RNF39 (ring finger protein 39)

Gene

• Entrez ID: 80352
• Gene name: Ring finger protein 39
• Gene symbol: RNF39
• Synonyms: FAP216, HZF, HZFW, LIRF
• Chromosome: 6
• Chromosome location: 6p22.1
• Summary: This gene lies within the major histocompatibility complex class I region on chromosome 6. Studies of a similar rat protein suggest that this gene encodes a protein that plays a role in an early phase of synaptic plasticity. Multiple transcript variants e

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1312903	hsa-miR-1257	CLIP-seq
MIRT1312904	hsa-miR-1278	CLIP-seq
MIRT1312905	hsa-miR-3918	CLIP-seq
MIRT1312906	hsa-miR-4434	CLIP-seq
MIRT1312907	hsa-miR-4481	CLIP-seq
MIRT1312908	hsa-miR-4516	CLIP-seq
MIRT1312909	hsa-miR-4745-5p	CLIP-seq
MIRT1312910	hsa-miR-4758-5p	CLIP-seq
MIRT1312911	hsa-miR-4790-3p	CLIP-seq
MIRT1312912	hsa-miR-873	CLIP-seq
MIRT2093077	hsa-miR-200b	CLIP-seq
MIRT2093078	hsa-miR-200c	CLIP-seq
MIRT2093079	hsa-miR-2052	CLIP-seq
MIRT2093080	hsa-miR-2681	CLIP-seq
MIRT2093081	hsa-miR-3150a-3p	CLIP-seq
MIRT2093082	hsa-miR-3175	CLIP-seq
MIRT2093083	hsa-miR-323b-3p	CLIP-seq
MIRT2093084	hsa-miR-4261	CLIP-seq
MIRT2093085	hsa-miR-429	CLIP-seq
MIRT2093086	hsa-miR-4468	CLIP-seq
MIRT2093087	hsa-miR-939	CLIP-seq
MIRT2317575	hsa-miR-1224-5p	CLIP-seq
MIRT2317576	hsa-miR-1255a	CLIP-seq
MIRT2317577	hsa-miR-1255b	CLIP-seq
MIRT2317578	hsa-miR-1270	CLIP-seq
MIRT2317579	hsa-miR-185	CLIP-seq
MIRT2317580	hsa-miR-1910	CLIP-seq
MIRT2317581	hsa-miR-1915	CLIP-seq
MIRT2093077	hsa-miR-200b	CLIP-seq
MIRT2093078	hsa-miR-200c	CLIP-seq
MIRT2317582	hsa-miR-2110	CLIP-seq
MIRT2317583	hsa-miR-2355-5p	CLIP-seq
MIRT2093080	hsa-miR-2681	CLIP-seq
MIRT2317584	hsa-miR-2861	CLIP-seq
MIRT2317585	hsa-miR-29a	CLIP-seq
MIRT2317586	hsa-miR-29b	CLIP-seq
MIRT2317587	hsa-miR-29c	CLIP-seq
MIRT2093081	hsa-miR-3150a-3p	CLIP-seq
MIRT2317588	hsa-miR-3150b-3p	CLIP-seq
MIRT2093082	hsa-miR-3175	CLIP-seq
MIRT2093083	hsa-miR-323b-3p	CLIP-seq
MIRT2317589	hsa-miR-3668	CLIP-seq
MIRT2317590	hsa-miR-3915	CLIP-seq
MIRT2317591	hsa-miR-3938	CLIP-seq
MIRT2317592	hsa-miR-4271	CLIP-seq
MIRT2093085	hsa-miR-429	CLIP-seq
MIRT2317593	hsa-miR-4306	CLIP-seq
MIRT1312906	hsa-miR-4434	CLIP-seq
MIRT2317594	hsa-miR-4512	CLIP-seq
MIRT1312908	hsa-miR-4516	CLIP-seq
MIRT2317595	hsa-miR-4528	CLIP-seq
MIRT2317596	hsa-miR-4530	CLIP-seq
MIRT2317597	hsa-miR-4531	CLIP-seq
MIRT2317598	hsa-miR-455-5p	CLIP-seq
MIRT2317599	hsa-miR-4644	CLIP-seq
MIRT2317600	hsa-miR-4650-5p	CLIP-seq
MIRT2317601	hsa-miR-4683	CLIP-seq
MIRT2317602	hsa-miR-4689	CLIP-seq
MIRT2317603	hsa-miR-4725-3p	CLIP-seq
MIRT2317604	hsa-miR-4726-3p	CLIP-seq
MIRT2317605	hsa-miR-4728-5p	CLIP-seq
MIRT2317606	hsa-miR-4747-5p	CLIP-seq
MIRT2317607	hsa-miR-4784	CLIP-seq
MIRT1312911	hsa-miR-4790-3p	CLIP-seq
MIRT2317608	hsa-miR-496	CLIP-seq
MIRT2317609	hsa-miR-520d-5p	CLIP-seq
MIRT2317610	hsa-miR-524-5p	CLIP-seq
MIRT2317611	hsa-miR-620	CLIP-seq
MIRT2317612	hsa-miR-634	CLIP-seq
MIRT2317613	hsa-miR-654-3p	CLIP-seq
MIRT2317614	hsa-miR-659	CLIP-seq
MIRT2317615	hsa-miR-765	CLIP-seq
MIRT2317616	hsa-miR-767-5p	CLIP-seq
MIRT2317617	hsa-miR-922	CLIP-seq
MIRT2093087	hsa-miR-939	CLIP-seq
MIRT2465986	hsa-miR-1273d	CLIP-seq
MIRT2465987	hsa-miR-3064-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005575	Component	Cellular_component	ND
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0008150	Process	Biological_process	ND
GO:0010468	Process	Regulation of gene expression	IBA	21873635
GO:0016567	Process	Protein ubiquitination	IBA	21873635
GO:0045087	Process	Innate immune response	IBA	21873635
GO:0046872	Function	Metal ion binding	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IBA	21873635

Other IDs

• MIM: 607524
• HGNC: 18064
• e!Ensembl: ENSG00000204618

Protein

• UniProt ID: Q9H2S5
• Protein name: RING finger protein 39 (EC 2.3.2.27) (Protein HZFw)
• Protein function: Plays an inhibitory role in anti-RNA viral innate immunity by targeting the adapter DDX3X and promoting its 'Lys-48'-linked polyubiquitination (PubMed:33674311). Alternatively, enhances the cGAS-STING pathway activation by promoting 'Lys-63'-lin
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00097	zf-C3HC4	88 → 134	Zinc finger, C3HC4 type (RING finger)	Domain
  PF13765	PRY	230 → 279	SPRY-associated domain	Family

• Sequence:

  MWWRDLTRLRLWLKREAIPGEGRKAAKVNAGVGEKGIYTASSRGGPPSARSKAVTVVAEG
  AASRSWLSMDAPELGPGLVERLEQLATCPLCGGSFEDPVLLACEHSFCRACLARRWGTPP
  ATGTEASPTACPCCGLPCPRRSLRSNVRLAVEVRISRELREKLAEPGARAGRRRGGRIPT
  MGCLDLPGEDMRKTWRRFEVPTSKSSNSEDDLPEDYPVVKKMLHRLTADLTLDPGTAHRR
  LLISADRRSVQLAPPGTPAPPDGPKRFDQLPAVLGAQGFGAGRHCWEVETADAASCRDSS
  GEDADDEESHYAVGAAGESVQRKGCVRLCPAGAVWAVEGRGGRLWALTAPEPTLLGGVEP
  PPRRIRVDLDWERGRVAFYDGRSLDLLYAFQAPGPLGERIFPLFCTCDPRAPLRIVPAES
  

• Sequence length: 420

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus, Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	17632545
Lung adenocarcinoma	Adenocarcinoma of lung (disorder)	rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370, rs760043106, rs1057519788, rs1131692238, rs1131692237, rs1554350382	19836008
Lung cancer	Malignant neoplasm of lung	rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135	22899653, 19654303
Myasthenia gravis	Myasthenia Gravis	rs5030818, rs121912815, rs121912817, rs121912818, rs121912821, rs75466054, rs121912822, rs121912823, rs794727516, rs764497513, rs376808313, rs1279554995, rs1554802792, rs369251527, rs372760913, rs1554802808, rs769234940, rs201439531, rs1272947184, rs757303526, rs760936252, rs1590576560, rs1838635262	23055271

Unknown
Disease name	Disease term	dbSNP ID	References
Lupus erythematosus	Lupus Erythematosus, Systemic		24871463