APOLD1 (apolipoprotein L domain containing 1)

Gene

• Entrez ID: 81575
• Gene name: Apolipoprotein L domain containing 1
• Gene symbol: APOLD1
• Synonyms: BDVAS, VERGE
• Chromosome: 12
• Chromosome location: 12p13.1
• Summary: APOLD1 is an endothelial cell early response protein that may play a role in regulation of endothelial cell signaling and vascular function (Regard et al., 2004 [PubMed 15102925]).[supplied by OMIM, Dec 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016472	hsa-miR-193b-3p	Microarray	20304954
MIRT024460	hsa-miR-215-5p	Microarray	19074876
MIRT026548	hsa-miR-192-5p	Microarray	19074876
MIRT030891	hsa-miR-21-5p	Microarray	18591254
MIRT049116	hsa-miR-92a-3p	CLASH	23622248
MIRT049116	hsa-miR-92a-3p	CLASH	23622248
MIRT042977	hsa-miR-324-3p	CLASH	23622248
MIRT040577	hsa-miR-92b-3p	CLASH	23622248
MIRT635457	hsa-miR-622	HITS-CLIP	23824327
MIRT635456	hsa-miR-204-3p	HITS-CLIP	23824327
MIRT635454	hsa-miR-4646-5p	HITS-CLIP	23824327
MIRT635455	hsa-miR-3192-5p	HITS-CLIP	23824327
MIRT635453	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT635451	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT635452	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT635450	hsa-miR-4314	HITS-CLIP	23824327
MIRT635449	hsa-miR-1302	HITS-CLIP	23824327
MIRT635448	hsa-miR-4298	HITS-CLIP	23824327
MIRT457126	hsa-miR-302f	PAR-CLIP	23592263
MIRT457125	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT457124	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT457123	hsa-miR-4433a-3p	PAR-CLIP	23592263
MIRT457122	hsa-miR-665	PAR-CLIP	23592263
MIRT457120	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT457121	hsa-miR-4649-3p	PAR-CLIP	23592263
MIRT457119	hsa-miR-219b-3p	PAR-CLIP	23592263
MIRT457118	hsa-miR-1827	PAR-CLIP	23592263
MIRT457117	hsa-miR-4785	PAR-CLIP	23592263
MIRT457116	hsa-miR-298	PAR-CLIP	23592263
MIRT457115	hsa-miR-1273e	PAR-CLIP	23592263
MIRT635457	hsa-miR-622	HITS-CLIP	23824327
MIRT635456	hsa-miR-204-3p	HITS-CLIP	23824327
MIRT635454	hsa-miR-4646-5p	HITS-CLIP	23824327
MIRT635455	hsa-miR-3192-5p	HITS-CLIP	23824327
MIRT635453	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT635451	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT635452	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT635450	hsa-miR-4314	HITS-CLIP	23824327
MIRT635449	hsa-miR-1302	HITS-CLIP	23824327
MIRT635448	hsa-miR-4298	HITS-CLIP	23824327
MIRT457126	hsa-miR-302f	PAR-CLIP	23592263
MIRT457125	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT457124	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT457123	hsa-miR-4433a-3p	PAR-CLIP	23592263
MIRT457122	hsa-miR-665	PAR-CLIP	23592263
MIRT457120	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT457121	hsa-miR-4649-3p	PAR-CLIP	23592263
MIRT457119	hsa-miR-219b-3p	PAR-CLIP	23592263
MIRT457118	hsa-miR-1827	PAR-CLIP	23592263
MIRT457117	hsa-miR-4785	PAR-CLIP	23592263
MIRT457116	hsa-miR-298	PAR-CLIP	23592263
MIRT457115	hsa-miR-1273e	PAR-CLIP	23592263
MIRT790391	hsa-miR-10a	CLIP-seq
MIRT790392	hsa-miR-10b	CLIP-seq
MIRT790393	hsa-miR-1224-5p	CLIP-seq
MIRT790394	hsa-miR-1266	CLIP-seq
MIRT790395	hsa-miR-1279	CLIP-seq
MIRT790396	hsa-miR-1304	CLIP-seq
MIRT790397	hsa-miR-1972	CLIP-seq
MIRT790398	hsa-miR-24	CLIP-seq
MIRT790399	hsa-miR-2964a-3p	CLIP-seq
MIRT790400	hsa-miR-3122	CLIP-seq
MIRT790401	hsa-miR-3126-3p	CLIP-seq
MIRT790402	hsa-miR-3135	CLIP-seq
MIRT790403	hsa-miR-3176	CLIP-seq
MIRT790404	hsa-miR-3192	CLIP-seq
MIRT790405	hsa-miR-339-5p	CLIP-seq
MIRT790406	hsa-miR-3607-3p	CLIP-seq
MIRT790407	hsa-miR-3664-3p	CLIP-seq
MIRT790408	hsa-miR-3672	CLIP-seq
MIRT790409	hsa-miR-3686	CLIP-seq
MIRT790410	hsa-miR-3913-5p	CLIP-seq
MIRT790411	hsa-miR-3915	CLIP-seq
MIRT790412	hsa-miR-3919	CLIP-seq
MIRT790413	hsa-miR-3922-3p	CLIP-seq
MIRT790414	hsa-miR-3925-3p	CLIP-seq
MIRT790415	hsa-miR-3926	CLIP-seq
MIRT790416	hsa-miR-3929	CLIP-seq
MIRT790417	hsa-miR-3941	CLIP-seq
MIRT790418	hsa-miR-3978	CLIP-seq
MIRT790419	hsa-miR-4284	CLIP-seq
MIRT790420	hsa-miR-4330	CLIP-seq
MIRT790421	hsa-miR-4419b	CLIP-seq
MIRT790422	hsa-miR-4421	CLIP-seq
MIRT790423	hsa-miR-4433	CLIP-seq
MIRT790424	hsa-miR-4435	CLIP-seq
MIRT790425	hsa-miR-4459	CLIP-seq
MIRT790426	hsa-miR-4478	CLIP-seq
MIRT790427	hsa-miR-4518	CLIP-seq
MIRT790428	hsa-miR-4650-5p	CLIP-seq
MIRT790429	hsa-miR-466	CLIP-seq
MIRT790430	hsa-miR-4672	CLIP-seq
MIRT790431	hsa-miR-4684-5p	CLIP-seq
MIRT790432	hsa-miR-4689	CLIP-seq
MIRT790433	hsa-miR-4695-5p	CLIP-seq
MIRT790434	hsa-miR-4733-3p	CLIP-seq
MIRT790435	hsa-miR-4747-5p	CLIP-seq
MIRT790436	hsa-miR-4751	CLIP-seq
MIRT790437	hsa-miR-4753-5p	CLIP-seq
MIRT790438	hsa-miR-4755-3p	CLIP-seq
MIRT790439	hsa-miR-4756-3p	CLIP-seq
MIRT790440	hsa-miR-4761-5p	CLIP-seq
MIRT790441	hsa-miR-4768-3p	CLIP-seq
MIRT790442	hsa-miR-4786-3p	CLIP-seq
MIRT790443	hsa-miR-4797-5p	CLIP-seq
MIRT790444	hsa-miR-485-5p	CLIP-seq
MIRT790445	hsa-miR-508-5p	CLIP-seq
MIRT790446	hsa-miR-510	CLIP-seq
MIRT790447	hsa-miR-512-5p	CLIP-seq
MIRT790448	hsa-miR-541	CLIP-seq
MIRT790449	hsa-miR-542-3p	CLIP-seq
MIRT790450	hsa-miR-548c-3p	CLIP-seq
MIRT790451	hsa-miR-548s	CLIP-seq
MIRT790452	hsa-miR-548u	CLIP-seq
MIRT790453	hsa-miR-593	CLIP-seq
MIRT790454	hsa-miR-654-5p	CLIP-seq
MIRT790455	hsa-miR-671-5p	CLIP-seq
MIRT790456	hsa-miR-759	CLIP-seq
MIRT790457	hsa-miR-766	CLIP-seq
MIRT790458	hsa-miR-1231	CLIP-seq
MIRT790459	hsa-miR-1912	CLIP-seq
MIRT790400	hsa-miR-3122	CLIP-seq
MIRT790460	hsa-miR-3617	CLIP-seq
MIRT790410	hsa-miR-3913-5p	CLIP-seq
MIRT790461	hsa-miR-4288	CLIP-seq
MIRT790435	hsa-miR-4747-5p	CLIP-seq
MIRT790440	hsa-miR-4761-5p	CLIP-seq
MIRT790442	hsa-miR-4786-3p	CLIP-seq
MIRT790448	hsa-miR-541	CLIP-seq
MIRT790462	hsa-miR-632	CLIP-seq
MIRT790463	hsa-miR-641	CLIP-seq
MIRT790454	hsa-miR-654-5p	CLIP-seq
MIRT790455	hsa-miR-671-5p	CLIP-seq
MIRT790391	hsa-miR-10a	CLIP-seq
MIRT790392	hsa-miR-10b	CLIP-seq
MIRT1933140	hsa-miR-1276	CLIP-seq
MIRT790395	hsa-miR-1279	CLIP-seq
MIRT1933141	hsa-miR-223	CLIP-seq
MIRT790405	hsa-miR-339-5p	CLIP-seq
MIRT790412	hsa-miR-3919	CLIP-seq
MIRT790415	hsa-miR-3926	CLIP-seq
MIRT1933142	hsa-miR-3942-3p	CLIP-seq
MIRT1933143	hsa-miR-3974	CLIP-seq
MIRT1933144	hsa-miR-4328	CLIP-seq
MIRT790422	hsa-miR-4421	CLIP-seq
MIRT1933145	hsa-miR-452	CLIP-seq
MIRT1933146	hsa-miR-4676-3p	CLIP-seq
MIRT790431	hsa-miR-4684-5p	CLIP-seq
MIRT1933147	hsa-miR-4693-5p	CLIP-seq
MIRT790439	hsa-miR-4756-3p	CLIP-seq
MIRT1933148	hsa-miR-548ag	CLIP-seq
MIRT1933149	hsa-miR-548ai	CLIP-seq
MIRT790451	hsa-miR-548s	CLIP-seq
MIRT1933150	hsa-miR-561	CLIP-seq
MIRT790453	hsa-miR-593	CLIP-seq
MIRT1933151	hsa-miR-873	CLIP-seq
MIRT790391	hsa-miR-10a	CLIP-seq
MIRT790392	hsa-miR-10b	CLIP-seq
MIRT790395	hsa-miR-1279	CLIP-seq
MIRT2173307	hsa-miR-128	CLIP-seq
MIRT2173308	hsa-miR-150	CLIP-seq
MIRT2173309	hsa-miR-1911	CLIP-seq
MIRT790459	hsa-miR-1912	CLIP-seq
MIRT2173310	hsa-miR-1913	CLIP-seq
MIRT2173311	hsa-miR-1915	CLIP-seq
MIRT2173312	hsa-miR-2115	CLIP-seq
MIRT1933141	hsa-miR-223	CLIP-seq
MIRT790398	hsa-miR-24	CLIP-seq
MIRT2173313	hsa-miR-27a	CLIP-seq
MIRT2173314	hsa-miR-27b	CLIP-seq
MIRT790399	hsa-miR-2964a-3p	CLIP-seq
MIRT2173315	hsa-miR-29a	CLIP-seq
MIRT2173316	hsa-miR-29b	CLIP-seq
MIRT2173317	hsa-miR-29c	CLIP-seq
MIRT2173318	hsa-miR-3065-3p	CLIP-seq
MIRT790400	hsa-miR-3122	CLIP-seq
MIRT2173319	hsa-miR-3183	CLIP-seq
MIRT2173320	hsa-miR-3189-5p	CLIP-seq
MIRT790405	hsa-miR-339-5p	CLIP-seq
MIRT2173321	hsa-miR-342-3p	CLIP-seq
MIRT2173322	hsa-miR-3607-5p	CLIP-seq
MIRT790460	hsa-miR-3617	CLIP-seq
MIRT790407	hsa-miR-3664-3p	CLIP-seq
MIRT2173323	hsa-miR-3689a-3p	CLIP-seq
MIRT2173324	hsa-miR-3689c	CLIP-seq
MIRT790410	hsa-miR-3913-5p	CLIP-seq
MIRT790412	hsa-miR-3919	CLIP-seq
MIRT2173325	hsa-miR-3921	CLIP-seq
MIRT790415	hsa-miR-3926	CLIP-seq
MIRT790416	hsa-miR-3929	CLIP-seq
MIRT1933142	hsa-miR-3942-3p	CLIP-seq
MIRT1933143	hsa-miR-3974	CLIP-seq
MIRT790419	hsa-miR-4284	CLIP-seq
MIRT2173326	hsa-miR-4300	CLIP-seq
MIRT1933144	hsa-miR-4328	CLIP-seq
MIRT790421	hsa-miR-4419b	CLIP-seq
MIRT790422	hsa-miR-4421	CLIP-seq
MIRT790423	hsa-miR-4433	CLIP-seq
MIRT790425	hsa-miR-4459	CLIP-seq
MIRT790426	hsa-miR-4478	CLIP-seq
MIRT2173327	hsa-miR-4514	CLIP-seq
MIRT2173328	hsa-miR-4639-3p	CLIP-seq
MIRT2173329	hsa-miR-4645-5p	CLIP-seq
MIRT2173330	hsa-miR-4653-5p	CLIP-seq
MIRT2173331	hsa-miR-4673	CLIP-seq
MIRT2173332	hsa-miR-4682	CLIP-seq
MIRT790431	hsa-miR-4684-5p	CLIP-seq
MIRT2173333	hsa-miR-4692	CLIP-seq
MIRT790433	hsa-miR-4695-5p	CLIP-seq
MIRT2173334	hsa-miR-4713-5p	CLIP-seq
MIRT2173335	hsa-miR-4723-3p	CLIP-seq
MIRT2173336	hsa-miR-4729	CLIP-seq
MIRT2173337	hsa-miR-4733-5p	CLIP-seq
MIRT790435	hsa-miR-4747-5p	CLIP-seq
MIRT2173338	hsa-miR-4753-3p	CLIP-seq
MIRT790439	hsa-miR-4756-3p	CLIP-seq
MIRT2173339	hsa-miR-4758-3p	CLIP-seq
MIRT790440	hsa-miR-4761-5p	CLIP-seq
MIRT790441	hsa-miR-4768-3p	CLIP-seq
MIRT790442	hsa-miR-4786-3p	CLIP-seq
MIRT790444	hsa-miR-485-5p	CLIP-seq
MIRT790446	hsa-miR-510	CLIP-seq
MIRT790447	hsa-miR-512-5p	CLIP-seq
MIRT2173340	hsa-miR-516a-3p	CLIP-seq
MIRT2173341	hsa-miR-532-3p	CLIP-seq
MIRT790448	hsa-miR-541	CLIP-seq
MIRT1933148	hsa-miR-548ag	CLIP-seq
MIRT1933149	hsa-miR-548ai	CLIP-seq
MIRT790451	hsa-miR-548s	CLIP-seq
MIRT2173342	hsa-miR-556-5p	CLIP-seq
MIRT790453	hsa-miR-593	CLIP-seq
MIRT790463	hsa-miR-641	CLIP-seq
MIRT790454	hsa-miR-654-5p	CLIP-seq
MIRT790455	hsa-miR-671-5p	CLIP-seq
MIRT2173343	hsa-miR-767-5p	CLIP-seq
MIRT1933151	hsa-miR-873	CLIP-seq
MIRT2173344	hsa-miR-889	CLIP-seq
MIRT2173345	hsa-miR-890	CLIP-seq
MIRT2173346	hsa-miR-920	CLIP-seq
MIRT2173347	hsa-miR-935	CLIP-seq
MIRT2173307	hsa-miR-128	CLIP-seq
MIRT790398	hsa-miR-24	CLIP-seq
MIRT2173313	hsa-miR-27a	CLIP-seq
MIRT2173314	hsa-miR-27b	CLIP-seq
MIRT790400	hsa-miR-3122	CLIP-seq
MIRT790410	hsa-miR-3913-5p	CLIP-seq
MIRT790416	hsa-miR-3929	CLIP-seq
MIRT790419	hsa-miR-4284	CLIP-seq
MIRT790421	hsa-miR-4419b	CLIP-seq
MIRT790423	hsa-miR-4433	CLIP-seq
MIRT790426	hsa-miR-4478	CLIP-seq
MIRT2173327	hsa-miR-4514	CLIP-seq
MIRT2173329	hsa-miR-4645-5p	CLIP-seq
MIRT2173331	hsa-miR-4673	CLIP-seq
MIRT2173333	hsa-miR-4692	CLIP-seq
MIRT790435	hsa-miR-4747-5p	CLIP-seq
MIRT790440	hsa-miR-4761-5p	CLIP-seq
MIRT790442	hsa-miR-4786-3p	CLIP-seq
MIRT790444	hsa-miR-485-5p	CLIP-seq
MIRT790448	hsa-miR-541	CLIP-seq
MIRT790454	hsa-miR-654-5p	CLIP-seq
MIRT790455	hsa-miR-671-5p	CLIP-seq
MIRT2426387	hsa-miR-4724-3p	CLIP-seq
MIRT790391	hsa-miR-10a	CLIP-seq
MIRT790392	hsa-miR-10b	CLIP-seq
MIRT790400	hsa-miR-3122	CLIP-seq
MIRT790405	hsa-miR-339-5p	CLIP-seq
MIRT2443833	hsa-miR-3613-3p	CLIP-seq
MIRT790410	hsa-miR-3913-5p	CLIP-seq
MIRT790415	hsa-miR-3926	CLIP-seq
MIRT790422	hsa-miR-4421	CLIP-seq
MIRT2443834	hsa-miR-4455	CLIP-seq
MIRT790431	hsa-miR-4684-5p	CLIP-seq
MIRT790435	hsa-miR-4747-5p	CLIP-seq
MIRT790440	hsa-miR-4761-5p	CLIP-seq
MIRT790442	hsa-miR-4786-3p	CLIP-seq
MIRT790448	hsa-miR-541	CLIP-seq
MIRT790450	hsa-miR-548c-3p	CLIP-seq
MIRT790451	hsa-miR-548s	CLIP-seq
MIRT790453	hsa-miR-593	CLIP-seq
MIRT790454	hsa-miR-654-5p	CLIP-seq
MIRT790455	hsa-miR-671-5p	CLIP-seq
MIRT790391	hsa-miR-10a	CLIP-seq
MIRT790392	hsa-miR-10b	CLIP-seq
MIRT790400	hsa-miR-3122	CLIP-seq
MIRT790405	hsa-miR-339-5p	CLIP-seq
MIRT2443833	hsa-miR-3613-3p	CLIP-seq
MIRT790410	hsa-miR-3913-5p	CLIP-seq
MIRT790415	hsa-miR-3926	CLIP-seq
MIRT790422	hsa-miR-4421	CLIP-seq
MIRT2443834	hsa-miR-4455	CLIP-seq
MIRT790431	hsa-miR-4684-5p	CLIP-seq
MIRT790435	hsa-miR-4747-5p	CLIP-seq
MIRT790440	hsa-miR-4761-5p	CLIP-seq
MIRT790442	hsa-miR-4786-3p	CLIP-seq
MIRT790448	hsa-miR-541	CLIP-seq
MIRT790450	hsa-miR-548c-3p	CLIP-seq
MIRT790451	hsa-miR-548s	CLIP-seq
MIRT790453	hsa-miR-593	CLIP-seq
MIRT790454	hsa-miR-654-5p	CLIP-seq
MIRT790455	hsa-miR-671-5p	CLIP-seq
MIRT790391	hsa-miR-10a	CLIP-seq
MIRT790392	hsa-miR-10b	CLIP-seq
MIRT2675188	hsa-miR-138	CLIP-seq
MIRT790399	hsa-miR-2964a-3p	CLIP-seq
MIRT790400	hsa-miR-3122	CLIP-seq
MIRT790405	hsa-miR-339-5p	CLIP-seq
MIRT2443833	hsa-miR-3613-3p	CLIP-seq
MIRT790410	hsa-miR-3913-5p	CLIP-seq
MIRT790415	hsa-miR-3926	CLIP-seq
MIRT790422	hsa-miR-4421	CLIP-seq
MIRT790423	hsa-miR-4433	CLIP-seq
MIRT2443834	hsa-miR-4455	CLIP-seq
MIRT790431	hsa-miR-4684-5p	CLIP-seq
MIRT790435	hsa-miR-4747-5p	CLIP-seq
MIRT790440	hsa-miR-4761-5p	CLIP-seq
MIRT790442	hsa-miR-4786-3p	CLIP-seq
MIRT790448	hsa-miR-541	CLIP-seq
MIRT790450	hsa-miR-548c-3p	CLIP-seq
MIRT790451	hsa-miR-548s	CLIP-seq
MIRT790453	hsa-miR-593	CLIP-seq
MIRT790454	hsa-miR-654-5p	CLIP-seq
MIRT790455	hsa-miR-671-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	IBA	21873635
GO:0001666	Process	Response to hypoxia	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0006869	Process	Lipid transport	IEA
GO:0008289	Function	Lipid binding	IBA	21873635
GO:0016021	Component	Integral component of membrane	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0042118	Process	Endothelial cell activation	IEA
GO:0042157	Process	Lipoprotein metabolic process	IEA
GO:0045601	Process	Regulation of endothelial cell differentiation	IBA	21873635

Other IDs

• MIM: 612456
• HGNC: 25268
• e!Ensembl: ENSG00000178878

Protein

• UniProt ID: Q96LR9
• Protein name: Apolipoprotein L domain-containing protein 1 (Vascular early response gene protein)
• Protein function: Is a modulator of endothelial barrier permeability, required for proper organization of endothelial cell-cell junctions and cytoskeleton (PubMed:35638551). It also plays a role in the modulation of secretory autophagy (PubMed:35638551). May affe
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05461	ApoL	55 → 174	Apolipoprotein L	Family

• Sequence:

  MFRAPCHRLRARGTRKARAGAWRGCTFPCLGKGMERPAAREPHGPDALRRFQGLLLDRRG
  RLHGQVLRLREVARRLERLRRRSLVANVAGSSLSATGALAAIVGLSLSPVTLGTSLLVSA
  VGLGVATAGGAVTITSDLSLIFCNSRELRRVQEIAATCQDQMREILSCLEFFCRWQGCGD
  RQLLQCGRNASIALYNSVYFIVFFGSRGFLIPRRAEGDTKVSQAVLKAKIQKLAESLESC
  TGALDELSEQLESRVQLCTKSSRGHDLKISADQRAGLFF

• Sequence length: 279

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Prostate carcinoma	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	31562322

Unknown
Disease name	Disease term	dbSNP ID	References
Cardiovascular diseases	Cardiovascular Diseases		30595370