ABHD16A (abhydrolase domain containing 16A, phospholipase)

Gene

• Entrez ID: 7920
• Gene name: Abhydrolase domain containing 16A, phospholipase
• Gene symbol: ABHD16A
• Synonyms: BAT5, D6S82E, NG26, PP199, SPG86, hBAT5
• Chromosome: 6
• Chromosome location: 6p21.33
• Summary: A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. The protein encoded by t

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020741	hsa-miR-155-5p	Proteomics	18668040
MIRT044614	hsa-miR-320a	CLASH	23622248
MIRT733181	hsa-miR-4646-5p	Immunohistochemistry (IHC), Immunoprecipitaion (IP), Luciferase reporter assay, qRT-PCR, Western blotting	33875796
MIRT759680	hsa-miR-1182	CLIP-seq
MIRT759681	hsa-miR-1193	CLIP-seq
MIRT759682	hsa-miR-1229	CLIP-seq
MIRT759683	hsa-miR-1253	CLIP-seq
MIRT759684	hsa-miR-193a-5p	CLIP-seq
MIRT759685	hsa-miR-3120-3p	CLIP-seq
MIRT759686	hsa-miR-3123	CLIP-seq
MIRT759687	hsa-miR-3154	CLIP-seq
MIRT759688	hsa-miR-3179	CLIP-seq
MIRT759689	hsa-miR-3183	CLIP-seq
MIRT759690	hsa-miR-361-3p	CLIP-seq
MIRT759691	hsa-miR-3692	CLIP-seq
MIRT759692	hsa-miR-3919	CLIP-seq
MIRT759693	hsa-miR-4279	CLIP-seq
MIRT759694	hsa-miR-4281	CLIP-seq
MIRT759695	hsa-miR-4286	CLIP-seq
MIRT759696	hsa-miR-4525	CLIP-seq
MIRT759697	hsa-miR-4710	CLIP-seq
MIRT759698	hsa-miR-4716-3p	CLIP-seq
MIRT759699	hsa-miR-4719	CLIP-seq
MIRT759700	hsa-miR-4723-3p	CLIP-seq
MIRT759701	hsa-miR-4792	CLIP-seq
MIRT1923902	hsa-miR-1265	CLIP-seq
MIRT1923903	hsa-miR-1286	CLIP-seq
MIRT1923904	hsa-miR-297	CLIP-seq
MIRT759686	hsa-miR-3123	CLIP-seq
MIRT1923905	hsa-miR-3171	CLIP-seq
MIRT1923906	hsa-miR-380	CLIP-seq
MIRT759692	hsa-miR-3919	CLIP-seq
MIRT759699	hsa-miR-4719	CLIP-seq
MIRT1923907	hsa-miR-4722-5p	CLIP-seq
MIRT1923908	hsa-miR-4781-3p	CLIP-seq
MIRT1923909	hsa-miR-567	CLIP-seq
MIRT759681	hsa-miR-1193	CLIP-seq
MIRT759686	hsa-miR-3123	CLIP-seq
MIRT759688	hsa-miR-3179	CLIP-seq
MIRT759692	hsa-miR-3919	CLIP-seq
MIRT759696	hsa-miR-4525	CLIP-seq
MIRT759698	hsa-miR-4716-3p	CLIP-seq
MIRT759699	hsa-miR-4719	CLIP-seq
MIRT759681	hsa-miR-1193	CLIP-seq
MIRT759683	hsa-miR-1253	CLIP-seq
MIRT759685	hsa-miR-3120-3p	CLIP-seq
MIRT2467386	hsa-miR-3125	CLIP-seq
MIRT759687	hsa-miR-3154	CLIP-seq
MIRT759688	hsa-miR-3179	CLIP-seq
MIRT2467387	hsa-miR-3184	CLIP-seq
MIRT759690	hsa-miR-361-3p	CLIP-seq
MIRT759691	hsa-miR-3692	CLIP-seq
MIRT2467388	hsa-miR-3916	CLIP-seq
MIRT2467389	hsa-miR-3928	CLIP-seq
MIRT2467390	hsa-miR-423-5p	CLIP-seq
MIRT759694	hsa-miR-4281	CLIP-seq
MIRT759695	hsa-miR-4286	CLIP-seq
MIRT759696	hsa-miR-4525	CLIP-seq
MIRT2467391	hsa-miR-4696	CLIP-seq
MIRT759697	hsa-miR-4710	CLIP-seq
MIRT759698	hsa-miR-4716-3p	CLIP-seq
MIRT759701	hsa-miR-4792	CLIP-seq
MIRT759681	hsa-miR-1193	CLIP-seq
MIRT759683	hsa-miR-1253	CLIP-seq
MIRT759685	hsa-miR-3120-3p	CLIP-seq
MIRT2467386	hsa-miR-3125	CLIP-seq
MIRT759687	hsa-miR-3154	CLIP-seq
MIRT759688	hsa-miR-3179	CLIP-seq
MIRT2467387	hsa-miR-3184	CLIP-seq
MIRT759690	hsa-miR-361-3p	CLIP-seq
MIRT759691	hsa-miR-3692	CLIP-seq
MIRT2467388	hsa-miR-3916	CLIP-seq
MIRT2467389	hsa-miR-3928	CLIP-seq
MIRT2467390	hsa-miR-423-5p	CLIP-seq
MIRT759694	hsa-miR-4281	CLIP-seq
MIRT759695	hsa-miR-4286	CLIP-seq
MIRT759696	hsa-miR-4525	CLIP-seq
MIRT2467391	hsa-miR-4696	CLIP-seq
MIRT759697	hsa-miR-4710	CLIP-seq
MIRT759698	hsa-miR-4716-3p	CLIP-seq
MIRT759701	hsa-miR-4792	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004620	Function	Phospholipase activity	IBA	21873635
GO:0004620	Function	Phospholipase activity	ISS
GO:0004622	Function	Lysophospholipase activity	IDA	25290914
GO:0005515	Function	Protein binding	IPI	14667819, 25416956, 29892012, 31515488, 32296183
GO:0006660	Process	Phosphatidylserine catabolic process	IBA	21873635
GO:0006660	Process	Phosphatidylserine catabolic process	ISS
GO:0008474	Function	Palmitoyl-(protein) hydrolase activity	IBA	21873635
GO:0016020	Component	Membrane	IBA	21873635
GO:0016021	Component	Integral component of membrane	IEA
GO:0018215	Process	Protein phosphopantetheinylation	IEA
GO:0047372	Function	Acylglycerol lipase activity	IBA	21873635
GO:0047372	Function	Acylglycerol lipase activity	IDA	25290914
GO:0052651	Process	Monoacylglycerol catabolic process	IBA	21873635
GO:0052651	Process	Monoacylglycerol catabolic process	IDA	25290914
GO:0098734	Process	Macromolecule depalmitoylation	IEA
GO:1905344	Process	Prostaglandin catabolic process	IDA	25290914

Other IDs

• MIM: 142620
• HGNC: 13921
• e!Ensembl: ENSG00000204427

Protein

• UniProt ID: O95870
• Protein name: Phosphatidylserine lipase ABHD16A (EC 3.1.-.-) (Alpha/beta hydrolase domain-containing protein 16A) (Abhydrolase domain-containing protein 16A) (HLA-B-associated transcript 5) (hBAT5) (Monoacylglycerol lipase ABHD16A) (EC 3.1.1.23) (Protein G5)
• Protein function: Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (By similarity). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By s
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00561	Abhydrolase_1	280 → 415	alpha/beta hydrolase fold	Domain

• Sequence:

  MAKLLSCVLGPRLYKIYRERDSERAPASVPETPTAVTAPHSSSWDTYYQPRALEKHADSI
  LALASVFWSISYYSSPFAFFYLYRKGYLSLSKVVPFSHYAGTLLLLLAGVACLRGIGRWT
  NPQYRQFITILEATHRNQSSENKRQLANYNFDFRSWPVDFHWEEPSSRKESRGGPSRRGV
  ALLRPEPLHRGTADTLLNRVKKLPCQITSYLVAHTLGRRMLYPGSVYLLQKALMPVLLQG
  QARLVEECNGRRAKLLACDGNEIDTMFVDRRGTAEPQGQKLVICCEGNAGFYEVGCVSTP
  LEAGYSVLGWNHPGFAGSTGVPFPQNEANAMDVVVQFAIHRLGFQPQDIIIYAWSIGGFT
  ATWAAMSYPDVSAMILDASFDDLVPLALKVMPDSWRGLVTRTVRQHLNLNNAEQLCRYQG
  PVLLIRRTKDEIITTTVPEDIMSNRGNDLLLKLLQHRYPRVMAEEGLRVVRQWLEASSQL
  EEASIYSRWEVEEDWCLSVLRSYQAEHGPDFPWSVGEDMSADGRRQLALFLARKHLHNFE
  ATHCTPLPAQNFQMPWHL

• Sequence length: 558

Pathways

KEGG:

Glycerolipid metabolism
Metabolic pathways

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus, Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	17632545