BCL2L14 (BCL2 like 14)

Gene

• Entrez ID: 79370
• Gene name: BCL2 like 14
• Gene symbol: BCL2L14
• Synonyms: BCLG
• Chromosome: 12
• Chromosome location: 12p13.2
• Summary: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Overexpression of this gene has be

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT450423	hsa-miR-3663-5p	PAR-CLIP	22100165
MIRT450422	hsa-miR-4677-3p	PAR-CLIP	22100165
MIRT450421	hsa-miR-4679	PAR-CLIP	22100165
MIRT450420	hsa-miR-4635	PAR-CLIP	22100165
MIRT450419	hsa-miR-570-3p	PAR-CLIP	22100165
MIRT450418	hsa-miR-8069	PAR-CLIP	22100165
MIRT450417	hsa-miR-4527	PAR-CLIP	22100165
MIRT450416	hsa-miR-6503-5p	PAR-CLIP	22100165
MIRT450415	hsa-miR-6753-3p	PAR-CLIP	22100165
MIRT450414	hsa-miR-7107-3p	PAR-CLIP	22100165
MIRT735759	hsa-miR-486-3p	Luciferase reporter assay, Western blotting, qRT-PCR	31815358
MIRT735760	hsa-miR-663a	Luciferase reporter assay, Western blotting, qRT-PCR	31815358
MIRT450423	hsa-miR-3663-5p	PAR-CLIP	22100165
MIRT450422	hsa-miR-4677-3p	PAR-CLIP	22100165
MIRT450421	hsa-miR-4679	PAR-CLIP	22100165
MIRT450420	hsa-miR-4635	PAR-CLIP	22100165
MIRT450419	hsa-miR-570-3p	PAR-CLIP	22100165
MIRT450418	hsa-miR-8069	PAR-CLIP	22100165
MIRT450417	hsa-miR-4527	PAR-CLIP	22100165
MIRT450416	hsa-miR-6503-5p	PAR-CLIP	22100165
MIRT450415	hsa-miR-6753-3p	PAR-CLIP	22100165
MIRT450414	hsa-miR-7107-3p	PAR-CLIP	22100165
MIRT819019	hsa-miR-101	CLIP-seq
MIRT819020	hsa-miR-1200	CLIP-seq
MIRT819021	hsa-miR-144	CLIP-seq
MIRT819022	hsa-miR-186	CLIP-seq
MIRT819023	hsa-miR-4502	CLIP-seq
MIRT819024	hsa-miR-4539	CLIP-seq
MIRT819025	hsa-miR-4762-5p	CLIP-seq
MIRT819026	hsa-miR-4797-3p	CLIP-seq
MIRT819027	hsa-miR-496	CLIP-seq
MIRT2180855	hsa-miR-1915	CLIP-seq
MIRT2180856	hsa-miR-3185	CLIP-seq
MIRT2180857	hsa-miR-3189-3p	CLIP-seq
MIRT2180858	hsa-miR-3649	CLIP-seq
MIRT2180859	hsa-miR-4726-3p	CLIP-seq
MIRT2180860	hsa-miR-4747-5p	CLIP-seq
MIRT2444752	hsa-miR-125a-5p	CLIP-seq
MIRT2444753	hsa-miR-125b	CLIP-seq
MIRT2180856	hsa-miR-3185	CLIP-seq
MIRT2444754	hsa-miR-4281	CLIP-seq
MIRT2444755	hsa-miR-4319	CLIP-seq
MIRT2444756	hsa-miR-4732-3p	CLIP-seq
MIRT2180860	hsa-miR-4747-5p	CLIP-seq
MIRT2444757	hsa-miR-670	CLIP-seq
MIRT2444752	hsa-miR-125a-5p	CLIP-seq
MIRT2444753	hsa-miR-125b	CLIP-seq
MIRT2484333	hsa-miR-1295	CLIP-seq
MIRT2180856	hsa-miR-3185	CLIP-seq
MIRT2484334	hsa-miR-4280	CLIP-seq
MIRT2444754	hsa-miR-4281	CLIP-seq
MIRT2444755	hsa-miR-4319	CLIP-seq
MIRT2484335	hsa-miR-4703-3p	CLIP-seq
MIRT2484336	hsa-miR-4717-5p	CLIP-seq
MIRT2444756	hsa-miR-4732-3p	CLIP-seq
MIRT2180860	hsa-miR-4747-5p	CLIP-seq
MIRT2444757	hsa-miR-670	CLIP-seq
MIRT2444752	hsa-miR-125a-5p	CLIP-seq
MIRT2444753	hsa-miR-125b	CLIP-seq
MIRT2180856	hsa-miR-3185	CLIP-seq
MIRT2444754	hsa-miR-4281	CLIP-seq
MIRT2444755	hsa-miR-4319	CLIP-seq
MIRT2444756	hsa-miR-4732-3p	CLIP-seq
MIRT2180860	hsa-miR-4747-5p	CLIP-seq
MIRT2444757	hsa-miR-670	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	11054413, 17280616, 30833792, 32296183
GO:0005829	Component	Cytosol	IDA	11054413
GO:0005829	Component	Cytosol	TAS
GO:0006915	Process	Apoptotic process	IDA	17280616
GO:0012505	Component	Endomembrane system	IEA
GO:0016020	Component	Membrane	IEA
GO:0019901	Function	Protein kinase binding	IPI	17280616
GO:0042981	Process	Regulation of apoptotic process	TAS
GO:0043229	Component	Intracellular organelle	IDA	11054413
GO:2001236	Process	Regulation of extrinsic apoptotic signaling pathway	IBA	21873635

Other IDs

• MIM: 606126
• HGNC: 16657
• e!Ensembl: ENSG00000121380

Protein

• UniProt ID: Q9BZR8
• Protein name: Apoptosis facilitator Bcl-2-like protein 14 (Bcl2-L-14) (Apoptosis regulator Bcl-G)
• Protein function: Plays a role in apoptosis.
• Sequence:

  MCSTSGCDLEEIPLDDDDLNTIEFKILAYYTRHHVFKSTPALFSPKLLRTRSLSQRGLGN
  CSANESWTEVSWPCRNSQSSEKAINLGKKKSSWKAFFGVVEKEDSQSTPAKVSAQGQRTL
  EYQDSHSQQWSRCLSNVEQCLEHEAVDPKVISIANRVAEIVYSWPPPQATQAGGFKSKEI
  FVTEGLSFQLQGHVPVASSSKKDEEEQILAKIVELLKYSGDQLERKLKKDKALMGHFQDG
  LSYSVFKTITDQVLMGVDPRGESEVKAQGFKAALVIDVTAKLTAIDNHPMNRVLGFGTKY
  LKENFSPWIQQHGGWEKILGISHEEVD

• Sequence length: 327

Pathways

Reactome:

TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Coronary artery disease	CORONARY ARTERY DISEASE, AUTOSOMAL DOMINANT 2 (disorder)	rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs405509, rs1555800701, rs1215189537
Tooth agenesis	TOOTH AGENESIS, SELECTIVE, 7	rs121908119, rs121908121, rs1881345182, rs104894467, rs28933970, rs2139108031, rs28933971, rs28933972, rs1594475481, rs2139106532, rs2139108874, rs121917720, rs121913129, rs104893852, rs104893850, rs121913130, rs1553877821, rs782540538, rs318240759, rs515726227, rs587776350, rs864309647, rs864309649, rs869320640, rs869320636, rs866789963, rs869320639, rs869320637, rs779326570, rs766021478, rs372993798, rs1057519288, rs1555316697, rs1131692057, rs1565611848, rs745522921, rs773036759

Unknown
Disease name	Disease term	dbSNP ID	References
Clinodactyly	Clinodactyly