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SUGCT (succinyl-CoA:glutarate-CoA transferase)
Gene
Gene SNPs Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
79783
Gene nameGene Name - the full gene name approved by the HGNC.
Succinyl-CoA:glutarate-CoA transferase
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
SUGCT
SynonymsGene synonyms aliases
C7orf10, DERP13, GA3, ORF19
ChromosomeChromosome number
7
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7p14.1
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a protein that is similar to members of the CaiB/baiF CoA-transferase protein family. Mutations in this gene are associated with glutaric aciduria type III. Alternate splicing results in multiple transcript variants. [provided by RefSeq,
SNPsSNP information provided by dbSNP.
Gene SNPs Gene ontology Other IDs Protein Associated diseases
SNP ID Visualize variation Clinical significance Consequence
rs137852860 C>T Pathogenic, conflicting-interpretations-of-pathogenicity Genic downstream transcript variant, missense variant, coding sequence variant
rs137852861 C>A,T Pathogenic Synonymous variant, coding sequence variant, stop gained
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs Gene ontology Other IDs Protein Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0005739 Component Mitochondrion IDA 23893049
GO:0047369 Function Succinate-hydroxymethylglutarate CoA-transferase activity IDA 23893049
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs Gene ontology Other IDs Protein Associated diseases
MIM
HGNC
e!Ensembl
Protein
Gene SNPs Gene ontology Other IDs Protein Associated diseases
UniProt ID Q9HAC7
Protein name Succinyl-CoA:glutarate CoA-transferase (EC 2.8.3.-) (Dermal papilla-derived protein 13) (Dicarboxyl-CoA:dicarboxylic acid coenzyme A transferase SUGCT) (Succinate--hydroxymethylglutarate CoA-transferase) (EC 2.8.3.13)
Protein function Coenzyme A (CoA) transferase that reversibly catalyzes the transfer of a CoA moiety from a dicarboxyl-CoA to a dicarboxylate in a metabolite recycling process. Displays preference for succinyl-CoA and glutarate-CoA as dicarboxyl-CoA donors and g
PDB 9BR6 , 9BR7
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02515 CoA_transf_3
48 → 415
CoA-transferase family III
 Family
Sequence
Sequence length 445
Interactions View interactions
Associated diseases
Gene SNPs Gene ontology Other IDs Protein Associated diseases
Causal
Disease name Disease term dbSNP ID References
Glutaric acidemia Glutaric Aciduria III, Glutaric acidemia type 3 rs104894677, rs2123572141, rs387907170, rs377656387 27604308, 18926513, 23893049
Hypertension Hypertensive disease rs13306026, rs13333226
Migraine Cervical Migraine Syndrome, Migraine Disorders rs794727411 23793025, 27182965, 23793025, 27322543
Pancreatic cancer Malignant neoplasm of pancreas rs118203998, rs180177143, rs587776417, rs587776527, rs864622498, rs876659571, rs587778587, rs886039619, rs745533713, rs1555460431, rs200612497 26098869
Unknown
Disease name Disease term dbSNP ID References
Abdominal migraine Abdominal Migraine 23793025
Acne Acne Vulgaris 30542056
Common migraine Common Migraine 23793025
Confusional migraine Acute Confusional Migraine 23793025

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