TET1 (tet methylcytosine dioxygenase 1)

Gene

• Entrez ID: 80312
• Gene name: Tet methylcytosine dioxygenase 1
• Gene symbol: TET1
• Synonyms: CXXC6, LCX, bA119F7.1
• Chromosome: 10
• Chromosome location: 10q21.3
• Summary: DNA methylation is an epigenetic mechanism that is important for controlling gene expression. The protein encoded by this gene is a demethylase that belongs to the TET (ten-eleven translocation) family. Members of the TET protein family play a role in the

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT004419	hsa-miR-29b-3p	qRT-PCR, Luciferase reporter assay, Western blot	19850741
MIRT004420	hsa-miR-29a-3p	qRT-PCR	19850741
MIRT030814	hsa-miR-21-5p	Microarray	18591254
MIRT039236	hsa-miR-454-3p	CLASH	23622248
MIRT037234	hsa-miR-877-5p	CLASH	23622248
MIRT004420	hsa-miR-29a-3p	Luciferase reporter assay, qRT-PCR, Western blot	23857059
MIRT004420	hsa-miR-29a-3p	Luciferase reporter assay, qRT-PCR, Western blot	23857059
MIRT004420	hsa-miR-29a-3p	Luciferase reporter assay, qRT-PCR, Western blot	23857059
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, qRT-PCR, Western blot	23857059
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, qRT-PCR, Western blot	23857059
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, qRT-PCR, Western blot	23857059
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, qRT-PCR, Western blot	23857059
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, qRT-PCR, Western blot	23857059
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, qRT-PCR, Western blot	23857059
MIRT004420	hsa-miR-29a-3p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	23820384
MIRT004420	hsa-miR-29a-3p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	23820384
MIRT004420	hsa-miR-29a-3p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	23820384
MIRT004420	hsa-miR-29a-3p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	23820384
MIRT640760	hsa-miR-205-3p	HITS-CLIP	23824327
MIRT640759	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT640758	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT640757	hsa-miR-505-3p	HITS-CLIP	23824327
MIRT640756	hsa-miR-421	HITS-CLIP	23824327
MIRT621854	hsa-miR-4263	HITS-CLIP	23824327
MIRT621852	hsa-miR-576-5p	HITS-CLIP	23824327
MIRT640755	hsa-miR-1305	HITS-CLIP	23824327
MIRT621857	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT621856	hsa-miR-4778-5p	HITS-CLIP	23824327
MIRT621855	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT621853	hsa-miR-3686	HITS-CLIP	23824327
MIRT621854	hsa-miR-4263	HITS-CLIP	23824327
MIRT621852	hsa-miR-576-5p	HITS-CLIP	23824327
MIRT004420	hsa-miR-29a-3p	Luciferase reporter assay, qRT-PCR, Western blot	27555295
MIRT004420	hsa-miR-29a-3p	Luciferase reporter assay, qRT-PCR, Western blot	27555295
MIRT382486	hsa-miR-141-3p	qRT-PCR	27198154
MIRT382486	hsa-miR-141-3p	qRT-PCR	27198154
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004419	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	26776158
MIRT004420	hsa-miR-29a-3p	Microarray, qRT-PCR	26251039
MIRT734564	hsa-miR-767-5p	Western blotting, Immunohistochemistry (IHC), qRT-PCR	31844675
MIRT736345	hsa-miR-191-5p	Luciferase reporter assay, Western blotting, qRT-PCR	32003827
MIRT640760	hsa-miR-205-3p	HITS-CLIP	23824327
MIRT640759	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT640758	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT640757	hsa-miR-505-3p	HITS-CLIP	23824327
MIRT640756	hsa-miR-421	HITS-CLIP	23824327
MIRT621854	hsa-miR-4263	HITS-CLIP	23824327
MIRT621852	hsa-miR-576-5p	HITS-CLIP	23824327
MIRT640755	hsa-miR-1305	HITS-CLIP	23824327
MIRT621857	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT621856	hsa-miR-4778-5p	HITS-CLIP	23824327
MIRT621855	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT621853	hsa-miR-3686	HITS-CLIP	23824327
MIRT621854	hsa-miR-4263	HITS-CLIP	23824327
MIRT621852	hsa-miR-576-5p	HITS-CLIP	23824327
MIRT755464	hsa-miR-27a-3p	Luciferase reporter assay, Western blotting, qRT-PCR, Immunohistochemistry (IHC)	35978806
MIRT1418577	hsa-miR-1200	CLIP-seq
MIRT1418578	hsa-miR-128	CLIP-seq
MIRT1418579	hsa-miR-1297	CLIP-seq
MIRT1418580	hsa-miR-1303	CLIP-seq
MIRT1418581	hsa-miR-155	CLIP-seq
MIRT1418582	hsa-miR-200b	CLIP-seq
MIRT1418583	hsa-miR-200c	CLIP-seq
MIRT1418584	hsa-miR-217	CLIP-seq
MIRT1418585	hsa-miR-26a	CLIP-seq
MIRT1418586	hsa-miR-26b	CLIP-seq
MIRT1418587	hsa-miR-27a	CLIP-seq
MIRT1418588	hsa-miR-27b	CLIP-seq
MIRT1418589	hsa-miR-3120-3p	CLIP-seq
MIRT1418590	hsa-miR-3123	CLIP-seq
MIRT1418591	hsa-miR-3140-3p	CLIP-seq
MIRT1418592	hsa-miR-3646	CLIP-seq
MIRT1418593	hsa-miR-365	CLIP-seq
MIRT1418594	hsa-miR-3653	CLIP-seq
MIRT1418595	hsa-miR-3658	CLIP-seq
MIRT1418596	hsa-miR-3919	CLIP-seq
MIRT1418597	hsa-miR-3923	CLIP-seq
MIRT1418598	hsa-miR-429	CLIP-seq
MIRT1418599	hsa-miR-4418	CLIP-seq
MIRT1418600	hsa-miR-4426	CLIP-seq
MIRT1418601	hsa-miR-4436b-3p	CLIP-seq
MIRT1418602	hsa-miR-4465	CLIP-seq
MIRT1418603	hsa-miR-450b-5p	CLIP-seq
MIRT1418604	hsa-miR-452	CLIP-seq
MIRT1418605	hsa-miR-4647	CLIP-seq
MIRT1418606	hsa-miR-4662b	CLIP-seq
MIRT1418607	hsa-miR-4666-5p	CLIP-seq
MIRT1418608	hsa-miR-4668-3p	CLIP-seq
MIRT1418609	hsa-miR-4672	CLIP-seq
MIRT1418610	hsa-miR-4676-3p	CLIP-seq
MIRT1418611	hsa-miR-4680-5p	CLIP-seq
MIRT1418612	hsa-miR-4698	CLIP-seq
MIRT1418613	hsa-miR-4719	CLIP-seq
MIRT1418614	hsa-miR-4761-5p	CLIP-seq
MIRT1418615	hsa-miR-4793-3p	CLIP-seq
MIRT1418616	hsa-miR-4795-3p	CLIP-seq
MIRT1418617	hsa-miR-498	CLIP-seq
MIRT1418618	hsa-miR-507	CLIP-seq
MIRT1418619	hsa-miR-509-3-5p	CLIP-seq
MIRT1418620	hsa-miR-509-5p	CLIP-seq
MIRT1418621	hsa-miR-513a-5p	CLIP-seq
MIRT1418622	hsa-miR-548ad	CLIP-seq
MIRT1418623	hsa-miR-548c-3p	CLIP-seq
MIRT1418624	hsa-miR-557	CLIP-seq
MIRT1418625	hsa-miR-569	CLIP-seq
MIRT1418626	hsa-miR-607	CLIP-seq
MIRT1418627	hsa-miR-618	CLIP-seq
MIRT1418628	hsa-miR-628-3p	CLIP-seq
MIRT1418629	hsa-miR-630	CLIP-seq
MIRT1418630	hsa-miR-649	CLIP-seq
MIRT1418631	hsa-miR-656	CLIP-seq
MIRT2125528	hsa-miR-1276	CLIP-seq
MIRT1418580	hsa-miR-1303	CLIP-seq
MIRT2125529	hsa-miR-150	CLIP-seq
MIRT2125530	hsa-miR-183	CLIP-seq
MIRT2125531	hsa-miR-191	CLIP-seq
MIRT2125532	hsa-miR-3152-3p	CLIP-seq
MIRT2125533	hsa-miR-337-3p	CLIP-seq
MIRT2125534	hsa-miR-3662	CLIP-seq
MIRT2125535	hsa-miR-376a	CLIP-seq
MIRT2125536	hsa-miR-376b	CLIP-seq
MIRT2125537	hsa-miR-4265	CLIP-seq
MIRT2125538	hsa-miR-4296	CLIP-seq
MIRT2125539	hsa-miR-4311	CLIP-seq
MIRT2125540	hsa-miR-4321	CLIP-seq
MIRT2125541	hsa-miR-4322	CLIP-seq
MIRT2125542	hsa-miR-4417	CLIP-seq
MIRT2125543	hsa-miR-4424	CLIP-seq
MIRT2125544	hsa-miR-4464	CLIP-seq
MIRT1418603	hsa-miR-450b-5p	CLIP-seq
MIRT1418609	hsa-miR-4672	CLIP-seq
MIRT2125545	hsa-miR-4732-5p	CLIP-seq
MIRT2125546	hsa-miR-4748	CLIP-seq
MIRT2125547	hsa-miR-4775	CLIP-seq
MIRT2125548	hsa-miR-494	CLIP-seq
MIRT1418618	hsa-miR-507	CLIP-seq
MIRT2125549	hsa-miR-516a-3p	CLIP-seq
MIRT1418624	hsa-miR-557	CLIP-seq
MIRT2125550	hsa-miR-587	CLIP-seq
MIRT2125551	hsa-miR-595	CLIP-seq
MIRT2347890	hsa-miR-1273g	CLIP-seq
MIRT1418578	hsa-miR-128	CLIP-seq
MIRT2347891	hsa-miR-141	CLIP-seq
MIRT2347892	hsa-miR-200a	CLIP-seq
MIRT2347893	hsa-miR-21	CLIP-seq
MIRT2347894	hsa-miR-29a	CLIP-seq
MIRT2347895	hsa-miR-29b	CLIP-seq
MIRT2347896	hsa-miR-29c	CLIP-seq
MIRT1418589	hsa-miR-3120-3p	CLIP-seq
MIRT1418592	hsa-miR-3646	CLIP-seq
MIRT1418594	hsa-miR-3653	CLIP-seq
MIRT1418595	hsa-miR-3658	CLIP-seq
MIRT2347897	hsa-miR-3682-3p	CLIP-seq
MIRT2347898	hsa-miR-3942-5p	CLIP-seq
MIRT2347899	hsa-miR-431	CLIP-seq
MIRT2125543	hsa-miR-4424	CLIP-seq
MIRT1418600	hsa-miR-4426	CLIP-seq
MIRT2347900	hsa-miR-4503	CLIP-seq
MIRT1418605	hsa-miR-4647	CLIP-seq
MIRT1418606	hsa-miR-4662b	CLIP-seq
MIRT1418609	hsa-miR-4672	CLIP-seq
MIRT1418611	hsa-miR-4680-5p	CLIP-seq
MIRT1418612	hsa-miR-4698	CLIP-seq
MIRT2347901	hsa-miR-4703-5p	CLIP-seq
MIRT2347902	hsa-miR-4711-3p	CLIP-seq
MIRT2125545	hsa-miR-4732-5p	CLIP-seq
MIRT2347903	hsa-miR-4764-5p	CLIP-seq
MIRT2347904	hsa-miR-590-5p	CLIP-seq
MIRT1418627	hsa-miR-618	CLIP-seq
MIRT2347905	hsa-miR-892a	CLIP-seq
MIRT1418579	hsa-miR-1297	CLIP-seq
MIRT1418585	hsa-miR-26a	CLIP-seq
MIRT1418586	hsa-miR-26b	CLIP-seq
MIRT2347894	hsa-miR-29a	CLIP-seq
MIRT2347895	hsa-miR-29b	CLIP-seq
MIRT2347896	hsa-miR-29c	CLIP-seq
MIRT2433800	hsa-miR-3121-3p	CLIP-seq
MIRT2433801	hsa-miR-3159	CLIP-seq
MIRT2433802	hsa-miR-4320	CLIP-seq
MIRT1418602	hsa-miR-4465	CLIP-seq
MIRT1418616	hsa-miR-4795-3p	CLIP-seq
MIRT1418617	hsa-miR-498	CLIP-seq
MIRT1418623	hsa-miR-548c-3p	CLIP-seq
MIRT1418631	hsa-miR-656	CLIP-seq
MIRT2440941	hsa-miR-147	CLIP-seq
MIRT2347893	hsa-miR-21	CLIP-seq
MIRT2440942	hsa-miR-3691-5p	CLIP-seq
MIRT2440943	hsa-miR-3911	CLIP-seq
MIRT2440944	hsa-miR-4752	CLIP-seq
MIRT2440945	hsa-miR-4760-3p	CLIP-seq
MIRT2347904	hsa-miR-590-5p	CLIP-seq
MIRT2440946	hsa-miR-644	CLIP-seq
MIRT2347905	hsa-miR-892a	CLIP-seq
MIRT2640724	hsa-miR-127-5p	CLIP-seq
MIRT1418597	hsa-miR-3923	CLIP-seq
MIRT1418628	hsa-miR-628-3p	CLIP-seq
MIRT2640725	hsa-miR-653	CLIP-seq
MIRT2640724	hsa-miR-127-5p	CLIP-seq
MIRT1418597	hsa-miR-3923	CLIP-seq
MIRT1418628	hsa-miR-628-3p	CLIP-seq
MIRT2640725	hsa-miR-653	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001826	Process	Inner cell mass cell differentiation	ISS
GO:0003677	Function	DNA binding	IDA	19372391
GO:0005506	Function	Iron ion binding	IDA	19372391
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IC	19372391
GO:0006211	Process	5-methylcytosine catabolic process	IEA
GO:0006325	Process	Chromatin organization	IEA
GO:0006493	Process	Protein O-linked glycosylation	ISS
GO:0008270	Function	Zinc ion binding	IDA	29276034
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	25284789
GO:0008327	Function	Methyl-CpG binding	IDA	29276034
GO:0019827	Process	Stem cell population maintenance	ISS
GO:0031062	Process	Positive regulation of histone methylation	IMP	25284789
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA	21873635
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	ISS
GO:0070579	Function	Methylcytosine dioxygenase activity	IBA	21873635
GO:0070579	Function	Methylcytosine dioxygenase activity	IDA	19372391
GO:0070579	Function	Methylcytosine dioxygenase activity	IMP	21496894, 25284789
GO:0070989	Process	Oxidative demethylation	IBA	21873635
GO:0080111	Process	DNA demethylation	IBA	21873635
GO:0080111	Process	DNA demethylation	IMP	21496894
GO:0090310	Process	Negative regulation of DNA methylation-dependent heterochromatin assembly	IMP	21496894

Other IDs

• MIM: 607790
• HGNC: 29484
• e!Ensembl: ENSG00000138336

Protein

• UniProt ID: Q8NFU7
• Protein name: Methylcytosine dioxygenase TET1 (EC 1.14.11.80) (CXXC-type zinc finger protein 6) (Leukemia-associated protein with a CXXC domain) (Ten-eleven translocation 1 gene protein)
• Protein function: Dioxygenase that plays a key role in active DNA demethylation, by catalyzing the sequential oxidation of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC)
• PDB: 6ASD
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02008	zf-CXXC	583 → 624	CXXC zinc finger domain	Domain
  PF12851	Tet_JBP	1580 → 2052	Oxygenase domain of the 2OGFeDO superfamily	Domain

• Sequence:

  MSRSRHARPSRLVRKEDVNKKKKNSQLRKTTKGANKNVASVKTLSPGKLKQLIQERDVKK
  KTEPKPPVPVRSLLTRAGAARMNLDRTEVLFQNPESLTCNGFTMALRSTSLSRRLSQPPL
  VVAKSKKVPLSKGLEKQHDCDYKILPALGVKHSENDSVPMQDTQVLPDIETLIGVQNPSL
  LKGKSQETTQFWSQRVEDSKINIPTHSGPAAEILPGPLEGTRCGEGLFSEETLNDTSGSP
  KMFAQDTVCAPFPQRATPKVTSQGNPSIQLEELGSRVESLKLSDSYLDPIKSEHDCYPTS
  SLNKVIPDLNLRNCLALGGSTSPTSVIKFLLAGSKQATLGAKPDHQEAFEATANQQEVSD
  TTSFLGQAFGAIPHQWELPGADPVHGEALGETPDLPEIPGAIPVQGEVFGTILDQQETLG
  MSGSVVPDLPVFLPVPPNPIATFNAPSKWPEPQSTVSYGLAVQGAIQILPLGSGHTPQSS
  SNSEKNSLPPVMAISNVENEKQVHISFLPANTQGFPLAPERGLFHASLGIAQLSQAGPSK
  SDRGSSQVSVTSTVHVVNTTVVTMPVPMVSTSSSSYTTLLPTLEKKKRKRCGVCEPCQQK
  TNCGECTYCKNRKNSHQICKKRKCEELKKKPSVVVPLEVIKENKRPQREKKPKVLKADFD
  NKPVNGPKSESMDYSRCGHGEEQKLELNPHTVENVTKNEDSMTGIEVEKWTQNKKSQLTD
  HVKGDFSANVPEAEKSKNSEVDKKRTKSPKLFVQTVRNGIKHVHCLPAETNVSFKKFNIE
  EFGKTLENNSYKFLKDTANHKNAMSSVATDMSCDHLKGRSNVLVFQQPGFNCSSIPHSSH
  SIINHHASIHNEGDQPKTPENIPSKEPKDGSPVQPSLLSLMKDRRLTLEQVVAIEALTQL
  SEAPSENSSPSKSEKDEESEQRTASLLNSCKAILYTVRKDLQDPNLQGEPPKLNHCPSLE
  KQSSCNTVVFNGQTTTLSNSHINSATNQASTKSHEYSKVTNSLSLFIPKSNSSKIDTNKS
  IAQGIITLDNCSNDLHQLPPRNNEVEYCNQLLDSSKKLDSDDLSCQDATHTQIEEDVATQ
  LTQLASIIKINYIKPEDKKVESTPTSLVTCNVQQKYNQEKGTIQQKPPSSVHNNHGSSLT
  KQKNPTQKKTKSTPSRDRRKKKPTVVSYQENDRQKWEKLSYMYGTICDIWIASKFQNFGQ
  FCPHDFPTVFGKISSSTKIWKPLAQTRSIMQPKTVFPPLTQIKLQRYPESAEEKVKVEPL
  DSLSLFHLKTESNGKAFTDKAYNSQVQLTVNANQKAHPLTQPSSPPNQCANVMAGDDQIR
  FQQVVKEQLMHQRLPTLPGISHETPLPESALTLRNVNVVCSGGITVVSTKSEEEVCSSSF
  GTSEFSTVDSAQKNFNDYAMNFFTNPTKNLVSITKDSELPTCSCLDRVIQKDKGPYYTHL
  GAGPSVAAVREIMENRYGQKGNAIRIEIVVYTGKEGKSSHGCPIAKWVLRRSSDEEKVLC
  LVRQRTGHHCPTAVMVVLIMVWDGIPLPMADRLYTELTENLKSYNGHPTDRRCTLNENRT
  CTCQGIDPETCGASFSFGCSWSMYFNGCKFGRSPSPRRFRIDPSSPLHEKNLEDNLQSLA
  TRLAPIYKQYAPVAYQNQVEYENVARECRLGSKEGRPFSGVTACLDFCAHPHRDIHNMNN
  GSTVVCTLTREDNRSLGVIPQDEQLHVLPLYKLSDTDEFGSKEGMEAKIKSGAIEVLAPR
  RKKRTCFTQPVPRSGKKRAAMMTEVLAHKIRAVEKKPIPRIKRKNNSTTTNNSKPSSLPT
  LGSNTETVQPEVKSETEPHFILKSSDNTKTYSLMPSAPHPVKEASPGFSWSPKTASATPA
  PLKNDATASCGFSERSSTPHCTMPSGRLSGANAAAADGPGISQLGEVAPLPTLSAPVMEP
  LINSEPSTGVTEPLTPHQPNHQPSFLTSPQDLASSPMEEDEQHSEADEPPSDEPLSDDPL
  SPAEEKLPHIDEYWSDSEHIFLDANIGGVAIAPAHGSVLIECARRELHATTPVEHPNRNH
  PTRLSLVFYQHKNLNKPQHGFELNKIKFEAKEAKNKKMKASEQKDQAANEGPEQSSEVNE
  LNQIPSHKALTLTHDNVVTVSPYALTHVAGPYNHWV

• Sequence length: 2136

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Autism spectrum disorder	Autism Spectrum Disorders	rs724159978, rs75184679, rs119103221, rs9332964, rs121912562, rs1594344233, rs727504317, rs111033204, rs1801086, rs587784464, rs724159948, rs764659822, rs794727977, rs796052733, rs796052728, rs762292772, rs864321694, rs869312878, rs758432471, rs750896617, rs886039692, rs886039770, rs201037487, rs200483989, rs1057518198, rs1057517708, rs780267761, rs1555910143, rs1057519632, rs775225727, rs751037529, rs1064794848, rs1064795655, rs1131691548, rs1135401811, rs1553248081, rs1454466097, rs1554480537, rs1553578503, rs1553518509, rs774152851, rs1554481395, rs1554464807, rs1554401434, rs1452048149, rs370498156, rs756691187, rs1557863430, rs1557863440, rs1557863546, rs769581210, rs202098093, rs1276388879, rs778792467, rs760059077, rs373783340, rs1557867853, rs772572695, rs753214391, rs749270162, rs548226228, rs1557870645, rs1557874046, rs749548928, rs754532606, rs1557901347, rs1557902023, rs1557909572, rs574335012, rs1557909821, rs1372713010, rs561369202, rs1476293577, rs1557910728, rs1557911386, rs375045125, rs998675361, rs1557916296, rs1557935477, rs866632178, rs1561824498, rs1396313317, rs1564801388, rs1564801473, rs1564950387, rs1565527302, rs1569513495, rs1569305431, rs143944436, rs1563183492, rs1561846159, rs1565819425, rs1562957809, rs1585645641, rs1585016242, rs1595127294, rs1585667374, rs1585653028, rs1585653240, rs1592919048, rs1585645384, rs1789927813	25290267
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	23938174

Unknown
Disease name	Disease term	dbSNP ID	References
Nonorganic psychosis	Nonorganic psychosis		22948384
Psychosis	Psychotic Disorders		22948384