ST8SIA2 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2)

Gene

• Entrez ID: 8128
• Gene name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
• Gene symbol: ST8SIA2
• Synonyms: HsT19690, SIAT8-B, SIAT8B, ST8SIA-II, ST8SiaII, STX
• Chromosome: 15
• Chromosome location: 15q26.1
• Summary: The protein encoded by this gene is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. The encoded protein may be found in the Golgi apparatus and may be

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029111	hsa-miR-26b-5p	Microarray	19088304
MIRT1393961	hsa-miR-1207-5p	CLIP-seq
MIRT1393962	hsa-miR-1299	CLIP-seq
MIRT1393963	hsa-miR-149	CLIP-seq
MIRT1393964	hsa-miR-1908	CLIP-seq
MIRT1393965	hsa-miR-3064-5p	CLIP-seq
MIRT1393966	hsa-miR-3143	CLIP-seq
MIRT1393967	hsa-miR-3922-5p	CLIP-seq
MIRT1393968	hsa-miR-4274	CLIP-seq
MIRT1393969	hsa-miR-4505	CLIP-seq
MIRT1393970	hsa-miR-4533	CLIP-seq
MIRT1393971	hsa-miR-4747-5p	CLIP-seq
MIRT1393972	hsa-miR-4763-3p	CLIP-seq
MIRT1393973	hsa-miR-4782-5p	CLIP-seq
MIRT1393974	hsa-miR-4790-3p	CLIP-seq
MIRT1393975	hsa-miR-4794	CLIP-seq
MIRT1393976	hsa-miR-494	CLIP-seq
MIRT1393977	hsa-miR-514	CLIP-seq
MIRT1393978	hsa-miR-514b-3p	CLIP-seq
MIRT1393979	hsa-miR-516b	CLIP-seq
MIRT1393980	hsa-miR-518a-5p	CLIP-seq
MIRT1393981	hsa-miR-527	CLIP-seq
MIRT1393982	hsa-miR-543	CLIP-seq
MIRT1393983	hsa-miR-548a-5p	CLIP-seq
MIRT1393984	hsa-miR-548ab	CLIP-seq
MIRT1393985	hsa-miR-548ak	CLIP-seq
MIRT1393986	hsa-miR-548b-5p	CLIP-seq
MIRT1393987	hsa-miR-548c-5p	CLIP-seq
MIRT1393988	hsa-miR-548d-5p	CLIP-seq
MIRT1393989	hsa-miR-548h	CLIP-seq
MIRT1393990	hsa-miR-548i	CLIP-seq
MIRT1393991	hsa-miR-548j	CLIP-seq
MIRT1393992	hsa-miR-548w	CLIP-seq
MIRT1393993	hsa-miR-548y	CLIP-seq
MIRT1393994	hsa-miR-559	CLIP-seq
MIRT1393995	hsa-miR-604	CLIP-seq
MIRT1393996	hsa-miR-622	CLIP-seq
MIRT1393997	hsa-miR-642b	CLIP-seq
MIRT1393998	hsa-miR-647	CLIP-seq
MIRT1393999	hsa-miR-663	CLIP-seq
MIRT1394000	hsa-miR-802	CLIP-seq
MIRT1394001	hsa-miR-875-3p	CLIP-seq
MIRT2118264	hsa-miR-182	CLIP-seq
MIRT2118265	hsa-miR-31	CLIP-seq
MIRT2118266	hsa-miR-3135b	CLIP-seq
MIRT2118267	hsa-miR-4271	CLIP-seq
MIRT2118268	hsa-miR-4434	CLIP-seq
MIRT2118269	hsa-miR-4516	CLIP-seq
MIRT2118270	hsa-miR-4686	CLIP-seq
MIRT2118271	hsa-miR-4705	CLIP-seq
MIRT2118272	hsa-miR-4725-3p	CLIP-seq
MIRT1393971	hsa-miR-4747-5p	CLIP-seq
MIRT2118273	hsa-miR-498	CLIP-seq
MIRT2118274	hsa-miR-499a-5p	CLIP-seq
MIRT2118275	hsa-miR-625	CLIP-seq
MIRT1393961	hsa-miR-1207-5p	CLIP-seq
MIRT2340289	hsa-miR-122	CLIP-seq
MIRT1393964	hsa-miR-1908	CLIP-seq
MIRT2340290	hsa-miR-2116	CLIP-seq
MIRT2340291	hsa-miR-2467-3p	CLIP-seq
MIRT2340292	hsa-miR-28-5p	CLIP-seq
MIRT2340293	hsa-miR-296-3p	CLIP-seq
MIRT2340294	hsa-miR-3139	CLIP-seq
MIRT2340295	hsa-miR-331-3p	CLIP-seq
MIRT2340296	hsa-miR-342-5p	CLIP-seq
MIRT2340297	hsa-miR-3659	CLIP-seq
MIRT2340298	hsa-miR-3678-3p	CLIP-seq
MIRT2340299	hsa-miR-4255	CLIP-seq
MIRT2340300	hsa-miR-4302	CLIP-seq
MIRT2340301	hsa-miR-4450	CLIP-seq
MIRT2340302	hsa-miR-4456	CLIP-seq
MIRT1393969	hsa-miR-4505	CLIP-seq
MIRT2340303	hsa-miR-4508	CLIP-seq
MIRT2340304	hsa-miR-4664-5p	CLIP-seq
MIRT2340305	hsa-miR-4677-5p	CLIP-seq
MIRT2340306	hsa-miR-4697-3p	CLIP-seq
MIRT2340307	hsa-miR-4757-3p	CLIP-seq
MIRT1393972	hsa-miR-4763-3p	CLIP-seq
MIRT2340308	hsa-miR-486-3p	CLIP-seq
MIRT2340309	hsa-miR-491-5p	CLIP-seq
MIRT1393980	hsa-miR-518a-5p	CLIP-seq
MIRT1393981	hsa-miR-527	CLIP-seq
MIRT2340310	hsa-miR-541	CLIP-seq
MIRT2340311	hsa-miR-569	CLIP-seq
MIRT2340312	hsa-miR-578	CLIP-seq
MIRT2340313	hsa-miR-581	CLIP-seq
MIRT2340314	hsa-miR-582-3p	CLIP-seq
MIRT2340315	hsa-miR-654-5p	CLIP-seq
MIRT1393999	hsa-miR-663	CLIP-seq
MIRT2340316	hsa-miR-708	CLIP-seq
MIRT2395266	hsa-miR-125a-3p	CLIP-seq
MIRT2395267	hsa-miR-3202	CLIP-seq
MIRT2395268	hsa-miR-3934	CLIP-seq
MIRT2395269	hsa-miR-4265	CLIP-seq
MIRT2395270	hsa-miR-4296	CLIP-seq
MIRT2395271	hsa-miR-4322	CLIP-seq
MIRT2395272	hsa-miR-764	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	TAS
GO:0001574	Process	Ganglioside biosynthetic process	IDA	10766765
GO:0003828	Function	Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity	IBA	21873635
GO:0003828	Function	Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity	IDA	10766765
GO:0005769	Component	Early endosome	IEA
GO:0005975	Process	Carbohydrate metabolic process	TAS	7559389
GO:0006464	Process	Cellular protein modification process	TAS	7559389
GO:0006486	Process	Protein glycosylation	IBA	21873635
GO:0006486	Process	Protein glycosylation	IDA	10766765
GO:0006486	Process	Protein glycosylation	IEA
GO:0006491	Process	N-glycan processing	IBA	21873635
GO:0006491	Process	N-glycan processing	IDA	10766765
GO:0007399	Process	Nervous system development	TAS	9054414
GO:0009311	Process	Oligosaccharide metabolic process	IBA	21873635
GO:0009311	Process	Oligosaccharide metabolic process	IDA	10766765
GO:0016021	Component	Integral component of membrane	IEA
GO:0033691	Function	Sialic acid binding	IC	10766765
GO:0055037	Component	Recycling endosome	IEA
GO:0097503	Process	Sialylation	IEA

Other IDs

• MIM: 602546
• HGNC: 10870
• e!Ensembl: ENSG00000140557

Protein

• UniProt ID: Q92186
• Protein name: Alpha-2,8-sialyltransferase 8B (EC 2.4.3.-) (Sialyltransferase 8B) (SIAT8-B) (Sialyltransferase St8Sia II) (ST8SiaII) (Sialyltransferase X) (STX)
• Protein function: Catalyzes the transfer of a sialic acid from a CMP-linked sialic acid donor onto a terminal alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid of an N-linked glycan acceptor through alpha-2,8-linkages (Probable) (PubMed:10766765, PubMed:117
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00777	Glyco_transf_29	109 → 368	Glycosyltransferase family 29 (sialyltransferase)	Family

• Sequence:

  MQLQFRSWMLAALTLLVVFLIFADISEIEEEIGNSGGRGTIRSAVNSLHSKSNRAEVVIN
  GSSSPAVVDRSNESIKHNIQPASSKWRHNQTLSLRIRKQILKFLDAEKDISVLKGTLKPG
  DIIHYIFDRDSTMNVSQNLYELLPRTSPLKNKHFGTCAIVGNSGVLLNSGCGQEIDAHSF
  VIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLHSLNGSILWI
  PAFMARGGKERVEWVNELILKHHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMY
  TLATRFCKQIYLYGFWPFPLDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFKALKSLHE
  QGALKLTVGQCDGAT

• Sequence length: 375

Pathways

Reactome:

Sialic acid metabolism
NCAM1 interactions
N-Glycan antennae elongation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Autism	Autistic Disorder	rs121964908, rs121912597, rs2710102, rs7794745, rs142990298, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699, rs1553510219, rs1684182454, rs1559060428, rs1553510677, rs1576352885, rs1574152522, rs1574152672, rs1696658542, rs1751123722, rs1750373491, rs1751075634	20663923
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	17126533, 22693595, 24070986, 24057454, 16969366

Unknown
Disease name	Disease term	dbSNP ID	References
Allergic rhinitis	Allergic rhinitis (disorder)		25085501
Bipolar disorder	Bipolar Disorder		25129258, 24651862