CCDC86 (coiled-coil domain containing 86)

Gene

• Entrez ID: 79080
• Gene name: Coiled-coil domain containing 86
• Gene symbol: CCDC86
• Synonyms: Cgr1
• Chromosome: 11
• Chromosome location: 11q12.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022797	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT049209	hsa-miR-92a-3p	CLASH	23622248
MIRT504903	hsa-miR-1226-3p	PAR-CLIP	23446348
MIRT504902	hsa-miR-4733-3p	PAR-CLIP	23446348
MIRT504901	hsa-miR-3622a-3p	PAR-CLIP	23446348
MIRT504900	hsa-miR-3622b-3p	PAR-CLIP	23446348
MIRT504898	hsa-miR-6765-3p	PAR-CLIP	23446348
MIRT504899	hsa-miR-4704-3p	PAR-CLIP	23446348
MIRT504897	hsa-miR-4267	PAR-CLIP	23446348
MIRT504896	hsa-miR-4722-3p	PAR-CLIP	23446348
MIRT504895	hsa-miR-6727-3p	PAR-CLIP	23446348
MIRT504903	hsa-miR-1226-3p	PAR-CLIP	23446348
MIRT504902	hsa-miR-4733-3p	PAR-CLIP	23446348
MIRT504901	hsa-miR-3622a-3p	PAR-CLIP	23446348
MIRT504900	hsa-miR-3622b-3p	PAR-CLIP	23446348
MIRT504898	hsa-miR-6765-3p	PAR-CLIP	23446348
MIRT504899	hsa-miR-4704-3p	PAR-CLIP	23446348
MIRT504897	hsa-miR-4267	PAR-CLIP	23446348
MIRT504896	hsa-miR-4722-3p	PAR-CLIP	23446348
MIRT504895	hsa-miR-6727-3p	PAR-CLIP	23446348
MIRT479850	hsa-miR-548az-5p	PAR-CLIP	23592263
MIRT479848	hsa-miR-548t-5p	PAR-CLIP	23592263
MIRT479847	hsa-miR-4796-3p	PAR-CLIP	23592263
MIRT479845	hsa-miR-3125	PAR-CLIP	23592263
MIRT479846	hsa-miR-3916	PAR-CLIP	23592263
MIRT479844	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT479843	hsa-miR-3914	PAR-CLIP	23592263
MIRT479842	hsa-miR-16-1-3p	PAR-CLIP	23592263
MIRT479841	hsa-miR-622	PAR-CLIP	23592263
MIRT479840	hsa-miR-93-3p	PAR-CLIP	23592263
MIRT479839	hsa-miR-3692-5p	PAR-CLIP	23592263
MIRT479838	hsa-miR-3928-3p	PAR-CLIP	23592263
MIRT479837	hsa-miR-4731-5p	PAR-CLIP	23592263
MIRT479836	hsa-miR-5589-5p	PAR-CLIP	23592263
MIRT479835	hsa-miR-185-5p	PAR-CLIP	23592263
MIRT479834	hsa-miR-4306	PAR-CLIP	23592263
MIRT479833	hsa-miR-4644	PAR-CLIP	23592263
MIRT479832	hsa-miR-5192	PAR-CLIP	23592263
MIRT479831	hsa-miR-222-5p	PAR-CLIP	23592263
MIRT479830	hsa-miR-6071	PAR-CLIP	23592263
MIRT479829	hsa-miR-30a-3p	PAR-CLIP	23592263
MIRT479828	hsa-miR-30d-3p	PAR-CLIP	23592263
MIRT479827	hsa-miR-30e-3p	PAR-CLIP	23592263
MIRT504903	hsa-miR-1226-3p	PAR-CLIP	26701625
MIRT504901	hsa-miR-3622a-3p	PAR-CLIP	26701625
MIRT504900	hsa-miR-3622b-3p	PAR-CLIP	26701625
MIRT504897	hsa-miR-4267	PAR-CLIP	26701625
MIRT504899	hsa-miR-4704-3p	PAR-CLIP	26701625
MIRT504896	hsa-miR-4722-3p	PAR-CLIP	26701625
MIRT504902	hsa-miR-4733-3p	PAR-CLIP	26701625
MIRT504895	hsa-miR-6727-3p	PAR-CLIP	26701625
MIRT504898	hsa-miR-6765-3p	PAR-CLIP	26701625
MIRT504903	hsa-miR-1226-3p	PAR-CLIP	23446348
MIRT504902	hsa-miR-4733-3p	PAR-CLIP	23446348
MIRT504901	hsa-miR-3622a-3p	PAR-CLIP	23446348
MIRT504900	hsa-miR-3622b-3p	PAR-CLIP	23446348
MIRT504898	hsa-miR-6765-3p	PAR-CLIP	23446348
MIRT504899	hsa-miR-4704-3p	PAR-CLIP	23446348
MIRT504897	hsa-miR-4267	PAR-CLIP	23446348
MIRT504896	hsa-miR-4722-3p	PAR-CLIP	23446348
MIRT504895	hsa-miR-6727-3p	PAR-CLIP	23446348
MIRT504903	hsa-miR-1226-3p	PAR-CLIP	23446348
MIRT504902	hsa-miR-4733-3p	PAR-CLIP	23446348
MIRT504901	hsa-miR-3622a-3p	PAR-CLIP	23446348
MIRT504900	hsa-miR-3622b-3p	PAR-CLIP	23446348
MIRT504898	hsa-miR-6765-3p	PAR-CLIP	23446348
MIRT504899	hsa-miR-4704-3p	PAR-CLIP	23446348
MIRT504897	hsa-miR-4267	PAR-CLIP	23446348
MIRT504896	hsa-miR-4722-3p	PAR-CLIP	23446348
MIRT504895	hsa-miR-6727-3p	PAR-CLIP	23446348
MIRT479850	hsa-miR-548az-5p	PAR-CLIP	23592263
MIRT479848	hsa-miR-548t-5p	PAR-CLIP	23592263
MIRT479847	hsa-miR-4796-3p	PAR-CLIP	23592263
MIRT479845	hsa-miR-3125	PAR-CLIP	23592263
MIRT479846	hsa-miR-3916	PAR-CLIP	23592263
MIRT479844	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT479843	hsa-miR-3914	PAR-CLIP	23592263
MIRT479842	hsa-miR-16-1-3p	PAR-CLIP	23592263
MIRT479841	hsa-miR-622	PAR-CLIP	23592263
MIRT479840	hsa-miR-93-3p	PAR-CLIP	23592263
MIRT479839	hsa-miR-3692-5p	PAR-CLIP	23592263
MIRT479838	hsa-miR-3928-3p	PAR-CLIP	23592263
MIRT479837	hsa-miR-4731-5p	PAR-CLIP	23592263
MIRT479836	hsa-miR-5589-5p	PAR-CLIP	23592263
MIRT479835	hsa-miR-185-5p	PAR-CLIP	23592263
MIRT479834	hsa-miR-4306	PAR-CLIP	23592263
MIRT479833	hsa-miR-4644	PAR-CLIP	23592263
MIRT479832	hsa-miR-5192	PAR-CLIP	23592263
MIRT479831	hsa-miR-222-5p	PAR-CLIP	23592263
MIRT479830	hsa-miR-6071	PAR-CLIP	23592263
MIRT479829	hsa-miR-30a-3p	PAR-CLIP	23592263
MIRT479828	hsa-miR-30d-3p	PAR-CLIP	23592263
MIRT479827	hsa-miR-30e-3p	PAR-CLIP	23592263
MIRT870071	hsa-miR-1207-5p	CLIP-seq
MIRT870072	hsa-miR-1231	CLIP-seq
MIRT870073	hsa-miR-133a	CLIP-seq
MIRT870074	hsa-miR-133b	CLIP-seq
MIRT870075	hsa-miR-136	CLIP-seq
MIRT870076	hsa-miR-1827	CLIP-seq
MIRT870077	hsa-miR-2682	CLIP-seq
MIRT870078	hsa-miR-3144-5p	CLIP-seq
MIRT870079	hsa-miR-3191	CLIP-seq
MIRT870080	hsa-miR-34a	CLIP-seq
MIRT870081	hsa-miR-34c-5p	CLIP-seq
MIRT870082	hsa-miR-3616-3p	CLIP-seq
MIRT870083	hsa-miR-3945	CLIP-seq
MIRT870084	hsa-miR-4251	CLIP-seq
MIRT870085	hsa-miR-4268	CLIP-seq
MIRT870086	hsa-miR-4288	CLIP-seq
MIRT870087	hsa-miR-4307	CLIP-seq
MIRT870088	hsa-miR-4436b-3p	CLIP-seq
MIRT870089	hsa-miR-449a	CLIP-seq
MIRT870090	hsa-miR-449b	CLIP-seq
MIRT870091	hsa-miR-449c	CLIP-seq
MIRT870092	hsa-miR-4652-5p	CLIP-seq
MIRT870093	hsa-miR-4663	CLIP-seq
MIRT870094	hsa-miR-4667-5p	CLIP-seq
MIRT870095	hsa-miR-4700-5p	CLIP-seq
MIRT870096	hsa-miR-4728-3p	CLIP-seq
MIRT870097	hsa-miR-4742-3p	CLIP-seq
MIRT870098	hsa-miR-4761-3p	CLIP-seq
MIRT870099	hsa-miR-4763-3p	CLIP-seq
MIRT870100	hsa-miR-4768-5p	CLIP-seq
MIRT870101	hsa-miR-4795-3p	CLIP-seq
MIRT870102	hsa-miR-539	CLIP-seq
MIRT870103	hsa-miR-601	CLIP-seq
MIRT870104	hsa-miR-632	CLIP-seq
MIRT870105	hsa-miR-9	CLIP-seq
MIRT870071	hsa-miR-1207-5p	CLIP-seq
MIRT1958322	hsa-miR-1236	CLIP-seq
MIRT1958323	hsa-miR-129-5p	CLIP-seq
MIRT1958324	hsa-miR-151-3p	CLIP-seq
MIRT1958325	hsa-miR-1915	CLIP-seq
MIRT1958326	hsa-miR-216b	CLIP-seq
MIRT1958327	hsa-miR-3160-3p	CLIP-seq
MIRT1958328	hsa-miR-3194-3p	CLIP-seq
MIRT870082	hsa-miR-3616-3p	CLIP-seq
MIRT1958329	hsa-miR-4258	CLIP-seq
MIRT870085	hsa-miR-4268	CLIP-seq
MIRT1958330	hsa-miR-4300	CLIP-seq
MIRT870088	hsa-miR-4436b-3p	CLIP-seq
MIRT1958331	hsa-miR-4463	CLIP-seq
MIRT1958332	hsa-miR-4499	CLIP-seq
MIRT870094	hsa-miR-4667-5p	CLIP-seq
MIRT870095	hsa-miR-4700-5p	CLIP-seq
MIRT1958333	hsa-miR-4718	CLIP-seq
MIRT1958334	hsa-miR-4726-3p	CLIP-seq
MIRT1958335	hsa-miR-4727-5p	CLIP-seq
MIRT1958336	hsa-miR-4755-3p	CLIP-seq
MIRT870099	hsa-miR-4763-3p	CLIP-seq
MIRT1958337	hsa-miR-4769-3p	CLIP-seq
MIRT1958338	hsa-miR-4772-3p	CLIP-seq
MIRT1958339	hsa-miR-767-3p	CLIP-seq
MIRT1958340	hsa-miR-920	CLIP-seq
MIRT870071	hsa-miR-1207-5p	CLIP-seq
MIRT2195101	hsa-miR-1226	CLIP-seq
MIRT870073	hsa-miR-133a	CLIP-seq
MIRT870074	hsa-miR-133b	CLIP-seq
MIRT870075	hsa-miR-136	CLIP-seq
MIRT870082	hsa-miR-3616-3p	CLIP-seq
MIRT2195102	hsa-miR-3915	CLIP-seq
MIRT2195103	hsa-miR-3928	CLIP-seq
MIRT870085	hsa-miR-4268	CLIP-seq
MIRT2195104	hsa-miR-4420	CLIP-seq
MIRT870088	hsa-miR-4436b-3p	CLIP-seq
MIRT870093	hsa-miR-4663	CLIP-seq
MIRT870098	hsa-miR-4761-3p	CLIP-seq
MIRT870099	hsa-miR-4763-3p	CLIP-seq
MIRT870105	hsa-miR-9	CLIP-seq
MIRT870094	hsa-miR-4667-5p	CLIP-seq
MIRT870095	hsa-miR-4700-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005515	Function	Protein binding	IPI	15607035
GO:0005654	Component	Nucleoplasm	IDA
GO:0005694	Component	Chromosome	IDA
GO:0005730	Component	Nucleolus	IBA	21873635
GO:0005730	Component	Nucleolus	IDA
GO:0016032	Process	Viral process	IEA

Other IDs

• MIM: 611293
• HGNC: 28359
• e!Ensembl: ENSG00000110104

Protein

• UniProt ID: Q9H6F5
• Protein name: Coiled-coil domain-containing protein 86 (Cytokine-induced protein with coiled-coil domain)
• Protein function: Required for proper chromosome segregation during mitosis and error-free mitotic progression.
• PDB: 8FL0, 8FL2, 8FL3, 8FL4, 8INK, 8IPD, 8IPX, 8IPY, 8IR1, 8IR3
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03879	Cgr1	236 → 342	Cgr1 family	Coiled-coil

• Sequence:

  MDTPLRRSRRLGGLRPESPESLTSVSRTRRALVEFESNPEETREPGSPPSVQRAGLGSPE
  RPPKTSPGSPRLQQGAGLESPQGQPEPGAASPQRQQDLHLESPQRQPEYSPESPRCQPKP
  SEEAPKCSQDQGVLASELAQNKEELTPGAPQHQLPPVPGSPEPYPGQQAPGPEPSQPLLE
  LTPRAPGSPRGQHEPSKPPPAGETVTGGFGAKKRKGSSSQAPASKKLNKEELPVIPKGKP
  KSGRVWKDRSKKRFSQMLQDKPLRTSWQRKMKERQERKLAKDFARHLEEEKERRRQEKKQ
  RRAENLKRRLENERKAEVVQVIRNPAKLKRAKKKQLRSIEKRDTLALLQKQPPQQPAAKI
  

• Sequence length: 360

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Diffuse lymphoma	Diffuse Large B-Cell Lymphoma	rs121912651, rs121913289, rs121913293, rs878854402, rs869025340, rs1349928568, rs1569115687, rs121913291	23828858
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	23439384