SPSB1 (splA/ryanodine receptor domain and SOCS box containing 1)

Gene

• Entrez ID: 80176
• Gene name: SplA/ryanodine receptor domain and SOCS box containing 1
• Gene symbol: SPSB1
• Synonyms: SSB-1, SSB1
• Chromosome: 1
• Chromosome location: 1p36.22

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017474	hsa-miR-335-5p	Microarray	18185580
MIRT509604	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT509603	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT520963	hsa-miR-656-3p	HITS-CLIP	21572407
MIRT509602	hsa-miR-567	HITS-CLIP	21572407
MIRT509601	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT509600	hsa-miR-3924	HITS-CLIP	21572407
MIRT509599	hsa-miR-297	HITS-CLIP	21572407
MIRT509604	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT509603	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT520963	hsa-miR-656-3p	PAR-CLIP	20371350
MIRT509602	hsa-miR-567	PAR-CLIP	20371350
MIRT509601	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT509600	hsa-miR-3924	PAR-CLIP	20371350
MIRT509599	hsa-miR-297	PAR-CLIP	20371350
MIRT509604	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT509603	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT520963	hsa-miR-656-3p	PAR-CLIP	21572407
MIRT509602	hsa-miR-567	PAR-CLIP	21572407
MIRT509601	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509600	hsa-miR-3924	PAR-CLIP	21572407
MIRT509599	hsa-miR-297	PAR-CLIP	21572407
MIRT509604	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT509603	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509602	hsa-miR-567	PAR-CLIP	21572407
MIRT509601	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509600	hsa-miR-3924	PAR-CLIP	21572407
MIRT509599	hsa-miR-297	PAR-CLIP	21572407
MIRT509604	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT509603	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT520963	hsa-miR-656-3p	PAR-CLIP	21572407
MIRT509602	hsa-miR-567	PAR-CLIP	21572407
MIRT509601	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509600	hsa-miR-3924	PAR-CLIP	21572407
MIRT509599	hsa-miR-297	PAR-CLIP	21572407
MIRT509604	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT509603	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT520963	hsa-miR-656-3p	PAR-CLIP	23446348
MIRT509602	hsa-miR-567	PAR-CLIP	23446348
MIRT509601	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509600	hsa-miR-3924	PAR-CLIP	23446348
MIRT509599	hsa-miR-297	PAR-CLIP	23446348
MIRT509604	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT509603	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT509602	hsa-miR-567	PAR-CLIP	23446348
MIRT509601	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509600	hsa-miR-3924	PAR-CLIP	23446348
MIRT509599	hsa-miR-297	PAR-CLIP	23446348
MIRT483927	hsa-miR-583	PAR-CLIP	23592263
MIRT483925	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT483924	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT483923	hsa-miR-3179	PAR-CLIP	23592263
MIRT483922	hsa-miR-219b-5p	PAR-CLIP	23592263
MIRT489366	hsa-miR-8075	PAR-CLIP	23592263
MIRT483921	hsa-miR-3202	PAR-CLIP	23592263
MIRT483920	hsa-miR-3153	PAR-CLIP	23592263
MIRT483919	hsa-miR-6733-5p	PAR-CLIP	23592263
MIRT483918	hsa-miR-6739-5p	PAR-CLIP	23592263
MIRT483917	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT483916	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT483915	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT483914	hsa-miR-425-3p	PAR-CLIP	23592263
MIRT483927	hsa-miR-583	PAR-CLIP	23592263
MIRT483925	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT483924	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT483923	hsa-miR-3179	PAR-CLIP	23592263
MIRT483922	hsa-miR-219b-5p	PAR-CLIP	23592263
MIRT483921	hsa-miR-3202	PAR-CLIP	23592263
MIRT483920	hsa-miR-3153	PAR-CLIP	23592263
MIRT483919	hsa-miR-6733-5p	PAR-CLIP	23592263
MIRT483918	hsa-miR-6739-5p	PAR-CLIP	23592263
MIRT483917	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT483916	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT483915	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT483914	hsa-miR-425-3p	PAR-CLIP	23592263
MIRT509604	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT509603	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT520963	hsa-miR-656-3p	HITS-CLIP	21572407
MIRT509602	hsa-miR-567	HITS-CLIP	21572407
MIRT509601	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT509600	hsa-miR-3924	HITS-CLIP	21572407
MIRT509599	hsa-miR-297	HITS-CLIP	21572407
MIRT509604	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT509603	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT520963	hsa-miR-656-3p	PAR-CLIP	20371350
MIRT509602	hsa-miR-567	PAR-CLIP	20371350
MIRT509601	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT509600	hsa-miR-3924	PAR-CLIP	20371350
MIRT509599	hsa-miR-297	PAR-CLIP	20371350
MIRT509604	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT509603	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT520963	hsa-miR-656-3p	PAR-CLIP	21572407
MIRT509602	hsa-miR-567	PAR-CLIP	21572407
MIRT509601	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509600	hsa-miR-3924	PAR-CLIP	21572407
MIRT509599	hsa-miR-297	PAR-CLIP	21572407
MIRT509604	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT509603	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509602	hsa-miR-567	PAR-CLIP	21572407
MIRT509601	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509600	hsa-miR-3924	PAR-CLIP	21572407
MIRT509599	hsa-miR-297	PAR-CLIP	21572407
MIRT509604	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT509603	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT520963	hsa-miR-656-3p	PAR-CLIP	21572407
MIRT509602	hsa-miR-567	PAR-CLIP	21572407
MIRT509601	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509600	hsa-miR-3924	PAR-CLIP	21572407
MIRT509599	hsa-miR-297	PAR-CLIP	21572407
MIRT509604	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT509603	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT520963	hsa-miR-656-3p	PAR-CLIP	23446348
MIRT509602	hsa-miR-567	PAR-CLIP	23446348
MIRT509601	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509600	hsa-miR-3924	PAR-CLIP	23446348
MIRT509599	hsa-miR-297	PAR-CLIP	23446348
MIRT509604	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT509603	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT509602	hsa-miR-567	PAR-CLIP	23446348
MIRT509601	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509600	hsa-miR-3924	PAR-CLIP	23446348
MIRT509599	hsa-miR-297	PAR-CLIP	23446348
MIRT483927	hsa-miR-583	PAR-CLIP	23592263
MIRT483925	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT483924	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT483923	hsa-miR-3179	PAR-CLIP	23592263
MIRT483922	hsa-miR-219b-5p	PAR-CLIP	23592263
MIRT489366	hsa-miR-8075	PAR-CLIP	23592263
MIRT483921	hsa-miR-3202	PAR-CLIP	23592263
MIRT483920	hsa-miR-3153	PAR-CLIP	23592263
MIRT483919	hsa-miR-6733-5p	PAR-CLIP	23592263
MIRT483918	hsa-miR-6739-5p	PAR-CLIP	23592263
MIRT483917	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT483916	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT483915	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT483914	hsa-miR-425-3p	PAR-CLIP	23592263
MIRT483927	hsa-miR-583	PAR-CLIP	23592263
MIRT483925	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT483924	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT483923	hsa-miR-3179	PAR-CLIP	23592263
MIRT483922	hsa-miR-219b-5p	PAR-CLIP	23592263
MIRT483921	hsa-miR-3202	PAR-CLIP	23592263
MIRT483920	hsa-miR-3153	PAR-CLIP	23592263
MIRT483919	hsa-miR-6733-5p	PAR-CLIP	23592263
MIRT483918	hsa-miR-6739-5p	PAR-CLIP	23592263
MIRT483917	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT483916	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT483915	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT483914	hsa-miR-425-3p	PAR-CLIP	23592263
MIRT1386535	hsa-miR-1229	CLIP-seq
MIRT1386536	hsa-miR-1237	CLIP-seq
MIRT1386537	hsa-miR-1248	CLIP-seq
MIRT1386538	hsa-miR-1249	CLIP-seq
MIRT1386539	hsa-miR-125a-5p	CLIP-seq
MIRT1386540	hsa-miR-125b	CLIP-seq
MIRT1386541	hsa-miR-1271	CLIP-seq
MIRT1386542	hsa-miR-1305	CLIP-seq
MIRT1386543	hsa-miR-150	CLIP-seq
MIRT1386544	hsa-miR-181a	CLIP-seq
MIRT1386545	hsa-miR-181b	CLIP-seq
MIRT1386546	hsa-miR-181c	CLIP-seq
MIRT1386547	hsa-miR-181d	CLIP-seq
MIRT1386548	hsa-miR-2113	CLIP-seq
MIRT1386549	hsa-miR-218	CLIP-seq
MIRT1386550	hsa-miR-2964a-5p	CLIP-seq
MIRT1386551	hsa-miR-3130-5p	CLIP-seq
MIRT1386552	hsa-miR-3184	CLIP-seq
MIRT1386553	hsa-miR-423-5p	CLIP-seq
MIRT1386554	hsa-miR-4257	CLIP-seq
MIRT1386555	hsa-miR-4261	CLIP-seq
MIRT1386556	hsa-miR-4262	CLIP-seq
MIRT1386557	hsa-miR-4287	CLIP-seq
MIRT1386558	hsa-miR-4290	CLIP-seq
MIRT1386559	hsa-miR-4319	CLIP-seq
MIRT1386560	hsa-miR-4469	CLIP-seq
MIRT1386561	hsa-miR-4482	CLIP-seq
MIRT1386562	hsa-miR-4648	CLIP-seq
MIRT1386563	hsa-miR-4654	CLIP-seq
MIRT1386564	hsa-miR-4685-3p	CLIP-seq
MIRT1386565	hsa-miR-4711-3p	CLIP-seq
MIRT1386566	hsa-miR-4713-5p	CLIP-seq
MIRT1386567	hsa-miR-4732-3p	CLIP-seq
MIRT1386568	hsa-miR-4769-5p	CLIP-seq
MIRT1386569	hsa-miR-494	CLIP-seq
MIRT1386570	hsa-miR-511	CLIP-seq
MIRT1386571	hsa-miR-532-3p	CLIP-seq
MIRT1386572	hsa-miR-543	CLIP-seq
MIRT1386573	hsa-miR-544b	CLIP-seq
MIRT1386574	hsa-miR-607	CLIP-seq
MIRT1386575	hsa-miR-624	CLIP-seq
MIRT1386576	hsa-miR-625	CLIP-seq
MIRT1386577	hsa-miR-636	CLIP-seq
MIRT1386578	hsa-miR-670	CLIP-seq
MIRT1386579	hsa-miR-96	CLIP-seq
MIRT2115689	hsa-miR-3199	CLIP-seq
MIRT2115690	hsa-miR-3663-5p	CLIP-seq
MIRT2115691	hsa-miR-4268	CLIP-seq
MIRT2115692	hsa-miR-4448	CLIP-seq
MIRT2115693	hsa-miR-4522	CLIP-seq
MIRT2115694	hsa-miR-4652-5p	CLIP-seq
MIRT2115695	hsa-miR-4740-5p	CLIP-seq
MIRT2115696	hsa-miR-4773	CLIP-seq
MIRT2115697	hsa-miR-767-3p	CLIP-seq
MIRT2338324	hsa-miR-1207-5p	CLIP-seq
MIRT2338325	hsa-miR-1914	CLIP-seq
MIRT2338326	hsa-miR-2467-5p	CLIP-seq
MIRT2338327	hsa-miR-298	CLIP-seq
MIRT2338328	hsa-miR-3145-5p	CLIP-seq
MIRT2338329	hsa-miR-3188	CLIP-seq
MIRT2338330	hsa-miR-3646	CLIP-seq
MIRT2338331	hsa-miR-3665	CLIP-seq
MIRT2338332	hsa-miR-3944-5p	CLIP-seq
MIRT2338333	hsa-miR-3975	CLIP-seq
MIRT2338334	hsa-miR-4316	CLIP-seq
MIRT2338335	hsa-miR-4505	CLIP-seq
MIRT2338336	hsa-miR-4699-3p	CLIP-seq
MIRT2338337	hsa-miR-4731-5p	CLIP-seq
MIRT2338338	hsa-miR-4736	CLIP-seq
MIRT2338339	hsa-miR-4763-3p	CLIP-seq
MIRT2338340	hsa-miR-485-5p	CLIP-seq
MIRT2338341	hsa-miR-508-5p	CLIP-seq
MIRT2338342	hsa-miR-764	CLIP-seq
MIRT2395111	hsa-miR-1294	CLIP-seq
MIRT2338334	hsa-miR-4316	CLIP-seq
MIRT2395112	hsa-miR-4677-3p	CLIP-seq
MIRT2395113	hsa-miR-4679	CLIP-seq
MIRT2631904	hsa-miR-1264	CLIP-seq
MIRT2631905	hsa-miR-1321	CLIP-seq
MIRT2631906	hsa-miR-4419a	CLIP-seq
MIRT2631907	hsa-miR-4459	CLIP-seq
MIRT2631908	hsa-miR-4510	CLIP-seq
MIRT2631909	hsa-miR-4739	CLIP-seq
MIRT2631910	hsa-miR-4756-5p	CLIP-seq
MIRT2631911	hsa-miR-4779	CLIP-seq
MIRT1386569	hsa-miR-494	CLIP-seq
MIRT2631912	hsa-miR-548n	CLIP-seq
MIRT2631913	hsa-miR-548t	CLIP-seq
MIRT2631914	hsa-miR-600	CLIP-seq
MIRT2631905	hsa-miR-1321	CLIP-seq
MIRT2631906	hsa-miR-4419a	CLIP-seq
MIRT2631907	hsa-miR-4459	CLIP-seq
MIRT2631908	hsa-miR-4510	CLIP-seq
MIRT2631909	hsa-miR-4739	CLIP-seq
MIRT2631910	hsa-miR-4756-5p	CLIP-seq
MIRT2631911	hsa-miR-4779	CLIP-seq
MIRT2631912	hsa-miR-548n	CLIP-seq
MIRT2631913	hsa-miR-548t	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000209	Process	Protein polyubiquitination	TAS
GO:0005515	Function	Protein binding	IPI	20561531, 21199876, 23455924, 25203322, 28931592, 32296183, 32814053
GO:0005829	Component	Cytosol	IDA	21199876
GO:0005829	Component	Cytosol	TAS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IDA	21199876
GO:0016567	Process	Protein ubiquitination	IDA	21199876
GO:0019005	Component	SCF ubiquitin ligase complex	IBA	21873635
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IBA	21873635
GO:0043687	Process	Post-translational protein modification	TAS
GO:1990756	Function	Ubiquitin ligase-substrate adaptor activity	IPI	21199876

Other IDs

• MIM: 611657
• HGNC: 30628
• e!Ensembl: ENSG00000171621

Protein

• UniProt ID: Q96BD6
• Protein name: SPRY domain-containing SOCS box protein 1 (SSB-1)
• Protein function: Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:21199
• PDB: 2JK9, 3F2O
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00622	SPRY	97 → 228	SPRY domain	Family
  PF07525	SOCS_box	234 → 272	SOCS box	Domain

• Sequence:

  MGQKVTGGIKTVDMRDPTYRPLKQELQGLDYCKPTRLDLLLDMPPVSYDVQLLHSWNNND
  RSLNVFVKEDDKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQITWAMRQRGTHAVVGVATA
  DAPLHSVGYTTLVGNNHESWGWDLGRNRLYHDGKNQPSKTYPAFLEPDETFIVPDSFLVA
  LDMDDGTLSFIVDGQYMGVAFRGLKGKKLYPVVSAVWGHCEIRMRYLNGLDPEPLPLMDL
  CRRSVRLALGRERLGEIHTLPLPASLKAYLLYQ

• Sequence length: 273

Pathways

Reactome:

Neddylation
Antigen processing: Ubiquitination & Proteasome degradation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Asthma	Asthma, Childhood asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	30929738
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601	27903959
Rheumatoid arthritis	Rheumatoid Arthritis	rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212	22491018