FAM83D (family with sequence similarity 83 member D)

Gene

• Entrez ID: 81610
• Gene name: Family with sequence similarity 83 member D
• Gene symbol: FAM83D
• Synonyms: C20orf129, CHICA, dJ616B8.3
• Chromosome: 20
• Chromosome location: 20q11.23

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022620	hsa-miR-124-3p	Microarray	18668037
MIRT024511	hsa-miR-215-5p	Microarray	19074876
MIRT026481	hsa-miR-192-5p	Microarray	19074876
MIRT658345	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT658344	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT658343	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT658342	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT658341	hsa-miR-635	HITS-CLIP	23824327
MIRT658340	hsa-miR-6774-5p	HITS-CLIP	23824327
MIRT658339	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT658338	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT658336	hsa-miR-4284	HITS-CLIP	23824327
MIRT658337	hsa-miR-3940-5p	HITS-CLIP	23824327
MIRT658334	hsa-miR-4507	HITS-CLIP	23824327
MIRT658335	hsa-miR-6839-3p	HITS-CLIP	23824327
MIRT523778	hsa-miR-4438	PAR-CLIP	23446348
MIRT523777	hsa-miR-6504-3p	PAR-CLIP	23446348
MIRT523776	hsa-miR-1292-3p	PAR-CLIP	23446348
MIRT523775	hsa-miR-6741-3p	PAR-CLIP	23446348
MIRT523774	hsa-miR-5095	PAR-CLIP	23446348
MIRT523773	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT523772	hsa-miR-5691	PAR-CLIP	23446348
MIRT523771	hsa-miR-6805-3p	PAR-CLIP	23446348
MIRT440673	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT440674	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT440673	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT727695	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT727694	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT727693	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT727692	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT153283	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT153284	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT440674	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT658343	hsa-miR-1304-3p	HITS-CLIP	27418678
MIRT658345	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT658344	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT658343	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT658342	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT658341	hsa-miR-635	HITS-CLIP	23824327
MIRT658340	hsa-miR-6774-5p	HITS-CLIP	23824327
MIRT658339	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT658338	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT658336	hsa-miR-4284	HITS-CLIP	23824327
MIRT658337	hsa-miR-3940-5p	HITS-CLIP	23824327
MIRT658334	hsa-miR-4507	HITS-CLIP	23824327
MIRT658335	hsa-miR-6839-3p	HITS-CLIP	23824327
MIRT523778	hsa-miR-4438	PAR-CLIP	23446348
MIRT523777	hsa-miR-6504-3p	PAR-CLIP	23446348
MIRT523776	hsa-miR-1292-3p	PAR-CLIP	23446348
MIRT523775	hsa-miR-6741-3p	PAR-CLIP	23446348
MIRT523774	hsa-miR-5095	PAR-CLIP	23446348
MIRT523773	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT523772	hsa-miR-5691	PAR-CLIP	23446348
MIRT523771	hsa-miR-6805-3p	PAR-CLIP	23446348
MIRT987660	hsa-miR-1183	CLIP-seq
MIRT987661	hsa-miR-1283	CLIP-seq
MIRT987662	hsa-miR-130a	CLIP-seq
MIRT987663	hsa-miR-130b	CLIP-seq
MIRT987664	hsa-miR-138	CLIP-seq
MIRT987665	hsa-miR-142-3p	CLIP-seq
MIRT987666	hsa-miR-194	CLIP-seq
MIRT987667	hsa-miR-200b	CLIP-seq
MIRT987668	hsa-miR-200c	CLIP-seq
MIRT987669	hsa-miR-217	CLIP-seq
MIRT987670	hsa-miR-301a	CLIP-seq
MIRT987671	hsa-miR-301b	CLIP-seq
MIRT987672	hsa-miR-3149	CLIP-seq
MIRT987673	hsa-miR-3666	CLIP-seq
MIRT987674	hsa-miR-3668	CLIP-seq
MIRT987675	hsa-miR-3713	CLIP-seq
MIRT987676	hsa-miR-3924	CLIP-seq
MIRT987677	hsa-miR-4282	CLIP-seq
MIRT987678	hsa-miR-429	CLIP-seq
MIRT987679	hsa-miR-4295	CLIP-seq
MIRT987680	hsa-miR-4299	CLIP-seq
MIRT987681	hsa-miR-4418	CLIP-seq
MIRT987682	hsa-miR-4427	CLIP-seq
MIRT987683	hsa-miR-4527	CLIP-seq
MIRT987684	hsa-miR-4528	CLIP-seq
MIRT987685	hsa-miR-454	CLIP-seq
MIRT987686	hsa-miR-4671-3p	CLIP-seq
MIRT987687	hsa-miR-4712-3p	CLIP-seq
MIRT987688	hsa-miR-4793-3p	CLIP-seq
MIRT987689	hsa-miR-4803	CLIP-seq
MIRT987690	hsa-miR-486-5p	CLIP-seq
MIRT987691	hsa-miR-495	CLIP-seq
MIRT987692	hsa-miR-499-3p	CLIP-seq
MIRT987693	hsa-miR-499a-3p	CLIP-seq
MIRT987694	hsa-miR-509-3-5p	CLIP-seq
MIRT987695	hsa-miR-509-5p	CLIP-seq
MIRT987696	hsa-miR-616	CLIP-seq
MIRT987697	hsa-miR-649	CLIP-seq
MIRT987660	hsa-miR-1183	CLIP-seq
MIRT987666	hsa-miR-194	CLIP-seq
MIRT987667	hsa-miR-200b	CLIP-seq
MIRT987668	hsa-miR-200c	CLIP-seq
MIRT1992676	hsa-miR-330-3p	CLIP-seq
MIRT987678	hsa-miR-429	CLIP-seq
MIRT1992677	hsa-miR-4422	CLIP-seq
MIRT987687	hsa-miR-4712-3p	CLIP-seq
MIRT987689	hsa-miR-4803	CLIP-seq
MIRT987660	hsa-miR-1183	CLIP-seq
MIRT987666	hsa-miR-194	CLIP-seq
MIRT987667	hsa-miR-200b	CLIP-seq
MIRT987668	hsa-miR-200c	CLIP-seq
MIRT987678	hsa-miR-429	CLIP-seq
MIRT987682	hsa-miR-4427	CLIP-seq
MIRT987688	hsa-miR-4793-3p	CLIP-seq
MIRT987689	hsa-miR-4803	CLIP-seq
MIRT1992676	hsa-miR-330-3p	CLIP-seq
MIRT1992677	hsa-miR-4422	CLIP-seq
MIRT2449431	hsa-miR-3145-3p	CLIP-seq
MIRT1992677	hsa-miR-4422	CLIP-seq
MIRT2449432	hsa-miR-4662a-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001837	Process	Epithelial to mesenchymal transition	IDA	24344117
GO:0005515	Function	Protein binding	IPI	23455922, 24344117, 29789297
GO:0005737	Component	Cytoplasm	IC	24736947, 25646692
GO:0005737	Component	Cytoplasm	IDA	18445686, 18485706
GO:0005819	Component	Spindle	IDA	18445686
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0007165	Process	Signal transduction	IBA	21873635
GO:0008017	Function	Microtubule binding	IDA	18485706
GO:0008283	Process	Cell population proliferation	IDA	24344117, 25646692
GO:0015630	Component	Microtubule cytoskeleton	IDA
GO:0016477	Process	Cell migration	IDA	24344117
GO:0019894	Function	Kinesin binding	IPI	18485706
GO:0019901	Function	Protein kinase binding	IBA	21873635
GO:0019901	Function	Protein kinase binding	IPI	24736947
GO:0032006	Process	Regulation of TOR signaling	IBA	21873635
GO:0032006	Process	Regulation of TOR signaling	IDA	24344117
GO:0042176	Process	Regulation of protein catabolic process	IDA	24344117
GO:0045171	Component	Intercellular bridge	IDA
GO:0051301	Process	Cell division	IEA
GO:0051310	Process	Metaphase plate congression	IMP	18485706
GO:0070372	Process	Regulation of ERK1 and ERK2 cascade	IBA	21873635
GO:0070372	Process	Regulation of ERK1 and ERK2 cascade	IMP	24736947, 25646692
GO:0072686	Component	Mitotic spindle	IDA
GO:0097431	Component	Mitotic spindle pole	IBA	21873635
GO:0097431	Component	Mitotic spindle pole	IDA	15561729, 18485706
GO:1902480	Process	Protein localization to mitotic spindle	IBA	21873635
GO:1902480	Process	Protein localization to mitotic spindle	IMP	18485706
GO:1902808	Process	Positive regulation of cell cycle G1/S phase transition	IBA	21873635
GO:1902808	Process	Positive regulation of cell cycle G1/S phase transition	IMP	25646692

Other IDs

• MIM: 618380
• HGNC: 16122
• e!Ensembl: ENSG00000101447

Protein

• UniProt ID: Q9H4H8
• Protein name: Protein FAM83D (Spindle protein CHICA)
• Protein function: Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC (PubMed:24344117). May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade (PubMed:2564
• PDB: 5E0L, 5E0M
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07894	FAM83	17 → 296	FAM83 A-H	Family

• Sequence:

  MALLSEGLDEVPAACLSPCGPPNPTELFSESRRLALEELVAGGPEAFAAFLRRERLARFL
  NPDEVHAILRAAERPGEEGAAAAAAAEDSFGSSHDCSSGTYFPEQSDLEPPLLELGWPAF
  YQGAYRGATRVETHFQPRGAGEGGPYGCKDALRQQLRSAREVIAVVMDVFTDIDIFRDLQ
  EICRKQGVAVYILLDQALLSQFLDMCMDLKVHPEQEKLMTVRTITGNIYYARSGTKIIGK
  VHEKFTLIDGIRVATGSYSFTWTDGKLNSSNLVILSGQVVEHFDLEFRILYAQSKPISPK
  LLSHFQSSNKFDHLTNRKPQSKELTLGNLLRMRLARLSSTPRKADLDPEMPAEGKAERKP
  HDCESSTVSEEDYFSSHRDELQSRKAIDAATQTEPGEEMPGLSVSEVGTQTSITTACAGT
  QTAVITRIASSQTTIWSRSTTTQTDMDENILFPRGTQSTEGSPVSKMSVSRSSSLKSSSS
  VSSQGSVASSTGSPASIRTTDFHNPGYPKYLGTPHLELYLSDSLRNLNKERQFHFAGIRS
  RLNHMLAMLSRRTLFTENHLGLHSGNFSRVNLLAVRDVALYPSYQ

• Sequence length: 585

Associated diseases

Unknown
Disease name	Disease term	dbSNP ID	References
Liver carcinoma	Liver carcinoma		28284560