Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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80829 |
Gene nameGene Name - the full gene name approved by the HGNC.
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ZFP91 zinc finger protein, atypical E3 ubiquitin ligase |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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ZFP91 |
SynonymsGene synonyms aliases
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DMS-8, DSM-8, DSM8, FKSG11, PZF, ZFP-91, ZNF757 |
ChromosomeChromosome number
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11 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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11q12.1 |
SummarySummary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regul |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
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UniProt ID |
Q96JP5 |
Protein name |
E3 ubiquitin-protein ligase ZFP91 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ZFP91) (Zinc finger protein 757) (Zinc finger protein 91 homolog) (Zfp-91) |
Protein function |
Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an imp |
PDB |
2M9A
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Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00096 |
zf-C2H2 |
372 → 394 |
Zinc finger, C2H2 type |
Domain |
PF00096 |
zf-C2H2 |
400 → 422 |
Zinc finger, C2H2 type |
Domain |
PF00096 |
zf-C2H2 |
430 → 453 |
Zinc finger, C2H2 type |
Domain |
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Sequence |
MPGETEEPRPPEQQDQEGGEAAKAAPEEPQQRPPEAVAAAPAGTTSSRVLRGGRDRGRAA AAAAAAAVSRRRKAEYPRRRRSSPSARPPDVPGQQPQAAKSPSPVQGKKSPRLLCIEKVT TDKDPKEEKEEEDDSALPQEVSIAASRPSRGWRSSRTSVSRHRDTENTRSSRSKTGSLQL ICKSEPNTDQLDYDVGEEHQSPGGISSEEEEEEEEEMLISEEEIPFKDDPRDETYKPHLE RETPKPRRKSGKVKEEKEKKEIKVEVEVEVKEEENEIREDEEPPRKRGRRRKDDKSPRLP KRRKKPPIQYVRCEMEGCGTVLAHPRYLQHHIKYQHLLKKKYVCPHPSCGRLFRLQKQLL RHAKHHTDQRDYICEYCARAFKSSHNLAVHRMIHTGEKPLQCEICGFTCRQKASLNWHMK KHDADSFYQFSCNICGKKFEKKDSVVAHKAKSHPEVLIAEALAANAGALITSTDILGTNP ESLTQPSDGQGLPLLPEPLGNSTSGECLLLEAEGMSKSYCSGTERVSLMADGKIFVGSGS SGGTEGLVMNSDILGATTEVLIEDSDSAGP
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Sequence length |
570 |
Interactions |
View interactions |
Associated diseases
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