CD276 (CD276 molecule)

Gene

• Entrez ID: 80381
• Gene name: CD276 molecule
• Gene symbol: CD276
• Synonyms: 4Ig-B7-H3, B7-H3, B7H3, B7RP-2
• Chromosome: 15
• Chromosome location: 15q24.1
• Summary: The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues an

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT003343	hsa-miR-29a-3p	Review	20026422
MIRT004631	hsa-miR-29c-3p	Review	20026422
MIRT003343	hsa-miR-29a-3p	Luciferase reporter assay, Western blot	19584290
MIRT003343	hsa-miR-29a-3p	Luciferase reporter assay, Western blot	19584290
MIRT018004	hsa-miR-335-5p	Microarray	18185580
MIRT052388	hsa-let-7a-5p	CLASH	23622248
MIRT050009	hsa-miR-28-5p	CLASH	23622248
MIRT049416	hsa-miR-92a-3p	CLASH	23622248
MIRT039444	hsa-miR-421	CLASH	23622248
MIRT036011	hsa-miR-1301-3p	CLASH	23622248
MIRT052669	hsa-miR-1260b	CLASH	23622248
MIRT004631	hsa-miR-29c-3p	Microarray, qRT-PCR	24590289
MIRT438714	hsa-miR-187-3p	Luciferase reporter assay, qRT-PCR	23916610
MIRT438714	hsa-miR-187-3p	Luciferase reporter assay, qRT-PCR	23916610
MIRT003343	hsa-miR-29a-3p	PAR-CLIP	26701625
MIRT004631	hsa-miR-29c-3p	PAR-CLIP	26701625
MIRT734596	hsa-miR-2909	Luciferase reporter assay, Western blotting	33676551
MIRT874453	hsa-let-7a	CLIP-seq
MIRT874454	hsa-let-7b	CLIP-seq
MIRT874455	hsa-let-7c	CLIP-seq
MIRT874456	hsa-let-7d	CLIP-seq
MIRT874457	hsa-let-7e	CLIP-seq
MIRT874458	hsa-let-7f	CLIP-seq
MIRT874459	hsa-let-7g	CLIP-seq
MIRT874460	hsa-let-7i	CLIP-seq
MIRT874461	hsa-miR-1207-5p	CLIP-seq
MIRT874462	hsa-miR-1294	CLIP-seq
MIRT874463	hsa-miR-1909	CLIP-seq
MIRT874464	hsa-miR-202	CLIP-seq
MIRT874465	hsa-miR-2392	CLIP-seq
MIRT874466	hsa-miR-2467-3p	CLIP-seq
MIRT874467	hsa-miR-3150a-3p	CLIP-seq
MIRT874468	hsa-miR-3158-5p	CLIP-seq
MIRT874469	hsa-miR-3175	CLIP-seq
MIRT874470	hsa-miR-3184	CLIP-seq
MIRT874471	hsa-miR-3605-5p	CLIP-seq
MIRT874472	hsa-miR-3678-3p	CLIP-seq
MIRT874473	hsa-miR-423-5p	CLIP-seq
MIRT874474	hsa-miR-4418	CLIP-seq
MIRT874475	hsa-miR-4458	CLIP-seq
MIRT874476	hsa-miR-4500	CLIP-seq
MIRT874477	hsa-miR-4505	CLIP-seq
MIRT874478	hsa-miR-4640-5p	CLIP-seq
MIRT874479	hsa-miR-4688	CLIP-seq
MIRT874480	hsa-miR-4695-5p	CLIP-seq
MIRT874481	hsa-miR-4710	CLIP-seq
MIRT874482	hsa-miR-4726-5p	CLIP-seq
MIRT874483	hsa-miR-4763-3p	CLIP-seq
MIRT874484	hsa-miR-485-5p	CLIP-seq
MIRT874485	hsa-miR-491-5p	CLIP-seq
MIRT874486	hsa-miR-509-3-5p	CLIP-seq
MIRT874487	hsa-miR-509-5p	CLIP-seq
MIRT874488	hsa-miR-625	CLIP-seq
MIRT874489	hsa-miR-665	CLIP-seq
MIRT874490	hsa-miR-671-5p	CLIP-seq
MIRT874491	hsa-miR-939	CLIP-seq
MIRT874492	hsa-miR-98	CLIP-seq
MIRT874453	hsa-let-7a	CLIP-seq
MIRT874454	hsa-let-7b	CLIP-seq
MIRT874455	hsa-let-7c	CLIP-seq
MIRT874456	hsa-let-7d	CLIP-seq
MIRT874457	hsa-let-7e	CLIP-seq
MIRT874458	hsa-let-7f	CLIP-seq
MIRT874459	hsa-let-7g	CLIP-seq
MIRT874460	hsa-let-7i	CLIP-seq
MIRT874461	hsa-miR-1207-5p	CLIP-seq
MIRT874493	hsa-miR-124	CLIP-seq
MIRT874494	hsa-miR-1253	CLIP-seq
MIRT874495	hsa-miR-1267	CLIP-seq
MIRT874496	hsa-miR-1270	CLIP-seq
MIRT874497	hsa-miR-1275	CLIP-seq
MIRT874498	hsa-miR-128	CLIP-seq
MIRT874499	hsa-miR-1293	CLIP-seq
MIRT874462	hsa-miR-1294	CLIP-seq
MIRT874500	hsa-miR-1321	CLIP-seq
MIRT874501	hsa-miR-148a	CLIP-seq
MIRT874502	hsa-miR-148b	CLIP-seq
MIRT874503	hsa-miR-152	CLIP-seq
MIRT874504	hsa-miR-187	CLIP-seq
MIRT874463	hsa-miR-1909	CLIP-seq
MIRT874505	hsa-miR-1913	CLIP-seq
MIRT874506	hsa-miR-1915	CLIP-seq
MIRT874464	hsa-miR-202	CLIP-seq
MIRT874507	hsa-miR-214	CLIP-seq
MIRT874508	hsa-miR-2278	CLIP-seq
MIRT874509	hsa-miR-27a	CLIP-seq
MIRT874510	hsa-miR-27b	CLIP-seq
MIRT874511	hsa-miR-296-5p	CLIP-seq
MIRT874512	hsa-miR-29a	CLIP-seq
MIRT874513	hsa-miR-29b	CLIP-seq
MIRT874514	hsa-miR-29c	CLIP-seq
MIRT874515	hsa-miR-3120-5p	CLIP-seq
MIRT874516	hsa-miR-3147	CLIP-seq
MIRT874517	hsa-miR-3173-3p	CLIP-seq
MIRT874518	hsa-miR-3185	CLIP-seq
MIRT874519	hsa-miR-3189-5p	CLIP-seq
MIRT874520	hsa-miR-3190	CLIP-seq
MIRT874521	hsa-miR-324-3p	CLIP-seq
MIRT874522	hsa-miR-339-5p	CLIP-seq
MIRT874523	hsa-miR-34c-3p	CLIP-seq
MIRT874524	hsa-miR-3545-5p	CLIP-seq
MIRT874525	hsa-miR-361-3p	CLIP-seq
MIRT874526	hsa-miR-3614-5p	CLIP-seq
MIRT874527	hsa-miR-3619-5p	CLIP-seq
MIRT874528	hsa-miR-3657	CLIP-seq
MIRT874529	hsa-miR-3665	CLIP-seq
MIRT874530	hsa-miR-3714	CLIP-seq
MIRT874531	hsa-miR-3910	CLIP-seq
MIRT874532	hsa-miR-3922-5p	CLIP-seq
MIRT874533	hsa-miR-4251	CLIP-seq
MIRT874534	hsa-miR-4260	CLIP-seq
MIRT874535	hsa-miR-4270	CLIP-seq
MIRT874536	hsa-miR-4284	CLIP-seq
MIRT874537	hsa-miR-4302	CLIP-seq
MIRT874538	hsa-miR-4318	CLIP-seq
MIRT874539	hsa-miR-4329	CLIP-seq
MIRT874540	hsa-miR-4421	CLIP-seq
MIRT874541	hsa-miR-4425	CLIP-seq
MIRT874542	hsa-miR-4434	CLIP-seq
MIRT874543	hsa-miR-4437	CLIP-seq
MIRT874544	hsa-miR-4441	CLIP-seq
MIRT874545	hsa-miR-4446-3p	CLIP-seq
MIRT874475	hsa-miR-4458	CLIP-seq
MIRT874546	hsa-miR-4476	CLIP-seq
MIRT874547	hsa-miR-4477a	CLIP-seq
MIRT874548	hsa-miR-4483	CLIP-seq
MIRT874549	hsa-miR-4488	CLIP-seq
MIRT874476	hsa-miR-4500	CLIP-seq
MIRT874550	hsa-miR-4516	CLIP-seq
MIRT874551	hsa-miR-451b	CLIP-seq
MIRT874552	hsa-miR-4527	CLIP-seq
MIRT874553	hsa-miR-4531	CLIP-seq
MIRT874554	hsa-miR-4533	CLIP-seq
MIRT874555	hsa-miR-4656	CLIP-seq
MIRT874556	hsa-miR-4665-5p	CLIP-seq
MIRT874557	hsa-miR-4668-5p	CLIP-seq
MIRT874558	hsa-miR-4669	CLIP-seq
MIRT874559	hsa-miR-4693-5p	CLIP-seq
MIRT874560	hsa-miR-4697-3p	CLIP-seq
MIRT874561	hsa-miR-4697-5p	CLIP-seq
MIRT874481	hsa-miR-4710	CLIP-seq
MIRT874562	hsa-miR-4711-3p	CLIP-seq
MIRT874563	hsa-miR-4711-5p	CLIP-seq
MIRT874564	hsa-miR-4728-5p	CLIP-seq
MIRT874565	hsa-miR-4739	CLIP-seq
MIRT874566	hsa-miR-4753-5p	CLIP-seq
MIRT874567	hsa-miR-4756-5p	CLIP-seq
MIRT874568	hsa-miR-4758-3p	CLIP-seq
MIRT874483	hsa-miR-4763-3p	CLIP-seq
MIRT874569	hsa-miR-4779	CLIP-seq
MIRT874570	hsa-miR-4790-3p	CLIP-seq
MIRT874571	hsa-miR-506	CLIP-seq
MIRT874572	hsa-miR-511	CLIP-seq
MIRT874573	hsa-miR-539	CLIP-seq
MIRT874574	hsa-miR-541	CLIP-seq
MIRT874575	hsa-miR-548an	CLIP-seq
MIRT874576	hsa-miR-583	CLIP-seq
MIRT874577	hsa-miR-586	CLIP-seq
MIRT874578	hsa-miR-620	CLIP-seq
MIRT874579	hsa-miR-657	CLIP-seq
MIRT874489	hsa-miR-665	CLIP-seq
MIRT874490	hsa-miR-671-5p	CLIP-seq
MIRT874580	hsa-miR-7	CLIP-seq
MIRT874581	hsa-miR-761	CLIP-seq
MIRT874582	hsa-miR-892a	CLIP-seq
MIRT874583	hsa-miR-9	CLIP-seq
MIRT874584	hsa-miR-940	CLIP-seq
MIRT874492	hsa-miR-98	CLIP-seq
MIRT874461	hsa-miR-1207-5p	CLIP-seq
MIRT874493	hsa-miR-124	CLIP-seq
MIRT874530	hsa-miR-3714	CLIP-seq
MIRT874531	hsa-miR-3910	CLIP-seq
MIRT874483	hsa-miR-4763-3p	CLIP-seq
MIRT874571	hsa-miR-506	CLIP-seq
MIRT874461	hsa-miR-1207-5p	CLIP-seq
MIRT874498	hsa-miR-128	CLIP-seq
MIRT874463	hsa-miR-1909	CLIP-seq
MIRT874535	hsa-miR-4270	CLIP-seq
MIRT874544	hsa-miR-4441	CLIP-seq
MIRT1959278	hsa-miR-4514	CLIP-seq
MIRT1959279	hsa-miR-4645-5p	CLIP-seq
MIRT1959280	hsa-miR-4673	CLIP-seq
MIRT1959281	hsa-miR-4692	CLIP-seq
MIRT1959282	hsa-miR-4703-3p	CLIP-seq
MIRT1959283	hsa-miR-4755-3p	CLIP-seq
MIRT874483	hsa-miR-4763-3p	CLIP-seq
MIRT874584	hsa-miR-940	CLIP-seq
MIRT2196309	hsa-miR-1179	CLIP-seq
MIRT2196310	hsa-miR-188-3p	CLIP-seq
MIRT874530	hsa-miR-3714	CLIP-seq
MIRT2196311	hsa-miR-4422	CLIP-seq
MIRT874461	hsa-miR-1207-5p	CLIP-seq
MIRT874499	hsa-miR-1293	CLIP-seq
MIRT874463	hsa-miR-1909	CLIP-seq
MIRT874505	hsa-miR-1913	CLIP-seq
MIRT874507	hsa-miR-214	CLIP-seq
MIRT874518	hsa-miR-3185	CLIP-seq
MIRT874519	hsa-miR-3189-5p	CLIP-seq
MIRT874520	hsa-miR-3190	CLIP-seq
MIRT874521	hsa-miR-324-3p	CLIP-seq
MIRT874523	hsa-miR-34c-3p	CLIP-seq
MIRT874527	hsa-miR-3619-5p	CLIP-seq
MIRT874529	hsa-miR-3665	CLIP-seq
MIRT874530	hsa-miR-3714	CLIP-seq
MIRT874545	hsa-miR-4446-3p	CLIP-seq
MIRT874548	hsa-miR-4483	CLIP-seq
MIRT874555	hsa-miR-4656	CLIP-seq
MIRT874568	hsa-miR-4758-3p	CLIP-seq
MIRT874483	hsa-miR-4763-3p	CLIP-seq
MIRT874575	hsa-miR-548an	CLIP-seq
MIRT874579	hsa-miR-657	CLIP-seq
MIRT874490	hsa-miR-671-5p	CLIP-seq
MIRT874580	hsa-miR-7	CLIP-seq
MIRT874581	hsa-miR-761	CLIP-seq
MIRT874499	hsa-miR-1293	CLIP-seq
MIRT874518	hsa-miR-3185	CLIP-seq
MIRT874548	hsa-miR-4483	CLIP-seq
MIRT874580	hsa-miR-7	CLIP-seq
MIRT2499329	hsa-miR-1178	CLIP-seq
MIRT874494	hsa-miR-1253	CLIP-seq
MIRT874506	hsa-miR-1915	CLIP-seq
MIRT874466	hsa-miR-2467-3p	CLIP-seq
MIRT874511	hsa-miR-296-5p	CLIP-seq
MIRT2499330	hsa-miR-3126-5p	CLIP-seq
MIRT2499331	hsa-miR-3137	CLIP-seq
MIRT874519	hsa-miR-3189-5p	CLIP-seq
MIRT874525	hsa-miR-361-3p	CLIP-seq
MIRT874530	hsa-miR-3714	CLIP-seq
MIRT2499332	hsa-miR-3913-3p	CLIP-seq
MIRT1959282	hsa-miR-4703-3p	CLIP-seq
MIRT874570	hsa-miR-4790-3p	CLIP-seq
MIRT2499333	hsa-miR-489	CLIP-seq
MIRT874576	hsa-miR-583	CLIP-seq
MIRT2499329	hsa-miR-1178	CLIP-seq
MIRT874506	hsa-miR-1915	CLIP-seq
MIRT874511	hsa-miR-296-5p	CLIP-seq
MIRT2499331	hsa-miR-3137	CLIP-seq
MIRT874519	hsa-miR-3189-5p	CLIP-seq
MIRT874525	hsa-miR-361-3p	CLIP-seq
MIRT2499332	hsa-miR-3913-3p	CLIP-seq
MIRT1959282	hsa-miR-4703-3p	CLIP-seq
MIRT874570	hsa-miR-4790-3p	CLIP-seq
MIRT2499333	hsa-miR-489	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001817	Process	Regulation of cytokine production	IBA	21873635
GO:0005102	Function	Signaling receptor binding	IBA	21873635
GO:0005102	Function	Signaling receptor binding	NAS	11224528
GO:0005515	Function	Protein binding	IPI	18650384
GO:0009897	Component	External side of plasma membrane	IBA	21873635
GO:0009897	Component	External side of plasma membrane	NAS	15188059
GO:0016021	Component	Integral component of membrane	NAS	15188059
GO:0032729	Process	Positive regulation of interferon-gamma production	IDA	11224528
GO:0042102	Process	Positive regulation of T cell proliferation	IDA	11224528
GO:0042110	Process	T cell activation	IDA	18650384
GO:0050776	Process	Regulation of immune response	NAS	11224528
GO:0050852	Process	T cell receptor signaling pathway	IBA	21873635

Other IDs

• MIM: 605715
• HGNC: 19137
• e!Ensembl: ENSG00000103855

Protein

• UniProt ID: Q5ZPR3
• Protein name: CD276 antigen (4Ig-B7-H3) (B7 homolog 3) (B7-H3) (Costimulatory molecule) (CD antigen CD276)
• Protein function: May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07686	V-set	32 → 138	Immunoglobulin V-set domain	Domain
  PF13927	Ig_3	144 → 224		Domain
  PF07686	V-set	250 → 356	Immunoglobulin V-set domain	Domain
  PF13927	Ig_3	362 → 442		Domain

• Sequence:

  MLRRRGSPGMGVHVGAALGALWFCLTGALEVQVPEDPVVALVGTDATLCCSFSPEPGFSL
  AQLNLIWQLTDTKQLVHSFAEGQDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEGSF
  TCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITCSSYQGYPEAEVFWQD
  GQGVPLTGNVTTSQMANEQGLFDVHSILRVVLGANGTYSCLVRNPVLQQDAHSSVTITPQ
  RSPTGAVEVQVPEDPVVALVGTDATLRCSFSPEPGFSLAQLNLIWQLTDTKQLVHSFTEG
  RDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEGSFTCFVSIRDFGSAAVSLQVAAPY
  SKPSMTLEPNKDLRPGDTVTITCSSYRGYPEAEVFWQDGQGVPLTGNVTTSQMANEQGLF
  DVHSVLRVVLGANGTYSCLVRNPVLQQDAHGSVTITGQPMTFPPEALWVTVGLSVCLIAL
  LVALAFVCWRKIKQSCEEENAGAEDQDGEGEGSKTALQPLKHSDSKEDDGQEIA

• Sequence length: 534

Pathways

KEGG:

Cell adhesion molecules

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	30614027

Unknown
Disease name	Disease term	dbSNP ID	References
Liver carcinoma	Liver carcinoma		16217749
Prostatic neoplasms	Prostatic Neoplasms		30614027