LRRTM4 (leucine rich repeat transmembrane neuronal 4)

Gene

• Entrez ID: 80059
• Gene name: Leucine rich repeat transmembrane neuronal 4
• Gene symbol: LRRTM4
• Synonyms: -
• Chromosome: 2
• Chromosome location: 2p12

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT527180	hsa-miR-205-5p	PAR-CLIP	22012620
MIRT527179	hsa-miR-1297	PAR-CLIP	22012620
MIRT527178	hsa-miR-26a-5p	PAR-CLIP	22012620
MIRT527177	hsa-miR-26b-5p	PAR-CLIP	22012620
MIRT527176	hsa-miR-4465	PAR-CLIP	22012620
MIRT527175	hsa-miR-6868-3p	PAR-CLIP	22012620
MIRT527173	hsa-miR-1305	PAR-CLIP	22012620
MIRT527179	hsa-miR-1297	PAR-CLIP	27292025
MIRT527173	hsa-miR-1305	PAR-CLIP	27292025
MIRT527180	hsa-miR-205-5p	PAR-CLIP	27292025
MIRT527178	hsa-miR-26a-5p	PAR-CLIP	27292025
MIRT527177	hsa-miR-26b-5p	PAR-CLIP	27292025
MIRT527176	hsa-miR-4465	PAR-CLIP	27292025
MIRT527175	hsa-miR-6868-3p	PAR-CLIP	27292025
MIRT527180	hsa-miR-205-5p	PAR-CLIP	22012620
MIRT527179	hsa-miR-1297	PAR-CLIP	22012620
MIRT527178	hsa-miR-26a-5p	PAR-CLIP	22012620
MIRT527177	hsa-miR-26b-5p	PAR-CLIP	22012620
MIRT527176	hsa-miR-4465	PAR-CLIP	22012620
MIRT527175	hsa-miR-6868-3p	PAR-CLIP	22012620
MIRT527173	hsa-miR-1305	PAR-CLIP	22012620
MIRT1121109	hsa-miR-1470	CLIP-seq
MIRT1121110	hsa-miR-3614-3p	CLIP-seq
MIRT1121111	hsa-miR-3651	CLIP-seq
MIRT1121112	hsa-miR-4290	CLIP-seq
MIRT1121113	hsa-miR-4469	CLIP-seq
MIRT1121114	hsa-miR-4493	CLIP-seq
MIRT1121115	hsa-miR-4540	CLIP-seq
MIRT1121116	hsa-miR-4667-3p	CLIP-seq
MIRT1121117	hsa-miR-1245	CLIP-seq
MIRT1121118	hsa-miR-1324	CLIP-seq
MIRT1121119	hsa-miR-3133	CLIP-seq
MIRT1121120	hsa-miR-338-3p	CLIP-seq
MIRT1121121	hsa-miR-3591-3p	CLIP-seq
MIRT1121122	hsa-miR-4530	CLIP-seq
MIRT1121123	hsa-miR-4668-3p	CLIP-seq
MIRT1121124	hsa-miR-4765	CLIP-seq
MIRT1121125	hsa-miR-548b-3p	CLIP-seq
MIRT2453428	hsa-miR-1273g	CLIP-seq
MIRT2453429	hsa-miR-331-3p	CLIP-seq
MIRT2453430	hsa-miR-3925-3p	CLIP-seq
MIRT2453431	hsa-miR-4690-3p	CLIP-seq
MIRT2453432	hsa-miR-515-5p	CLIP-seq
MIRT2453433	hsa-miR-766	CLIP-seq
MIRT1121119	hsa-miR-3133	CLIP-seq
MIRT2563604	hsa-miR-323-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0016021	Component	Integral component of membrane	IEA
GO:0031012	Component	Extracellular matrix	IBA	21873635
GO:0045211	Component	Postsynaptic membrane	IEA

Other IDs

• MIM: 610870
• HGNC: 19411
• e!Ensembl: ENSG00000176204

Protein

• UniProt ID: Q86VH4
• Protein name: Leucine-rich repeat transmembrane neuronal protein 4
• Protein function: May play a role in the development and maintenance of the vertebrate nervous system. Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation (By similarity).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13855	LRR_8	64 → 121	Leucine rich repeat	Repeat
  PF13855	LRR_8	109 → 169	Leucine rich repeat	Repeat
  PF13855	LRR_8	157 → 217	Leucine rich repeat	Repeat
  PF13855	LRR_8	229 → 289	Leucine rich repeat	Repeat

• Sequence:

  MGFHLITQLKGMSVVLVLLPTLLLVMLTGAQRACPKNCRCDGKIVYCESHAFADIPENIS
  GGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNK
  ITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDC
  RNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNR
  IRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAW
  ISLISITLSGNMWECSRSICPLFYWLKNFKGNKESTMICAGPKHIQGEKVSDAVETYNIC
  SEVQVVNTERSHLVPQTPQKPLIIPRPTIFKPDVTQSTFETPSPSPGFQIPGAEQEYEHV
  SFHKIIAGSVALFLSVAMILLVIYVSWKRYPASMKQLQQHSLMKRRRKKARESERQMNSP
  LQEYYVDYKPTNSETMDISVNGSGPCTYTISGSRECEMPHHMKPLPYYSYDQPVIGYCQA
  HQPLHVTKGYETVSPEQDESPGLELGRDHSFIATIARSAAPAIYLERIAN

• Sequence length: 590

Pathways

Reactome:

Neurexins and neuroligins

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601	27903959
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	26198764, 30285260, 28991256

Unknown
Disease name	Disease term	dbSNP ID	References
Vascular diseases	Peripheral Arterial Diseases		27082954