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PNPLA3 (patatin like domain 3, 1-acylglycerol-3-phosphate O-acyltransferase)

Gene

80339

Patatin like domain 3, 1-acylglycerol-3-phosphate O-acyltransferase

PNPLA3

ADPN, C22orf20, iPLA(2)epsilon

22q13.31

The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes. [provided b

Show/Hide all(1)

SNP ID	Visualize variation	Clinical significance	Consequence
rs738409	C>G,T	Risk-factor, likely-benign, drug-response	Coding sequence variant, missense variant, synonymous variant

Show/Hide all(398)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016844	hsa-miR-335-5p	Microarray	18185580
MIRT686091	hsa-miR-4438	HITS-CLIP	23313552
MIRT686090	hsa-miR-4687-5p	HITS-CLIP	23313552
MIRT686089	hsa-miR-6504-3p	HITS-CLIP	23313552
MIRT686088	hsa-miR-130b-5p	HITS-CLIP	23313552
MIRT686087	hsa-miR-5095	HITS-CLIP	23313552
MIRT686086	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT686085	hsa-miR-6807-5p	HITS-CLIP	23313552
MIRT686084	hsa-miR-30a-3p	HITS-CLIP	23313552
MIRT686083	hsa-miR-30d-3p	HITS-CLIP	23313552
MIRT686082	hsa-miR-30e-3p	HITS-CLIP	23313552
MIRT686081	hsa-miR-4763-5p	HITS-CLIP	23313552
MIRT621429	hsa-miR-8062	HITS-CLIP	23824327
MIRT665151	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT621428	hsa-miR-4308	HITS-CLIP	23824327
MIRT621427	hsa-miR-4292	HITS-CLIP	23824327
MIRT621426	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT621425	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT621424	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT621423	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT677806	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT677805	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT677804	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT621422	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT621421	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT621420	hsa-miR-1976	HITS-CLIP	23824327
MIRT621419	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT677803	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT677802	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT621418	hsa-miR-656-5p	HITS-CLIP	23824327
MIRT677801	hsa-miR-1297	HITS-CLIP	23824327
MIRT677800	hsa-miR-26a-5p	HITS-CLIP	23824327
MIRT677799	hsa-miR-26b-5p	HITS-CLIP	23824327
MIRT677798	hsa-miR-4465	HITS-CLIP	23824327
MIRT677797	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT677796	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT621417	hsa-miR-4279	HITS-CLIP	23824327
MIRT621429	hsa-miR-8062	HITS-CLIP	23824327
MIRT665151	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT621428	hsa-miR-4308	HITS-CLIP	23824327
MIRT621427	hsa-miR-4292	HITS-CLIP	23824327
MIRT621426	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT621425	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT621424	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT621423	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT621422	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT621421	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT621420	hsa-miR-1976	HITS-CLIP	23824327
MIRT621419	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT650814	hsa-miR-4731-5p	HITS-CLIP	23824327
MIRT650813	hsa-miR-5589-5p	HITS-CLIP	23824327
MIRT621418	hsa-miR-656-5p	HITS-CLIP	23824327
MIRT621417	hsa-miR-4279	HITS-CLIP	23824327
MIRT621429	hsa-miR-8062	HITS-CLIP	23824327
MIRT621428	hsa-miR-4308	HITS-CLIP	23824327
MIRT621427	hsa-miR-4292	HITS-CLIP	23824327
MIRT621426	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT621425	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT621424	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT621423	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT621422	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT621421	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT621420	hsa-miR-1976	HITS-CLIP	23824327
MIRT621419	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT650814	hsa-miR-4731-5p	HITS-CLIP	23824327
MIRT650813	hsa-miR-5589-5p	HITS-CLIP	23824327
MIRT621418	hsa-miR-656-5p	HITS-CLIP	23824327
MIRT621417	hsa-miR-4279	HITS-CLIP	23824327
MIRT621429	hsa-miR-8062	HITS-CLIP	23824327
MIRT621428	hsa-miR-4308	HITS-CLIP	23824327
MIRT621427	hsa-miR-4292	HITS-CLIP	23824327
MIRT621426	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT621425	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT621424	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT621423	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT621422	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT621421	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT621420	hsa-miR-1976	HITS-CLIP	23824327
MIRT621419	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT621418	hsa-miR-656-5p	HITS-CLIP	23824327
MIRT621417	hsa-miR-4279	HITS-CLIP	23824327
MIRT630117	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT630116	hsa-miR-520g-3p	HITS-CLIP	23824327
MIRT630115	hsa-miR-520h	HITS-CLIP	23824327
MIRT630114	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT630113	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT630112	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT630111	hsa-miR-4769-3p	HITS-CLIP	23824327
MIRT630110	hsa-miR-6817-5p	HITS-CLIP	23824327
MIRT630109	hsa-miR-5189-3p	HITS-CLIP	23824327
MIRT630108	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT630107	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT630106	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT630105	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT621429	hsa-miR-8062	HITS-CLIP	23824327
MIRT621428	hsa-miR-4308	HITS-CLIP	23824327
MIRT621427	hsa-miR-4292	HITS-CLIP	23824327
MIRT621426	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT621425	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT621424	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT621423	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT621422	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT621421	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT621420	hsa-miR-1976	HITS-CLIP	23824327
MIRT621419	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT621418	hsa-miR-656-5p	HITS-CLIP	23824327
MIRT621417	hsa-miR-4279	HITS-CLIP	23824327
MIRT519493	hsa-miR-590-3p	PAR-CLIP	23446348
MIRT519492	hsa-miR-4524b-3p	PAR-CLIP	23446348
MIRT519482	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT519491	hsa-miR-1228-3p	PAR-CLIP	23446348
MIRT519490	hsa-miR-6765-3p	PAR-CLIP	23446348
MIRT519489	hsa-miR-6823-5p	PAR-CLIP	23446348
MIRT519488	hsa-miR-4735-5p	PAR-CLIP	23446348
MIRT519487	hsa-miR-4794	PAR-CLIP	23446348
MIRT519486	hsa-miR-664a-5p	PAR-CLIP	23446348
MIRT519485	hsa-miR-4524a-3p	PAR-CLIP	23446348
MIRT519484	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT519483	hsa-miR-4775	PAR-CLIP	23446348
MIRT519482	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT519481	hsa-miR-197-3p	PAR-CLIP	23446348
MIRT519480	hsa-miR-5096	PAR-CLIP	23446348
MIRT519479	hsa-miR-2113	PAR-CLIP	23446348
MIRT519478	hsa-miR-5010-3p	PAR-CLIP	23446348
MIRT519477	hsa-miR-4701-5p	PAR-CLIP	23446348
MIRT686091	hsa-miR-4438	HITS-CLIP	23313552
MIRT686090	hsa-miR-4687-5p	HITS-CLIP	23313552
MIRT686089	hsa-miR-6504-3p	HITS-CLIP	23313552
MIRT686088	hsa-miR-130b-5p	HITS-CLIP	23313552
MIRT686087	hsa-miR-5095	HITS-CLIP	23313552
MIRT686086	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT686085	hsa-miR-6807-5p	HITS-CLIP	23313552
MIRT686084	hsa-miR-30a-3p	HITS-CLIP	23313552
MIRT686083	hsa-miR-30d-3p	HITS-CLIP	23313552
MIRT686082	hsa-miR-30e-3p	HITS-CLIP	23313552
MIRT686081	hsa-miR-4763-5p	HITS-CLIP	23313552
MIRT621429	hsa-miR-8062	HITS-CLIP	23824327
MIRT665151	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT621428	hsa-miR-4308	HITS-CLIP	23824327
MIRT621427	hsa-miR-4292	HITS-CLIP	23824327
MIRT621426	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT621425	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT621424	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT621423	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT677806	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT677805	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT677804	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT621422	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT621421	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT621420	hsa-miR-1976	HITS-CLIP	23824327
MIRT621419	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT677803	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT677802	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT621418	hsa-miR-656-5p	HITS-CLIP	23824327
MIRT677801	hsa-miR-1297	HITS-CLIP	23824327
MIRT677800	hsa-miR-26a-5p	HITS-CLIP	23824327
MIRT677799	hsa-miR-26b-5p	HITS-CLIP	23824327
MIRT677798	hsa-miR-4465	HITS-CLIP	23824327
MIRT677797	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT677796	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT621417	hsa-miR-4279	HITS-CLIP	23824327
MIRT621429	hsa-miR-8062	HITS-CLIP	23824327
MIRT665151	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT621428	hsa-miR-4308	HITS-CLIP	23824327
MIRT621427	hsa-miR-4292	HITS-CLIP	23824327
MIRT621426	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT621425	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT621424	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT621423	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT621422	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT621421	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT621420	hsa-miR-1976	HITS-CLIP	23824327
MIRT621419	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT650814	hsa-miR-4731-5p	HITS-CLIP	23824327
MIRT650813	hsa-miR-5589-5p	HITS-CLIP	23824327
MIRT621418	hsa-miR-656-5p	HITS-CLIP	23824327
MIRT621417	hsa-miR-4279	HITS-CLIP	23824327
MIRT621429	hsa-miR-8062	HITS-CLIP	23824327
MIRT621428	hsa-miR-4308	HITS-CLIP	23824327
MIRT621427	hsa-miR-4292	HITS-CLIP	23824327
MIRT621426	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT621425	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT621424	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT621423	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT621422	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT621421	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT621420	hsa-miR-1976	HITS-CLIP	23824327
MIRT621419	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT650814	hsa-miR-4731-5p	HITS-CLIP	23824327
MIRT650813	hsa-miR-5589-5p	HITS-CLIP	23824327
MIRT621418	hsa-miR-656-5p	HITS-CLIP	23824327
MIRT621417	hsa-miR-4279	HITS-CLIP	23824327
MIRT621429	hsa-miR-8062	HITS-CLIP	23824327
MIRT621428	hsa-miR-4308	HITS-CLIP	23824327
MIRT621427	hsa-miR-4292	HITS-CLIP	23824327
MIRT621426	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT621425	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT621424	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT621423	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT621422	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT621421	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT621420	hsa-miR-1976	HITS-CLIP	23824327
MIRT621419	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT621418	hsa-miR-656-5p	HITS-CLIP	23824327
MIRT621417	hsa-miR-4279	HITS-CLIP	23824327
MIRT630117	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT630116	hsa-miR-520g-3p	HITS-CLIP	23824327
MIRT630115	hsa-miR-520h	HITS-CLIP	23824327
MIRT630114	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT630113	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT630112	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT630111	hsa-miR-4769-3p	HITS-CLIP	23824327
MIRT630110	hsa-miR-6817-5p	HITS-CLIP	23824327
MIRT630109	hsa-miR-5189-3p	HITS-CLIP	23824327
MIRT630108	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT630107	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT630106	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT630105	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT621429	hsa-miR-8062	HITS-CLIP	23824327
MIRT621428	hsa-miR-4308	HITS-CLIP	23824327
MIRT621427	hsa-miR-4292	HITS-CLIP	23824327
MIRT621426	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT621425	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT621424	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT621423	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT621422	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT621421	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT621420	hsa-miR-1976	HITS-CLIP	23824327
MIRT621419	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT621418	hsa-miR-656-5p	HITS-CLIP	23824327
MIRT621417	hsa-miR-4279	HITS-CLIP	23824327
MIRT519493	hsa-miR-590-3p	PAR-CLIP	23446348
MIRT519492	hsa-miR-4524b-3p	PAR-CLIP	23446348
MIRT519482	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT519491	hsa-miR-1228-3p	PAR-CLIP	23446348
MIRT519490	hsa-miR-6765-3p	PAR-CLIP	23446348
MIRT519489	hsa-miR-6823-5p	PAR-CLIP	23446348
MIRT519488	hsa-miR-4735-5p	PAR-CLIP	23446348
MIRT519487	hsa-miR-4794	PAR-CLIP	23446348
MIRT519486	hsa-miR-664a-5p	PAR-CLIP	23446348
MIRT519485	hsa-miR-4524a-3p	PAR-CLIP	23446348
MIRT519484	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT519483	hsa-miR-4775	PAR-CLIP	23446348
MIRT519482	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT519481	hsa-miR-197-3p	PAR-CLIP	23446348
MIRT519480	hsa-miR-5096	PAR-CLIP	23446348
MIRT519479	hsa-miR-2113	PAR-CLIP	23446348
MIRT519478	hsa-miR-5010-3p	PAR-CLIP	23446348
MIRT519477	hsa-miR-4701-5p	PAR-CLIP	23446348
MIRT1245421	hsa-miR-1343	CLIP-seq
MIRT1245422	hsa-miR-26a	CLIP-seq
MIRT1245423	hsa-miR-26b	CLIP-seq
MIRT1245424	hsa-miR-3614-3p	CLIP-seq
MIRT1245425	hsa-miR-4297	CLIP-seq
MIRT2072603	hsa-miR-1254	CLIP-seq
MIRT2072604	hsa-miR-1257	CLIP-seq
MIRT2072605	hsa-miR-1281	CLIP-seq
MIRT1245421	hsa-miR-1343	CLIP-seq
MIRT2072606	hsa-miR-146b-3p	CLIP-seq
MIRT2072607	hsa-miR-216a	CLIP-seq
MIRT1245422	hsa-miR-26a	CLIP-seq
MIRT1245423	hsa-miR-26b	CLIP-seq
MIRT2072608	hsa-miR-3116	CLIP-seq
MIRT2072609	hsa-miR-3149	CLIP-seq
MIRT2072610	hsa-miR-3173-5p	CLIP-seq
MIRT2072611	hsa-miR-365	CLIP-seq
MIRT2072612	hsa-miR-4656	CLIP-seq
MIRT2072613	hsa-miR-4704-5p	CLIP-seq
MIRT2072614	hsa-miR-4781-3p	CLIP-seq
MIRT2072615	hsa-miR-637	CLIP-seq
MIRT2072616	hsa-miR-661	CLIP-seq
MIRT2072617	hsa-miR-874	CLIP-seq
MIRT2072603	hsa-miR-1254	CLIP-seq
MIRT2072604	hsa-miR-1257	CLIP-seq
MIRT2072605	hsa-miR-1281	CLIP-seq
MIRT1245421	hsa-miR-1343	CLIP-seq
MIRT2072606	hsa-miR-146b-3p	CLIP-seq
MIRT2072607	hsa-miR-216a	CLIP-seq
MIRT1245422	hsa-miR-26a	CLIP-seq
MIRT1245423	hsa-miR-26b	CLIP-seq
MIRT2299761	hsa-miR-28-3p	CLIP-seq
MIRT2072608	hsa-miR-3116	CLIP-seq
MIRT2072610	hsa-miR-3173-5p	CLIP-seq
MIRT1245424	hsa-miR-3614-3p	CLIP-seq
MIRT2072611	hsa-miR-365	CLIP-seq
MIRT2299762	hsa-miR-4637	CLIP-seq
MIRT2072612	hsa-miR-4656	CLIP-seq
MIRT2072613	hsa-miR-4704-5p	CLIP-seq
MIRT2072615	hsa-miR-637	CLIP-seq
MIRT2072616	hsa-miR-661	CLIP-seq
MIRT2072617	hsa-miR-874	CLIP-seq
MIRT2072603	hsa-miR-1254	CLIP-seq
MIRT2072604	hsa-miR-1257	CLIP-seq
MIRT2072606	hsa-miR-146b-3p	CLIP-seq
MIRT2299761	hsa-miR-28-3p	CLIP-seq
MIRT2072608	hsa-miR-3116	CLIP-seq
MIRT2072610	hsa-miR-3173-5p	CLIP-seq
MIRT2072611	hsa-miR-365	CLIP-seq
MIRT2072612	hsa-miR-4656	CLIP-seq
MIRT2072613	hsa-miR-4704-5p	CLIP-seq
MIRT2072615	hsa-miR-637	CLIP-seq
MIRT2072616	hsa-miR-661	CLIP-seq
MIRT2072617	hsa-miR-874	CLIP-seq
MIRT2072605	hsa-miR-1281	CLIP-seq
MIRT1245421	hsa-miR-1343	CLIP-seq
MIRT1245422	hsa-miR-26a	CLIP-seq
MIRT1245423	hsa-miR-26b	CLIP-seq
MIRT1245424	hsa-miR-3614-3p	CLIP-seq
MIRT1245425	hsa-miR-4297	CLIP-seq
MIRT2596446	hsa-miR-1236	CLIP-seq
MIRT2596447	hsa-miR-1260	CLIP-seq
MIRT2596448	hsa-miR-1260b	CLIP-seq
MIRT2072605	hsa-miR-1281	CLIP-seq
MIRT1245421	hsa-miR-1343	CLIP-seq
MIRT2596449	hsa-miR-1470	CLIP-seq
MIRT2596450	hsa-miR-188-3p	CLIP-seq
MIRT2596451	hsa-miR-2110	CLIP-seq
MIRT2596452	hsa-miR-2682	CLIP-seq
MIRT1245422	hsa-miR-26a	CLIP-seq
MIRT1245423	hsa-miR-26b	CLIP-seq
MIRT2596453	hsa-miR-3127-3p	CLIP-seq
MIRT2596454	hsa-miR-3130-3p	CLIP-seq
MIRT2596455	hsa-miR-3144-5p	CLIP-seq
MIRT2072609	hsa-miR-3149	CLIP-seq
MIRT2596456	hsa-miR-3150a-3p	CLIP-seq
MIRT2596457	hsa-miR-3156-3p	CLIP-seq
MIRT2596458	hsa-miR-3191	CLIP-seq
MIRT2596459	hsa-miR-34a	CLIP-seq
MIRT2596460	hsa-miR-34c-5p	CLIP-seq
MIRT1245424	hsa-miR-3614-3p	CLIP-seq
MIRT2596461	hsa-miR-411	CLIP-seq
MIRT2596462	hsa-miR-4271	CLIP-seq
MIRT1245425	hsa-miR-4297	CLIP-seq
MIRT2596463	hsa-miR-449a	CLIP-seq
MIRT2596464	hsa-miR-449b	CLIP-seq
MIRT2596465	hsa-miR-449c	CLIP-seq
MIRT2596466	hsa-miR-450b-3p	CLIP-seq
MIRT2596467	hsa-miR-4514	CLIP-seq
MIRT2596468	hsa-miR-4652-5p	CLIP-seq
MIRT2596469	hsa-miR-4654	CLIP-seq
MIRT2596470	hsa-miR-4667-3p	CLIP-seq
MIRT2596471	hsa-miR-4692	CLIP-seq
MIRT2596472	hsa-miR-4713-3p	CLIP-seq
MIRT2596473	hsa-miR-4725-3p	CLIP-seq
MIRT2596474	hsa-miR-4753-3p	CLIP-seq
MIRT2596475	hsa-miR-4769-5p	CLIP-seq
MIRT2596476	hsa-miR-4795-5p	CLIP-seq
MIRT2596477	hsa-miR-501-3p	CLIP-seq
MIRT2596478	hsa-miR-502-3p	CLIP-seq
MIRT2596479	hsa-miR-635	CLIP-seq
MIRT2596480	hsa-miR-638	CLIP-seq
MIRT2596481	hsa-miR-642a	CLIP-seq
MIRT2596482	hsa-miR-767-5p	CLIP-seq
MIRT2596483	hsa-miR-769-3p	CLIP-seq
MIRT2596446	hsa-miR-1236	CLIP-seq
MIRT2596447	hsa-miR-1260	CLIP-seq
MIRT2596448	hsa-miR-1260b	CLIP-seq
MIRT2072605	hsa-miR-1281	CLIP-seq
MIRT1245421	hsa-miR-1343	CLIP-seq
MIRT2596449	hsa-miR-1470	CLIP-seq
MIRT2596450	hsa-miR-188-3p	CLIP-seq
MIRT2596451	hsa-miR-2110	CLIP-seq
MIRT2596452	hsa-miR-2682	CLIP-seq
MIRT1245422	hsa-miR-26a	CLIP-seq
MIRT1245423	hsa-miR-26b	CLIP-seq
MIRT2596453	hsa-miR-3127-3p	CLIP-seq
MIRT2596454	hsa-miR-3130-3p	CLIP-seq
MIRT2596455	hsa-miR-3144-5p	CLIP-seq
MIRT2072609	hsa-miR-3149	CLIP-seq
MIRT2596456	hsa-miR-3150a-3p	CLIP-seq
MIRT2596457	hsa-miR-3156-3p	CLIP-seq
MIRT2596458	hsa-miR-3191	CLIP-seq
MIRT2596459	hsa-miR-34a	CLIP-seq
MIRT2596460	hsa-miR-34c-5p	CLIP-seq
MIRT1245424	hsa-miR-3614-3p	CLIP-seq
MIRT2596462	hsa-miR-4271	CLIP-seq
MIRT1245425	hsa-miR-4297	CLIP-seq
MIRT2596463	hsa-miR-449a	CLIP-seq
MIRT2596464	hsa-miR-449b	CLIP-seq
MIRT2596465	hsa-miR-449c	CLIP-seq
MIRT2596466	hsa-miR-450b-3p	CLIP-seq
MIRT2596467	hsa-miR-4514	CLIP-seq
MIRT2596468	hsa-miR-4652-5p	CLIP-seq
MIRT2596469	hsa-miR-4654	CLIP-seq
MIRT2596470	hsa-miR-4667-3p	CLIP-seq
MIRT2596471	hsa-miR-4692	CLIP-seq
MIRT2596472	hsa-miR-4713-3p	CLIP-seq
MIRT2596473	hsa-miR-4725-3p	CLIP-seq
MIRT2596474	hsa-miR-4753-3p	CLIP-seq
MIRT2596475	hsa-miR-4769-5p	CLIP-seq
MIRT2596476	hsa-miR-4795-5p	CLIP-seq
MIRT2596477	hsa-miR-501-3p	CLIP-seq
MIRT2596478	hsa-miR-502-3p	CLIP-seq
MIRT2596479	hsa-miR-635	CLIP-seq
MIRT2596480	hsa-miR-638	CLIP-seq
MIRT2596481	hsa-miR-642a	CLIP-seq
MIRT2596482	hsa-miR-767-5p	CLIP-seq
MIRT2596483	hsa-miR-769-3p	CLIP-seq

Show/Hide all(31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001676	Process	Long-chain fatty acid metabolic process	IDA	22560221
GO:0003841	Function	1-acylglycerol-3-phosphate O-acyltransferase activity	IDA	22560221
GO:0004623	Function	Phospholipase A2 activity	IDA	15364929
GO:0004806	Function	Triglyceride lipase activity	IBA	21873635
GO:0004806	Function	Triglyceride lipase activity	IDA	15364929, 20034933, 22560221
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005811	Component	Lipid droplet	IBA	21873635
GO:0005811	Component	Lipid droplet	IDA	20034933, 22560221, 23398201
GO:0006650	Process	Glycerophospholipid metabolic process	IDA	22560221
GO:0006654	Process	Phosphatidic acid biosynthetic process	IDA	22560221
GO:0009744	Process	Response to sucrose	IEA
GO:0016020	Component	Membrane	IBA	21873635
GO:0016020	Component	Membrane	IDA	22560221
GO:0016020	Component	Membrane	ISS
GO:0016021	Component	Integral component of membrane	IEA
GO:0019432	Process	Triglyceride biosynthetic process	IDA	15364929, 22560221
GO:0019433	Process	Triglyceride catabolic process	IBA	21873635
GO:0019433	Process	Triglyceride catabolic process	IDA	15364929, 22560221
GO:0032869	Process	Cellular response to insulin stimulus	IEA
GO:0034389	Process	Lipid droplet organization	IMP	23398201
GO:0035727	Function	Lysophosphatidic acid binding	IDA	22560221
GO:0036042	Function	Long-chain fatty acyl-CoA binding	IDA	22560221
GO:0036153	Process	Triglyceride acyl-chain remodeling	IDA	24511104
GO:0036155	Process	Acylglycerol acyl-chain remodeling	TAS
GO:0042171	Function	Lysophosphatidic acid acyltransferase activity	IDA	22560221
GO:0050872	Process	White fat cell differentiation	IEA
GO:0051264	Function	Mono-olein transacylation activity	IDA	15364929
GO:0051265	Function	Diolein transacylation activity	IDA	15364929
GO:0055088	Process	Lipid homeostasis	IBA	21873635
GO:1905243	Process	Cellular response to 3,3',5-triiodo-L-thyronine	IEA

MIM	HGNC	e!Ensembl
609567	18590	ENSG00000100344

Protein

UniProt ID

Q9NST1

Protein name

1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 (EC 2.3.1.51) (Acylglycerol transacylase) (Adiponutrin) (ADPN) (Calcium-independent phospholipase A2-epsilon) (iPLA2-epsilon) (EC 3.1.1.4) (Lysophosphatidic acid acyltransferase) (Patatin-like phospholip

Protein function

Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerop

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01734	Patatin	10 → 179	Patatin-like phospholipase	Family

Sequence

MYDAERGWSLSFAGCGFLGFYHVGATRCLSEHAPHLLRDARMLFGASAGALHCVGVLSGI
PLEQTLQVLSDLVRKARSRNIGIFHPSFNLSKFLRQGLCKCLPANVHQLISGKIGISLTR
VSDGENVLVSDFRSKDEVVDALVCSCFIPFYSGLIPPSFRGVRYVDGGVSDNVPFIDAKT
TITVSPFYGEYDICPKVKSTNFLHVDITKLSLRLCTGNLYLLSRAFVPPDLKVLGEICLR
GYLDAFRFLEEKGICNRPQPGLKSSSEGMDPEVAMPSWANMSLDSSPESAALAVRLEGDE
LLDHLRLSILPWDESILDTLSPRLATALSEEMKDKGGYMSKICNLLPIRIMSYVMLPCTL
PVESAIAIVQRLVTWLPDMPDDVLWLQWVTSQVFTRVLMCLLPASRSQMPVSSQQASPCT
PEQDWPCWTPCSPKGCPAETKAEATPRSILRSSLNFFLGNKVPAGAEGLSTFPSFSLEKS
L

Sequence length

481

Interactions

View interactions

	KEGG		Reactome
	Glycerolipid metabolism Metabolic pathways		Acyl chain remodeling of DAG and TAG

Associated diseases

Show/Hide Causal Diseases (3)

Causal
Disease name	Disease term	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	29632382
Lymphoblastic leukemia	Precursor Cell Lymphoblastic Leukemia Lymphoma	rs387906351, rs104894562, rs398122513, rs398122840, rs398123063, rs1057524466, rs1064796115, rs1064795660, rs1064793129, rs1064796227, rs1567887558, rs1161194345, rs1597558200, rs1406320425, rs1597566470, rs1597566699, rs1597567692, rs1597567985, rs1438890364, rs1288977950, rs1597552140, rs1597566356, rs1597566726, rs1597568117, rs2069719445, rs2069729948, rs2070018439, rs745708044, rs1169577591	28090653
Obesity	Obesity	rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840	25246029

Show/Hide Unknown Diseases (5)

Unknown
Disease name	Disease term	dbSNP ID	References
Alcoholic liver cirrhosis	Liver Cirrhosis, Alcoholic		26482880, 19946271
Fatty liver	Fatty Liver, Steatohepatitis, Fatty Liver Disease		25678388, 25678388, 29385134, 23477746
Liver carcinoma	Liver carcinoma		29385134
Liver cirrhosis	Liver Cirrhosis		23535911
Non-alcoholic fatty liver disease	Non-alcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis, NON RARE IN EUROPE: Non-alcoholic fatty liver disease		21423719, 23535911, 24531328, 31311600, 22719876, 27180240, 29385134, 18820647, 29271184, 29385134, 24531328, 18820647, 27180240

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