ST7 (suppression of tumorigenicity 7)

Gene

• Entrez ID: 7982
• Gene name: Suppression of tumorigenicity 7
• Gene symbol: ST7
• Synonyms: ETS7q, FAM4A, FAM4A1, HELG, RAY1, SEN4, TSG7
• Chromosome: 7
• Chromosome location: 7q31.2
• Summary: The gene for this product maps to a region on chromosome 7 identified as an autism-susceptibility locus. Mutation screening of the entire coding region in autistic individuals failed to identify phenotype-specific variants, suggesting that coding mutation

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1393806	hsa-miR-1273f	CLIP-seq
MIRT1393807	hsa-miR-1294	CLIP-seq
MIRT1393808	hsa-miR-3656	CLIP-seq
MIRT1393809	hsa-miR-3960	CLIP-seq
MIRT1393810	hsa-miR-4710	CLIP-seq
MIRT1393811	hsa-miR-885-3p	CLIP-seq
MIRT1393812	hsa-miR-124	CLIP-seq
MIRT1393813	hsa-miR-19a	CLIP-seq
MIRT1393814	hsa-miR-19b	CLIP-seq
MIRT1393815	hsa-miR-4708-3p	CLIP-seq
MIRT1393816	hsa-miR-4729	CLIP-seq
MIRT1393817	hsa-miR-506	CLIP-seq
MIRT1393818	hsa-miR-518a-5p	CLIP-seq
MIRT1393819	hsa-miR-527	CLIP-seq
MIRT1393820	hsa-miR-556-5p	CLIP-seq
MIRT1393821	hsa-miR-570	CLIP-seq
MIRT1393813	hsa-miR-19a	CLIP-seq
MIRT1393814	hsa-miR-19b	CLIP-seq
MIRT2395262	hsa-miR-3179	CLIP-seq
MIRT2395263	hsa-miR-4761-3p	CLIP-seq
MIRT2433622	hsa-miR-3150a-3p	CLIP-seq
MIRT2634122	hsa-miR-1180	CLIP-seq
MIRT2634123	hsa-miR-1193	CLIP-seq
MIRT2634124	hsa-miR-186	CLIP-seq
MIRT2634125	hsa-miR-299-3p	CLIP-seq
MIRT2634126	hsa-miR-3133	CLIP-seq
MIRT2433622	hsa-miR-3150a-3p	CLIP-seq
MIRT2634127	hsa-miR-3151	CLIP-seq
MIRT2634128	hsa-miR-3163	CLIP-seq
MIRT2634129	hsa-miR-3165	CLIP-seq
MIRT2634130	hsa-miR-3175	CLIP-seq
MIRT2634131	hsa-miR-3202	CLIP-seq
MIRT2634132	hsa-miR-320a	CLIP-seq
MIRT2634133	hsa-miR-320b	CLIP-seq
MIRT2634134	hsa-miR-320c	CLIP-seq
MIRT2634135	hsa-miR-320d	CLIP-seq
MIRT2634136	hsa-miR-3611	CLIP-seq
MIRT2634137	hsa-miR-3691-5p	CLIP-seq
MIRT2634138	hsa-miR-411	CLIP-seq
MIRT2634139	hsa-miR-4429	CLIP-seq
MIRT2634140	hsa-miR-4446-3p	CLIP-seq
MIRT2634141	hsa-miR-4447	CLIP-seq
MIRT2634142	hsa-miR-4472	CLIP-seq
MIRT2634143	hsa-miR-4493	CLIP-seq
MIRT2634144	hsa-miR-4511	CLIP-seq
MIRT2634145	hsa-miR-4533	CLIP-seq
MIRT2634146	hsa-miR-4651	CLIP-seq
MIRT2634147	hsa-miR-4664-3p	CLIP-seq
MIRT2634148	hsa-miR-4709-3p	CLIP-seq
MIRT2634149	hsa-miR-4730	CLIP-seq
MIRT2634150	hsa-miR-4764-5p	CLIP-seq
MIRT2634151	hsa-miR-491-5p	CLIP-seq
MIRT2634152	hsa-miR-496	CLIP-seq
MIRT2634153	hsa-miR-512-5p	CLIP-seq
MIRT2634154	hsa-miR-608	CLIP-seq
MIRT2634155	hsa-miR-658	CLIP-seq
MIRT2634156	hsa-miR-939	CLIP-seq
MIRT2634122	hsa-miR-1180	CLIP-seq
MIRT2634123	hsa-miR-1193	CLIP-seq
MIRT2692133	hsa-miR-1255a	CLIP-seq
MIRT2692134	hsa-miR-1255b	CLIP-seq
MIRT2692135	hsa-miR-1293	CLIP-seq
MIRT2634124	hsa-miR-186	CLIP-seq
MIRT2634125	hsa-miR-299-3p	CLIP-seq
MIRT2692136	hsa-miR-3120-3p	CLIP-seq
MIRT2634126	hsa-miR-3133	CLIP-seq
MIRT2433622	hsa-miR-3150a-3p	CLIP-seq
MIRT2634127	hsa-miR-3151	CLIP-seq
MIRT2634128	hsa-miR-3163	CLIP-seq
MIRT2634129	hsa-miR-3165	CLIP-seq
MIRT2634130	hsa-miR-3175	CLIP-seq
MIRT2395262	hsa-miR-3179	CLIP-seq
MIRT2634131	hsa-miR-3202	CLIP-seq
MIRT2634132	hsa-miR-320a	CLIP-seq
MIRT2634133	hsa-miR-320b	CLIP-seq
MIRT2634134	hsa-miR-320c	CLIP-seq
MIRT2634135	hsa-miR-320d	CLIP-seq
MIRT2634136	hsa-miR-3611	CLIP-seq
MIRT2692137	hsa-miR-3681	CLIP-seq
MIRT2634137	hsa-miR-3691-5p	CLIP-seq
MIRT2634138	hsa-miR-411	CLIP-seq
MIRT2634139	hsa-miR-4429	CLIP-seq
MIRT2634140	hsa-miR-4446-3p	CLIP-seq
MIRT2634141	hsa-miR-4447	CLIP-seq
MIRT2692138	hsa-miR-4468	CLIP-seq
MIRT2634142	hsa-miR-4472	CLIP-seq
MIRT2692139	hsa-miR-4483	CLIP-seq
MIRT2634143	hsa-miR-4493	CLIP-seq
MIRT2634144	hsa-miR-4511	CLIP-seq
MIRT2634145	hsa-miR-4533	CLIP-seq
MIRT2692140	hsa-miR-4645-3p	CLIP-seq
MIRT2634146	hsa-miR-4651	CLIP-seq
MIRT2634147	hsa-miR-4664-3p	CLIP-seq
MIRT2634148	hsa-miR-4709-3p	CLIP-seq
MIRT2395263	hsa-miR-4761-3p	CLIP-seq
MIRT2634150	hsa-miR-4764-5p	CLIP-seq
MIRT2634151	hsa-miR-491-5p	CLIP-seq
MIRT2634152	hsa-miR-496	CLIP-seq
MIRT2634153	hsa-miR-512-5p	CLIP-seq
MIRT2692141	hsa-miR-542-3p	CLIP-seq
MIRT2692142	hsa-miR-545	CLIP-seq
MIRT2634154	hsa-miR-608	CLIP-seq
MIRT2634156	hsa-miR-939	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0016021	Component	Integral component of membrane	IEA
GO:0030198	Process	Extracellular matrix organization	NAS	16474848
GO:0045595	Process	Regulation of cell differentiation	NAS	16474848

Other IDs

• MIM: 600833
• HGNC: 11351
• e!Ensembl: ENSG00000004866

Protein

• UniProt ID: Q9NRC1
• Protein name: Suppressor of tumorigenicity 7 protein (Protein FAM4A1) (Protein HELG)
• Protein function: May act as a tumor suppressor.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04184	ST7	17 → 562	ST7 protein	Family

• Sequence:

  MAEAATGFLEQLKSCIVWSWTYLWTVWFFIVLFLVYILRVPLKINDNLSTVSMFLNTLTP
  KFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSVSHLRPLLGGVDNNSSNNSNSSN
  GDSDSNRQSVSECKVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFTCDS
  DHLRPADAIMQKAWRERNPQARISAAHEALEINEIRSRVEVPLIASSTIWEIKLLPKCAT
  AYILLAEEEATTIAEAEKLFKQALKAGDGCYRRSQQLQHHGSQYEAQHRRDTNVLVYIKR
  RLAMCARRLGRTREAVKMMRDLMKEFPLLSMFNIHENLLEALLELQAYADVQAVLAKYDD
  ISLPKSATICYTAALLKARAVSDKFSPEAASRRGLSTAEMNAVEAIHRAVEFNPHVPKYL
  LEMKSLILPPEHILKRGDSEAIAYAFFHLAHWKRVEGALNLLHCTWEGTFRMIPYPLEKG
  HLFYPYPICTETADRELLPSFHEVSVYPKKELPFFILFTAGLCSFTAMLALLTHQFPELM
  GVFAKAMIDIFCSAEFRDWNCKSIFMRVEDELEIPPAPQSQHFQN

• Sequence length: 585

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Developmental delay	Global developmental delay	rs28941770, rs199469464, rs281865469, rs143747297, rs398123009, rs587777428, rs786205133, rs606231459, rs797044854, rs797045027, rs864309504, rs878853160, rs886039902, rs886042046, rs886041291, rs886041382, rs1057518991, rs1057518699, rs753254213, rs748294403, rs762552974, rs1135401795, rs1553121073, rs1553122926, rs1364690005, rs1554086554, rs1554210415, rs1554168326, rs1554776342, rs1553873247, rs1567860112, rs779009256, rs1557447255, rs1564568350, rs780011005, rs1597464953, rs1200336864, rs1569513017, rs1587459606, rs1570332505, rs748888652, rs1575155995, rs2087029320, rs1589669105, rs1601769604, rs1184981709, rs749201074

Unknown
Disease name	Disease term	dbSNP ID	References
Brain atrophy	Brain atrophy