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PLA2G7 (phospholipase A2 group VII)
Gene
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7941
Gene nameGene Name - the full gene name approved by the HGNC.
Phospholipase A2 group VII
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
PLA2G7
SynonymsGene synonyms aliases
LDL-PLA2, LP-PLA2, PAFAD, PAFAH
ChromosomeChromosome number
6
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p12.3
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript
SNPsSNP information provided by dbSNP.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
SNP ID Visualize variation Clinical significance Consequence
rs1051931 A>G,T Risk-factor, not-provided Coding sequence variant, non coding transcript variant, missense variant
rs1805018 A>G Risk-factor Coding sequence variant, non coding transcript variant, missense variant
rs76863441 C>A Risk-factor, pathogenic Intron variant, coding sequence variant, missense variant, non coding transcript variant
rs201899866 C>T Pathogenic, risk-factor Splice donor variant
miRNAmiRNA information provided by mirtarbase database.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
miRTarBase ID miRNA Experiments Reference
MIRT017286 hsa-miR-335-5p Microarray 18185580
MIRT022422 hsa-miR-124-3p Microarray 18668037
MIRT611762 hsa-miR-590-3p HITS-CLIP 19536157
MIRT611761 hsa-miR-8485 HITS-CLIP 19536157
MIRT611760 hsa-miR-4789-3p HITS-CLIP 19536157
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0003847 Function 1-alkyl-2-acetylglycerophosphocholine esterase activity IBA 21873635
GO:0003847 Function 1-alkyl-2-acetylglycerophosphocholine esterase activity IDA 8624782, 10066756, 10504265, 11590221, 16371369
GO:0005543 Function Phospholipid binding IDA 8624782
GO:0005576 Component Extracellular region TAS
GO:0005737 Component Cytoplasm IEA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM
HGNC
e!Ensembl
Protein
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q13093
Protein name Platelet-activating factor acetylhydrolase (PAF acetylhydrolase) (EC 3.1.1.47) (1-alkyl-2-acetylglycerophosphocholine esterase) (2-acetyl-1-alkylglycerophosphocholine esterase) (Group-VIIA phospholipase A2) (gVIIA-PLA2) (LDL-associated phospholipase A2) (
Protein function Lipoprotein-associated calcium-independent phospholipase A2 involved in phospholipid catabolism during inflammatory and oxidative stress response (PubMed:10066756, PubMed:16371369, PubMed:17090529, PubMed:2040620, PubMed:7700381, PubMed:8624782)
PDB 3D59 , 3D5E , 3F96 , 3F97 , 3F98 , 3F9C , 5I8P , 5I9I , 5JAD , 5JAH , 5JAL , 5JAN , 5JAO , 5JAP , 5JAR , 5JAS , 5JAT , 5JAU , 5LP1 , 5LYY , 5LZ2 , 5LZ4 , 5LZ5 , 5LZ7 , 5LZ8 , 5LZ9 , 5YE7 , 5YE8 , 5YE9 , 5YEA , 6M06 , 6M07 , 6M08
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03403 PAF-AH_p_II
48 → 416
Platelet-activating factor acetylhydrolase, isoform II
 Domain
Sequence
Sequence length 441
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
 
KEGG
  
Reactome
  Ether lipid metabolism
Metabolic pathways 		  Synthesis, secretion, and deacylation of Ghrelin
Associated diseases
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Causal
Disease name Disease term dbSNP ID References
Asthma Asthma rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283 10733466
Unknown
Disease name Disease term dbSNP ID References
Allergic rhinitis Allergic rhinitis (disorder)
Coronary heart disease Coronary heart disease rs9289231, rs281864746 21356620, 28753643
Coronary syndrome Acute Coronary Syndrome rs4986893 28753643
Eczema Eczema

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