPILSSALGTIFSKWDLPVFTLPFNITVTLYLAATGHYNLFF
  PTTLLQPASAMPNITWSEVQVPLLLRAIPVGIGQVYGCDNPWTGGIFLIALFISSPLICL
  HAAIGSTMGMLAALTIATPFDSIYFGLCGFNSTLACIAIGGMFYVITWQTHLLAIACALF
  AAYLGAALANMLSVFGLPPCTWPFCLSALTFLLLTTNNPAIYKLPLSKVTYPEANRIYYL
  SQERNRRASIITKYQAYDVS

• Sequence length: 920

Pathways

Reactome:

Transport of bile salts and organic acids, metal ions and amine compounds

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451, rs397507859, rs80359709, rs80359742, rs80359205, rs80357627, rs80357004, rs80357571, rs80357767, rs80357653, rs80358086, rs80357608, rs28897696, rs41293465, rs146650273, rs63751017, rs63750617, rs63750726, rs63750199, rs63749848, rs398122618, rs398122653, rs397509211, rs80357791, rs121912666, rs587778541, rs121908698, rs536907995, rs587781302, rs140342925, rs587781506, rs587782652, rs587782849, rs587783057, rs10520699, rs11852999, rs139770721, rs374950566, rs786202800, rs863224451, rs377153250, rs747727055, rs876658804, rs780001540, rs760815829, rs878854926, rs775248597, rs886040658, rs886040192, rs786203523, rs886040319, rs397508006, rs587782011, rs1060502772, rs1555461727, rs1553333072, rs1114167702, rs1257401983, rs886040950, rs1060502759, rs774684620, rs142947311, rs1555580883, rs748513310, rs376170600, rs863224499, rs1593909229, rs748453607, rs1294578913, rs1574737047, rs1593909960, rs2081922847, rs2082559544, rs2053694038	29059683
Narcolepsy	Narcolepsy	rs104894574, rs387906655	19629137

Unknown
Disease name	Disease term	dbSNP ID	References
Alopecia	Alopecia		28196072
Alopecia, male pattern	Alopecia, Male Pattern		22693459, 29146897, 27182965
Androgenetic alopecia	Androgenetic Alopecia, Alopecia, Androgenetic, 3, Alopecia, Androgenetic, 2, Alopecia, Androgenetic, 1		29146897, 27182965, 22693459, 22693459, 27182965, 29146897, 27182965, 22693459, 29146897
B-cell neoplasm	Mature B-Cell Neoplasm		25279986