STEAP4 (STEAP4 metalloreductase)

Gene

• Entrez ID: 79689
• Gene name: STEAP4 metalloreductase
• Gene symbol: STEAP4
• Synonyms: STAMP2, SchLAH, TIARP, TNFAIP9
• Chromosome: 7
• Chromosome location: 7q21.12
• Summary: The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019488	hsa-miR-148b-3p	Microarray	17612493
MIRT048618	hsa-miR-99a-5p	CLASH	23622248
MIRT644974	hsa-miR-548ac	HITS-CLIP	23824327
MIRT644973	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT644972	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT644971	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT644970	hsa-miR-548z	HITS-CLIP	23824327
MIRT644969	hsa-miR-3529-3p	HITS-CLIP	23824327
MIRT644968	hsa-miR-3938	HITS-CLIP	23824327
MIRT644967	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT644966	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT644964	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT644965	hsa-miR-6758-3p	HITS-CLIP	23824327
MIRT644963	hsa-miR-623	HITS-CLIP	23824327
MIRT644962	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT644961	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT644960	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT644959	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT644958	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT644974	hsa-miR-548ac	HITS-CLIP	23824327
MIRT644973	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT644972	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT644971	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT644970	hsa-miR-548z	HITS-CLIP	23824327
MIRT644969	hsa-miR-3529-3p	HITS-CLIP	23824327
MIRT644968	hsa-miR-3938	HITS-CLIP	23824327
MIRT644967	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT644966	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT644964	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT644965	hsa-miR-6758-3p	HITS-CLIP	23824327
MIRT644963	hsa-miR-623	HITS-CLIP	23824327
MIRT644962	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT644961	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT644960	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT644959	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT644958	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT735932	hsa-miR-1265	Luciferase reporter assay, Western blotting, Immunoprecipitaion (IP), qRT-PCR, In situ hybridization	31648990
MIRT644974	hsa-miR-548ac	HITS-CLIP	23824327
MIRT644973	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT644972	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT644971	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT644970	hsa-miR-548z	HITS-CLIP	23824327
MIRT644969	hsa-miR-3529-3p	HITS-CLIP	23824327
MIRT644968	hsa-miR-3938	HITS-CLIP	23824327
MIRT644967	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT644966	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT644964	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT644965	hsa-miR-6758-3p	HITS-CLIP	23824327
MIRT644963	hsa-miR-623	HITS-CLIP	23824327
MIRT644962	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT644961	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT644960	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT644959	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT644958	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT644974	hsa-miR-548ac	HITS-CLIP	23824327
MIRT644973	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT644972	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT644971	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT644970	hsa-miR-548z	HITS-CLIP	23824327
MIRT644969	hsa-miR-3529-3p	HITS-CLIP	23824327
MIRT644968	hsa-miR-3938	HITS-CLIP	23824327
MIRT644967	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT644966	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT644964	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT644965	hsa-miR-6758-3p	HITS-CLIP	23824327
MIRT644963	hsa-miR-623	HITS-CLIP	23824327
MIRT644962	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT644961	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT644960	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT644959	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT644958	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT1396924	hsa-miR-1827	CLIP-seq
MIRT1396925	hsa-miR-3145-5p	CLIP-seq
MIRT1396926	hsa-miR-338-3p	CLIP-seq
MIRT1396927	hsa-miR-3612	CLIP-seq
MIRT1396928	hsa-miR-3614-5p	CLIP-seq
MIRT1396929	hsa-miR-3653	CLIP-seq
MIRT1396930	hsa-miR-3658	CLIP-seq
MIRT1396931	hsa-miR-4514	CLIP-seq
MIRT1396932	hsa-miR-4692	CLIP-seq
MIRT1396933	hsa-miR-4764-3p	CLIP-seq
MIRT1396934	hsa-miR-548u	CLIP-seq
MIRT1396935	hsa-miR-650	CLIP-seq
MIRT1396936	hsa-miR-656	CLIP-seq
MIRT1396937	hsa-miR-940	CLIP-seq
MIRT1396938	hsa-miR-10a	CLIP-seq
MIRT1396939	hsa-miR-10b	CLIP-seq
MIRT1396940	hsa-miR-2114	CLIP-seq
MIRT1396941	hsa-miR-3192	CLIP-seq
MIRT1396942	hsa-miR-339-5p	CLIP-seq
MIRT1396943	hsa-miR-3689a-3p	CLIP-seq
MIRT1396944	hsa-miR-3689c	CLIP-seq
MIRT1396945	hsa-miR-3929	CLIP-seq
MIRT1396946	hsa-miR-4293	CLIP-seq
MIRT1396947	hsa-miR-4419b	CLIP-seq
MIRT1396948	hsa-miR-4421	CLIP-seq
MIRT1396949	hsa-miR-4478	CLIP-seq
MIRT1396950	hsa-miR-4502	CLIP-seq
MIRT1396951	hsa-miR-451b	CLIP-seq
MIRT1396952	hsa-miR-4684-5p	CLIP-seq
MIRT1396953	hsa-miR-4696	CLIP-seq
MIRT1396954	hsa-miR-4728-5p	CLIP-seq
MIRT1396955	hsa-miR-4729	CLIP-seq
MIRT1396956	hsa-miR-4775	CLIP-seq
MIRT1396957	hsa-miR-485-5p	CLIP-seq
MIRT1396958	hsa-miR-490-3p	CLIP-seq
MIRT1396959	hsa-miR-508-5p	CLIP-seq
MIRT1396960	hsa-miR-548k	CLIP-seq
MIRT1396961	hsa-miR-548n	CLIP-seq
MIRT1396962	hsa-miR-548t	CLIP-seq
MIRT1396963	hsa-miR-579	CLIP-seq
MIRT1396964	hsa-miR-590-3p	CLIP-seq
MIRT1396965	hsa-miR-593	CLIP-seq
MIRT1396966	hsa-miR-765	CLIP-seq
MIRT1396967	hsa-miR-766	CLIP-seq
MIRT1396968	hsa-miR-1285	CLIP-seq
MIRT1396969	hsa-miR-3187-5p	CLIP-seq
MIRT1396970	hsa-miR-3677-5p	CLIP-seq
MIRT1396971	hsa-miR-3945	CLIP-seq
MIRT1396972	hsa-miR-4253	CLIP-seq
MIRT1396973	hsa-miR-612	CLIP-seq
MIRT2118855	hsa-miR-3155	CLIP-seq
MIRT2118856	hsa-miR-3155b	CLIP-seq
MIRT2118857	hsa-miR-4464	CLIP-seq
MIRT2118858	hsa-miR-450b-5p	CLIP-seq
MIRT1396953	hsa-miR-4696	CLIP-seq
MIRT2118859	hsa-miR-4748	CLIP-seq
MIRT2118860	hsa-miR-484	CLIP-seq
MIRT2118861	hsa-miR-507	CLIP-seq
MIRT2118862	hsa-miR-557	CLIP-seq
MIRT2118863	hsa-miR-583	CLIP-seq
MIRT2118864	hsa-miR-759	CLIP-seq
MIRT2341207	hsa-miR-1227	CLIP-seq
MIRT1396924	hsa-miR-1827	CLIP-seq
MIRT1396940	hsa-miR-2114	CLIP-seq
MIRT2341208	hsa-miR-3197	CLIP-seq
MIRT1396927	hsa-miR-3612	CLIP-seq
MIRT1396928	hsa-miR-3614-5p	CLIP-seq
MIRT1396945	hsa-miR-3929	CLIP-seq
MIRT2341209	hsa-miR-4252	CLIP-seq
MIRT1396947	hsa-miR-4419b	CLIP-seq
MIRT1396949	hsa-miR-4478	CLIP-seq
MIRT1396950	hsa-miR-4502	CLIP-seq
MIRT1396931	hsa-miR-4514	CLIP-seq
MIRT1396932	hsa-miR-4692	CLIP-seq
MIRT1396957	hsa-miR-485-5p	CLIP-seq
MIRT1396935	hsa-miR-650	CLIP-seq
MIRT2341210	hsa-miR-658	CLIP-seq
MIRT1396937	hsa-miR-940	CLIP-seq
MIRT2341207	hsa-miR-1227	CLIP-seq
MIRT2395344	hsa-miR-3153	CLIP-seq
MIRT1396941	hsa-miR-3192	CLIP-seq
MIRT2395345	hsa-miR-3649	CLIP-seq
MIRT1396943	hsa-miR-3689a-3p	CLIP-seq
MIRT1396944	hsa-miR-3689c	CLIP-seq
MIRT2341209	hsa-miR-4252	CLIP-seq
MIRT2395346	hsa-miR-4270	CLIP-seq
MIRT1396946	hsa-miR-4293	CLIP-seq
MIRT2395347	hsa-miR-4441	CLIP-seq
MIRT1396954	hsa-miR-4728-5p	CLIP-seq
MIRT2395348	hsa-miR-4793-3p	CLIP-seq
MIRT1396958	hsa-miR-490-3p	CLIP-seq
MIRT2395349	hsa-miR-492	CLIP-seq
MIRT1396959	hsa-miR-508-5p	CLIP-seq
MIRT1396966	hsa-miR-765	CLIP-seq
MIRT1396967	hsa-miR-766	CLIP-seq
MIRT1396938	hsa-miR-10a	CLIP-seq
MIRT1396939	hsa-miR-10b	CLIP-seq
MIRT1396968	hsa-miR-1285	CLIP-seq
MIRT1396940	hsa-miR-2114	CLIP-seq
MIRT1396969	hsa-miR-3187-5p	CLIP-seq
MIRT1396942	hsa-miR-339-5p	CLIP-seq
MIRT2460660	hsa-miR-34b	CLIP-seq
MIRT1396928	hsa-miR-3614-5p	CLIP-seq
MIRT1396945	hsa-miR-3929	CLIP-seq
MIRT1396971	hsa-miR-3945	CLIP-seq
MIRT1396972	hsa-miR-4253	CLIP-seq
MIRT1396947	hsa-miR-4419b	CLIP-seq
MIRT1396948	hsa-miR-4421	CLIP-seq
MIRT1396949	hsa-miR-4478	CLIP-seq
MIRT1396952	hsa-miR-4684-5p	CLIP-seq
MIRT1396957	hsa-miR-485-5p	CLIP-seq
MIRT1396958	hsa-miR-490-3p	CLIP-seq
MIRT1396960	hsa-miR-548k	CLIP-seq
MIRT1396961	hsa-miR-548n	CLIP-seq
MIRT1396962	hsa-miR-548t	CLIP-seq
MIRT1396965	hsa-miR-593	CLIP-seq
MIRT1396973	hsa-miR-612	CLIP-seq
MIRT1396938	hsa-miR-10a	CLIP-seq
MIRT1396939	hsa-miR-10b	CLIP-seq
MIRT1396942	hsa-miR-339-5p	CLIP-seq
MIRT1396948	hsa-miR-4421	CLIP-seq
MIRT1396952	hsa-miR-4684-5p	CLIP-seq
MIRT1396960	hsa-miR-548k	CLIP-seq
MIRT1396961	hsa-miR-548n	CLIP-seq
MIRT1396962	hsa-miR-548t	CLIP-seq
MIRT1396965	hsa-miR-593	CLIP-seq
MIRT1396938	hsa-miR-10a	CLIP-seq
MIRT1396939	hsa-miR-10b	CLIP-seq
MIRT2692208	hsa-miR-1182	CLIP-seq
MIRT2692209	hsa-miR-1183	CLIP-seq
MIRT1396968	hsa-miR-1285	CLIP-seq
MIRT1396940	hsa-miR-2114	CLIP-seq
MIRT2692210	hsa-miR-3065-3p	CLIP-seq
MIRT2395344	hsa-miR-3153	CLIP-seq
MIRT1396969	hsa-miR-3187-5p	CLIP-seq
MIRT1396941	hsa-miR-3192	CLIP-seq
MIRT2692211	hsa-miR-326	CLIP-seq
MIRT2692212	hsa-miR-330-5p	CLIP-seq
MIRT1396942	hsa-miR-339-5p	CLIP-seq
MIRT1396945	hsa-miR-3929	CLIP-seq
MIRT1396971	hsa-miR-3945	CLIP-seq
MIRT1396972	hsa-miR-4253	CLIP-seq
MIRT1396946	hsa-miR-4293	CLIP-seq
MIRT2692213	hsa-miR-4314	CLIP-seq
MIRT1396947	hsa-miR-4419b	CLIP-seq
MIRT1396948	hsa-miR-4421	CLIP-seq
MIRT1396949	hsa-miR-4478	CLIP-seq
MIRT1396950	hsa-miR-4502	CLIP-seq
MIRT2692214	hsa-miR-4522	CLIP-seq
MIRT2692215	hsa-miR-4646-5p	CLIP-seq
MIRT2692216	hsa-miR-4668-5p	CLIP-seq
MIRT1396952	hsa-miR-4684-5p	CLIP-seq
MIRT2692217	hsa-miR-4757-5p	CLIP-seq
MIRT1396957	hsa-miR-485-5p	CLIP-seq
MIRT1396960	hsa-miR-548k	CLIP-seq
MIRT1396961	hsa-miR-548n	CLIP-seq
MIRT1396962	hsa-miR-548t	CLIP-seq
MIRT1396965	hsa-miR-593	CLIP-seq
MIRT1396973	hsa-miR-612	CLIP-seq
MIRT2692218	hsa-miR-888	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005768	Component	Endosome	IBA	21873635
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	ISS
GO:0008823	Function	Cupric reductase activity	IBA	21873635
GO:0009055	Function	Electron transfer activity	IDA	30337524
GO:0015677	Process	Copper ion import	IBA	21873635
GO:0016021	Component	Integral component of membrane	IDA	30337524
GO:0020037	Function	Heme binding	IDA	30337524
GO:0022900	Process	Electron transport chain	IEA
GO:0031901	Component	Early endosome membrane	IEA
GO:0045444	Process	Fat cell differentiation	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0052851	Function	Ferric-chelate reductase (NADPH) activity	IBA	21873635
GO:0052851	Function	Ferric-chelate reductase (NADPH) activity	IDA	30337524
GO:0055072	Process	Iron ion homeostasis	IEA
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0070207	Process	Protein homotrimerization	IDA	30337524
GO:0071949	Function	FAD binding	IDA	30337524

Other IDs

• MIM: 611098
• HGNC: 21923
• e!Ensembl: ENSG00000127954

Protein

• UniProt ID: Q687X5
• Protein name: Metalloreductase STEAP4 (EC 1.16.1.-) (Six-transmembrane epithelial antigen of prostate 4) (SixTransMembrane protein of prostate 2) (Tumor necrosis factor, alpha-induced protein 9)
• Protein function: Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane. Mediates sequential transmembrane elect
• PDB: 6HCY, 6HD1
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03807	F420_oxidored	21 → 107	NADP oxidoreductase coenzyme F420-dependent	Family
  PF01794	Ferric_reduct	247 → 395	Ferric reductase like transmembrane component	Family

• Sequence:

  MEKTCIDALPLTMNSSEKQETVCIFGTGDFGRSLGLKMLQCGYSVVFGSRNPQKTTLLPS
  GAEVLSYSEAAKKSGIIIIAIHREHYDFLTELTEVLNGKILVDISNNLKINQYPESNAEY
  LAHLVPGAHVVKAFNTISAWALQSGALDASRQVFVCGNDSKAKQRVMDIVRNLGLTPMDQ
  GSLMAAKEIEKYPLQLFPMWRFPFYLSAVLCVFLFFYCVIRDVIYPYVYEKKDNTFRMAI
  SIPNRIFPITALTLLALVYLPGVIAAILQLYRGTKYRRFPDWLDHWMLCRKQLGLVALGF
  AFLHVLYTLVIPIRYYVRWRLGNLTVTQAILKKENPFSTSSAWLSDSYVALGILGFFLFV
  LLGITSLPSVSNAVNWREFRFVQSKLGYLTLILCTAHTLVYGGKRFLSPSNLRWYLPAAY
  VLGLIIPCTVLVIKFVLIMPCVDNTLTRIRQGWERNSKH

• Sequence length: 459

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	25320179

Unknown
Disease name	Disease term	dbSNP ID	References
Prostatic neoplasms	Prostatic Neoplasms		25320179