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ADM2 (adrenomedullin 2)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
79924
Gene nameGene Name - the full gene name approved by the HGNC.
Adrenomedullin 2
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
ADM2
SynonymsGene synonyms aliases
AM2, dJ579N16.4
ChromosomeChromosome number
22
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
22q13.33
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the calcitonin gene-related peptide (CGRP)/calcitonin family of hormones that play a role in the regulation of cardiovascular homeostasis, prolactin release, anti-diuresis, anti-natriuresis, and regulation of food and water i
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT662322 hsa-miR-1245a HITS-CLIP 23824327
MIRT662321 hsa-miR-8079 HITS-CLIP 23824327
MIRT662320 hsa-miR-6513-3p HITS-CLIP 23824327
MIRT662319 hsa-miR-6840-3p HITS-CLIP 23824327
MIRT662318 hsa-miR-1915-3p HITS-CLIP 23824327
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis IDA 20596610
GO:0005179 Function Hormone activity IEA
GO:0005576 Component Extracellular region TAS
GO:0006468 Process Protein phosphorylation IDA 20596610
GO:0007186 Process G protein-coupled receptor signaling pathway TAS
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q7Z4H4
Protein name Protein ADM2 (Intermedin) [Cleaved into: Adrenomedullin-2 (AM2) (Intermedin-long) (IMDL); Intermedin-short (IMDS)]
Protein function Intermedin/ADM2 is a peptide hormone that plays a role as physiological regulator of gastrointestinal and cardiovascular bioactivities mediated by the CALCRL-RAMPs receptor complexes (PubMed:14615490). Activates the cAMP-dependent pathway throug
PDB 6D1U , 6UVA
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00214 Calc_CGRP_IAPP
45 148
Calcitonin / CGRP / IAPP family
Family
Sequence
Sequence length 148
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
  G alpha (s) signalling events
Calcitonin-like ligand receptors
ADORA2B mediated anti-inflammatory cytokines production
Associated diseases
Unknown
Disease name Disease term dbSNP ID References
Myocardial ischemia Myocardial Ischemia 16987513
Vascular diseases Vascular Diseases 19910445

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