CENPM (centromere protein M)

Gene

• Entrez ID: 79019
• Gene name: Centromere protein M
• Gene symbol: CENPM
• Synonyms: C22orf18, CENP-M, PANE1
• Chromosome: 22
• Chromosome location: 22q13.2
• Summary: The protein encoded by this gene is an inner protein of the kinetochore, the multi-protein complex that binds spindle microtubules to regulate chromosome segregation during cell division. It belongs to the constitutive centromere-associated network protei

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT044255	hsa-miR-106b-5p	CLASH	23622248
MIRT709253	hsa-miR-6072	HITS-CLIP	19536157
MIRT709251	hsa-miR-6891-3p	HITS-CLIP	19536157
MIRT709252	hsa-miR-136-5p	HITS-CLIP	19536157
MIRT709249	hsa-miR-4468	HITS-CLIP	19536157
MIRT709250	hsa-miR-4792	HITS-CLIP	19536157
MIRT709248	hsa-miR-130a-5p	HITS-CLIP	19536157
MIRT709247	hsa-miR-23a-3p	HITS-CLIP	19536157
MIRT709246	hsa-miR-23b-3p	HITS-CLIP	19536157
MIRT709245	hsa-miR-23c	HITS-CLIP	19536157
MIRT691293	hsa-miR-34b-3p	HITS-CLIP	23313552
MIRT631272	hsa-miR-216a-5p	HITS-CLIP	23313552
MIRT691292	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT691291	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT691290	hsa-miR-940	HITS-CLIP	23313552
MIRT691289	hsa-miR-3929	HITS-CLIP	23313552
MIRT691288	hsa-miR-4419b	HITS-CLIP	23313552
MIRT691287	hsa-miR-4478	HITS-CLIP	23313552
MIRT691286	hsa-miR-3614-5p	HITS-CLIP	23313552
MIRT691285	hsa-miR-6500-3p	HITS-CLIP	23313552
MIRT691284	hsa-miR-1207-3p	HITS-CLIP	23313552
MIRT691283	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT691282	hsa-miR-6787-3p	HITS-CLIP	23313552
MIRT691281	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT691280	hsa-miR-1827	HITS-CLIP	23313552
MIRT691279	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT691278	hsa-miR-423-3p	HITS-CLIP	23313552
MIRT691277	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT691276	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT691275	hsa-miR-665	HITS-CLIP	23313552
MIRT631272	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT631271	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT631269	hsa-miR-8088	HITS-CLIP	23824327
MIRT631270	hsa-miR-1267	HITS-CLIP	23824327
MIRT631268	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT631267	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT631266	hsa-miR-3135b	HITS-CLIP	23824327
MIRT631265	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT631264	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT631262	hsa-miR-3652	HITS-CLIP	23824327
MIRT631263	hsa-miR-4430	HITS-CLIP	23824327
MIRT631261	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT631260	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT631259	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT631258	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT631257	hsa-miR-5698	HITS-CLIP	23824327
MIRT631272	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT631271	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT631269	hsa-miR-8088	HITS-CLIP	23824327
MIRT631270	hsa-miR-1267	HITS-CLIP	23824327
MIRT631268	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT631266	hsa-miR-3135b	HITS-CLIP	23824327
MIRT631265	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT631264	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT631262	hsa-miR-3652	HITS-CLIP	23824327
MIRT631263	hsa-miR-4430	HITS-CLIP	23824327
MIRT631261	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT631260	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT631259	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT631258	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT631257	hsa-miR-5698	HITS-CLIP	23824327
MIRT644037	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT644036	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT644035	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT644034	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT644033	hsa-miR-29b-1-5p	HITS-CLIP	23824327
MIRT644032	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT644031	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT644030	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT644029	hsa-miR-29b-2-5p	HITS-CLIP	23824327
MIRT644028	hsa-miR-498	HITS-CLIP	23824327
MIRT631272	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT631271	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT631269	hsa-miR-8088	HITS-CLIP	23824327
MIRT631270	hsa-miR-1267	HITS-CLIP	23824327
MIRT631268	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT631267	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT631266	hsa-miR-3135b	HITS-CLIP	23824327
MIRT631265	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT631264	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT631262	hsa-miR-3652	HITS-CLIP	23824327
MIRT631263	hsa-miR-4430	HITS-CLIP	23824327
MIRT631261	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT631260	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT631259	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT631258	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT631257	hsa-miR-5698	HITS-CLIP	23824327
MIRT709253	hsa-miR-6072	HITS-CLIP	19536157
MIRT709251	hsa-miR-6891-3p	HITS-CLIP	19536157
MIRT709252	hsa-miR-136-5p	HITS-CLIP	19536157
MIRT709249	hsa-miR-4468	HITS-CLIP	19536157
MIRT709250	hsa-miR-4792	HITS-CLIP	19536157
MIRT709248	hsa-miR-130a-5p	HITS-CLIP	19536157
MIRT709247	hsa-miR-23a-3p	HITS-CLIP	19536157
MIRT709246	hsa-miR-23b-3p	HITS-CLIP	19536157
MIRT709245	hsa-miR-23c	HITS-CLIP	19536157
MIRT691293	hsa-miR-34b-3p	HITS-CLIP	23313552
MIRT631272	hsa-miR-216a-5p	HITS-CLIP	23313552
MIRT691292	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT691291	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT691290	hsa-miR-940	HITS-CLIP	23313552
MIRT691289	hsa-miR-3929	HITS-CLIP	23313552
MIRT691288	hsa-miR-4419b	HITS-CLIP	23313552
MIRT691287	hsa-miR-4478	HITS-CLIP	23313552
MIRT691286	hsa-miR-3614-5p	HITS-CLIP	23313552
MIRT691285	hsa-miR-6500-3p	HITS-CLIP	23313552
MIRT691284	hsa-miR-1207-3p	HITS-CLIP	23313552
MIRT691283	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT691282	hsa-miR-6787-3p	HITS-CLIP	23313552
MIRT691281	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT691280	hsa-miR-1827	HITS-CLIP	23313552
MIRT691279	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT691278	hsa-miR-423-3p	HITS-CLIP	23313552
MIRT691277	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT691276	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT691275	hsa-miR-665	HITS-CLIP	23313552
MIRT631272	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT631271	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT631269	hsa-miR-8088	HITS-CLIP	23824327
MIRT631270	hsa-miR-1267	HITS-CLIP	23824327
MIRT631268	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT631267	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT631266	hsa-miR-3135b	HITS-CLIP	23824327
MIRT631265	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT631264	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT631262	hsa-miR-3652	HITS-CLIP	23824327
MIRT631263	hsa-miR-4430	HITS-CLIP	23824327
MIRT631261	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT631260	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT631259	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT631258	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT631257	hsa-miR-5698	HITS-CLIP	23824327
MIRT631272	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT631271	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT631269	hsa-miR-8088	HITS-CLIP	23824327
MIRT631270	hsa-miR-1267	HITS-CLIP	23824327
MIRT631268	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT631266	hsa-miR-3135b	HITS-CLIP	23824327
MIRT631265	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT631264	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT631262	hsa-miR-3652	HITS-CLIP	23824327
MIRT631263	hsa-miR-4430	HITS-CLIP	23824327
MIRT631261	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT631260	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT631259	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT631258	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT631257	hsa-miR-5698	HITS-CLIP	23824327
MIRT644037	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT644036	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT644035	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT644034	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT644033	hsa-miR-29b-1-5p	HITS-CLIP	23824327
MIRT644032	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT644031	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT644030	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT644029	hsa-miR-29b-2-5p	HITS-CLIP	23824327
MIRT644028	hsa-miR-498	HITS-CLIP	23824327
MIRT631272	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT631271	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT631269	hsa-miR-8088	HITS-CLIP	23824327
MIRT631270	hsa-miR-1267	HITS-CLIP	23824327
MIRT631268	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT631267	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT631266	hsa-miR-3135b	HITS-CLIP	23824327
MIRT631265	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT631264	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT631262	hsa-miR-3652	HITS-CLIP	23824327
MIRT631263	hsa-miR-4430	HITS-CLIP	23824327
MIRT631261	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT631260	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT631259	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT631258	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT631257	hsa-miR-5698	HITS-CLIP	23824327
MIRT885028	hsa-miR-139-5p	CLIP-seq
MIRT885029	hsa-miR-1913	CLIP-seq
MIRT885030	hsa-miR-296-5p	CLIP-seq
MIRT885031	hsa-miR-324-3p	CLIP-seq
MIRT885032	hsa-miR-3689a-3p	CLIP-seq
MIRT885033	hsa-miR-3689c	CLIP-seq
MIRT885034	hsa-miR-4313	CLIP-seq
MIRT885035	hsa-miR-4481	CLIP-seq
MIRT885036	hsa-miR-4489	CLIP-seq
MIRT885037	hsa-miR-4648	CLIP-seq
MIRT885038	hsa-miR-4654	CLIP-seq
MIRT885039	hsa-miR-4727-5p	CLIP-seq
MIRT885040	hsa-miR-4728-5p	CLIP-seq
MIRT885041	hsa-miR-4745-5p	CLIP-seq
MIRT885042	hsa-miR-4769-5p	CLIP-seq
MIRT885043	hsa-miR-548v	CLIP-seq
MIRT885044	hsa-miR-639	CLIP-seq
MIRT885045	hsa-miR-720	CLIP-seq
MIRT885046	hsa-miR-103a	CLIP-seq
MIRT885047	hsa-miR-107	CLIP-seq
MIRT885048	hsa-miR-1184	CLIP-seq
MIRT885049	hsa-miR-1205	CLIP-seq
MIRT885050	hsa-miR-370	CLIP-seq
MIRT885051	hsa-miR-4418	CLIP-seq
MIRT885052	hsa-miR-509-3-5p	CLIP-seq
MIRT885053	hsa-miR-509-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000777	Component	Condensed chromosome kinetochore	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0034080	Process	CENP-A containing nucleosome assembly	TAS

Other IDs

• MIM: 610152
• HGNC: 18352
• e!Ensembl: ENSG00000100162

Protein

• UniProt ID: Q9NSP4
• Protein name: Centromere protein M (CENP-M) (Interphase centromere complex protein 39) (Proliferation-associated nuclear element protein 1)
• Protein function: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal)
• PDB: 4P0T, 4WAU, 7PKN, 7QOO, 7R5S, 7R5V, 7XHN, 7XHO, 7YWX, 7YYH
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF11111	CENP-M	1 → 172	Centromere protein M (CENP-M)	Family

• Sequence:

  MSVLRPLDKLPGLNTATILLVGTEDALLQQLADSMLKEDCASELKVHLAKSLPLPSSVNR
  PRIDLIVFVVNLHSKYSLQNTEESLRHVDASFFLGKVCFLATGAGRESHCSIHRHTVVKL
  AHTYQSPLLYCDLEVEGFRATMAQRLVRVLQICAGHVPGVSALNLLSLLRSSEGPSLEDL
  

• Sequence length: 180

Pathways

Reactome:

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Deposition of new CENPA-containing nucleosomes at the centromere
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	26198764

Unknown
Disease name	Disease term	dbSNP ID	References
Liver carcinoma	Liver carcinoma		28284560