KCNH6 (potassium voltage-gated channel subfamily H member 6)

Gene

• Entrez ID: 81033
• Gene name: Potassium voltage-gated channel subfamily H member 6
• Gene symbol: KCNH6
• Synonyms: ERG-2, ERG2, HERG2, Kv11.2, hERG-2
• Chromosome: 17
• Chromosome location: 17q23.3
• Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuro

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT657050	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT657051	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT657049	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT657048	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT657047	hsa-miR-1976	HITS-CLIP	23824327
MIRT657046	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT657045	hsa-miR-1206	HITS-CLIP	23824327
MIRT657044	hsa-miR-2355-5p	HITS-CLIP	23824327
MIRT657043	hsa-miR-4279	HITS-CLIP	23824327
MIRT657050	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT657051	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT657049	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT657048	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT657047	hsa-miR-1976	HITS-CLIP	23824327
MIRT657046	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT657045	hsa-miR-1206	HITS-CLIP	23824327
MIRT657044	hsa-miR-2355-5p	HITS-CLIP	23824327
MIRT657043	hsa-miR-4279	HITS-CLIP	23824327
MIRT1081084	hsa-miR-1200	CLIP-seq
MIRT1081085	hsa-miR-1273f	CLIP-seq
MIRT1081086	hsa-miR-1289	CLIP-seq
MIRT1081087	hsa-miR-1297	CLIP-seq
MIRT1081088	hsa-miR-1307	CLIP-seq
MIRT1081089	hsa-miR-143	CLIP-seq
MIRT1081090	hsa-miR-26a	CLIP-seq
MIRT1081091	hsa-miR-26b	CLIP-seq
MIRT1081092	hsa-miR-2909	CLIP-seq
MIRT1081093	hsa-miR-296-3p	CLIP-seq
MIRT1081094	hsa-miR-3157-5p	CLIP-seq
MIRT1081095	hsa-miR-3198	CLIP-seq
MIRT1081096	hsa-miR-3664-5p	CLIP-seq
MIRT1081097	hsa-miR-3977	CLIP-seq
MIRT1081098	hsa-miR-4258	CLIP-seq
MIRT1081099	hsa-miR-4284	CLIP-seq
MIRT1081100	hsa-miR-4294	CLIP-seq
MIRT1081101	hsa-miR-4309	CLIP-seq
MIRT1081102	hsa-miR-4324	CLIP-seq
MIRT1081103	hsa-miR-4438	CLIP-seq
MIRT1081104	hsa-miR-4465	CLIP-seq
MIRT1081105	hsa-miR-4509	CLIP-seq
MIRT1081106	hsa-miR-4534	CLIP-seq
MIRT1081107	hsa-miR-4638-5p	CLIP-seq
MIRT1081108	hsa-miR-4639-3p	CLIP-seq
MIRT1081109	hsa-miR-4707-3p	CLIP-seq
MIRT1081110	hsa-miR-4708-5p	CLIP-seq
MIRT1081111	hsa-miR-4770	CLIP-seq
MIRT1081112	hsa-miR-4772-3p	CLIP-seq
MIRT1081113	hsa-miR-5095	CLIP-seq
MIRT1081114	hsa-miR-544b	CLIP-seq
MIRT1081098	hsa-miR-4258	CLIP-seq
MIRT1081103	hsa-miR-4438	CLIP-seq
MIRT1081109	hsa-miR-4707-3p	CLIP-seq
MIRT1081113	hsa-miR-5095	CLIP-seq
MIRT2251908	hsa-miR-130a	CLIP-seq
MIRT2251909	hsa-miR-130b	CLIP-seq
MIRT2251910	hsa-miR-301a	CLIP-seq
MIRT2251911	hsa-miR-301b	CLIP-seq
MIRT2251912	hsa-miR-3666	CLIP-seq
MIRT1081098	hsa-miR-4258	CLIP-seq
MIRT2251913	hsa-miR-4295	CLIP-seq
MIRT1081103	hsa-miR-4438	CLIP-seq
MIRT2251914	hsa-miR-454	CLIP-seq
MIRT2251915	hsa-miR-4671-3p	CLIP-seq
MIRT1081109	hsa-miR-4707-3p	CLIP-seq
MIRT1081113	hsa-miR-5095	CLIP-seq
MIRT1081096	hsa-miR-3664-5p	CLIP-seq
MIRT1081098	hsa-miR-4258	CLIP-seq
MIRT1081100	hsa-miR-4294	CLIP-seq
MIRT1081105	hsa-miR-4509	CLIP-seq
MIRT1081108	hsa-miR-4639-3p	CLIP-seq
MIRT2452182	hsa-miR-4675	CLIP-seq
MIRT1081109	hsa-miR-4707-3p	CLIP-seq
MIRT2452183	hsa-miR-4741	CLIP-seq
MIRT1081098	hsa-miR-4258	CLIP-seq
MIRT1081103	hsa-miR-4438	CLIP-seq
MIRT1081105	hsa-miR-4509	CLIP-seq
MIRT1081109	hsa-miR-4707-3p	CLIP-seq
MIRT1081113	hsa-miR-5095	CLIP-seq
MIRT1081098	hsa-miR-4258	CLIP-seq
MIRT1081103	hsa-miR-4438	CLIP-seq
MIRT1081105	hsa-miR-4509	CLIP-seq
MIRT1081109	hsa-miR-4707-3p	CLIP-seq
MIRT1081113	hsa-miR-5095	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005249	Function	Voltage-gated potassium channel activity	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0034765	Process	Regulation of ion transmembrane transport	IEA
GO:0042391	Process	Regulation of membrane potential	IBA	21873635
GO:0071805	Process	Potassium ion transmembrane transport	IBA	21873635
GO:0086091	Process	Regulation of heart rate by cardiac conduction	IBA	21873635

Other IDs

• MIM: 608168
• HGNC: 18862
• e!Ensembl: ENSG00000173826

Protein

• UniProt ID: Q9H252
• Protein name: Voltage-gated inwardly rectifying potassium channel KCNH6 (Ether-a-go-go-related gene potassium channel 2) (ERG-2) (Eag-related protein 2) (Ether-a-go-go-related protein 2) (hERG-2) (hERG2) (Potassium voltage-gated channel subfamily H member 6) (Voltage-g
• Protein function: Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subseque
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13426	PAS_9	29 → 134	PAS domain	Domain
  PF00520	Ion_trans	256 → 523	Ion transport protein	Family
  PF00027	cNMP_binding	612 → 697	Cyclic nucleotide-binding domain	Domain

• Sequence:

  MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVM
  QQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDG
  AVIMFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTISQ
  IPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKLQ
  APRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPL
  TVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLI
  FRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWY
  AIGNVERPYLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFG
  NVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQ
  IPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGK
  GCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEP
  VSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTFNLRDAAGG
  LHSSPRQAPGSQDHQGFFLSDNQSGSPHELGPQFPSKGYSLLGPGSQNSMGAGPCAPGHP
  DAAPPLSISDASGLWPELLQEMPPRHSPQSPQEDPDCWPLKLGSRLEQLQAQMNRLESRV
  SSDLSRILQLLQKPMPQGHASYILEAPASNDLALVPIASETTSPGPRLPQGFLPPAQTPS
  YGDLDDCSPKHRNSSPRMPHLAVATDKTLAPSSEQEQPEGLWPPLASPLHPLEVQGLICG
  PCFSSLPEHLGSVPKQLDFQRHGSDPGFAGSWGH

• Sequence length: 994

Pathways

Reactome:

Voltage gated Potassium channels

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	20507645

Unknown
Disease name	Disease term	dbSNP ID	References
Nonorganic psychosis	Nonorganic psychosis		20507645
Psychosis	Psychotic Disorders		20507645