CALB2 (calbindin 2)

Gene

• Entrez ID: 794
• Gene name: Calbindin 2
• Gene symbol: CALB2
• Synonyms: CAB29, CAL2, CR
• Chromosome: 16
• Chromosome location: 16q22.2
• Summary: This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targ

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018745	hsa-miR-335-5p	Microarray	18185580
MIRT858748	hsa-miR-1231	CLIP-seq
MIRT858749	hsa-miR-1267	CLIP-seq
MIRT858750	hsa-miR-1275	CLIP-seq
MIRT858751	hsa-miR-1293	CLIP-seq
MIRT858752	hsa-miR-2467-3p	CLIP-seq
MIRT858753	hsa-miR-298	CLIP-seq
MIRT858754	hsa-miR-30a	CLIP-seq
MIRT858755	hsa-miR-30b	CLIP-seq
MIRT858756	hsa-miR-30c	CLIP-seq
MIRT858757	hsa-miR-30d	CLIP-seq
MIRT858758	hsa-miR-30e	CLIP-seq
MIRT858759	hsa-miR-3123	CLIP-seq
MIRT858760	hsa-miR-3127-5p	CLIP-seq
MIRT858761	hsa-miR-3132	CLIP-seq
MIRT858762	hsa-miR-3144-5p	CLIP-seq
MIRT858763	hsa-miR-3162-5p	CLIP-seq
MIRT858764	hsa-miR-3170	CLIP-seq
MIRT858765	hsa-miR-342-5p	CLIP-seq
MIRT858766	hsa-miR-3529	CLIP-seq
MIRT858767	hsa-miR-3607-3p	CLIP-seq
MIRT858768	hsa-miR-3622b-5p	CLIP-seq
MIRT858769	hsa-miR-3664-5p	CLIP-seq
MIRT858770	hsa-miR-3670	CLIP-seq
MIRT858771	hsa-miR-3686	CLIP-seq
MIRT858772	hsa-miR-376c	CLIP-seq
MIRT858773	hsa-miR-379	CLIP-seq
MIRT858774	hsa-miR-3918	CLIP-seq
MIRT858775	hsa-miR-3921	CLIP-seq
MIRT858776	hsa-miR-4260	CLIP-seq
MIRT858777	hsa-miR-4288	CLIP-seq
MIRT858778	hsa-miR-4300	CLIP-seq
MIRT858779	hsa-miR-4313	CLIP-seq
MIRT858780	hsa-miR-4419a	CLIP-seq
MIRT858781	hsa-miR-4436b-3p	CLIP-seq
MIRT858782	hsa-miR-4483	CLIP-seq
MIRT858783	hsa-miR-4510	CLIP-seq
MIRT858784	hsa-miR-4520a-3p	CLIP-seq
MIRT858785	hsa-miR-4520b-3p	CLIP-seq
MIRT858786	hsa-miR-4525	CLIP-seq
MIRT858787	hsa-miR-4651	CLIP-seq
MIRT858788	hsa-miR-4653-5p	CLIP-seq
MIRT858789	hsa-miR-4664-5p	CLIP-seq
MIRT858790	hsa-miR-4665-5p	CLIP-seq
MIRT858791	hsa-miR-4682	CLIP-seq
MIRT858792	hsa-miR-4711-5p	CLIP-seq
MIRT858793	hsa-miR-4716-5p	CLIP-seq
MIRT858794	hsa-miR-4723-5p	CLIP-seq
MIRT858795	hsa-miR-4778-3p	CLIP-seq
MIRT858796	hsa-miR-485-3p	CLIP-seq
MIRT858797	hsa-miR-487a	CLIP-seq
MIRT858798	hsa-miR-490-3p	CLIP-seq
MIRT858799	hsa-miR-587	CLIP-seq
MIRT858800	hsa-miR-593	CLIP-seq
MIRT858801	hsa-miR-608	CLIP-seq
MIRT858802	hsa-miR-619	CLIP-seq
MIRT858803	hsa-miR-625	CLIP-seq
MIRT858804	hsa-miR-627	CLIP-seq
MIRT858805	hsa-miR-632	CLIP-seq
MIRT858806	hsa-miR-9	CLIP-seq
MIRT858807	hsa-miR-920	CLIP-seq
MIRT858808	hsa-miR-922	CLIP-seq
MIRT858809	hsa-miR-924	CLIP-seq
MIRT858810	hsa-miR-939	CLIP-seq
MIRT858750	hsa-miR-1275	CLIP-seq
MIRT858753	hsa-miR-298	CLIP-seq
MIRT858754	hsa-miR-30a	CLIP-seq
MIRT858755	hsa-miR-30b	CLIP-seq
MIRT858756	hsa-miR-30c	CLIP-seq
MIRT858757	hsa-miR-30d	CLIP-seq
MIRT858758	hsa-miR-30e	CLIP-seq
MIRT858759	hsa-miR-3123	CLIP-seq
MIRT858760	hsa-miR-3127-5p	CLIP-seq
MIRT858763	hsa-miR-3162-5p	CLIP-seq
MIRT1954962	hsa-miR-3689d	CLIP-seq
MIRT858774	hsa-miR-3918	CLIP-seq
MIRT858779	hsa-miR-4313	CLIP-seq
MIRT858781	hsa-miR-4436b-3p	CLIP-seq
MIRT858786	hsa-miR-4525	CLIP-seq
MIRT858790	hsa-miR-4665-5p	CLIP-seq
MIRT858792	hsa-miR-4711-5p	CLIP-seq
MIRT858793	hsa-miR-4716-5p	CLIP-seq
MIRT858794	hsa-miR-4723-5p	CLIP-seq
MIRT858803	hsa-miR-625	CLIP-seq
MIRT858808	hsa-miR-922	CLIP-seq
MIRT858750	hsa-miR-1275	CLIP-seq
MIRT2192584	hsa-miR-22	CLIP-seq
MIRT858776	hsa-miR-4260	CLIP-seq
MIRT858786	hsa-miR-4525	CLIP-seq
MIRT858787	hsa-miR-4651	CLIP-seq
MIRT858790	hsa-miR-4665-5p	CLIP-seq
MIRT858794	hsa-miR-4723-5p	CLIP-seq
MIRT858801	hsa-miR-608	CLIP-seq
MIRT858803	hsa-miR-625	CLIP-seq
MIRT858770	hsa-miR-3670	CLIP-seq
MIRT858778	hsa-miR-4300	CLIP-seq
MIRT858780	hsa-miR-4419a	CLIP-seq
MIRT858783	hsa-miR-4510	CLIP-seq
MIRT858792	hsa-miR-4711-5p	CLIP-seq
MIRT858807	hsa-miR-920	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IBA	21873635
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0005921	Component	Gap junction	IEA
GO:0030425	Component	Dendrite	IBA	21873635
GO:0032420	Component	Stereocilium	IEA
GO:0032437	Component	Cuticular plate	IEA
GO:0043005	Component	Neuron projection	IBA	21873635
GO:0043195	Component	Terminal bouton	IBA	21873635
GO:0045202	Component	Synapse	IBA	21873635
GO:0051480	Process	Regulation of cytosolic calcium ion concentration	IBA	21873635
GO:0097060	Component	Synaptic membrane	IEA
GO:0098688	Component	Parallel fiber to Purkinje cell synapse	IEA
GO:0099509	Process	Regulation of presynaptic cytosolic calcium ion concentration	IBA	21873635
GO:0099534	Function	Calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration	IEA
GO:1900271	Process	Regulation of long-term synaptic potentiation	IBA	21873635

Other IDs

• MIM: 114051
• HGNC: 1435
• e!Ensembl: ENSG00000172137

Protein

• UniProt ID: P22676
• Protein name: Calretinin (CR) (29 kDa calbindin)
• Protein function: Calcium-binding protein involved in calcium homeostasis and signal transduction. It plays a critical role in buffering intracellular calcium levels and modulating calcium-dependent signaling pathways (PubMed:2001709). Predominantly expressed in
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13499	EF-hand_7	18 → 92	EF-hand domain pair	Domain
  PF13499	EF-hand_7	109 → 180	EF-hand domain pair	Domain
  PF13202	EF-hand_5	157 → 180	EF hand	Domain
  PF13405	EF-hand_6	199 → 234	EF-hand domain	Domain

• Sequence:

  MAGPQQQPPYLHLAELTASQFLEIWKHFDADGNGYIEGKELENFFQELEKARKGSGMMSK
  SDNFGEKMKEFMQKYDKNSDGKIEMAELAQILPTEENFLLCFRQHVGSSAEFMEAWRKYD
  TDRSGYIEANELKGFLSDLLKKANRPYDEPKLQEYTQTILRMFDLNGDGKLGLSEMSRLL
  PVQENFLLKFQGMKLTSEEFNAIFTFYDKDRSGYIDEHELDALLKDLYEKNKKEMNIQQL
  TNYRKSVMSLAEAGKLYRKDLEIVLCSEPPM

• Sequence length: 271

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Amyotrophic lateral sclerosis	Amyotrophic Lateral Sclerosis, Familial	rs267607084, rs312262720, rs312262752, rs121908287, rs121908288, rs29001584, rs28941475, rs121434378, rs386134173, rs386134174, rs80356730, rs80356727, rs4884357, rs80356717, rs80356733, rs80356731, rs80356726, rs267606928, rs267606929, rs1885090126, rs121434591, rs121912431, rs121912432, rs121912433, rs121912434, rs121912435, rs121912440, rs121912436, rs121912437, rs121912438, rs121912439, rs74315452, rs121912442, rs121912443, rs121912444, rs121912446, rs121912447, rs1197141604, rs121912448, rs121912449, rs121912450, rs121912451, rs121912452, rs121912453, rs121912454, rs369600566, rs121912455, rs121912456, rs121912457, rs121912458, rs1555836889, rs121909667, rs121909668, rs121909669, rs121909671, rs121909535, rs121909537, rs121909538, rs121909539, rs121909540, rs121909542, rs121909544, rs80356734, rs367543041, rs80356740, rs80356719, rs80356721, rs80356723, rs80356725, rs387906627, rs387906628, rs387906709, rs387906710, rs387906711, rs387906829, rs387907264, rs387907265, rs387907266, rs312262739, rs312262709, rs312262749, rs200793464, rs147713329, rs312262788, rs397514262, rs63751180, rs587777132, rs730880025, rs730880026, rs730880027, rs368743618, rs730880029, rs730882255, rs730882256, rs786205611, rs121912441, rs199947197, rs780136067, rs772731615, rs879253926, rs879254294, rs764717219, rs886041390, rs750159428, rs753207473, rs267607087, rs767350733, rs778305085, rs1554707680, rs1554707622, rs1393363759, rs750959420, rs1555509569, rs1554716504, rs11556620, rs1247392012, rs142083484, rs140385286, rs749428135, rs371575563, rs1402429085, rs1218712729, rs1555179091, rs1555179087, rs746971952, rs1555836950, rs368276916, rs140376902, rs747220413, rs76731700, rs770684782, rs1200906022, rs1804449, rs1482760341, rs769898852, rs140599944, rs757972700, rs1555451521, rs1592362719, rs1555836803, rs763455928, rs1378590183, rs1583695322, rs1362178149, rs1197928094, rs368751524, rs1555509609, rs1574787779, rs1601157750, rs1301635320, rs1341055534, rs1402092579, rs1568809172, rs1555836170, rs1315541036, rs1339283341, rs1643659556, rs1644506661, rs1435710212, rs1553122918, rs1689580631, rs374047961, rs775935265, rs2076486420, rs1820836522, rs757260058, rs1844420892, rs1833371664, rs1833438306, rs1833451208, rs2083790483, rs1303294230, rs1226110412, rs2053207945, rs2053208751, rs2053501632, rs2053539304, rs1567479067, rs544088874, rs1228194239, rs1568807400, rs1169198442, rs2049594204, rs2049594311, rs1568810641, rs1568811372, rs2049618449, rs1476760624, rs2079347087	11796754
Lateral sclerosis	AMYOTROPHIC LATERAL SCLEROSIS 1, Amyotrophic Lateral Sclerosis, Sporadic	rs386134181, rs386134176, rs386134174, rs386134184, rs386134178, rs1693780539, rs1574698048	11796754
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	26198764

Unknown
Disease name	Disease term	dbSNP ID	References
Malignant mesothelioma	Malignant mesothelioma		22784439
Peritoneal neoplasms	Peritoneal Neoplasms		22784439
Peritoneal carcinomatosis	Carcinomatosis of peritoneal cavity		22784439
Uveitis	Uveitis		19578012