TM4SF20 (transmembrane 4 L six family member 20)

Gene

• Entrez ID: 79853
• Gene name: Transmembrane 4 L six family member 20
• Gene symbol: TM4SF20
• Synonyms: PRO994, SLI5, TCCE518
• Chromosome: 2
• Chromosome location: 2q36.3
• Summary: The protein encoded by this gene is a member of the four-transmembrane L6 superfamily. Members of this family function in various cellular processes including cell proliferation, motility, and adhesion via their interactions with integrins. In human brain

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT648229	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT648228	hsa-miR-4793-5p	HITS-CLIP	23824327
MIRT648227	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT648226	hsa-miR-5193	HITS-CLIP	23824327
MIRT648225	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT648224	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT648223	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT648222	hsa-miR-6870-3p	HITS-CLIP	23824327
MIRT648221	hsa-miR-623	HITS-CLIP	23824327
MIRT648220	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT648219	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT648218	hsa-miR-4279	HITS-CLIP	23824327
MIRT648217	hsa-miR-4684-5p	HITS-CLIP	23824327
MIRT648216	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT648214	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT648215	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT648213	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT648212	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT614417	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT614416	hsa-miR-5003-3p	HITS-CLIP	23824327
MIRT614415	hsa-miR-6838-3p	HITS-CLIP	23824327
MIRT614414	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT614413	hsa-miR-486-5p	HITS-CLIP	23824327
MIRT641268	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT641267	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT641266	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT614412	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT614411	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT614410	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT614417	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT614416	hsa-miR-5003-3p	HITS-CLIP	23824327
MIRT614415	hsa-miR-6838-3p	HITS-CLIP	23824327
MIRT614414	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT614413	hsa-miR-486-5p	HITS-CLIP	23824327
MIRT614412	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT614411	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT614410	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT648229	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT648228	hsa-miR-4793-5p	HITS-CLIP	23824327
MIRT648227	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT648226	hsa-miR-5193	HITS-CLIP	23824327
MIRT648225	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT648224	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT648223	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT648222	hsa-miR-6870-3p	HITS-CLIP	23824327
MIRT648221	hsa-miR-623	HITS-CLIP	23824327
MIRT648220	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT648219	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT648218	hsa-miR-4279	HITS-CLIP	23824327
MIRT648217	hsa-miR-4684-5p	HITS-CLIP	23824327
MIRT648216	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT648214	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT648215	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT648213	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT648212	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT614417	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT614416	hsa-miR-5003-3p	HITS-CLIP	23824327
MIRT614415	hsa-miR-6838-3p	HITS-CLIP	23824327
MIRT614414	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT614413	hsa-miR-486-5p	HITS-CLIP	23824327
MIRT641268	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT641267	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT641266	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT614412	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT614411	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT614410	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT614417	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT614416	hsa-miR-5003-3p	HITS-CLIP	23824327
MIRT614415	hsa-miR-6838-3p	HITS-CLIP	23824327
MIRT614414	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT614413	hsa-miR-486-5p	HITS-CLIP	23824327
MIRT614412	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT614411	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT614410	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT1427262	hsa-miR-1183	CLIP-seq
MIRT1427263	hsa-miR-1225-3p	CLIP-seq
MIRT1427264	hsa-miR-1233	CLIP-seq
MIRT1427265	hsa-miR-1304	CLIP-seq
MIRT1427266	hsa-miR-1827	CLIP-seq
MIRT1427267	hsa-miR-219-1-3p	CLIP-seq
MIRT1427268	hsa-miR-2276	CLIP-seq
MIRT1427269	hsa-miR-2467-5p	CLIP-seq
MIRT1427270	hsa-miR-3145-5p	CLIP-seq
MIRT1427271	hsa-miR-3188	CLIP-seq
MIRT1427272	hsa-miR-320e	CLIP-seq
MIRT1427273	hsa-miR-3607-5p	CLIP-seq
MIRT1427274	hsa-miR-3614-5p	CLIP-seq
MIRT1427275	hsa-miR-3622a-3p	CLIP-seq
MIRT1427276	hsa-miR-3622b-3p	CLIP-seq
MIRT1427277	hsa-miR-3929	CLIP-seq
MIRT1427278	hsa-miR-3934	CLIP-seq
MIRT1427279	hsa-miR-3973	CLIP-seq
MIRT1427280	hsa-miR-3975	CLIP-seq
MIRT1427281	hsa-miR-4251	CLIP-seq
MIRT1427282	hsa-miR-4255	CLIP-seq
MIRT1427283	hsa-miR-4266	CLIP-seq
MIRT1427284	hsa-miR-4282	CLIP-seq
MIRT1427285	hsa-miR-4419b	CLIP-seq
MIRT1427286	hsa-miR-4459	CLIP-seq
MIRT1427287	hsa-miR-4478	CLIP-seq
MIRT1427288	hsa-miR-4514	CLIP-seq
MIRT1427289	hsa-miR-4649-3p	CLIP-seq
MIRT1427290	hsa-miR-4692	CLIP-seq
MIRT1427291	hsa-miR-4695-5p	CLIP-seq
MIRT1427292	hsa-miR-4698	CLIP-seq
MIRT1427293	hsa-miR-4712-3p	CLIP-seq
MIRT1427294	hsa-miR-4779	CLIP-seq
MIRT1427295	hsa-miR-485-5p	CLIP-seq
MIRT1427296	hsa-miR-508-5p	CLIP-seq
MIRT1427297	hsa-miR-520g	CLIP-seq
MIRT1427298	hsa-miR-520h	CLIP-seq
MIRT1427299	hsa-miR-571	CLIP-seq
MIRT1427300	hsa-miR-580	CLIP-seq
MIRT1427301	hsa-miR-595	CLIP-seq
MIRT1427302	hsa-miR-627	CLIP-seq
MIRT1427303	hsa-miR-651	CLIP-seq
MIRT1427304	hsa-miR-665	CLIP-seq
MIRT1427305	hsa-miR-670	CLIP-seq
MIRT1427306	hsa-miR-766	CLIP-seq
MIRT1427307	hsa-miR-940	CLIP-seq
MIRT2127977	hsa-miR-3682-5p	CLIP-seq
MIRT2127978	hsa-miR-371-5p	CLIP-seq
MIRT2127979	hsa-miR-4760-3p	CLIP-seq
MIRT2127980	hsa-miR-513c	CLIP-seq
MIRT2127981	hsa-miR-514b-5p	CLIP-seq
MIRT1427265	hsa-miR-1304	CLIP-seq
MIRT2349645	hsa-miR-1321	CLIP-seq
MIRT1427266	hsa-miR-1827	CLIP-seq
MIRT2349646	hsa-miR-2114	CLIP-seq
MIRT1427269	hsa-miR-2467-5p	CLIP-seq
MIRT2349647	hsa-miR-3162-5p	CLIP-seq
MIRT1427271	hsa-miR-3188	CLIP-seq
MIRT1427272	hsa-miR-320e	CLIP-seq
MIRT1427274	hsa-miR-3614-5p	CLIP-seq
MIRT1427277	hsa-miR-3929	CLIP-seq
MIRT1427280	hsa-miR-3975	CLIP-seq
MIRT1427283	hsa-miR-4266	CLIP-seq
MIRT1427285	hsa-miR-4419b	CLIP-seq
MIRT1427287	hsa-miR-4478	CLIP-seq
MIRT1427288	hsa-miR-4514	CLIP-seq
MIRT1427289	hsa-miR-4649-3p	CLIP-seq
MIRT1427290	hsa-miR-4692	CLIP-seq
MIRT1427291	hsa-miR-4695-5p	CLIP-seq
MIRT2349648	hsa-miR-4739	CLIP-seq
MIRT2349649	hsa-miR-4756-5p	CLIP-seq
MIRT1427294	hsa-miR-4779	CLIP-seq
MIRT1427295	hsa-miR-485-5p	CLIP-seq
MIRT2349650	hsa-miR-564	CLIP-seq
MIRT1427303	hsa-miR-651	CLIP-seq
MIRT1427307	hsa-miR-940	CLIP-seq
MIRT2461526	hsa-miR-10a	CLIP-seq
MIRT2461527	hsa-miR-10b	CLIP-seq
MIRT2461528	hsa-miR-3148	CLIP-seq
MIRT2461529	hsa-miR-339-5p	CLIP-seq
MIRT2461530	hsa-miR-3591-3p	CLIP-seq
MIRT2461531	hsa-miR-3647-3p	CLIP-seq
MIRT2127978	hsa-miR-371-5p	CLIP-seq
MIRT2461532	hsa-miR-4421	CLIP-seq
MIRT2461533	hsa-miR-4725-5p	CLIP-seq
MIRT2461534	hsa-miR-4786-5p	CLIP-seq
MIRT2461535	hsa-miR-504	CLIP-seq
MIRT2461536	hsa-miR-587	CLIP-seq
MIRT2461537	hsa-miR-769-5p	CLIP-seq
MIRT1427263	hsa-miR-1225-3p	CLIP-seq
MIRT1427264	hsa-miR-1233	CLIP-seq
MIRT2643176	hsa-miR-1273f	CLIP-seq
MIRT2643177	hsa-miR-1285	CLIP-seq
MIRT2643178	hsa-miR-143	CLIP-seq
MIRT2461528	hsa-miR-3148	CLIP-seq
MIRT2643179	hsa-miR-3187-5p	CLIP-seq
MIRT1427275	hsa-miR-3622a-3p	CLIP-seq
MIRT1427276	hsa-miR-3622b-3p	CLIP-seq
MIRT2643180	hsa-miR-3675-3p	CLIP-seq
MIRT2643181	hsa-miR-3688-3p	CLIP-seq
MIRT1427283	hsa-miR-4266	CLIP-seq
MIRT2643182	hsa-miR-4453	CLIP-seq
MIRT2643183	hsa-miR-4538	CLIP-seq
MIRT2643184	hsa-miR-4642	CLIP-seq
MIRT1427291	hsa-miR-4695-5p	CLIP-seq
MIRT2643185	hsa-miR-4708-5p	CLIP-seq
MIRT2643186	hsa-miR-4770	CLIP-seq
MIRT1427294	hsa-miR-4779	CLIP-seq
MIRT2643187	hsa-miR-548c-3p	CLIP-seq
MIRT2643188	hsa-miR-612	CLIP-seq
MIRT1427303	hsa-miR-651	CLIP-seq
MIRT2643189	hsa-miR-661	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	27499293
GO:0005886	Component	Plasma membrane	IDA
GO:0005925	Component	Focal adhesion	IDA
GO:0016021	Component	Integral component of membrane	IBA	21873635
GO:0045861	Process	Negative regulation of proteolysis	IDA	25310401, 27499293

Other IDs

• MIM: 615404
• HGNC: 26230
• e!Ensembl: ENSG00000168955

Protein

• UniProt ID: Q53R12
• Protein name: Transmembrane 4 L6 family member 20
• Protein function: Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis (PubMed:25310401, PubMed:27499293). In response to ceramide, which alters TM4SF
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05805	L6_membrane	2 → 223	L6 membrane protein	Family

• Sequence:

  MTCCEGWTSCNGFSLLVLLLLGVVLNAIPLIVSLVEEDQFSQNPISCFEWWFPGIIGAGL
  MAIPATTMSLTARKRACCNNRTGMFLSSLFSVITVIGALYCMLISIQALLKGPLMCNSPS
  NSNANCEFSLKNISDIHPESFNLQWFFNDSCAPPTGFNKPTSNDTMASGWRASSFHFDSE
  ENKHRLIHFSVFLGLLLVGILEVLFGLSQIVIGFLGCLCGVSKRRSQIV

• Sequence length: 229

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Autism	Autistic behavior	rs121964908, rs121912597, rs2710102, rs7794745, rs142990298, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699, rs1553510219, rs1684182454, rs1559060428, rs1553510677, rs1576352885, rs1574152522, rs1574152672, rs1696658542, rs1751123722, rs1750373491, rs1751075634

Unknown
Disease name	Disease term	dbSNP ID	References
Language disorders	Language Disorders
Specific language impairment	SPECIFIC LANGUAGE IMPAIRMENT 5		23810381