CCDC134 (coiled-coil domain containing 134)

Gene

• Entrez ID: 79879
• Gene name: Coiled-coil domain containing 134
• Gene symbol: CCDC134
• Synonyms: OI22
• Chromosome: 22
• Chromosome location: 22q13.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023784	hsa-miR-1-3p	Proteomics	18668040
MIRT032346	hsa-let-7b-5p	Proteomics	18668040
MIRT650062	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT650061	hsa-miR-4267	HITS-CLIP	23824327
MIRT650060	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT650059	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT650056	hsa-miR-6862-3p	HITS-CLIP	23824327
MIRT650069	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT650068	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT650067	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT650066	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT650065	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT650064	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT650063	hsa-miR-3943	HITS-CLIP	23824327
MIRT650062	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT650061	hsa-miR-4267	HITS-CLIP	23824327
MIRT650060	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT650059	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT650058	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT650057	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT650056	hsa-miR-6862-3p	HITS-CLIP	23824327
MIRT650062	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT650061	hsa-miR-4267	HITS-CLIP	23824327
MIRT650060	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT650059	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT650056	hsa-miR-6862-3p	HITS-CLIP	23824327
MIRT650069	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT650068	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT650067	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT650066	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT650065	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT650064	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT650063	hsa-miR-3943	HITS-CLIP	23824327
MIRT650062	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT650061	hsa-miR-4267	HITS-CLIP	23824327
MIRT650060	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT650059	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT650058	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT650057	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT650056	hsa-miR-6862-3p	HITS-CLIP	23824327
MIRT868020	hsa-miR-1182	CLIP-seq
MIRT868021	hsa-miR-1207-3p	CLIP-seq
MIRT868022	hsa-miR-214	CLIP-seq
MIRT868023	hsa-miR-3119	CLIP-seq
MIRT868024	hsa-miR-3127-3p	CLIP-seq
MIRT868025	hsa-miR-3157-5p	CLIP-seq
MIRT868026	hsa-miR-3619-5p	CLIP-seq
MIRT868027	hsa-miR-4257	CLIP-seq
MIRT868028	hsa-miR-4291	CLIP-seq
MIRT868029	hsa-miR-4435	CLIP-seq
MIRT868030	hsa-miR-4459	CLIP-seq
MIRT868031	hsa-miR-4493	CLIP-seq
MIRT868032	hsa-miR-4527	CLIP-seq
MIRT868033	hsa-miR-4691-3p	CLIP-seq
MIRT868034	hsa-miR-4722-5p	CLIP-seq
MIRT868035	hsa-miR-761	CLIP-seq
MIRT868036	hsa-miR-922	CLIP-seq
MIRT1957558	hsa-miR-1910	CLIP-seq
MIRT1957559	hsa-miR-24	CLIP-seq
MIRT1957560	hsa-miR-4264	CLIP-seq
MIRT1957561	hsa-miR-455-3p	CLIP-seq
MIRT2194618	hsa-miR-1227	CLIP-seq
MIRT2194619	hsa-miR-15a	CLIP-seq
MIRT2194620	hsa-miR-15b	CLIP-seq
MIRT2194621	hsa-miR-16	CLIP-seq
MIRT2194622	hsa-miR-1914	CLIP-seq
MIRT2194623	hsa-miR-195	CLIP-seq
MIRT868022	hsa-miR-214	CLIP-seq
MIRT2194624	hsa-miR-3151	CLIP-seq
MIRT2194625	hsa-miR-3184	CLIP-seq
MIRT868026	hsa-miR-3619-5p	CLIP-seq
MIRT2194626	hsa-miR-3649	CLIP-seq
MIRT2194627	hsa-miR-423-5p	CLIP-seq
MIRT2194628	hsa-miR-424	CLIP-seq
MIRT2194629	hsa-miR-4489	CLIP-seq
MIRT2194630	hsa-miR-4492	CLIP-seq
MIRT2194631	hsa-miR-4498	CLIP-seq
MIRT2194632	hsa-miR-4505	CLIP-seq
MIRT2194633	hsa-miR-4514	CLIP-seq
MIRT2194634	hsa-miR-4530	CLIP-seq
MIRT2194635	hsa-miR-4640-5p	CLIP-seq
MIRT2194636	hsa-miR-4645-5p	CLIP-seq
MIRT2194637	hsa-miR-4673	CLIP-seq
MIRT2194638	hsa-miR-4685-5p	CLIP-seq
MIRT2194639	hsa-miR-4692	CLIP-seq
MIRT2194640	hsa-miR-4726-5p	CLIP-seq
MIRT2194641	hsa-miR-4755-3p	CLIP-seq
MIRT2194642	hsa-miR-492	CLIP-seq
MIRT2194643	hsa-miR-497	CLIP-seq
MIRT868035	hsa-miR-761	CLIP-seq
MIRT2194644	hsa-miR-762	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	IEA
GO:0001890	Process	Placenta development	IEA
GO:0005515	Function	Protein binding	IPI	22644376, 32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0021591	Process	Ventricular system development	IEA
GO:0035162	Process	Embryonic hemopoiesis	IEA
GO:1990402	Process	Embryonic liver development	IEA

Other IDs

• MIM: 618788
• HGNC: 26185
• e!Ensembl: ENSG00000100147

Protein

• UniProt ID: Q9H6E4
• Protein name: Coiled-coil domain-containing protein 134
• Protein function: Molecular adapter required to prevent protein hyperglycosylation of HSP90B1: during translation, associates with nascent HSP90B1 and the STT3A catalytic component of the OST-A complex and tethers them to a specialized translocon that forms a mic
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15002	ERK-JNK_inhib	22 → 223	ERK and JNK pathways, inhibitor	Family

• Sequence:

  MDLLQFLAFLFVLLLSGMGATGTLRTSLDPSLEIYKKMFEVKRREQLLALKNLAQLNDIH
  QQYKILDVMLKGLFKVLEDSRTVLTAADVLPDGPFPQDEKLKDAFSHVVENTAFFGDVVL
  RFPRIVHYYFDHNSNWNLLIRWGISFCNQTGVFNQGPHSPILSLMAQELGISEKDSNFQN
  PFKIDRTEFIPSTDPFQKALREEEKRRKKEEKRKEIRKGPRISRSQSEL

• Sequence length: 229

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Alzheimer disease	Alzheimer`s Disease	rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039, rs63750973, rs63749810, rs63750643, rs193922916, rs63750306, rs63750590, rs63750526, rs63751235, rs661, rs63751037, rs63749885, rs63750231, rs63751229, rs63751272, rs63751223, rs63750391, rs63751163, rs281875357, rs63751141, rs63750082, rs121917807, rs63751399, rs63750265, rs63751144, rs63750886, rs63751068, rs121917808, rs63749891, rs63750083, rs63749824, rs63750577, rs267606983, rs63750218, rs63751287, rs63750900, rs145518263, rs63751475, rs63750450, rs63749805, rs63751278, rs63751106, rs63750004, rs63749806, rs63751024, rs63750248, rs63750779, rs63751139, rs63750219, rs63750298, rs63750687, rs63750851, rs1553268799, rs1561901881, rs1561905293, rs866101707, rs1566638673, rs63750009, rs1566656702, rs1566657804, rs1567885728, rs1568339995, rs1566630791, rs1555358260, rs63750964, rs1594998354, rs63751316	21123754
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451, rs397507859, rs80359709, rs80359742, rs80359205, rs80357627, rs80357004, rs80357571, rs80357767, rs80357653, rs80358086, rs80357608, rs28897696, rs41293465, rs146650273, rs63751017, rs63750617, rs63750726, rs63750199, rs63749848, rs398122618, rs398122653, rs397509211, rs80357791, rs121912666, rs587778541, rs121908698, rs536907995, rs587781302, rs140342925, rs587781506, rs587782652, rs587782849, rs587783057, rs10520699, rs11852999, rs139770721, rs374950566, rs786202800, rs863224451, rs377153250, rs747727055, rs876658804, rs780001540, rs760815829, rs878854926, rs775248597, rs886040658, rs886040192, rs786203523, rs886040319, rs397508006, rs587782011, rs1060502772, rs1555461727, rs1553333072, rs1114167702, rs1257401983, rs886040950, rs1060502759, rs774684620, rs142947311, rs1555580883, rs748513310, rs376170600, rs863224499, rs1593909229, rs748453607, rs1294578913, rs1574737047, rs1593909960, rs2081922847, rs2082559544, rs2053694038	29059683

Unknown
Disease name	Disease term	dbSNP ID	References
Liver neoplasms	Liver neoplasms		19233941
Liver cancer	Malignant neoplasm of liver		19233941