GCC1 (GRIP and coiled-coil domain containing 1)

Gene

• Entrez ID: 79571
• Gene name: GRIP and coiled-coil domain containing 1
• Gene symbol: GCC1
• Synonyms: GCC1P, GCC88
• Chromosome: 7
• Chromosome location: 7q32.1
• Summary: The protein encoded by this gene is a peripheral membrane protein. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. It may play a role in the organization of trans-Golgi network subcompa

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT025007	hsa-miR-183-5p	Sequencing	20371350
MIRT027226	hsa-miR-103a-3p	Sequencing	20371350
MIRT031853	hsa-miR-16-5p	Sequencing	20371350
MIRT657923	hsa-miR-545-3p	HITS-CLIP	23824327
MIRT657922	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT657921	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT657920	hsa-miR-3158-5p	HITS-CLIP	23824327
MIRT657919	hsa-miR-1184	HITS-CLIP	23824327
MIRT657918	hsa-miR-1205	HITS-CLIP	23824327
MIRT657917	hsa-miR-17-3p	HITS-CLIP	23824327
MIRT027226	hsa-miR-103a-3p	HITS-CLIP	23824327
MIRT657916	hsa-miR-107	HITS-CLIP	23824327
MIRT657915	hsa-miR-626	HITS-CLIP	23824327
MIRT657914	hsa-miR-6876-3p	HITS-CLIP	23824327
MIRT657913	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT657912	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT220298	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT657911	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT657910	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT567464	hsa-miR-583	PAR-CLIP	20371350
MIRT567463	hsa-miR-5582-5p	PAR-CLIP	20371350
MIRT567462	hsa-miR-665	PAR-CLIP	20371350
MIRT567461	hsa-miR-188-3p	PAR-CLIP	20371350
MIRT567460	hsa-miR-1260a	PAR-CLIP	20371350
MIRT567459	hsa-miR-1260b	PAR-CLIP	20371350
MIRT567458	hsa-miR-3156-3p	PAR-CLIP	20371350
MIRT657923	hsa-miR-545-3p	HITS-CLIP	23824327
MIRT657922	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT657921	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT657920	hsa-miR-3158-5p	HITS-CLIP	23824327
MIRT657919	hsa-miR-1184	HITS-CLIP	23824327
MIRT657918	hsa-miR-1205	HITS-CLIP	23824327
MIRT657917	hsa-miR-17-3p	HITS-CLIP	23824327
MIRT027226	hsa-miR-103a-3p	HITS-CLIP	23824327
MIRT657916	hsa-miR-107	HITS-CLIP	23824327
MIRT657915	hsa-miR-626	HITS-CLIP	23824327
MIRT657914	hsa-miR-6876-3p	HITS-CLIP	23824327
MIRT657913	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT657912	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT220298	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT657911	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT657910	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT567464	hsa-miR-583	PAR-CLIP	20371350
MIRT567463	hsa-miR-5582-5p	PAR-CLIP	20371350
MIRT567462	hsa-miR-665	PAR-CLIP	20371350
MIRT567461	hsa-miR-188-3p	PAR-CLIP	20371350
MIRT567460	hsa-miR-1260a	PAR-CLIP	20371350
MIRT567459	hsa-miR-1260b	PAR-CLIP	20371350
MIRT567458	hsa-miR-3156-3p	PAR-CLIP	20371350
MIRT1014282	hsa-miR-103a	CLIP-seq
MIRT1014283	hsa-miR-1251	CLIP-seq
MIRT1014284	hsa-miR-1252	CLIP-seq
MIRT1014285	hsa-miR-1256	CLIP-seq
MIRT1014286	hsa-miR-1296	CLIP-seq
MIRT1014287	hsa-miR-15a	CLIP-seq
MIRT1014288	hsa-miR-15b	CLIP-seq
MIRT1014289	hsa-miR-16	CLIP-seq
MIRT1014290	hsa-miR-186	CLIP-seq
MIRT1014291	hsa-miR-1913	CLIP-seq
MIRT1014292	hsa-miR-195	CLIP-seq
MIRT1014293	hsa-miR-3133	CLIP-seq
MIRT1014294	hsa-miR-3189-5p	CLIP-seq
MIRT1014295	hsa-miR-324-3p	CLIP-seq
MIRT1014296	hsa-miR-3675-3p	CLIP-seq
MIRT1014297	hsa-miR-3915	CLIP-seq
MIRT1014298	hsa-miR-3928	CLIP-seq
MIRT1014299	hsa-miR-424	CLIP-seq
MIRT1014300	hsa-miR-4310	CLIP-seq
MIRT1014301	hsa-miR-4422	CLIP-seq
MIRT1014302	hsa-miR-4512	CLIP-seq
MIRT1014303	hsa-miR-4521	CLIP-seq
MIRT1014304	hsa-miR-4662a-3p	CLIP-seq
MIRT1014305	hsa-miR-4682	CLIP-seq
MIRT1014306	hsa-miR-4726-3p	CLIP-seq
MIRT1014307	hsa-miR-4738-3p	CLIP-seq
MIRT1014308	hsa-miR-4758-3p	CLIP-seq
MIRT1014309	hsa-miR-497	CLIP-seq
MIRT1014310	hsa-miR-548p	CLIP-seq
MIRT1014284	hsa-miR-1252	CLIP-seq
MIRT1549177	hsa-miR-1285	CLIP-seq
MIRT1014290	hsa-miR-186	CLIP-seq
MIRT1014293	hsa-miR-3133	CLIP-seq
MIRT1549178	hsa-miR-3187-5p	CLIP-seq
MIRT1014307	hsa-miR-4738-3p	CLIP-seq
MIRT1549179	hsa-miR-612	CLIP-seq
MIRT1549177	hsa-miR-1285	CLIP-seq
MIRT2000388	hsa-miR-132	CLIP-seq
MIRT2000389	hsa-miR-145	CLIP-seq
MIRT2000390	hsa-miR-194	CLIP-seq
MIRT2000391	hsa-miR-212	CLIP-seq
MIRT2000392	hsa-miR-2355-5p	CLIP-seq
MIRT1549178	hsa-miR-3187-5p	CLIP-seq
MIRT2000393	hsa-miR-3677-5p	CLIP-seq
MIRT2000394	hsa-miR-3926	CLIP-seq
MIRT2000395	hsa-miR-4269	CLIP-seq
MIRT2000396	hsa-miR-4460	CLIP-seq
MIRT2000397	hsa-miR-4645-5p	CLIP-seq
MIRT2000398	hsa-miR-4673	CLIP-seq
MIRT2000399	hsa-miR-4727-3p	CLIP-seq
MIRT2000400	hsa-miR-548s	CLIP-seq
MIRT1549179	hsa-miR-612	CLIP-seq
MIRT2000401	hsa-miR-802	CLIP-seq
MIRT1014282	hsa-miR-103a	CLIP-seq
MIRT2233867	hsa-miR-1178	CLIP-seq
MIRT2233868	hsa-miR-1183	CLIP-seq
MIRT2233869	hsa-miR-1193	CLIP-seq
MIRT2233870	hsa-miR-1208	CLIP-seq
MIRT1014283	hsa-miR-1251	CLIP-seq
MIRT1014285	hsa-miR-1256	CLIP-seq
MIRT2233871	hsa-miR-1260	CLIP-seq
MIRT2233872	hsa-miR-1264	CLIP-seq
MIRT2233873	hsa-miR-1265	CLIP-seq
MIRT2233874	hsa-miR-128	CLIP-seq
MIRT1549177	hsa-miR-1285	CLIP-seq
MIRT2233875	hsa-miR-129-3p	CLIP-seq
MIRT2233876	hsa-miR-1302	CLIP-seq
MIRT2000392	hsa-miR-2355-5p	CLIP-seq
MIRT2233877	hsa-miR-2392	CLIP-seq
MIRT2233878	hsa-miR-3122	CLIP-seq
MIRT2233879	hsa-miR-3180-5p	CLIP-seq
MIRT2233880	hsa-miR-3183	CLIP-seq
MIRT2233881	hsa-miR-3185	CLIP-seq
MIRT1549178	hsa-miR-3187-5p	CLIP-seq
MIRT2233882	hsa-miR-3189-3p	CLIP-seq
MIRT2233883	hsa-miR-3199	CLIP-seq
MIRT2233884	hsa-miR-3646	CLIP-seq
MIRT2233885	hsa-miR-3680	CLIP-seq
MIRT2233886	hsa-miR-3681	CLIP-seq
MIRT2233887	hsa-miR-3913-5p	CLIP-seq
MIRT2233888	hsa-miR-3935	CLIP-seq
MIRT2233889	hsa-miR-4298	CLIP-seq
MIRT2233890	hsa-miR-4494	CLIP-seq
MIRT2233891	hsa-miR-4520b-3p	CLIP-seq
MIRT2233892	hsa-miR-4529-3p	CLIP-seq
MIRT2000397	hsa-miR-4645-5p	CLIP-seq
MIRT2000398	hsa-miR-4673	CLIP-seq
MIRT2233893	hsa-miR-4687-5p	CLIP-seq
MIRT2233894	hsa-miR-4723-3p	CLIP-seq
MIRT2233895	hsa-miR-4742-5p	CLIP-seq
MIRT2233896	hsa-miR-4776-5p	CLIP-seq
MIRT2233897	hsa-miR-520a-5p	CLIP-seq
MIRT2233898	hsa-miR-525-5p	CLIP-seq
MIRT2233899	hsa-miR-544	CLIP-seq
MIRT2233900	hsa-miR-577	CLIP-seq
MIRT1549179	hsa-miR-612	CLIP-seq
MIRT2233901	hsa-miR-668	CLIP-seq
MIRT2233902	hsa-miR-767-3p	CLIP-seq
MIRT2537814	hsa-miR-1266	CLIP-seq
MIRT2537815	hsa-miR-154	CLIP-seq
MIRT2537816	hsa-miR-1972	CLIP-seq
MIRT2537817	hsa-miR-216a	CLIP-seq
MIRT2537818	hsa-miR-3664-3p	CLIP-seq
MIRT2000395	hsa-miR-4269	CLIP-seq
MIRT2537819	hsa-miR-4514	CLIP-seq
MIRT2537820	hsa-miR-4518	CLIP-seq
MIRT2537821	hsa-miR-4650-5p	CLIP-seq
MIRT2537822	hsa-miR-4692	CLIP-seq
MIRT2233895	hsa-miR-4742-5p	CLIP-seq
MIRT2537814	hsa-miR-1266	CLIP-seq
MIRT2537815	hsa-miR-154	CLIP-seq
MIRT2537816	hsa-miR-1972	CLIP-seq
MIRT2537817	hsa-miR-216a	CLIP-seq
MIRT2537818	hsa-miR-3664-3p	CLIP-seq
MIRT2000395	hsa-miR-4269	CLIP-seq
MIRT2537819	hsa-miR-4514	CLIP-seq
MIRT2537820	hsa-miR-4518	CLIP-seq
MIRT2537821	hsa-miR-4650-5p	CLIP-seq
MIRT2537822	hsa-miR-4692	CLIP-seq
MIRT2233895	hsa-miR-4742-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000138	Component	Golgi trans cisterna	ISS
GO:0000139	Component	Golgi membrane	IEA
GO:0005515	Function	Protein binding	IPI	16189514, 19060904, 21516116, 25416956, 29892012, 31515488, 32296183
GO:0005794	Component	Golgi apparatus	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0031267	Function	Small GTPase binding	ISS

Other IDs

• MIM: 607418
• HGNC: 19095
• e!Ensembl: ENSG00000179562

Protein

• UniProt ID: Q96CN9
• Protein name: GRIP and coiled-coil domain-containing protein 1 (Golgi coiled-coil protein 1)
• Protein function: Probably involved in maintaining Golgi structure.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01465	GRIP	717 → 760	GRIP domain	Family

• Sequence:

  MEKFGMNFGGGPSKKDLLETIETQKKQLLQYQARLKDVVRAYKSLLKEKEALEASIKVLS
  VSHEADVGLAGVQLPGLTFPDSVDDRCSTHSEDSTGTATSLDTAASLTSTKGEFGVEDDR
  PARGPPPPKSEEASWSESGVSSSSGDGPFAGGEVDKRLHQLKTQLATLTSSLATVTQEKS
  RMEASYLADKKKMKQDLEDASNKAEEERARLEGELKGLQEQIAETKARLITQQHDRAQEQ
  SDHALMLRELQKLLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVE
  ELKSELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEE
  QRVAALENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDS
  HGEESSLDVNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALY
  YQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEE
  LEHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKD
  LELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQL
  ARKEVEITSLRKQKHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNIRDQSREGANL
  EYLKNIIYRFLTLPDSLGRQQTLTAILTILHFSPEEKQVIMRLPTSASWWPSGKR

• Sequence length: 775

Pathways

Reactome:

Retrograde transport at the Trans-Golgi-Network

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	22158537