SPAG16 (sperm associated antigen 16)

Gene

• Entrez ID: 79582
• Gene name: Sperm associated antigen 16
• Gene symbol: SPAG16
• Synonyms: PF20, WDR29
• Chromosome: 2
• Chromosome location: 2q34
• Summary: Cilia and flagella are comprised of a microtubular backbone, the axoneme, which is organized by the basal body and surrounded by plasma membrane. SPAG16 encodes 2 major proteins that associate with the axoneme of sperm tail and the nucleus of postmeiotic

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT712970	hsa-miR-3662	HITS-CLIP	19536157
MIRT712969	hsa-miR-651-3p	HITS-CLIP	19536157
MIRT712968	hsa-miR-6828-5p	HITS-CLIP	19536157
MIRT712970	hsa-miR-3662	HITS-CLIP	19536157
MIRT712969	hsa-miR-651-3p	HITS-CLIP	19536157
MIRT712968	hsa-miR-6828-5p	HITS-CLIP	19536157
MIRT643600	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT643599	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT643598	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT643597	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT643596	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT643595	hsa-miR-1260a	HITS-CLIP	23824327
MIRT643594	hsa-miR-1260b	HITS-CLIP	23824327
MIRT643593	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT643592	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT643591	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT643600	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT643599	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT643598	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT643597	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT643596	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT643595	hsa-miR-1260a	HITS-CLIP	23824327
MIRT643594	hsa-miR-1260b	HITS-CLIP	23824327
MIRT643593	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT643592	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT643591	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT712970	hsa-miR-3662	HITS-CLIP	19536157
MIRT712969	hsa-miR-651-3p	HITS-CLIP	19536157
MIRT712968	hsa-miR-6828-5p	HITS-CLIP	19536157
MIRT712970	hsa-miR-3662	HITS-CLIP	19536157
MIRT712969	hsa-miR-651-3p	HITS-CLIP	19536157
MIRT712968	hsa-miR-6828-5p	HITS-CLIP	19536157
MIRT643600	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT643599	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT643598	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT643597	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT643596	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT643595	hsa-miR-1260a	HITS-CLIP	23824327
MIRT643594	hsa-miR-1260b	HITS-CLIP	23824327
MIRT643593	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT643592	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT643591	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT643600	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT643599	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT643598	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT643597	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT643596	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT643595	hsa-miR-1260a	HITS-CLIP	23824327
MIRT643594	hsa-miR-1260b	HITS-CLIP	23824327
MIRT643593	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT643592	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT643591	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT2114208	hsa-miR-4528	CLIP-seq
MIRT2114209	hsa-miR-656	CLIP-seq
MIRT2433373	hsa-miR-1237	CLIP-seq
MIRT2433374	hsa-miR-1248	CLIP-seq
MIRT2433375	hsa-miR-1299	CLIP-seq
MIRT2433376	hsa-miR-1305	CLIP-seq
MIRT2433377	hsa-miR-3671	CLIP-seq
MIRT2433378	hsa-miR-4434	CLIP-seq
MIRT2433379	hsa-miR-4516	CLIP-seq
MIRT2433380	hsa-miR-4531	CLIP-seq
MIRT2433381	hsa-miR-4782-5p	CLIP-seq
MIRT2433382	hsa-miR-516b	CLIP-seq
MIRT2433383	hsa-miR-607	CLIP-seq
MIRT2114208	hsa-miR-4528	CLIP-seq
MIRT2114208	hsa-miR-4528	CLIP-seq
MIRT2114208	hsa-miR-4528	CLIP-seq
MIRT2114209	hsa-miR-656	CLIP-seq
MIRT2433373	hsa-miR-1237	CLIP-seq
MIRT2433374	hsa-miR-1248	CLIP-seq
MIRT2433375	hsa-miR-1299	CLIP-seq
MIRT2433378	hsa-miR-4434	CLIP-seq
MIRT2433379	hsa-miR-4516	CLIP-seq
MIRT2114208	hsa-miR-4528	CLIP-seq
MIRT2433380	hsa-miR-4531	CLIP-seq
MIRT2433381	hsa-miR-4782-5p	CLIP-seq
MIRT2691799	hsa-miR-4795-3p	CLIP-seq
MIRT2433382	hsa-miR-516b	CLIP-seq
MIRT2114209	hsa-miR-656	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005576	Component	Extracellular region	IEA
GO:0005930	Component	Axoneme	ISS
GO:0007288	Process	Sperm axoneme assembly	IEA
GO:0035082	Process	Axoneme assembly	IBA	21873635
GO:0035082	Process	Axoneme assembly	IMP	17699735
GO:0036126	Component	Sperm flagellum	IEA
GO:0060271	Process	Cilium assembly	ISS
GO:0090660	Process	Cerebrospinal fluid circulation	IEA
GO:0120197	Process	Mucociliary clearance	IEA
GO:1990716	Component	Axonemal central apparatus	IBA	21873635

Other IDs

• MIM: 612173
• HGNC: 23225
• e!Ensembl: ENSG00000144451

Protein

• UniProt ID: Q8N0X2
• Protein name: Sperm-associated antigen 16 protein (Pf20 protein homolog)
• Protein function: Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia (By sim
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00400	WD40	383 → 422	WD domain, G-beta repeat	Repeat
  PF00400	WD40	426 → 464	WD domain, G-beta repeat	Repeat
  PF00400	WD40	468 → 506	WD domain, G-beta repeat	Repeat
  PF00400	WD40	510 → 548	WD domain, G-beta repeat	Repeat
  PF00400	WD40	594 → 631	WD domain, G-beta repeat	Repeat

• Sequence:

  MAAQRGMPSSAVRVLEEALGMGLTAAGDARDTADAVAAEGAYYLEQVTITEASEDDYEYE
  EIPDDNFSIPEGEEDLAKAIQMAQEQATDTEILERKTVLPSKHAVPEVIEDFLCNFLIKM
  GMTRTLDCFQSEWYELIQKGVTELRTVGNVPDVYTQIMLLENENKNLKKDLKHYKQAADK
  AREDLLKIQKERDFHRMHHKRIVQEKNKLINDLKGLKLHYASYEPTIRVLHEKHHTLLKE
  KMLTSLERDKVVGQISGLQETLKKLQRGHSYHGPQIKVDHSREKENAPEGPTQKGLREAR
  EQNKCKTKMKGNTKDSEFPIDMQPNPNLNVSKESLSPAKFDYKLKNIFRLHELPVSCVSM
  QPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKL
  WDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDS
  VNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDA
  CGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEIHKLM
  GHENEAHTVVFSHDGEILFSGGSDGTVRTWS

• Sequence length: 631

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Attention deficit hyperactivity disorder	Attention deficit hyperactivity disorder	rs120074176, rs786205019	30478444
Chronic obstructive pulmonary disease	Chronic Obstructive Airway Disease	rs2227956, rs1008438, rs1043618, rs562047, rs1061581, rs2763979, rs6457452, rs13147758, rs1828591, rs13118928	26634245