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SLC7A5 (solute carrier family 7 member 5)
Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8140
Gene nameGene Name - the full gene name approved by the HGNC.
Solute carrier family 7 member 5
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
SLC7A5
SynonymsGene synonyms aliases
4F2LC, CD98, D16S469E, E16, LAT1, MPE16
ChromosomeChromosome number
16
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16q24.2
miRNAmiRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
miRTarBase ID miRNA Experiments Reference
MIRT004528 hsa-miR-7-5p Immunofluorescence, Luciferase reporter assay, qRT-PCR, Western blot, Immunoprecipitation 19892711
MIRT004144 hsa-miR-626 Immunofluorescence, Luciferase reporter assay, qRT-PCR, Western blot, Immunoprecipitation 19892711
MIRT006088 hsa-miR-663a Microarray, qRT-PCR 21378144
MIRT006088 hsa-miR-663a Microarray, qRT-PCR 21378144
MIRT006088 hsa-miR-663a Microarray, qRT-PCR 21378144
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Transcription factor Regulation Reference
SP1 Unknown 17023546
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0002720 Process Positive regulation of cytokine production involved in immune response TAS 24038088
GO:0003333 Process Amino acid transmembrane transport IBA 21873635
GO:0005515 Function Protein binding IPI 25998567, 30867591, 30996345, 31160781
GO:0005765 Component Lysosomal membrane IEA
GO:0005829 Component Cytosol IDA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM
HGNC
e!Ensembl
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q01650
Protein name Large neutral amino acids transporter small subunit 1 (4F2 light chain) (4F2 LC) (4F2LC) (CD98 light chain) (Integral membrane protein E16) (E16) (L-type amino acid transporter 1) (hLAT1) (Solute carrier family 7 member 5) (y+ system cationic amino acid t
Protein function The heterodimer with SLC3A2 functions as a sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, leucine, histidine, methionine, tryptophan, valine, isoleucine and alanin
PDB 6IRS , 6IRT , 6JMQ , 7DSK , 7DSL , 7DSN , 7DSQ , 8IDA , 8J8L , 8J8M , 8KDD , 8KDF , 8KDG , 8KDH , 8KDI , 8KDJ , 8KDN , 8KDO , 8KDP , 8X0W , 8XPU
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13520 AA_permease_2
50 → 476
Amino acid permease
 Family
Sequence
Sequence length 507
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
 
KEGG
  
Reactome
  mTOR signaling pathway
Central carbon metabolism in cancer 		  Basigin interactions
Amino acid transport across the plasma membrane
Tryptophan catabolism
Associated diseases
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Causal
Disease name Disease term dbSNP ID References
Dermatitis Dermatitis, Allergic Contact rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174 17374397
Lung cancer Malignant neoplasm of lung rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135 26621329
Unknown
Disease name Disease term dbSNP ID References
Lung neoplasms Lung Neoplasms 26621329

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