AKAP1 (A-kinase anchoring protein 1)

Gene

• Entrez ID: 8165
• Gene name: A-kinase anchoring protein 1
• Gene symbol: AKAP1
• Synonyms: AKAP, AKAP121, AKAP149, AKAP84, D-AKAP1, PPP1R43, PRKA1, SAKAP84, TDRD17
• Chromosome: 17
• Chromosome location: 17q22
• Summary: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT005814	hsa-miR-204-5p	Microarray	21282569
MIRT037317	hsa-miR-877-5p	CLASH	23622248
MIRT549404	hsa-miR-409-5p	PAR-CLIP	21572407
MIRT078141	hsa-miR-3121-3p	PAR-CLIP	21572407
MIRT078134	hsa-miR-224-3p	PAR-CLIP	21572407
MIRT078137	hsa-miR-522-3p	PAR-CLIP	21572407
MIRT288386	hsa-miR-4797-5p	PAR-CLIP	21572407
MIRT549403	hsa-miR-4699-3p	PAR-CLIP	21572407
MIRT078143	hsa-miR-4719	PAR-CLIP	21572407
MIRT078136	hsa-miR-520d-5p	PAR-CLIP	21572407
MIRT078135	hsa-miR-524-5p	PAR-CLIP	21572407
MIRT078138	hsa-miR-507	PAR-CLIP	21572407
MIRT078139	hsa-miR-557	PAR-CLIP	21572407
MIRT446603	hsa-miR-7-5p	PAR-CLIP	22100165
MIRT446601	hsa-miR-6077	PAR-CLIP	22100165
MIRT446600	hsa-miR-3652	PAR-CLIP	22100165
MIRT446599	hsa-miR-4430	PAR-CLIP	22100165
MIRT446598	hsa-miR-4505	PAR-CLIP	22100165
MIRT446597	hsa-miR-5787	PAR-CLIP	22100165
MIRT446596	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT446595	hsa-miR-6842-3p	PAR-CLIP	22100165
MIRT446594	hsa-miR-4474-3p	PAR-CLIP	22100165
MIRT549404	hsa-miR-409-5p	PAR-CLIP	21572407
MIRT078141	hsa-miR-3121-3p	PAR-CLIP	21572407
MIRT078134	hsa-miR-224-3p	PAR-CLIP	21572407
MIRT078137	hsa-miR-522-3p	PAR-CLIP	21572407
MIRT288386	hsa-miR-4797-5p	PAR-CLIP	21572407
MIRT549403	hsa-miR-4699-3p	PAR-CLIP	21572407
MIRT078143	hsa-miR-4719	PAR-CLIP	21572407
MIRT078136	hsa-miR-520d-5p	PAR-CLIP	21572407
MIRT078135	hsa-miR-524-5p	PAR-CLIP	21572407
MIRT078138	hsa-miR-507	PAR-CLIP	21572407
MIRT078139	hsa-miR-557	PAR-CLIP	21572407
MIRT446603	hsa-miR-7-5p	PAR-CLIP	22100165
MIRT446601	hsa-miR-6077	PAR-CLIP	22100165
MIRT446600	hsa-miR-3652	PAR-CLIP	22100165
MIRT446599	hsa-miR-4430	PAR-CLIP	22100165
MIRT446598	hsa-miR-4505	PAR-CLIP	22100165
MIRT446597	hsa-miR-5787	PAR-CLIP	22100165
MIRT446596	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT446595	hsa-miR-6842-3p	PAR-CLIP	22100165
MIRT446594	hsa-miR-4474-3p	PAR-CLIP	22100165
MIRT775480	hsa-miR-103a	CLIP-seq
MIRT775481	hsa-miR-107	CLIP-seq
MIRT775482	hsa-miR-1207-3p	CLIP-seq
MIRT775483	hsa-miR-1207-5p	CLIP-seq
MIRT775484	hsa-miR-1266	CLIP-seq
MIRT775485	hsa-miR-1273d	CLIP-seq
MIRT775486	hsa-miR-130a	CLIP-seq
MIRT775487	hsa-miR-130b	CLIP-seq
MIRT775488	hsa-miR-148a	CLIP-seq
MIRT775489	hsa-miR-148b	CLIP-seq
MIRT775490	hsa-miR-152	CLIP-seq
MIRT775491	hsa-miR-15a	CLIP-seq
MIRT775492	hsa-miR-15b	CLIP-seq
MIRT775493	hsa-miR-16	CLIP-seq
MIRT775494	hsa-miR-195	CLIP-seq
MIRT775495	hsa-miR-19a	CLIP-seq
MIRT775496	hsa-miR-19b	CLIP-seq
MIRT775497	hsa-miR-2053	CLIP-seq
MIRT775498	hsa-miR-301a	CLIP-seq
MIRT775499	hsa-miR-301b	CLIP-seq
MIRT775500	hsa-miR-3119	CLIP-seq
MIRT775501	hsa-miR-3121-5p	CLIP-seq
MIRT775502	hsa-miR-3613-3p	CLIP-seq
MIRT775503	hsa-miR-362-5p	CLIP-seq
MIRT775504	hsa-miR-3664-3p	CLIP-seq
MIRT775505	hsa-miR-3666	CLIP-seq
MIRT775506	hsa-miR-3925-5p	CLIP-seq
MIRT775507	hsa-miR-421	CLIP-seq
MIRT775508	hsa-miR-424	CLIP-seq
MIRT775509	hsa-miR-4295	CLIP-seq
MIRT775510	hsa-miR-4432	CLIP-seq
MIRT775511	hsa-miR-450a	CLIP-seq
MIRT775512	hsa-miR-4518	CLIP-seq
MIRT775513	hsa-miR-454	CLIP-seq
MIRT775514	hsa-miR-4709-5p	CLIP-seq
MIRT775515	hsa-miR-4736	CLIP-seq
MIRT775516	hsa-miR-4763-3p	CLIP-seq
MIRT775517	hsa-miR-497	CLIP-seq
MIRT775518	hsa-miR-500b	CLIP-seq
MIRT775519	hsa-miR-501-5p	CLIP-seq
MIRT775520	hsa-miR-548u	CLIP-seq
MIRT775521	hsa-miR-589	CLIP-seq
MIRT775522	hsa-miR-873	CLIP-seq
MIRT775523	hsa-miR-1245b-3p	CLIP-seq
MIRT775524	hsa-miR-1279	CLIP-seq
MIRT775525	hsa-miR-1825	CLIP-seq
MIRT775526	hsa-miR-199a-5p	CLIP-seq
MIRT775527	hsa-miR-199b-5p	CLIP-seq
MIRT775528	hsa-miR-2117	CLIP-seq
MIRT775529	hsa-miR-3925-3p	CLIP-seq
MIRT775530	hsa-miR-3974	CLIP-seq
MIRT775531	hsa-miR-4273	CLIP-seq
MIRT775532	hsa-miR-4677-5p	CLIP-seq
MIRT775533	hsa-miR-4684-3p	CLIP-seq
MIRT775534	hsa-miR-4789-3p	CLIP-seq
MIRT775535	hsa-miR-515-5p	CLIP-seq
MIRT775536	hsa-miR-576-3p	CLIP-seq
MIRT775537	hsa-miR-582-5p	CLIP-seq
MIRT775538	hsa-miR-591	CLIP-seq
MIRT775539	hsa-miR-643	CLIP-seq
MIRT775540	hsa-miR-766	CLIP-seq
MIRT1928833	hsa-miR-1206	CLIP-seq
MIRT775525	hsa-miR-1825	CLIP-seq
MIRT775526	hsa-miR-199a-5p	CLIP-seq
MIRT775527	hsa-miR-199b-5p	CLIP-seq
MIRT1928834	hsa-miR-2467-3p	CLIP-seq
MIRT1928835	hsa-miR-3158-5p	CLIP-seq
MIRT1928836	hsa-miR-320e	CLIP-seq
MIRT1928837	hsa-miR-329	CLIP-seq
MIRT1928838	hsa-miR-362-3p	CLIP-seq
MIRT1928839	hsa-miR-3678-3p	CLIP-seq
MIRT1928840	hsa-miR-3681	CLIP-seq
MIRT1928841	hsa-miR-380	CLIP-seq
MIRT1928842	hsa-miR-3924	CLIP-seq
MIRT1928843	hsa-miR-4418	CLIP-seq
MIRT1928844	hsa-miR-4495	CLIP-seq
MIRT1928845	hsa-miR-4658	CLIP-seq
MIRT1928846	hsa-miR-4718	CLIP-seq
MIRT1928847	hsa-miR-4758-5p	CLIP-seq
MIRT775534	hsa-miR-4789-3p	CLIP-seq
MIRT1928848	hsa-miR-4793-3p	CLIP-seq
MIRT1928849	hsa-miR-509-3-5p	CLIP-seq
MIRT1928850	hsa-miR-509-5p	CLIP-seq
MIRT775480	hsa-miR-103a	CLIP-seq
MIRT775481	hsa-miR-107	CLIP-seq
MIRT1928833	hsa-miR-1206	CLIP-seq
MIRT775483	hsa-miR-1207-5p	CLIP-seq
MIRT775484	hsa-miR-1266	CLIP-seq
MIRT775485	hsa-miR-1273d	CLIP-seq
MIRT2169596	hsa-miR-128	CLIP-seq
MIRT2169597	hsa-miR-1286	CLIP-seq
MIRT2169598	hsa-miR-1291	CLIP-seq
MIRT2169599	hsa-miR-1305	CLIP-seq
MIRT775486	hsa-miR-130a	CLIP-seq
MIRT775487	hsa-miR-130b	CLIP-seq
MIRT775488	hsa-miR-148a	CLIP-seq
MIRT775489	hsa-miR-148b	CLIP-seq
MIRT775490	hsa-miR-152	CLIP-seq
MIRT775491	hsa-miR-15a	CLIP-seq
MIRT775492	hsa-miR-15b	CLIP-seq
MIRT775493	hsa-miR-16	CLIP-seq
MIRT775525	hsa-miR-1825	CLIP-seq
MIRT775494	hsa-miR-195	CLIP-seq
MIRT2169600	hsa-miR-198	CLIP-seq
MIRT775526	hsa-miR-199a-5p	CLIP-seq
MIRT775527	hsa-miR-199b-5p	CLIP-seq
MIRT775495	hsa-miR-19a	CLIP-seq
MIRT775496	hsa-miR-19b	CLIP-seq
MIRT775497	hsa-miR-2053	CLIP-seq
MIRT2169601	hsa-miR-27a	CLIP-seq
MIRT2169602	hsa-miR-27b	CLIP-seq
MIRT775498	hsa-miR-301a	CLIP-seq
MIRT775499	hsa-miR-301b	CLIP-seq
MIRT775500	hsa-miR-3119	CLIP-seq
MIRT2169603	hsa-miR-3120-3p	CLIP-seq
MIRT775501	hsa-miR-3121-5p	CLIP-seq
MIRT1928836	hsa-miR-320e	CLIP-seq
MIRT775502	hsa-miR-3613-3p	CLIP-seq
MIRT2169604	hsa-miR-3622a-3p	CLIP-seq
MIRT2169605	hsa-miR-3622b-3p	CLIP-seq
MIRT775503	hsa-miR-362-5p	CLIP-seq
MIRT775504	hsa-miR-3664-3p	CLIP-seq
MIRT775505	hsa-miR-3666	CLIP-seq
MIRT1928840	hsa-miR-3681	CLIP-seq
MIRT1928841	hsa-miR-380	CLIP-seq
MIRT1928842	hsa-miR-3924	CLIP-seq
MIRT775506	hsa-miR-3925-5p	CLIP-seq
MIRT2169606	hsa-miR-3944-5p	CLIP-seq
MIRT775507	hsa-miR-421	CLIP-seq
MIRT775508	hsa-miR-424	CLIP-seq
MIRT775509	hsa-miR-4295	CLIP-seq
MIRT2169607	hsa-miR-4302	CLIP-seq
MIRT775510	hsa-miR-4432	CLIP-seq
MIRT1928844	hsa-miR-4495	CLIP-seq
MIRT775511	hsa-miR-450a	CLIP-seq
MIRT775512	hsa-miR-4518	CLIP-seq
MIRT775513	hsa-miR-454	CLIP-seq
MIRT1928845	hsa-miR-4658	CLIP-seq
MIRT2169608	hsa-miR-4684-5p	CLIP-seq
MIRT2169609	hsa-miR-4704-3p	CLIP-seq
MIRT775514	hsa-miR-4709-5p	CLIP-seq
MIRT1928846	hsa-miR-4718	CLIP-seq
MIRT2169610	hsa-miR-4722-5p	CLIP-seq
MIRT2169611	hsa-miR-4729	CLIP-seq
MIRT775515	hsa-miR-4736	CLIP-seq
MIRT1928847	hsa-miR-4758-5p	CLIP-seq
MIRT775516	hsa-miR-4763-3p	CLIP-seq
MIRT2169612	hsa-miR-4786-3p	CLIP-seq
MIRT775517	hsa-miR-497	CLIP-seq
MIRT775518	hsa-miR-500b	CLIP-seq
MIRT775519	hsa-miR-501-5p	CLIP-seq
MIRT2169613	hsa-miR-513c	CLIP-seq
MIRT2169614	hsa-miR-514b-5p	CLIP-seq
MIRT2169615	hsa-miR-545	CLIP-seq
MIRT2169616	hsa-miR-548p	CLIP-seq
MIRT775520	hsa-miR-548u	CLIP-seq
MIRT775521	hsa-miR-589	CLIP-seq
MIRT2169617	hsa-miR-648	CLIP-seq
MIRT2169618	hsa-miR-671-5p	CLIP-seq
MIRT775522	hsa-miR-873	CLIP-seq
MIRT2443447	hsa-miR-548g	CLIP-seq
MIRT775523	hsa-miR-1245b-3p	CLIP-seq
MIRT775524	hsa-miR-1279	CLIP-seq
MIRT2472239	hsa-miR-1303	CLIP-seq
MIRT2472240	hsa-miR-204	CLIP-seq
MIRT2472241	hsa-miR-211	CLIP-seq
MIRT775528	hsa-miR-2117	CLIP-seq
MIRT2472242	hsa-miR-375	CLIP-seq
MIRT775530	hsa-miR-3974	CLIP-seq
MIRT775531	hsa-miR-4273	CLIP-seq
MIRT775532	hsa-miR-4677-5p	CLIP-seq
MIRT775533	hsa-miR-4684-3p	CLIP-seq
MIRT2472243	hsa-miR-4755-5p	CLIP-seq
MIRT775535	hsa-miR-515-5p	CLIP-seq
MIRT2472244	hsa-miR-526b	CLIP-seq
MIRT775536	hsa-miR-576-3p	CLIP-seq
MIRT775537	hsa-miR-582-5p	CLIP-seq
MIRT775538	hsa-miR-591	CLIP-seq
MIRT2472245	hsa-miR-623	CLIP-seq
MIRT2472246	hsa-miR-7	CLIP-seq
MIRT775523	hsa-miR-1245b-3p	CLIP-seq
MIRT775524	hsa-miR-1279	CLIP-seq
MIRT775530	hsa-miR-3974	CLIP-seq
MIRT775533	hsa-miR-4684-3p	CLIP-seq
MIRT775536	hsa-miR-576-3p	CLIP-seq
MIRT775537	hsa-miR-582-5p	CLIP-seq
MIRT775538	hsa-miR-591	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005515	Function	Protein binding	IPI	16642035, 24083380, 24981860, 26496610, 31522117
GO:0005739	Component	Mitochondrion	IDA
GO:0005741	Component	Mitochondrial outer membrane	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006915	Process	Apoptotic process	ISS
GO:0007596	Process	Blood coagulation	TAS
GO:0016020	Component	Membrane	HDA	19946888
GO:0016021	Component	Integral component of membrane	IEA
GO:0034237	Function	Protein kinase A regulatory subunit binding	IPI	17911601
GO:0140374	Process	Antiviral innate immune response	IMP	31522117

Other IDs

• MIM: 602449
• HGNC: 367
• e!Ensembl: ENSG00000121057

Protein

• UniProt ID: Q92667
• Protein name: A-kinase anchor protein 1, mitochondrial (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein 84) (S-AKAP84)
• Protein function: Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane (By similarity). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Promotes
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00013	KH_1	609 → 673	KH domain	Domain
  PF00567	TUDOR	704 → 828	Tudor domain	Domain

• Sequence:

  MAIQFRSLFPLALPGMLALLGWWWFFSRKKGHVSSHDEQQVEAGAVQLRADPAIKEPLPV
  EDVCPKVVSTPPSVTEPPEKELSTVSKLPAEPPALLQTHPPCRRSESSGILPNTTDMRLR
  PGTRRDDSTKLELALTGGEAKSIPLECPLSSPKGVLFSSKSAEVCKQDSPFSRVPRKVQP
  GYPVVPAEKRSSGERARETGGAEGTGDAVLGEKVLEEALLSREHVLELENSKGPSLASLE
  GEEDKGKSSSSQVVGPVQEEEYVAEKLPSRFIESAHTELAKDDAAPAPPVADAKAQDRGV
  EGELGNEESLDRNEEGLDRNEEGLDRNEESLDRNEEGLDRNEEIKRAAFQIISQVISEAT
  EQVLATTVGKVAGRVCQASQLQGQKEESCVPVHQKTVLGPDTAEPATAEAAVAPPDAGLP
  LPGLPAEGSPPPKTYVSCLKSLLSSPTKDSKPNISAHHISLASCLALTTPSEELPDRAGI
  LVEDATCVTCMSDSSQSVPLVASPGHCSDSFSTSGLEDSCTETSSSPRDKAITPPLPEST
  VPFSNGVLKGELSDLGAEDGWTMDAEADHSGGSDRNSMDSVDSCCSLKKTESFQNAQAGS
  NPKKVDLIIWEIEVPKHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQSVQICHIEGS
  QHHVDKALNLIGKKFKELNLTNIYAPPLPSLALPSLPMTSWLMLPDGITVEVIVVNQVNA
  GHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEITVICAAPGADGAWWRAQVV
  ASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQGAEVLLDSVMPLSDDDQFSP
  EADAAMSEMTGNTALLAQVTSYSPTGLPLIQLWSVVGDEVVLINRSLVERGLAQWVDSYY
  TSL

• Sequence length: 903

Pathways

Reactome:

Factors involved in megakaryocyte development and platelet production

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Obesity	Obesity	rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840	20975297