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CEP70 (centrosomal protein 70)

Gene

80321

Centrosomal protein 70

CEP70

BITE

3q22.3

Show/Hide all(113)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020024	hsa-miR-375	Microarray	20215506
MIRT639180	hsa-miR-1272	HITS-CLIP	23824327
MIRT639179	hsa-miR-1470	HITS-CLIP	23824327
MIRT639178	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT639177	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT639176	hsa-miR-3682-3p	HITS-CLIP	23824327
MIRT639175	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT639174	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT639173	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT639172	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT639180	hsa-miR-1272	HITS-CLIP	23824327
MIRT639179	hsa-miR-1470	HITS-CLIP	23824327
MIRT639178	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT639177	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT639176	hsa-miR-3682-3p	HITS-CLIP	23824327
MIRT639175	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT639174	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT639173	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT639172	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT886422	hsa-miR-106a	CLIP-seq
MIRT886423	hsa-miR-106b	CLIP-seq
MIRT886424	hsa-miR-17	CLIP-seq
MIRT886425	hsa-miR-20a	CLIP-seq
MIRT886426	hsa-miR-20b	CLIP-seq
MIRT886427	hsa-miR-3163	CLIP-seq
MIRT886428	hsa-miR-3179	CLIP-seq
MIRT886429	hsa-miR-340	CLIP-seq
MIRT886430	hsa-miR-4509	CLIP-seq
MIRT886431	hsa-miR-4724-3p	CLIP-seq
MIRT886432	hsa-miR-4744	CLIP-seq
MIRT886433	hsa-miR-499-3p	CLIP-seq
MIRT886434	hsa-miR-499a-3p	CLIP-seq
MIRT886435	hsa-miR-519a	CLIP-seq
MIRT886436	hsa-miR-519b-3p	CLIP-seq
MIRT886437	hsa-miR-519c-3p	CLIP-seq
MIRT886438	hsa-miR-519d	CLIP-seq
MIRT886439	hsa-miR-548t	CLIP-seq
MIRT886440	hsa-miR-561	CLIP-seq
MIRT886441	hsa-miR-93	CLIP-seq
MIRT1962895	hsa-miR-1976	CLIP-seq
MIRT1962896	hsa-miR-370	CLIP-seq
MIRT1962897	hsa-miR-4659a-3p	CLIP-seq
MIRT1962898	hsa-miR-4659b-3p	CLIP-seq
MIRT1962899	hsa-miR-4691-5p	CLIP-seq
MIRT2199230	hsa-miR-4503	CLIP-seq
MIRT2199231	hsa-miR-513a-3p	CLIP-seq
MIRT2199232	hsa-miR-590-3p	CLIP-seq
MIRT2502009	hsa-miR-1202	CLIP-seq
MIRT2502010	hsa-miR-1227	CLIP-seq
MIRT2502011	hsa-miR-1233	CLIP-seq
MIRT2502012	hsa-miR-1256	CLIP-seq
MIRT2502013	hsa-miR-129-3p	CLIP-seq
MIRT2502014	hsa-miR-1303	CLIP-seq
MIRT2502015	hsa-miR-193a-3p	CLIP-seq
MIRT2502016	hsa-miR-193b	CLIP-seq
MIRT2502017	hsa-miR-2278	CLIP-seq
MIRT2502018	hsa-miR-302f	CLIP-seq
MIRT2502019	hsa-miR-3126-5p	CLIP-seq
MIRT886428	hsa-miR-3179	CLIP-seq
MIRT2502020	hsa-miR-362-5p	CLIP-seq
MIRT2502021	hsa-miR-3646	CLIP-seq
MIRT2502022	hsa-miR-3650	CLIP-seq
MIRT2502023	hsa-miR-3685	CLIP-seq
MIRT2502024	hsa-miR-3972	CLIP-seq
MIRT2502025	hsa-miR-4419a	CLIP-seq
MIRT2502026	hsa-miR-4474-3p	CLIP-seq
MIRT2199230	hsa-miR-4503	CLIP-seq
MIRT2502027	hsa-miR-4510	CLIP-seq
MIRT2502028	hsa-miR-455-5p	CLIP-seq
MIRT2502029	hsa-miR-4642	CLIP-seq
MIRT2502030	hsa-miR-4719	CLIP-seq
MIRT2502031	hsa-miR-4755-3p	CLIP-seq
MIRT2502032	hsa-miR-4768-3p	CLIP-seq
MIRT2502033	hsa-miR-4794	CLIP-seq
MIRT2502034	hsa-miR-500a	CLIP-seq
MIRT2502035	hsa-miR-500b	CLIP-seq
MIRT2502036	hsa-miR-502-5p	CLIP-seq
MIRT2199231	hsa-miR-513a-3p	CLIP-seq
MIRT2502037	hsa-miR-516a-3p	CLIP-seq
MIRT2199232	hsa-miR-590-3p	CLIP-seq
MIRT2502038	hsa-miR-644	CLIP-seq
MIRT2502039	hsa-miR-665	CLIP-seq
MIRT2502040	hsa-miR-892b	CLIP-seq
MIRT2502009	hsa-miR-1202	CLIP-seq
MIRT2502010	hsa-miR-1227	CLIP-seq
MIRT2502011	hsa-miR-1233	CLIP-seq
MIRT2502012	hsa-miR-1256	CLIP-seq
MIRT2502013	hsa-miR-129-3p	CLIP-seq
MIRT2502014	hsa-miR-1303	CLIP-seq
MIRT2502015	hsa-miR-193a-3p	CLIP-seq
MIRT2502016	hsa-miR-193b	CLIP-seq
MIRT2502017	hsa-miR-2278	CLIP-seq
MIRT2502019	hsa-miR-3126-5p	CLIP-seq
MIRT2502020	hsa-miR-362-5p	CLIP-seq
MIRT2502023	hsa-miR-3685	CLIP-seq
MIRT2502024	hsa-miR-3972	CLIP-seq
MIRT2502025	hsa-miR-4419a	CLIP-seq
MIRT2199230	hsa-miR-4503	CLIP-seq
MIRT2502027	hsa-miR-4510	CLIP-seq
MIRT2502028	hsa-miR-455-5p	CLIP-seq
MIRT2502029	hsa-miR-4642	CLIP-seq
MIRT2502030	hsa-miR-4719	CLIP-seq
MIRT2502031	hsa-miR-4755-3p	CLIP-seq
MIRT2502032	hsa-miR-4768-3p	CLIP-seq
MIRT2502033	hsa-miR-4794	CLIP-seq
MIRT2502034	hsa-miR-500a	CLIP-seq
MIRT2502035	hsa-miR-500b	CLIP-seq
MIRT2502036	hsa-miR-502-5p	CLIP-seq
MIRT2199231	hsa-miR-513a-3p	CLIP-seq
MIRT2502037	hsa-miR-516a-3p	CLIP-seq
MIRT2199232	hsa-miR-590-3p	CLIP-seq
MIRT2502039	hsa-miR-665	CLIP-seq
MIRT2502040	hsa-miR-892b	CLIP-seq

Show/Hide all(10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000086	Process	G2/M transition of mitotic cell cycle	TAS
GO:0005515	Function	Protein binding	IPI	16189514, 16713569, 19060904, 21900206, 23455924, 25416956, 25910212, 26871637, 27107012, 29892012, 31515488, 32296183, 32814053
GO:0005813	Component	Centrosome	IBA	21873635
GO:0005813	Component	Centrosome	IDA	21399614
GO:0005829	Component	Cytosol	TAS
GO:0010389	Process	Regulation of G2/M transition of mitotic cell cycle	TAS
GO:0042802	Function	Identical protein binding	IPI	25416956, 27107012
GO:0043015	Function	Gamma-tubulin binding	IEA
GO:0070507	Process	Regulation of microtubule cytoskeleton organization	IEA
GO:0097711	Process	Ciliary basal body-plasma membrane docking	TAS

MIM	HGNC	e!Ensembl
614310	29972	ENSG00000114107

Protein

UniProt ID

Q8NHQ1

Protein name

Centrosomal protein of 70 kDa (Cep70) (p10-binding protein)

Protein function

Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.

Family and domains

Sequence

MFPVAPKPQDSSQPSDRLMTEKQQEEAEWESINVLLMMHGLKPLSLVKRTDLKDLIIFDK
QSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIME
SVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEVC
RLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQS
EEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYK
QQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQRYFQVLCSINSIIH
NPRAPVIIYKQTKGGVQNFNKDLVQDCGFEHLVPVIEMWADQLTSLKDLYKSLKTLSAEL
VPWLNLKKQDENEGIKVEDLLFIVDTMLEEVENKEKDSNMPHFQTLQAIVSHFQKLFDVP
SLNGVYPRMNEVYTRLGEMNNAVRNLQELLELDSSSSLCVLVSTVGKLCRLINEDVNEQV
MQVLGPEDLQSIIYKLEEHEEFFPAFQAFTNDLLEILEIDDLDAIVPAVKKLKVLSY

Sequence length

597

Interactions

View interactions

	Reactome
			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Chronic obstructive pulmonary disease	Chronic Obstructive Airway Disease	rs2227956, rs1008438, rs1043618, rs562047, rs1061581, rs2763979, rs6457452, rs13147758, rs1828591, rs13118928	29631575

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