TSPAN14 (tetraspanin 14)

Gene

• Entrez ID: 81619
• Gene name: Tetraspanin 14
• Gene symbol: TSPAN14
• Synonyms: DC-TM4F2, TM4SF14, tspan-14
• Chromosome: 10
• Chromosome location: 10q23.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020709	hsa-miR-155-5p	Reporter assay;Other	20584899
MIRT020709	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT025376	hsa-miR-34a-5p	Sequencing	20371350
MIRT027896	hsa-miR-96-5p	Sequencing	20371350
MIRT030452	hsa-miR-24-3p	Microarray	19748357
MIRT039092	hsa-miR-769-3p	CLASH	23622248
MIRT127324	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT127328	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT127336	hsa-miR-603	HITS-CLIP	23824327
MIRT127377	hsa-miR-3941	HITS-CLIP	23824327
MIRT127416	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT127416	hsa-miR-6741-3p	HITS-CLIP	27418678
MIRT127434	hsa-miR-8485	HITS-CLIP	23824327
MIRT382608	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT439385	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT444655	hsa-miR-6790-5p	PAR-CLIP	22100165
MIRT444656	hsa-miR-4658	PAR-CLIP	22100165
MIRT444657	hsa-miR-4758-5p	PAR-CLIP	22100165
MIRT444658	hsa-miR-1238-5p	PAR-CLIP	22100165
MIRT444659	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT444660	hsa-miR-1909-5p	PAR-CLIP	22100165
MIRT444661	hsa-miR-3976	PAR-CLIP	22100165
MIRT444662	hsa-miR-512-3p	PAR-CLIP	22100165
MIRT444663	hsa-miR-3123	PAR-CLIP	22100165
MIRT444664	hsa-miR-3925-5p	PAR-CLIP	22100165
MIRT444665	hsa-miR-1264	PAR-CLIP	22100165
MIRT553319	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT553320	hsa-miR-6083	PAR-CLIP	21572407
MIRT553321	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT553322	hsa-miR-6834-3p	PAR-CLIP	21572407
MIRT609759	hsa-miR-4729	HITS-CLIP	23824327
MIRT631185	hsa-miR-3689d	HITS-CLIP	23824327
MIRT631186	hsa-miR-7641	HITS-CLIP	23824327
MIRT631187	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT631188	hsa-miR-3650	HITS-CLIP	23824327
MIRT631189	hsa-miR-5698	HITS-CLIP	23824327
MIRT631190	hsa-miR-4284	HITS-CLIP	23824327
MIRT631190	hsa-miR-4284	HITS-CLIP	27418678
MIRT631191	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT631192	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT631193	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT631193	hsa-miR-2276-3p	HITS-CLIP	27418678
MIRT631194	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT631195	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT631196	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT631196	hsa-miR-1304-3p	HITS-CLIP	27418678
MIRT631197	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT631197	hsa-miR-4485-5p	HITS-CLIP	27418678
MIRT631198	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT631198	hsa-miR-6890-3p	HITS-CLIP	27418678
MIRT652073	hsa-miR-5096	HITS-CLIP	23824327
MIRT652074	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT652075	hsa-miR-588	HITS-CLIP	23824327
MIRT652076	hsa-miR-548s	HITS-CLIP	23824327
MIRT652077	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT652078	hsa-miR-411-5p	HITS-CLIP	23824327
MIRT652079	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT652080	hsa-miR-6823-5p	HITS-CLIP	23824327
MIRT652081	hsa-miR-4524a-3p	HITS-CLIP	23824327
MIRT652082	hsa-miR-4524b-3p	HITS-CLIP	23824327
MIRT763142	hsa-miR-1827	PAR-CLIP	27292025
MIRT764263	hsa-miR-25-5p	PAR-CLIP	27292025
MIRT770218	hsa-miR-4537	PAR-CLIP	27292025
MIRT771598	hsa-miR-4722-5p	PAR-CLIP	27292025
MIRT773525	hsa-miR-5186	PAR-CLIP	27292025
MIRT775711	hsa-miR-6087	PAR-CLIP	27292025
MIRT779728	hsa-miR-6808-5p	PAR-CLIP	27292025
MIRT781260	hsa-miR-6893-5p	PAR-CLIP	27292025
MIRT782953	hsa-miR-940	PAR-CLIP	27292025
MIRT783145	hsa-miR-1225-3p	HITS-CLIP	27418678
MIRT783172	hsa-miR-1228-3p	HITS-CLIP	27418678
MIRT783185	hsa-miR-1233-3p	HITS-CLIP	27418678
MIRT783368	hsa-miR-1281	HITS-CLIP	27418678
MIRT783627	hsa-miR-129-5p	HITS-CLIP	27418678
MIRT783753	hsa-miR-1343-3p	HITS-CLIP	27418678
MIRT784305	hsa-miR-23a-5p	HITS-CLIP	27418678
MIRT784308	hsa-miR-23b-5p	HITS-CLIP	27418678
MIRT785373	hsa-miR-377-3p	HITS-CLIP	27418678
MIRT788406	hsa-miR-660-3p	HITS-CLIP	27418678
MIRT788527	hsa-miR-6742-3p	HITS-CLIP	27418678
MIRT788711	hsa-miR-6783-3p	HITS-CLIP	27418678
MIRT788750	hsa-miR-6791-3p	HITS-CLIP	27418678
MIRT788860	hsa-miR-6807-5p	HITS-CLIP	27418678
MIRT788980	hsa-miR-6829-3p	HITS-CLIP	27418678
MIRT789084	hsa-miR-6852-5p	HITS-CLIP	27418678
MIRT789747	hsa-miR-8055	HITS-CLIP	27418678
MIRT789989	hsa-miR-939-3p	HITS-CLIP	27418678

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	23091066, 26686862
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005886	Component	Plasma membrane	IDA	23091066
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0009986	Component	Cell surface	IEA
GO:0019899	Function	Enzyme binding	IPI	23091066
GO:0035579	Component	Specific granule membrane	TAS
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0044267	Process	Cellular protein metabolic process	TAS
GO:0045747	Process	Positive regulation of Notch signaling pathway	IMP	23091066
GO:0051604	Process	Protein maturation	IMP	23091066
GO:0070821	Component	Tertiary granule membrane	TAS
GO:0072659	Process	Protein localization to plasma membrane	IMP	23035126, 23091066
GO:0097197	Component	Tetraspanin-enriched microdomain	IEA

Other IDs

• MIM: HGNC

Protein

• UniProt ID: Q8NG11
• Protein name: Tetraspanin-14 (Tspan-14) (DC-TM4F2) (Transmembrane 4 superfamily member 14)
• Protein function: Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26668317, PubMed:23035126, PubMed:26686862). Negatively regulates ADAM10-mediated cleavage of GP6 (By similarity). Promotes ADAM10-mediated cleavage of CDH5 (By similarity).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00335	Tetraspanin	15 → 260	Tetraspanin family	Family

• Sequence:

  MHYYRYSNAKVSCWYKYLLFSYNIIFWLAGVVFLGVGLWAWSEKGVLSDLTKVTRMHGID
  PVVLVLMVGVVMFTLGFAGCVGALRENICLLNFFCGTIVLIFFLELAVAVLAFLFQDWVR
  DRFREFFESNIKSYRDDIDLQNLIDSLQKANQCCGAYGPEDWDLNVYFNCSGASYSREKC
  GVPFSCCVPDPAQKVVNTQCGYDVRIQLKSKWDESIFTKGCIQALESWLPRNIYIVAGVF
  IAISLLQIFGIFLARTLISDIEAVKAGHHF

• Sequence length: 270

Pathways

Reactome:

Neutrophil degranulation
Amyloid fiber formation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Inflammatory bowel disease	Inflammatory Bowel Diseases	rs137853579, rs137853580, rs121909601, rs149491038, rs368287711, rs387907326, rs587777338, rs758439420, rs1329427406, rs1264862631, rs1192830343, rs1373354533, rs1419560997, rs1591263883, rs-1, rs1989014468	28067908, 23128233, 26192919
Coronary artery disease	Coronary Artery Disease	rs137852988, rs121918313, rs-1, rs121918529, rs121918531, rs137852340, rs405509, rs1555800701, rs1215189537	29212778
Psoriasis	Psoriasis	rs-1, rs281875215, rs587777763, rs281875213, rs281875212	26974007
Chronic obstructive pulmonary disease	Chronic Obstructive Airway Disease	rs-1	30804561

Unknown
Disease name	Disease term	dbSNP ID	References
Crohn disease	Crohn Disease	rs2066847, rs2066844, rs886052047, rs5743265, rs111608429, rs104895438	26974007, 26192919, 28067908
Ankylosing spondylitis	Ankylosing spondylitis		26974007
Cholangitis	Cholangitis, Sclerosing		26974007
Respiratory tract diseases	Respiratory Tract Diseases		30595370
Ulcerative colitis	Ulcerative Colitis		26974007