TAF15 (TATA-box binding protein associated factor 15)

Gene

• Entrez ID: 8148
• Gene name: TATA-box binding protein associated factor 15
• Gene symbol: TAF15
• Synonyms: Npl3, RBP56, TAF2N, TAFII68
• Chromosome: 17
• Chromosome location: 17q12
• Summary: This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocat

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT021732	hsa-miR-132-3p	Microarray	17612493
MIRT025067	hsa-miR-181a-5p	Microarray	17612493
MIRT030412	hsa-miR-24-3p	Microarray	19748357
MIRT031463	hsa-miR-16-5p	Proteomics	18668040
MIRT048160	hsa-miR-196a-5p	CLASH	23622248
MIRT047604	hsa-miR-10a-5p	CLASH	23622248
MIRT046039	hsa-miR-125b-5p	CLASH	23622248
MIRT044517	hsa-miR-320a	CLASH	23622248
MIRT041143	hsa-miR-501-5p	CLASH	23622248
MIRT040091	hsa-miR-615-3p	CLASH	23622248
MIRT040091	hsa-miR-615-3p	CLASH	23622248
MIRT040091	hsa-miR-615-3p	CLASH	23622248
MIRT037061	hsa-miR-877-3p	CLASH	23622248
MIRT1409126	hsa-miR-1246	CLIP-seq
MIRT1409127	hsa-miR-1271	CLIP-seq
MIRT1409128	hsa-miR-132	CLIP-seq
MIRT1409129	hsa-miR-1323	CLIP-seq
MIRT1409130	hsa-miR-137	CLIP-seq
MIRT1409131	hsa-miR-15a	CLIP-seq
MIRT1409132	hsa-miR-15b	CLIP-seq
MIRT1409133	hsa-miR-16	CLIP-seq
MIRT1409134	hsa-miR-181a	CLIP-seq
MIRT1409135	hsa-miR-181b	CLIP-seq
MIRT1409136	hsa-miR-181c	CLIP-seq
MIRT1409137	hsa-miR-181d	CLIP-seq
MIRT1409138	hsa-miR-182	CLIP-seq
MIRT1409139	hsa-miR-195	CLIP-seq
MIRT1409140	hsa-miR-2110	CLIP-seq
MIRT1409141	hsa-miR-212	CLIP-seq
MIRT1409142	hsa-miR-214	CLIP-seq
MIRT1409143	hsa-miR-216a	CLIP-seq
MIRT1409144	hsa-miR-25	CLIP-seq
MIRT1409145	hsa-miR-296-3p	CLIP-seq
MIRT1409146	hsa-miR-3128	CLIP-seq
MIRT1409147	hsa-miR-3150a-3p	CLIP-seq
MIRT1409148	hsa-miR-3175	CLIP-seq
MIRT1409149	hsa-miR-32	CLIP-seq
MIRT1409150	hsa-miR-3619-5p	CLIP-seq
MIRT1409151	hsa-miR-363	CLIP-seq
MIRT1409152	hsa-miR-367	CLIP-seq
MIRT1409153	hsa-miR-3912	CLIP-seq
MIRT1409154	hsa-miR-3919	CLIP-seq
MIRT1409155	hsa-miR-3978	CLIP-seq
MIRT1409156	hsa-miR-424	CLIP-seq
MIRT1409157	hsa-miR-4261	CLIP-seq
MIRT1409158	hsa-miR-4262	CLIP-seq
MIRT1409159	hsa-miR-4434	CLIP-seq
MIRT1409160	hsa-miR-4509	CLIP-seq
MIRT1409161	hsa-miR-4516	CLIP-seq
MIRT1409162	hsa-miR-4668-3p	CLIP-seq
MIRT1409163	hsa-miR-4690-5p	CLIP-seq
MIRT1409164	hsa-miR-4716-3p	CLIP-seq
MIRT1409165	hsa-miR-4717-5p	CLIP-seq
MIRT1409166	hsa-miR-4720-5p	CLIP-seq
MIRT1409167	hsa-miR-4742-5p	CLIP-seq
MIRT1409168	hsa-miR-4756-3p	CLIP-seq
MIRT1409169	hsa-miR-4775	CLIP-seq
MIRT1409170	hsa-miR-4799-3p	CLIP-seq
MIRT1409171	hsa-miR-497	CLIP-seq
MIRT1409172	hsa-miR-520d-5p	CLIP-seq
MIRT1409173	hsa-miR-524-5p	CLIP-seq
MIRT1409174	hsa-miR-543	CLIP-seq
MIRT1409175	hsa-miR-548c-3p	CLIP-seq
MIRT1409176	hsa-miR-548o	CLIP-seq
MIRT1409177	hsa-miR-579	CLIP-seq
MIRT1409178	hsa-miR-625	CLIP-seq
MIRT1409179	hsa-miR-668	CLIP-seq
MIRT1409180	hsa-miR-761	CLIP-seq
MIRT1409181	hsa-miR-92a	CLIP-seq
MIRT1409182	hsa-miR-92b	CLIP-seq
MIRT1409183	hsa-miR-939	CLIP-seq
MIRT1409184	hsa-miR-96	CLIP-seq
MIRT1409129	hsa-miR-1323	CLIP-seq
MIRT1409131	hsa-miR-15a	CLIP-seq
MIRT1409132	hsa-miR-15b	CLIP-seq
MIRT1409133	hsa-miR-16	CLIP-seq
MIRT1409139	hsa-miR-195	CLIP-seq
MIRT1409142	hsa-miR-214	CLIP-seq
MIRT1409143	hsa-miR-216a	CLIP-seq
MIRT1409150	hsa-miR-3619-5p	CLIP-seq
MIRT1409156	hsa-miR-424	CLIP-seq
MIRT1409162	hsa-miR-4668-3p	CLIP-seq
MIRT1409163	hsa-miR-4690-5p	CLIP-seq
MIRT1409165	hsa-miR-4717-5p	CLIP-seq
MIRT1409167	hsa-miR-4742-5p	CLIP-seq
MIRT1409169	hsa-miR-4775	CLIP-seq
MIRT2122704	hsa-miR-4777-5p	CLIP-seq
MIRT1409171	hsa-miR-497	CLIP-seq
MIRT2122705	hsa-miR-518d-5p	CLIP-seq
MIRT2122706	hsa-miR-519b-5p	CLIP-seq
MIRT2122707	hsa-miR-519c-5p	CLIP-seq
MIRT2122708	hsa-miR-520c-5p	CLIP-seq
MIRT2122709	hsa-miR-526a	CLIP-seq
MIRT1409175	hsa-miR-548c-3p	CLIP-seq
MIRT1409176	hsa-miR-548o	CLIP-seq
MIRT1409179	hsa-miR-668	CLIP-seq
MIRT1409180	hsa-miR-761	CLIP-seq
MIRT1409126	hsa-miR-1246	CLIP-seq
MIRT1409127	hsa-miR-1271	CLIP-seq
MIRT1409129	hsa-miR-1323	CLIP-seq
MIRT1409131	hsa-miR-15a	CLIP-seq
MIRT1409132	hsa-miR-15b	CLIP-seq
MIRT1409133	hsa-miR-16	CLIP-seq
MIRT1409134	hsa-miR-181a	CLIP-seq
MIRT1409135	hsa-miR-181b	CLIP-seq
MIRT1409136	hsa-miR-181c	CLIP-seq
MIRT1409137	hsa-miR-181d	CLIP-seq
MIRT1409138	hsa-miR-182	CLIP-seq
MIRT1409139	hsa-miR-195	CLIP-seq
MIRT1409142	hsa-miR-214	CLIP-seq
MIRT1409146	hsa-miR-3128	CLIP-seq
MIRT1409150	hsa-miR-3619-5p	CLIP-seq
MIRT1409153	hsa-miR-3912	CLIP-seq
MIRT1409154	hsa-miR-3919	CLIP-seq
MIRT1409156	hsa-miR-424	CLIP-seq
MIRT1409158	hsa-miR-4262	CLIP-seq
MIRT1409162	hsa-miR-4668-3p	CLIP-seq
MIRT1409163	hsa-miR-4690-5p	CLIP-seq
MIRT1409165	hsa-miR-4717-5p	CLIP-seq
MIRT1409166	hsa-miR-4720-5p	CLIP-seq
MIRT1409167	hsa-miR-4742-5p	CLIP-seq
MIRT1409168	hsa-miR-4756-3p	CLIP-seq
MIRT1409169	hsa-miR-4775	CLIP-seq
MIRT1409170	hsa-miR-4799-3p	CLIP-seq
MIRT1409171	hsa-miR-497	CLIP-seq
MIRT1409172	hsa-miR-520d-5p	CLIP-seq
MIRT1409173	hsa-miR-524-5p	CLIP-seq
MIRT1409174	hsa-miR-543	CLIP-seq
MIRT1409175	hsa-miR-548c-3p	CLIP-seq
MIRT1409176	hsa-miR-548o	CLIP-seq
MIRT1409177	hsa-miR-579	CLIP-seq
MIRT1409179	hsa-miR-668	CLIP-seq
MIRT1409180	hsa-miR-761	CLIP-seq
MIRT1409184	hsa-miR-96	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	IEA
GO:0003712	Function	Transcription coregulator activity	IBA	21873635
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA	21873635
GO:0003723	Function	RNA binding	IDA	27378374
GO:0005515	Function	Protein binding	IPI	18509338, 19124016, 21988832, 23975937, 27460707
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	19124016
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA	19124016
GO:0005737	Component	Cytoplasm	IDA	19124016
GO:0006366	Process	Transcription by RNA polymerase II	TAS
GO:0006367	Process	Transcription initiation from RNA polymerase II promoter	TAS
GO:0045893	Process	Positive regulation of transcription, DNA-templated	TAS	19124016
GO:0046872	Function	Metal ion binding	IEA
GO:0048255	Process	MRNA stabilization	IDA	27378374
GO:1901796	Process	Regulation of signal transduction by p53 class mediator	TAS

Other IDs

• MIM: 601574
• HGNC: 11547
• e!Ensembl: ENSG00000270647

Protein

• UniProt ID: Q92804
• Protein name: TATA-binding protein-associated factor 2N (68 kDa TATA-binding protein-associated factor) (TAF(II)68) (TAFII68) (RNA-binding protein 56)
• Protein function: RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Can enter the preinitiation complex together with
• PDB: 2MMY, 8ONS
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00076	RRM_1	236 → 314	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
  PF00641	zf-RanBP	354 → 385	Zn-finger in Ran binding protein and others	Domain

• Sequence:

  MSDSGSYGQSGGEQQSYSTYGNPGSQGYGQASQSYSGYGQTTDSSYGQNYSGYSSYGQSQ
  SGYSQSYGGYENQKQSSYSQQPYNNQGQQQNMESSGSQGGRAPSYDQPDYGQQDSYDQQS
  GYDQHQGSYDEQSNYDQQHDSYSQNQQSYHSQRENYSHHTQDDRRDVSRYGEDNRGYGGS
  QGGGRGRGGYDKDGRGPMTGSSGGDRGGFKNFGGHRDYGPRTDADSESDNSDNNTIFVQG
  LGEGVSTDQVGEFFKQIGIIKTNKKTGKPMINLYTDKDTGKPKGEATVSFDDPPSAKAAI
  DWFDGKEFHGNIIKVSFATRRPEFMRGGGSGGGRRGRGGYRGRGGFQGRGGDPKSGDWVC
  PNPSCGNMNFARRNSCNQCNEPRPEDSRPSGGDFRGRGYGGERGYRGRGGRGGDRGGYGG
  DRSGGGYGGDRSSGGGYSGDRSGGGYGGDRSGGGYGGDRGGGYGGDRGGGYGGDRGGGYG
  GDRGGYGGDRGGGYGGDRGGYGGDRGGYGGDRGGYGGDRGGYGGDRSRGGYGGDRGGGSG
  YGGDRSGGYGGDRSGGGYGGDRGGGYGGDRGGYGGKMGGRNDYRNDQRNRPY

• Sequence length: 592

Pathways

KEGG:

Basal transcription factors
Transcriptional misregulation in cancer

Reactome:

RNA Polymerase II Pre-transcription Events
Regulation of TP53 Activity through Phosphorylation
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Initiation And Promoter Clearance

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Amyotrophic lateral sclerosis	Amyotrophic Lateral Sclerosis	rs267607084, rs312262720, rs312262752, rs121908287, rs121908288, rs29001584, rs28941475, rs121434378, rs386134173, rs386134174, rs80356730, rs80356727, rs4884357, rs80356717, rs80356733, rs80356731, rs80356726, rs267606928, rs267606929, rs1885090126, rs121434591, rs121912431, rs121912432, rs121912433, rs121912434, rs121912435, rs121912440, rs121912436, rs121912437, rs121912438, rs121912439, rs74315452, rs121912442, rs121912443, rs121912444, rs121912446, rs121912447, rs1197141604, rs121912448, rs121912449, rs121912450, rs121912451, rs121912452, rs121912453, rs121912454, rs369600566, rs121912455, rs121912456, rs121912457, rs121912458, rs1555836889, rs121909667, rs121909668, rs121909669, rs121909671, rs121909535, rs121909537, rs121909538, rs121909539, rs121909540, rs121909542, rs121909544, rs80356734, rs367543041, rs80356740, rs80356719, rs80356721, rs80356723, rs80356725, rs387906627, rs387906628, rs387906709, rs387906710, rs387906711, rs387906829, rs387907264, rs387907265, rs387907266, rs312262739, rs312262709, rs312262749, rs200793464, rs147713329, rs312262788, rs397514262, rs63751180, rs587777132, rs730880025, rs730880026, rs730880027, rs368743618, rs730880029, rs730882255, rs730882256, rs786205611, rs121912441, rs199947197, rs780136067, rs772731615, rs879253926, rs879254294, rs764717219, rs886041390, rs750159428, rs753207473, rs267607087, rs767350733, rs778305085, rs1554707680, rs1554707622, rs1393363759, rs750959420, rs1555509569, rs1554716504, rs11556620, rs1247392012, rs142083484, rs140385286, rs749428135, rs371575563, rs1402429085, rs1218712729, rs1555179091, rs1555179087, rs746971952, rs1555836950, rs368276916, rs140376902, rs747220413, rs76731700, rs770684782, rs1200906022, rs1804449, rs1482760341, rs769898852, rs140599944, rs757972700, rs1555451521, rs1592362719, rs1555836803, rs763455928, rs1378590183, rs1583695322, rs1362178149, rs1197928094, rs368751524, rs1555509609, rs1574787779, rs1601157750, rs1301635320, rs1341055534, rs1402092579, rs1568809172, rs1555836170, rs1315541036, rs1339283341, rs1643659556, rs1644506661, rs1435710212, rs1553122918, rs1689580631, rs374047961, rs775935265, rs2076486420, rs1820836522, rs757260058, rs1844420892, rs1833371664, rs1833438306, rs1833451208, rs2083790483, rs1303294230, rs1226110412, rs2053207945, rs2053208751, rs2053501632, rs2053539304, rs1567479067, rs544088874, rs1228194239, rs1568807400, rs1169198442, rs2049594204, rs2049594311, rs1568810641, rs1568811372, rs2049618449, rs1476760624, rs2079347087	26601740, 21438137
Chondrosarcoma	Chondrosarcoma	rs587776540, rs1586279285, rs886039356, rs1554578798, rs1817895168
Gastric cancer	Hereditary Diffuse Gastric Cancer	rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802, rs28933369, rs121912469, rs80358011, rs397507262, rs80359439, rs397507333, rs80359543, rs80358831, rs80359596, rs80358920, rs80358972, rs80359659, rs397507404, rs397514661, rs80359516, rs200495564, rs80358419, rs80359274, rs80359283, rs80358427, rs80358428, rs80358435, rs81002805, rs397507660, rs397507663, rs80359391, rs80359443, rs81002797, rs80359466, rs397507752, rs80359484, rs80359603, rs397507954, rs80359058, rs80359071, rs397507981, rs80359121, rs80357086, rs80357064, rs397508936, rs80357695, rs80357661, rs397509035, rs80357544, rs80357577, rs80357881, rs80357296, rs80356923, rs80356866, rs80357504, rs80357390, rs80357239, rs80358099, rs397509284, rs80357258, rs199474738, rs199474747, rs587779204, rs63750439, rs267608076, rs587779246, rs63749999, rs267608078, rs63751327, rs267607719, rs267607734, rs63750706, rs63751711, rs587779047, rs587779075, rs267607949, rs63750633, rs63750803, rs63751618, rs267608154, rs200640585, rs80358018, rs80357857, rs80357882, rs180177103, rs587779815, rs587779865, rs587779872, rs587780059, rs121912666, rs587780088, rs587780104, rs200432447, rs180177100, rs587780226, rs587780784, rs587776416, rs587781276, rs587781629, rs587781694, rs587781727, rs587781730, rs587781807, rs587781894, rs587781948, rs121913344, rs587782292, rs587782350, rs587782558, rs587782719, rs587782885, rs587783057, rs730881833, rs730881411, rs730881336, rs139770721, rs730881869, rs730881633, rs730882007, rs786203115, rs765123255, rs1553333738, rs762083530, rs786202800, rs17174393, rs55996097, rs750621215, rs786203451, rs747604569, rs764389018, rs786204433, rs786204862, rs772821016, rs779582317, rs863225406, rs193922343, rs759965045, rs63749919, rs760228510, rs746481984, rs762307622, rs876659736, rs876660933, rs747727055, rs1450394308, rs876658348, rs876658431, rs876659326, rs876660444, rs730881369, rs878853865, rs753862052, rs587780024, rs138941496, rs886040739, rs886040744, rs886040347, rs878854957, rs886040123, rs398122662, rs886040942, rs1057517104, rs1057516320, rs1057516683, rs879254046, rs1057517253, rs587781927, rs985033810, rs1057519989, rs775464903, rs374230313, rs758304323, rs1060501599, rs758081262, rs1060500126, rs1060502734, rs587776408, rs1060501695, rs1114167816, rs1114167596, rs1114167667, rs1555460315, rs1135402788, rs1554086196, rs730881919, rs773356478, rs769237459, rs1553653158, rs587782087, rs1555107263, rs1555119940, rs1403784434, rs1342519012, rs751710099, rs1553616361, rs1553619721, rs1270783041, rs775036118, rs1555288557, rs1555460548, rs1555461154, rs1298667185, rs1553622218, rs63751101, rs1349928568, rs771936821, rs1021662947, rs1555921011, rs81002831, rs1555124506, rs1555574803, rs1060502716, rs1555605362, rs747057367, rs1565385010, rs1567554500, rs1567516230, rs1558644995, rs1555591308, rs778306619, rs1566231194, rs1603328466, rs1570406302, rs1586108714, rs768362387, rs1597713777, rs1060502926, rs1597867185, rs1591517571, rs1591663236, rs1593903006, rs1555284779, rs1597096243, rs45459799, rs1597360340, rs587781905, rs864622481, rs1601753141, rs1966858562, rs1966967065, rs1967016153, rs1967113484, rs2080473458, rs1591387978, rs1224428422, rs1597747184, rs2082309297, rs2051929740, rs147542208	21364753
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	31374203

Unknown
Disease name	Disease term	dbSNP ID	References
Anxiety disorder	Anxiety
Extraskeletal myxoid chondrosarcoma	Extraskeletal Myxoid Chondrosarcoma		18330903
Laryngospasm	Laryngospasm
Mental depression	Depressive disorder	rs587778876, rs587778877
Mood swings	Mood swings
Osteosarcoma	Osteosarcoma		14767549
Respiratory failure	Respiratory Failure
Stomach neoplasms	Malignant neoplasm of stomach, Stomach Neoplasms		21364753