MOB2 (MOB kinase activator 2)

Gene

• Entrez ID: 81532
• Gene name: MOB kinase activator 2
• Gene symbol: MOB2
• Synonyms: HCCA2
• Chromosome: 11
• Chromosome location: 11p15.5

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1154173	hsa-miR-1228	CLIP-seq
MIRT1154174	hsa-miR-1245b-3p	CLIP-seq
MIRT1154175	hsa-miR-1827	CLIP-seq
MIRT1154176	hsa-miR-185	CLIP-seq
MIRT1154177	hsa-miR-214	CLIP-seq
MIRT1154178	hsa-miR-2276	CLIP-seq
MIRT1154179	hsa-miR-3179	CLIP-seq
MIRT1154180	hsa-miR-3202	CLIP-seq
MIRT1154181	hsa-miR-329	CLIP-seq
MIRT1154182	hsa-miR-3612	CLIP-seq
MIRT1154183	hsa-miR-3614-3p	CLIP-seq
MIRT1154184	hsa-miR-3619-5p	CLIP-seq
MIRT1154185	hsa-miR-3621	CLIP-seq
MIRT1154186	hsa-miR-362-3p	CLIP-seq
MIRT1154187	hsa-miR-3925-5p	CLIP-seq
MIRT1154188	hsa-miR-3936	CLIP-seq
MIRT1154189	hsa-miR-4297	CLIP-seq
MIRT1154190	hsa-miR-4306	CLIP-seq
MIRT1154191	hsa-miR-4476	CLIP-seq
MIRT1154192	hsa-miR-4644	CLIP-seq
MIRT1154193	hsa-miR-4695-5p	CLIP-seq
MIRT1154194	hsa-miR-4722-5p	CLIP-seq
MIRT1154195	hsa-miR-4768-3p	CLIP-seq
MIRT1154196	hsa-miR-4772-3p	CLIP-seq
MIRT1154197	hsa-miR-4802-5p	CLIP-seq
MIRT1154198	hsa-miR-548ag	CLIP-seq
MIRT1154199	hsa-miR-548ai	CLIP-seq
MIRT1154200	hsa-miR-556-3p	CLIP-seq
MIRT1154201	hsa-miR-572	CLIP-seq
MIRT1154202	hsa-miR-650	CLIP-seq
MIRT1154203	hsa-miR-761	CLIP-seq
MIRT1154204	hsa-miR-765	CLIP-seq
MIRT2044108	hsa-miR-3944-5p	CLIP-seq
MIRT2431226	hsa-miR-1304	CLIP-seq
MIRT2431227	hsa-miR-15a	CLIP-seq
MIRT2431228	hsa-miR-15b	CLIP-seq
MIRT2431229	hsa-miR-16	CLIP-seq
MIRT2431230	hsa-miR-195	CLIP-seq
MIRT2431231	hsa-miR-3065-3p	CLIP-seq
MIRT2431232	hsa-miR-424	CLIP-seq
MIRT2431233	hsa-miR-4419a	CLIP-seq
MIRT2431234	hsa-miR-4510	CLIP-seq
MIRT2431235	hsa-miR-4530	CLIP-seq
MIRT2431236	hsa-miR-497	CLIP-seq
MIRT1154175	hsa-miR-1827	CLIP-seq
MIRT1154177	hsa-miR-214	CLIP-seq
MIRT1154179	hsa-miR-3179	CLIP-seq
MIRT1154180	hsa-miR-3202	CLIP-seq
MIRT1154182	hsa-miR-3612	CLIP-seq
MIRT1154184	hsa-miR-3619-5p	CLIP-seq
MIRT1154188	hsa-miR-3936	CLIP-seq
MIRT1154191	hsa-miR-4476	CLIP-seq
MIRT1154193	hsa-miR-4695-5p	CLIP-seq
MIRT2438777	hsa-miR-542-3p	CLIP-seq
MIRT1154202	hsa-miR-650	CLIP-seq
MIRT1154203	hsa-miR-761	CLIP-seq
MIRT2572308	hsa-miR-1182	CLIP-seq
MIRT2572309	hsa-miR-1224-3p	CLIP-seq
MIRT1154173	hsa-miR-1228	CLIP-seq
MIRT2572310	hsa-miR-140-3p	CLIP-seq
MIRT2572311	hsa-miR-22	CLIP-seq
MIRT2572312	hsa-miR-3160-3p	CLIP-seq
MIRT2572313	hsa-miR-3173-3p	CLIP-seq
MIRT2572314	hsa-miR-361-3p	CLIP-seq
MIRT2572315	hsa-miR-3921	CLIP-seq
MIRT2572316	hsa-miR-4303	CLIP-seq
MIRT2572317	hsa-miR-4432	CLIP-seq
MIRT2572318	hsa-miR-4487	CLIP-seq
MIRT2572319	hsa-miR-4533	CLIP-seq
MIRT2572320	hsa-miR-4650-5p	CLIP-seq
MIRT2572321	hsa-miR-4653-5p	CLIP-seq
MIRT2572322	hsa-miR-4677-3p	CLIP-seq
MIRT2572323	hsa-miR-4679	CLIP-seq
MIRT2572324	hsa-miR-4747-5p	CLIP-seq
MIRT2572325	hsa-miR-4779	CLIP-seq
MIRT2572326	hsa-miR-558	CLIP-seq
MIRT2572327	hsa-miR-593	CLIP-seq
MIRT2572309	hsa-miR-1224-3p	CLIP-seq
MIRT1154173	hsa-miR-1228	CLIP-seq
MIRT2572310	hsa-miR-140-3p	CLIP-seq
MIRT2572311	hsa-miR-22	CLIP-seq
MIRT2572312	hsa-miR-3160-3p	CLIP-seq
MIRT2572313	hsa-miR-3173-3p	CLIP-seq
MIRT2572314	hsa-miR-361-3p	CLIP-seq
MIRT2572315	hsa-miR-3921	CLIP-seq
MIRT2572316	hsa-miR-4303	CLIP-seq
MIRT2572317	hsa-miR-4432	CLIP-seq
MIRT2572318	hsa-miR-4487	CLIP-seq
MIRT2572319	hsa-miR-4533	CLIP-seq
MIRT2572320	hsa-miR-4650-5p	CLIP-seq
MIRT2572321	hsa-miR-4653-5p	CLIP-seq
MIRT2572324	hsa-miR-4747-5p	CLIP-seq
MIRT2572325	hsa-miR-4779	CLIP-seq
MIRT2572326	hsa-miR-558	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	24366813, 25852190, 28514442, 30108113, 32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005829	Component	Cytosol	IDA
GO:0046872	Function	Metal ion binding	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA

Other IDs

• MIM: 611969
• HGNC: 24904
• e!Ensembl: ENSG00000182208

Protein

• UniProt ID: Q70IA6
• Protein name: MOB kinase activator 2 (HCCA2) (Mob2 homolog) (Mps one binder kinase activator-like 2)
• Protein function: Stimulates the autophosphorylation and kinase activity of STK38 and STK38L.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03637	Mob1_phocein	32 → 200	Mob1/phocein family	Family

• Sequence:

  MDWLMGKSKAKPNGKKPAAEERKAYLEPEHTKARITDFQFKELVVLPREIDLNEWLASNT
  TTFFHHINLQYSTISEFCTGETCQTMAVCNTQYYWYDERGKKVKCTAPQYVDFVMSSVQK
  LVTDEDVFPTKYGREFPSSFESLVRKICRHLFHVLAHIYWAHFKETLALELHGHLNTLYV
  HFILFAREFNLLDPKETAIMDDLTEVLCSGAGGVHSGGSGDGAGSGGPGAQNHVKER

• Sequence length: 237

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Prostate carcinoma, Prostate cancer, familial	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	29892016
Prostate cancer, hereditary	PROSTATE CANCER, HEREDITARY, 1	rs387906327, rs193929331, rs74315365, rs10993994, rs397516896, rs794729219, rs121913349, rs587782641, rs1114167673, rs1597371666, rs2073394466	29892016