USP7 (ubiquitin specific peptidase 7)

Gene

• Entrez ID: 7874
• Gene name: Ubiquitin specific peptidase 7
• Gene symbol: USP7
• Synonyms: C16DELp13.2, DEL16P13.2, HAFOUS, HAUSP, TEF1
• Chromosome: 16
• Chromosome location: 16p13.2
• Summary: The protein encoded by this gene belongs to the peptidase C19 family, which includes ubiquitinyl hydrolases. This protein deubiquitinates target proteins such as p53 (a tumor suppressor protein) and WASH (essential for endosomal protein recycling), and re

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs781247345	G>A,T	Pathogenic	Coding sequence variant, non coding transcript variant, stop gained, synonymous variant
rs1555462347	CT>-	Likely-pathogenic	Frameshift variant, non coding transcript variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT030771	hsa-miR-21-5p	Microarray	18591254
MIRT031560	hsa-miR-16-5p	Proteomics	18668040
MIRT050139	hsa-miR-26a-5p	CLASH	23622248
MIRT040289	hsa-miR-615-3p	CLASH	23622248
MIRT036837	hsa-miR-877-3p	CLASH	23622248
MIRT036643	hsa-miR-935	CLASH	23622248
MIRT1480621	hsa-miR-1206	CLIP-seq
MIRT1480622	hsa-miR-1226	CLIP-seq
MIRT1480623	hsa-miR-1298	CLIP-seq
MIRT1480624	hsa-miR-3160-5p	CLIP-seq
MIRT1480625	hsa-miR-3163	CLIP-seq
MIRT1480626	hsa-miR-3180-5p	CLIP-seq
MIRT1480627	hsa-miR-338-3p	CLIP-seq
MIRT1480628	hsa-miR-340	CLIP-seq
MIRT1480629	hsa-miR-3591-3p	CLIP-seq
MIRT1480630	hsa-miR-3613-3p	CLIP-seq
MIRT1480631	hsa-miR-3655	CLIP-seq
MIRT1480632	hsa-miR-371b-5p	CLIP-seq
MIRT1480633	hsa-miR-3919	CLIP-seq
MIRT1480634	hsa-miR-3943	CLIP-seq
MIRT1480635	hsa-miR-4282	CLIP-seq
MIRT1480636	hsa-miR-4436b-3p	CLIP-seq
MIRT1480637	hsa-miR-4436b-5p	CLIP-seq
MIRT1480638	hsa-miR-4477a	CLIP-seq
MIRT1480639	hsa-miR-4530	CLIP-seq
MIRT1480640	hsa-miR-4642	CLIP-seq
MIRT1480641	hsa-miR-4666-5p	CLIP-seq
MIRT1480642	hsa-miR-4700-3p	CLIP-seq
MIRT1480643	hsa-miR-4724-5p	CLIP-seq
MIRT1480644	hsa-miR-4786-3p	CLIP-seq
MIRT1480645	hsa-miR-4797-5p	CLIP-seq
MIRT1480646	hsa-miR-545	CLIP-seq
MIRT1480647	hsa-miR-548an	CLIP-seq
MIRT1480648	hsa-miR-548p	CLIP-seq
MIRT1480649	hsa-miR-571	CLIP-seq
MIRT1480650	hsa-miR-578	CLIP-seq
MIRT1480651	hsa-miR-618	CLIP-seq
MIRT1480652	hsa-miR-634	CLIP-seq
MIRT1480653	hsa-miR-664	CLIP-seq
MIRT2144588	hsa-miR-1178	CLIP-seq
MIRT2144589	hsa-miR-1207-3p	CLIP-seq
MIRT2144590	hsa-miR-3135b	CLIP-seq
MIRT2144591	hsa-miR-3150b-3p	CLIP-seq
MIRT1480624	hsa-miR-3160-5p	CLIP-seq
MIRT2144592	hsa-miR-3166	CLIP-seq
MIRT2144593	hsa-miR-3179	CLIP-seq
MIRT1480626	hsa-miR-3180-5p	CLIP-seq
MIRT2144594	hsa-miR-3202	CLIP-seq
MIRT1480630	hsa-miR-3613-3p	CLIP-seq
MIRT2144595	hsa-miR-361-3p	CLIP-seq
MIRT1480631	hsa-miR-3655	CLIP-seq
MIRT1480632	hsa-miR-371b-5p	CLIP-seq
MIRT2144596	hsa-miR-374a	CLIP-seq
MIRT2144597	hsa-miR-374b	CLIP-seq
MIRT1480633	hsa-miR-3919	CLIP-seq
MIRT2144598	hsa-miR-4290	CLIP-seq
MIRT2144599	hsa-miR-4418	CLIP-seq
MIRT1480636	hsa-miR-4436b-3p	CLIP-seq
MIRT1480637	hsa-miR-4436b-5p	CLIP-seq
MIRT2144600	hsa-miR-4476	CLIP-seq
MIRT1480639	hsa-miR-4530	CLIP-seq
MIRT2144601	hsa-miR-4632	CLIP-seq
MIRT2144602	hsa-miR-4639-5p	CLIP-seq
MIRT1480640	hsa-miR-4642	CLIP-seq
MIRT1480643	hsa-miR-4724-5p	CLIP-seq
MIRT2144603	hsa-miR-4729	CLIP-seq
MIRT2144604	hsa-miR-4763-5p	CLIP-seq
MIRT2144605	hsa-miR-4771	CLIP-seq
MIRT2144606	hsa-miR-4784	CLIP-seq
MIRT1480644	hsa-miR-4786-3p	CLIP-seq
MIRT1480645	hsa-miR-4797-5p	CLIP-seq
MIRT2144607	hsa-miR-509-3-5p	CLIP-seq
MIRT2144608	hsa-miR-509-5p	CLIP-seq
MIRT1480650	hsa-miR-578	CLIP-seq
MIRT2144609	hsa-miR-579	CLIP-seq
MIRT2144610	hsa-miR-589	CLIP-seq
MIRT1480651	hsa-miR-618	CLIP-seq
MIRT2144611	hsa-miR-628-5p	CLIP-seq
MIRT2144612	hsa-miR-765	CLIP-seq
MIRT2144588	hsa-miR-1178	CLIP-seq
MIRT2144589	hsa-miR-1207-3p	CLIP-seq
MIRT1480622	hsa-miR-1226	CLIP-seq
MIRT2364965	hsa-miR-124	CLIP-seq
MIRT2364966	hsa-miR-1264	CLIP-seq
MIRT2364967	hsa-miR-1323	CLIP-seq
MIRT2144590	hsa-miR-3135b	CLIP-seq
MIRT2144591	hsa-miR-3150b-3p	CLIP-seq
MIRT2144592	hsa-miR-3166	CLIP-seq
MIRT2364968	hsa-miR-3173-3p	CLIP-seq
MIRT2364969	hsa-miR-3177-5p	CLIP-seq
MIRT1480626	hsa-miR-3180-5p	CLIP-seq
MIRT2364970	hsa-miR-329	CLIP-seq
MIRT1480627	hsa-miR-338-3p	CLIP-seq
MIRT2364971	hsa-miR-346	CLIP-seq
MIRT1480630	hsa-miR-3613-3p	CLIP-seq
MIRT2364972	hsa-miR-3614-5p	CLIP-seq
MIRT2364973	hsa-miR-3616-3p	CLIP-seq
MIRT2364974	hsa-miR-3622a-3p	CLIP-seq
MIRT2364975	hsa-miR-3622b-3p	CLIP-seq
MIRT2364976	hsa-miR-362-3p	CLIP-seq
MIRT2364977	hsa-miR-3678-3p	CLIP-seq
MIRT2364978	hsa-miR-3714	CLIP-seq
MIRT1480632	hsa-miR-371b-5p	CLIP-seq
MIRT2144596	hsa-miR-374a	CLIP-seq
MIRT2144597	hsa-miR-374b	CLIP-seq
MIRT1480633	hsa-miR-3919	CLIP-seq
MIRT2364979	hsa-miR-3941	CLIP-seq
MIRT2364980	hsa-miR-4276	CLIP-seq
MIRT1480635	hsa-miR-4282	CLIP-seq
MIRT2364981	hsa-miR-4305	CLIP-seq
MIRT2144599	hsa-miR-4418	CLIP-seq
MIRT1480636	hsa-miR-4436b-3p	CLIP-seq
MIRT2364982	hsa-miR-4480	CLIP-seq
MIRT2364983	hsa-miR-4514	CLIP-seq
MIRT1480639	hsa-miR-4530	CLIP-seq
MIRT2144601	hsa-miR-4632	CLIP-seq
MIRT2364984	hsa-miR-4637	CLIP-seq
MIRT2364985	hsa-miR-4645-3p	CLIP-seq
MIRT2364986	hsa-miR-4645-5p	CLIP-seq
MIRT2364987	hsa-miR-4673	CLIP-seq
MIRT2364988	hsa-miR-4692	CLIP-seq
MIRT1480642	hsa-miR-4700-3p	CLIP-seq
MIRT2364989	hsa-miR-4727-5p	CLIP-seq
MIRT2144604	hsa-miR-4763-5p	CLIP-seq
MIRT2364990	hsa-miR-4769-3p	CLIP-seq
MIRT2144605	hsa-miR-4771	CLIP-seq
MIRT2364991	hsa-miR-4779	CLIP-seq
MIRT2144606	hsa-miR-4784	CLIP-seq
MIRT1480644	hsa-miR-4786-3p	CLIP-seq
MIRT1480645	hsa-miR-4797-5p	CLIP-seq
MIRT2364992	hsa-miR-500a	CLIP-seq
MIRT2364993	hsa-miR-501-5p	CLIP-seq
MIRT2364994	hsa-miR-503	CLIP-seq
MIRT2364995	hsa-miR-506	CLIP-seq
MIRT2144607	hsa-miR-509-3-5p	CLIP-seq
MIRT2144608	hsa-miR-509-5p	CLIP-seq
MIRT2364996	hsa-miR-5096	CLIP-seq
MIRT2364997	hsa-miR-520d-5p	CLIP-seq
MIRT2364998	hsa-miR-524-5p	CLIP-seq
MIRT1480646	hsa-miR-545	CLIP-seq
MIRT1480647	hsa-miR-548an	CLIP-seq
MIRT2364999	hsa-miR-548o	CLIP-seq
MIRT1480648	hsa-miR-548p	CLIP-seq
MIRT1480649	hsa-miR-571	CLIP-seq
MIRT2144609	hsa-miR-579	CLIP-seq
MIRT2144610	hsa-miR-589	CLIP-seq
MIRT2365000	hsa-miR-603	CLIP-seq
MIRT2144611	hsa-miR-628-5p	CLIP-seq
MIRT1480652	hsa-miR-634	CLIP-seq
MIRT2144612	hsa-miR-765	CLIP-seq
MIRT2365001	hsa-miR-922	CLIP-seq
MIRT2144589	hsa-miR-1207-3p	CLIP-seq
MIRT2144590	hsa-miR-3135b	CLIP-seq
MIRT2144591	hsa-miR-3150b-3p	CLIP-seq
MIRT2364973	hsa-miR-3616-3p	CLIP-seq
MIRT2364983	hsa-miR-4514	CLIP-seq
MIRT2364988	hsa-miR-4692	CLIP-seq
MIRT2144606	hsa-miR-4784	CLIP-seq
MIRT2144610	hsa-miR-589	CLIP-seq
MIRT2144612	hsa-miR-765	CLIP-seq
MIRT2396766	hsa-miR-767-5p	CLIP-seq
MIRT2144588	hsa-miR-1178	CLIP-seq
MIRT2144589	hsa-miR-1207-3p	CLIP-seq
MIRT2658722	hsa-miR-1273g	CLIP-seq
MIRT2658723	hsa-miR-1976	CLIP-seq
MIRT2658724	hsa-miR-2052	CLIP-seq
MIRT2658725	hsa-miR-2117	CLIP-seq
MIRT2144590	hsa-miR-3135b	CLIP-seq
MIRT2658726	hsa-miR-3148	CLIP-seq
MIRT2144591	hsa-miR-3150b-3p	CLIP-seq
MIRT1480625	hsa-miR-3163	CLIP-seq
MIRT2144593	hsa-miR-3179	CLIP-seq
MIRT2144594	hsa-miR-3202	CLIP-seq
MIRT1480628	hsa-miR-340	CLIP-seq
MIRT1480630	hsa-miR-3613-3p	CLIP-seq
MIRT2144595	hsa-miR-361-3p	CLIP-seq
MIRT2658727	hsa-miR-3688-5p	CLIP-seq
MIRT2658728	hsa-miR-3690	CLIP-seq
MIRT1480632	hsa-miR-371b-5p	CLIP-seq
MIRT1480633	hsa-miR-3919	CLIP-seq
MIRT2658729	hsa-miR-3925-3p	CLIP-seq
MIRT1480634	hsa-miR-3943	CLIP-seq
MIRT2658730	hsa-miR-409-5p	CLIP-seq
MIRT2658731	hsa-miR-4254	CLIP-seq
MIRT2658732	hsa-miR-4277	CLIP-seq
MIRT2658733	hsa-miR-4312	CLIP-seq
MIRT2658734	hsa-miR-4318	CLIP-seq
MIRT2658735	hsa-miR-4325	CLIP-seq
MIRT2658736	hsa-miR-4423-5p	CLIP-seq
MIRT1480636	hsa-miR-4436b-3p	CLIP-seq
MIRT2658737	hsa-miR-4470	CLIP-seq
MIRT2144600	hsa-miR-4476	CLIP-seq
MIRT1480638	hsa-miR-4477a	CLIP-seq
MIRT2364983	hsa-miR-4514	CLIP-seq
MIRT1480640	hsa-miR-4642	CLIP-seq
MIRT2364985	hsa-miR-4645-3p	CLIP-seq
MIRT2364986	hsa-miR-4645-5p	CLIP-seq
MIRT1480641	hsa-miR-4666-5p	CLIP-seq
MIRT2658738	hsa-miR-4672	CLIP-seq
MIRT2364987	hsa-miR-4673	CLIP-seq
MIRT2364988	hsa-miR-4692	CLIP-seq
MIRT2658739	hsa-miR-4704-3p	CLIP-seq
MIRT1480643	hsa-miR-4724-5p	CLIP-seq
MIRT2658740	hsa-miR-4768-5p	CLIP-seq
MIRT2144606	hsa-miR-4784	CLIP-seq
MIRT1480644	hsa-miR-4786-3p	CLIP-seq
MIRT1480645	hsa-miR-4797-5p	CLIP-seq
MIRT2658741	hsa-miR-548ac	CLIP-seq
MIRT2658742	hsa-miR-548ae	CLIP-seq
MIRT2658743	hsa-miR-548aj	CLIP-seq
MIRT2658744	hsa-miR-548am	CLIP-seq
MIRT2658745	hsa-miR-548d-3p	CLIP-seq
MIRT2658746	hsa-miR-548x	CLIP-seq
MIRT2658747	hsa-miR-548z	CLIP-seq
MIRT2144609	hsa-miR-579	CLIP-seq
MIRT2144610	hsa-miR-589	CLIP-seq
MIRT1480651	hsa-miR-618	CLIP-seq
MIRT2658748	hsa-miR-642b	CLIP-seq
MIRT2144612	hsa-miR-765	CLIP-seq
MIRT2658749	hsa-miR-766	CLIP-seq
MIRT2658750	hsa-miR-875-3p	CLIP-seq
MIRT2144588	hsa-miR-1178	CLIP-seq
MIRT2144589	hsa-miR-1207-3p	CLIP-seq
MIRT2658722	hsa-miR-1273g	CLIP-seq
MIRT2658723	hsa-miR-1976	CLIP-seq
MIRT2658725	hsa-miR-2117	CLIP-seq
MIRT2144590	hsa-miR-3135b	CLIP-seq
MIRT2658726	hsa-miR-3148	CLIP-seq
MIRT2144591	hsa-miR-3150b-3p	CLIP-seq
MIRT1480625	hsa-miR-3163	CLIP-seq
MIRT2144593	hsa-miR-3179	CLIP-seq
MIRT2144594	hsa-miR-3202	CLIP-seq
MIRT1480628	hsa-miR-340	CLIP-seq
MIRT1480630	hsa-miR-3613-3p	CLIP-seq
MIRT2144595	hsa-miR-361-3p	CLIP-seq
MIRT2658728	hsa-miR-3690	CLIP-seq
MIRT1480632	hsa-miR-371b-5p	CLIP-seq
MIRT2658729	hsa-miR-3925-3p	CLIP-seq
MIRT1480634	hsa-miR-3943	CLIP-seq
MIRT2658730	hsa-miR-409-5p	CLIP-seq
MIRT2658731	hsa-miR-4254	CLIP-seq
MIRT2658732	hsa-miR-4277	CLIP-seq
MIRT2658733	hsa-miR-4312	CLIP-seq
MIRT2658734	hsa-miR-4318	CLIP-seq
MIRT2658735	hsa-miR-4325	CLIP-seq
MIRT2658736	hsa-miR-4423-5p	CLIP-seq
MIRT2144600	hsa-miR-4476	CLIP-seq
MIRT1480638	hsa-miR-4477a	CLIP-seq
MIRT2364983	hsa-miR-4514	CLIP-seq
MIRT1480640	hsa-miR-4642	CLIP-seq
MIRT2364985	hsa-miR-4645-3p	CLIP-seq
MIRT2364986	hsa-miR-4645-5p	CLIP-seq
MIRT2658738	hsa-miR-4672	CLIP-seq
MIRT2364987	hsa-miR-4673	CLIP-seq
MIRT2364988	hsa-miR-4692	CLIP-seq
MIRT2658739	hsa-miR-4704-3p	CLIP-seq
MIRT2658740	hsa-miR-4768-5p	CLIP-seq
MIRT2144606	hsa-miR-4784	CLIP-seq
MIRT2658741	hsa-miR-548ac	CLIP-seq
MIRT2658742	hsa-miR-548ae	CLIP-seq
MIRT2658743	hsa-miR-548aj	CLIP-seq
MIRT2658744	hsa-miR-548am	CLIP-seq
MIRT2658745	hsa-miR-548d-3p	CLIP-seq
MIRT2658746	hsa-miR-548x	CLIP-seq
MIRT2658747	hsa-miR-548z	CLIP-seq
MIRT2144609	hsa-miR-579	CLIP-seq
MIRT2144610	hsa-miR-589	CLIP-seq
MIRT1480651	hsa-miR-618	CLIP-seq
MIRT2658748	hsa-miR-642b	CLIP-seq
MIRT2144612	hsa-miR-765	CLIP-seq
MIRT2658749	hsa-miR-766	CLIP-seq
MIRT2658750	hsa-miR-875-3p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
ATF1	Unknown	7642633
NPM1	Unknown	23183427
SP1	Unknown	7642633
STAT3	Repression	22750444

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002039	Function	P53 binding	IDA	20096447
GO:0004197	Function	Cysteine-type endopeptidase activity	IBA	21873635
GO:0004197	Function	Cysteine-type endopeptidase activity	IMP	21745816
GO:0004843	Function	Thiol-dependent ubiquitin-specific protease activity	IBA	21873635
GO:0004843	Function	Thiol-dependent ubiquitin-specific protease activity	IDA	16964248, 21745816, 26280536, 28655758
GO:0004843	Function	Thiol-dependent ubiquitin-specific protease activity	IMP	11923872, 26678539
GO:0004843	Function	Thiol-dependent ubiquitin-specific protease activity	TAS
GO:0005515	Function	Protein binding	IPI	11279055, 11923872, 15916963, 16402859, 16474402, 16713569, 16845383, 17268548, 17936559, 18566590, 18716620, 18729074, 20601937, 20697359, 21170034, 21258371, 21745816, 21988832, 22056774, 22466611, 22466612, 22653443, 22810586, 22863774, 24823443, 24981860, 25172512, 25266658, 255
GO:0005634	Component	Nucleus	HDA	16791210
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	11279055, 12093161, 16964248, 18410486, 20096447, 21258371, 26365382, 26678539
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA	11279055, 26365382
GO:0005829	Component	Cytosol	TAS
GO:0006111	Process	Regulation of gluconeogenesis	IDA	28655758
GO:0006283	Process	Transcription-coupled nucleotide-excision repair	IMP	22466612
GO:0006283	Process	Transcription-coupled nucleotide-excision repair	TAS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IEA
GO:0007275	Process	Multicellular organism development	IEA
GO:0008022	Function	Protein C-terminus binding	IPI	12093161
GO:0008134	Function	Transcription factor binding	IPI	16964248
GO:0010216	Process	Maintenance of DNA methylation	IMP	21745816
GO:0016032	Process	Viral process	IEA
GO:0016567	Process	Protein ubiquitination	TAS
GO:0016579	Process	Protein deubiquitination	IBA	21873635
GO:0016579	Process	Protein deubiquitination	IDA	16964248, 21258371, 21745816, 25172512
GO:0016579	Process	Protein deubiquitination	IMP	11923872, 18410486, 26678539, 27123980
GO:0016579	Process	Protein deubiquitination	TAS
GO:0016604	Component	Nuclear body	HDA	16791210
GO:0016605	Component	PML body	IEA
GO:0018215	Process	Protein phosphopantetheinylation	IEA
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	11279055, 18410486, 18566590
GO:0031647	Process	Regulation of protein stability	IBA	21873635
GO:0031647	Process	Regulation of protein stability	IDA	27123980
GO:0032088	Process	Negative regulation of NF-kappaB transcription factor activity	IDA	11279055
GO:0032435	Process	Negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP	26678539
GO:0032991	Component	Protein-containing complex	IDA	26678539
GO:0035520	Process	Monoubiquitinated protein deubiquitination	IDA	26280536
GO:0035616	Process	Histone H2B conserved C-terminal lysine deubiquitination	ISS
GO:0042752	Process	Regulation of circadian rhythm	IDA	27123980
GO:0048511	Process	Rhythmic process	IEA
GO:0050821	Process	Protein stabilization	IDA	21258371, 25172512
GO:0050821	Process	Protein stabilization	IMP	18410486
GO:0051090	Process	Regulation of DNA-binding transcription factor activity	IDA	16964248
GO:0070536	Process	Protein K63-linked deubiquitination	IDA	28655758
GO:0071108	Process	Protein K48-linked deubiquitination	IEA
GO:0101005	Function	Ubiquitinyl hydrolase activity	IMP	18410486
GO:1901537	Process	Positive regulation of DNA demethylation	IDA	25944111
GO:1904353	Process	Regulation of telomere capping	TAS	25172512
GO:1905279	Process	Regulation of retrograde transport, endosome to Golgi	IMP	26365382
GO:1990380	Function	Lys48-specific deubiquitinase activity	IDA	25944111

Other IDs

• MIM: 602519
• HGNC: 12630
• e!Ensembl: ENSG00000187555

Protein

• UniProt ID: Q93009
• Protein name: Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7)
• Protein function: Hydrolase that deubiquitinates target proteins such as ARMC5, FOXO4, DEPTOR, KAT5, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX (PubMed:11923872, PubMed:15053880, PubMed:16964248, PubMed:18716620, PubMed:25283148, PubMed:258657
• PDB: 1NB8, 1NBF, 1YY6, 1YZE, 2F1W, 2F1X, 2F1Y, 2F1Z, 2FOJ, 2FOO, 2FOP, 2KVR, 2XXN, 2YLM, 3MQR, 3MQS, 4JJQ, 4KG9, 4M5W, 4M5X, 4PYZ, 4WPH, 4WPI, 4YOC, 4YSI, 4Z96, 4Z97, 5C56, 5C6D, 5FWI, 5GG4, 5J7T, 5JTJ, 5JTV, 5KYB, 5KYC, 5KYD, 5KYE, 5KYF, 5N9R, 5N9T, 5NGE, 5NGF, 5UQV, 5UQX, 5VS6, 5VSB, 5VSK, 5WHC, 6F5H, 6M1K
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00917	MATH	74 → 196	MATH domain	Domain
  PF00443	UCH	214 → 518	Ubiquitin carboxyl-terminal hydrolase	Family
  PF12436	USP7_ICP0_bdg	620 → 865	ICP0-binding domain of Ubiquitin-specific protease 7	Family
  PF14533	USP7_C2	875 → 1086	Ubiquitin-specific protease C-terminal	Family

• Sequence:

  MNHQQQQQQQKAGEQQLSEPEDMEMEAGDTDDPPRITQNPVINGNVALSDGHNTAEEDME
  DDTSWRSEATFQFTVERFSRLSESVLSPPCFVRNLPWKIMVMPRFYPDRPHQKSVGFFLQ
  CNAESDSTSWSCHAQAVLKIINYRDDEKSFSRRISHLFFHKENDWGFSNFMAWSEVTDPE
  KGFIDDDKVTFEVFVQADAPHGVAWDSKKHTGYVGLKNQGATCYMNSLLQTLFFTNQLRK
  AVYMMPTEGDDSSKSVPLALQRVFYELQHSDKPVGTKKLTKSFGWETLDSFMQHDVQELC
  RVLLDNVENKMKGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKNI
  FESFVDYVAVEQLDGDNKYDAGEHGLQEAEKGVKFLTLPPVLHLQLMRFMYDPQTDQNIK
  INDRFEFPEQLPLDEFLQKTDPKDPANYILHAVLVHSGDNHGGHYVVYLNPKGDGKWCKF
  DDDVVSRCTKEEAIEHNYGGHDDDLSVRHCTNAYMLVYIRESKLSEVLQAVTDHDIPQQL
  VERLQEEKRIEAQKRKERQEAHLYMQVQIVAEDQFCGHQGNDMYDEEKVKYTVFKVLKNS
  SLAEFVQSLSQTMGFPQDQIRLWPMQARSNGTKRPAMLDNEADGNKTMIELSDNENPWTI
  FLETVDPELAASGATLPKFDKDHDVMLFLKMYDPKTRSLNYCGHIYTPISCKIRDLLPVM
  CDRAGFIQDTSLILYEEVKPNLTERIQDYDVSLDKALDELMDGDIIVFQKDDPENDNSEL
  PTAKEYFRDLYHRVDVIFCDKTIPNDPGFVVTLSNRMNYFQVAKTVAQRLNTDPMLLQFF
  KSQGYRDGPGNPLRHNYEGTLRDLLQFFKPRQPKKLYYQQLKMKITDFENRRSFKCIWLN
  SQFREEEITLYPDKHGCVRDLLEECKKAVELGEKASGKLRLLEIVSYKIIGVHQEDELLE
  CLSPATSRTFRIEEIPLDQVDIDKENEMLVTVAHFHKEVFGTFGIPFLLRIHQGEHFREV
  MKRIQSLLDIQEKEFEKFKFAIVMMGRHQYINEDEYEVNLKDFEPQPGNMSHPRPWLGLD
  HFNKAPKRSRYTYLEKAIKIHN

• Sequence length: 1102

Pathways

KEGG:

Polycomb repressive complex
FoxO signaling pathway
Epstein-Barr virus infection
Viral carcinogenesis

Reactome:

Ub-specific processing proteases
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Regulation of TP53 Degradation
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Regulation of PTEN localization

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Developmental delay	Gross motor development delay	rs28941770, rs199469464, rs281865469, rs143747297, rs398123009, rs587777428, rs786205133, rs606231459, rs797044854, rs797045027, rs864309504, rs878853160, rs886039902, rs886042046, rs886041291, rs886041382, rs1057518991, rs1057518699, rs753254213, rs748294403, rs762552974, rs1135401795, rs1553121073, rs1553122926, rs1364690005, rs1554086554, rs1554210415, rs1554168326, rs1554776342, rs1553873247, rs1567860112, rs779009256, rs1557447255, rs1564568350, rs780011005, rs1597464953, rs1200336864, rs1569513017, rs1587459606, rs1570332505, rs748888652, rs1575155995, rs2087029320, rs1589669105, rs1601769604, rs1184981709, rs749201074
Dysautonomia	Autonomic bladder dysfunction	rs111033171, rs137853022, rs28939712, rs754348901, rs749052963, rs1057517169, rs1057516865, rs763445509, rs767527819, rs781333644, rs1239081703, rs1554696574, rs539544212, rs1201626345, rs774890086, rs1554703061, rs1554703613, rs1319053366, rs1554703851, rs868073099, rs926177767, rs376078668, rs1554695299, rs1554696648, rs1554696934, rs1554699327, rs1554691572, rs1554695846, rs1554697001, rs770668926, rs1554698037, rs759412460, rs1554702142, rs765572951, rs1554702880, rs1554703831, rs760774999, rs1554696650, rs757972943, rs1554703874, rs1554703907, rs571348995
Mental retardation	Mild Mental Retardation	rs5742905, rs267607136, rs267607137, rs2131714307, rs267607038, rs267607042, rs80338685, rs137853127, rs80338815, rs28940893, rs387906309, rs121908096, rs121908099, rs587784365, rs121918315, rs121918316, rs397515320, rs121434489, rs1585215916, rs267607233, rs267606752, rs137852214, rs606231193, rs132630297, rs80338758, rs137852815, rs122455132, rs28935171, rs122453113, rs122445108, rs28934904, rs28934908, rs28935468, rs61748421, rs121918624, rs202060209, rs80338708, rs113994198, rs199422192, rs387906635, rs1554770064, rs1057519611, rs1060499526, rs387906636, rs1057519612, rs281875189, rs281875322, rs387906799, rs387906804, rs875989800, rs797045262, rs387906845, rs387906846, rs876657378, rs281875227, rs281875228, rs281875229, rs281875230, rs387906861, rs370667926, rs387906932, rs387906943, rs1557612719, rs387907190, rs387907191, rs2126499522, rs587776908, rs1560982564, rs80359505, rs398123009, rs587776929, rs587776930, rs397514555, rs398122824, rs398122825, rs397514556, rs2147483647, rs587776937, rs397514627, rs397514655, rs397514656, rs730882192, rs1587520018, rs1581995953, rs1554121970, rs1581987445, rs397514670, rs376395543, rs137854128, rs397509411, rs397509412, rs397514741, rs398122394, rs879255516, rs397518483, rs398122406, rs398122412, rs398123561, rs200667343, rs587777162, rs587777202, rs62507350, rs587777219, rs587777225, rs587777226, rs587779750, rs587777326, rs587777334, rs281875332, rs587780470, rs587780474, rs587780486, rs587777378, rs587777406, rs587777408, rs587777409, rs587777411, rs587777522, rs527236034, rs527236035, rs267608571, rs267608382, rs267608597, rs61753979, rs61751444, rs267608493, rs587777644, rs587777645, rs587777646, rs587777703, rs587779388, rs606231266, rs606231267, rs672601340, rs606231268, rs672601341, rs606231269, rs672601342, rs606231270, rs606231271, rs606231272, rs606231273, rs587784566, rs587784092, rs587783749, rs587783747, rs587783640, rs587783483, rs606231456, rs606231457, rs606231458, rs606231459, rs672601370, rs672601369, rs672601371, rs672601367, rs672601366, rs672601365, rs672601364, rs672601363, rs672601362, rs672601376, rs672601377, rs672601378, rs724159949, rs724159950, rs724159948, rs724159956, rs724159953, rs727502860, rs727502861, rs730882197, rs749995448, rs786205143, rs794726770, rs1135401808, rs786205583, rs786205595, rs786205859, rs794727792, rs794727928, rs794729221, rs797044519, rs797044523, rs797044521, rs797044524, rs797044526, rs797044522, rs797044520, rs794727642, rs796052719, rs781746113, rs796052510, rs796052733, rs796052724, rs796052728, rs796052676, rs796053353, rs796053366, rs796053368, rs1555103986, rs1555110818, rs796052571, rs1555110843, rs796052626, rs796052618, rs796053290, rs796052217, rs672601368, rs797045164, rs797044961, rs797044962, rs200070245, rs797044963, rs869320675, rs869320676, rs797045012, rs752746786, rs797044885, rs797044925, rs797044854, rs797044849, rs797044930, rs797044901, rs797044918, rs797044884, rs797045177, rs797045178, rs797045050, rs797045036, rs797045053, rs797045047, rs797045037, rs797045042, rs797045041, rs879255261, rs782397980, rs797045263, rs797045264, rs797045655, rs797045586, rs545185248, rs797046031, rs797046028, rs797046029, rs797046030, rs797045249, rs797045529, rs797045952, rs797045984, rs797045540, rs797045539, rs797045989, rs863224930, rs869025202, rs863225264, rs863225077, rs876661308, rs869025222, rs864309560, rs758252808, rs745756308, rs869025286, rs869025287, rs869025578, rs143038880, rs869025579, rs869025580, rs869025581, rs869312704, rs869312674, rs869312677, rs869312689, rs869312693, rs869312698, rs869312708, rs869312711, rs869312826, rs869312825, rs869312824, rs869312823, rs758432471, rs869312821, rs761993070, rs869312844, rs869312842, rs869312843, rs869312841, rs869312847, rs869320632, rs869312955, rs773432002, rs869320713, rs869320772, rs869320773, rs879255270, rs875989848, rs875989849, rs1716457622, rs2108414289, rs878854401, rs875989786, rs1085307109, rs1085307108, rs876657679, rs876661167, rs876661076, rs876661055, rs876661219, rs876661064, rs876661151, rs876661041, rs200440467, rs876661295, rs878853045, rs878853143, rs878853142, rs878853149, rs1555910048, rs878853152, rs878853146, rs878853145, rs878853141, rs878853151, rs878853144, rs878853148, rs878853147, rs878853251, rs878853269, rs879253762, rs886037841, rs879253888, rs879253931, rs879254016, rs879255618, rs879255619, rs879255620, rs886037847, rs879255621, rs886039332, rs746177928, rs886039520, rs886041003, rs886041058, rs750035706, rs886041059, rs886041060, rs886041061, rs886041090, rs886041088, rs886041089, rs886041095, rs886041097, rs886041989, rs886041944, rs886041692, rs886041593, rs886041687, rs886041207, rs886041309, rs886041239, rs886041448, rs138336847, rs149644940, rs886041295, rs886041521, rs886041125, rs886042041, rs886041238, rs886041469, rs886041197, rs886041291, rs886041658, rs886041705, rs886041876, rs139716296, rs1057516030, rs1057517408, rs749655461, rs141179774, rs370916968, rs1057517676, rs1057517933, rs1057517708, rs1057518352, rs1057518183, rs1057518474, rs1057518204, rs1057517825, rs1057518796, rs1057518961, rs1057518772, rs1057518988, rs1057519004, rs1057518700, rs772450541, rs371310428, rs1057519019, rs1057519491, rs1057519546, rs1057519560, rs1057519565, rs1057519400, rs1057519402, rs1057519405, rs1057519593, rs1057519594, rs1057519628, rs1556912828, rs1060505029, rs1060505030, rs147001633, rs1057519947, rs1057519617, rs1057524832, rs774592932, rs797045045, rs1039571136, rs1555910821, rs1060499626, rs1060499655, rs1554770185, rs1060499936, rs1060501153, rs1060501151, rs1064792984, rs1060503378, rs1060503386, rs1060503383, rs1060500046, rs1064792999, rs1060505033, rs1064796564, rs1064797002, rs1064793161, rs150802299, rs1064796830, rs1064794996, rs1064795444, rs1064796034, rs1064796403, rs1064794979, rs1064796765, rs1064793539, rs760933323, rs1064793546, rs1064796406, rs1064796367, rs780441716, rs1064794894, rs1064796023, rs1064797355, rs1085307484, rs1064794935, rs1085307547, rs1131690804, rs757511770, rs1131691875, rs1131691979, rs398122823, rs1131691866, rs1131692159, rs1131692228, rs1131692154, rs113331868, rs1554121872, rs1554121875, rs926027867, rs1554122123, rs1554122129, rs1287121256, rs1554122526, rs1554123982, rs1554385102, rs1554385111, rs1554385305, rs1554386687, rs1554389088, rs1554402092, rs1554434435, rs1135401778, rs1135401760, rs1135401770, rs1135401771, rs1135401768, rs1135401779, rs1135401805, rs1135401797, rs1135401799, rs1135401816, rs1135401823, rs1135401824, rs1555769968, rs1135401825, rs1135401955, rs1135401956, rs1135401957, rs1135401958, rs1554129040, rs1554150543, rs1553188463, rs1553146165, rs1485978447, rs1361547443, rs750079325, rs369692236, rs1554231836, rs749188610, rs1554122735, rs1554689877, rs1174482090, rs781053477, rs1554623112, rs1555409836, rs1555411305, rs770014321, rs1555984461, rs1555990958, rs762292772, rs1554944271, rs1057524157, rs1485749468, rs1555984343, rs1293450628, rs373584239, rs1553722309, rs1553738686, rs1376334317, rs1553722294, rs1553283831, rs1554120589, rs1555985554, rs1555877287, rs1555411378, rs750922282, rs1553264873, rs1554263326, rs1554264268, rs1554263626, rs1554263625, rs766614772, rs1553620494, rs1555050158, rs1555050165, rs1555050171, rs1555050174, rs765556214, rs1402086660, rs1554645052, rs1555661648, rs1293246328, rs749494995, rs775592405, rs1553265189, rs1553242856, rs1553247374, rs1553241570, rs1553997065, rs1553998565, rs1380822792, rs1555028154, rs1555023232, rs1553194155, rs1553130904, rs1553152590, rs1553567864, rs1553638614, rs120074160, rs1554486894, rs1554767754, rs1554843977, rs1555443581, rs1555443600, rs1555439545, rs1555525088, rs770680174, rs1555889130, rs373178770, rs1555985532, rs1553519853, rs781325598, rs1410587479, rs1553638086, rs150259543, rs1554093891, rs1554121228, rs1554120498, rs1554121189, rs1212517874, rs1554770628, rs1555979158, rs1554770054, rs771610568, rs1451230055, rs1554770624, rs1555906707, rs1555906768, rs1555906781, rs1555907620, rs1555907623, rs1555907626, rs1555907653, rs1555907864, rs1554094145, rs1554202698, rs1554200722, rs773327091, rs1555607621, rs1555604778, rs1555607159, rs1555607682, rs1553364018, rs1553324416, rs1555411394, rs1554102556, rs1554122363, rs1555705966, rs1555103971, rs1555408401, rs1554461593, rs1554304254, rs1554120978, rs1047509819, rs1555982601, rs767774867, rs1554789246, rs1555111511, rs1555950676, rs1555954380, rs1555985649, rs1553194162, rs1553518509, rs1274633498, rs1554274371, rs1554122252, rs1554122458, rs1554122729, rs1554297905, rs1554776342, rs1554770046, rs1554770667, rs1554792556, rs1452715535, rs1555444885, rs1555534147, rs1427624649, rs1555611722, rs1555744282, rs1555706391, rs1178702025, rs1555984102, rs1554770589, rs1554121443, rs1559791842, rs1559824939, rs1555889127, rs1236702036, rs1553510280, rs1553511175, rs1553511226, rs1554150552, rs1554275163, rs1554201137, rs1553517991, rs1553518511, rs1553517984, rs1553518752, rs1554119814, rs1554122293, rs1554122341, rs1554122689, rs1554770243, rs1554770444, rs1557045250, rs959316981, rs1556270312, rs1553270640, rs978179634, rs1554093884, rs1491240980, rs1555943484, rs1554121453, rs1334099693, rs1554048616, rs1555660806, rs1555644480, rs1555651572, rs1567844992, rs1567855081, rs1567855669, rs1567855704, rs1567856045, rs1567856331, rs1567860075, rs1567860112, rs1567860640, rs1567860891, rs754919272, rs1567860919, rs1567861468, rs1567861489, rs1567861501, rs1567861894, rs1567863732, rs1567864750, rs1567877108, rs1567878511, rs758785463, rs1553808301, rs1553245038, rs1553789166, rs1553813646, rs1553631860, rs1554121265, rs1554770262, rs1555034768, rs1555984433, rs779009256, rs1553994814, rs1553996086, rs1553996072, rs1553270599, rs1553153291, rs760262127, rs1554119274, rs1554121878, rs1554387293, rs1554385203, rs757077698, rs750612085, rs1554776500, rs1564360978, rs1554776933, rs1554776938, rs1565278132, rs1567368243, rs1558478047, rs375695605, rs1558479778, rs1558501648, rs1565240833, rs114727354, rs1557591264, rs1557620758, rs1559099927, rs1561788984, rs369459721, rs1563831738, rs1562159088, rs1562159562, rs1562159599, rs1559094754, rs1559328283, rs755634856, rs1561784687, rs1554122296, rs1561789313, rs1562720119, rs1564363665, rs1561697465, rs1561785003, rs1561787845, rs1561789215, rs1554122305, rs1561784553, rs1561784560, rs1561787690, rs1554122888, rs749632782, rs1567139896, rs1569370887, rs1569371303, rs1564493599, rs1561875779, rs1569146542, rs1569146649, rs1275489527, rs1560115921, rs1468772495, rs749969789, rs1560108090, rs1569376809, rs1569355102, rs1560103306, rs1564365418, rs1559855453, rs1562928193, rs1558149913, rs1253072668, rs141976414, rs1558371790, rs1557898800, rs1567758622, rs1567844041, rs1567844114, rs1567920106, rs1567920209, rs138247472, rs1567974030, rs1567995650, rs1283838287, rs1568003569, rs1568006217, rs1568018905, rs1562505675, rs1561783309, rs1555980234, rs1559087186, rs1560966086, rs1560330387, rs769471341, rs1562493608, rs1562505335, rs1554121861, rs1554122200, rs1562957809, rs1568097623, rs1391600900, rs1568234874, rs1568235086, rs1555990955, rs1567870541, rs1557570794, rs1562869207, rs1571818248, rs1431778557, rs369691608, rs1595808957, rs1597665063, rs1597846084, rs1603401125, rs1603350606, rs1601946481, rs1601932069, rs1602880906, rs1602308324, rs1574554519, rs1573882268, rs1603198937, rs1558148010, rs1558498928, rs1569459580, rs1569380375, rs1560062082, rs1557889974, rs1558414255, rs756429763, rs781663444, rs1569016820, rs1569017025, rs1569017160, rs1557612048, rs1568504941, rs1581987022, rs1576983339, rs1599892470, rs1265340906, rs1602284689, rs1574949440, rs1576220938, rs1576280892, rs1576288424, rs1574459612, rs1574511051, rs1575654528, rs1577094794, rs1294683568, rs771819481, rs1580984895, rs1581338441, rs1580988138, rs1581980317, rs1581986872, rs1554121207, rs1581987268, rs1581987476, rs1581987885, rs763770519, rs1581991929, rs1581992099, rs1581992998, rs1581995453, rs1554122242, rs1581996778, rs1581997228, rs1588735247, rs1555980467, rs1555985742, rs1601319086, rs1601970168, rs1574451881, rs876661168, rs1576994053, rs1573589807, rs1581036396, rs1601267617, rs1572531830, rs1573483715, rs1590954686, rs1601315812, rs1573965358, rs1573972562, rs529087882, rs1570609440, rs1598940393, rs1575333081, rs1576028676, rs1596476657, rs1599375711, rs1603290366, rs1603060007, rs1603069440, rs1592939069, rs1591612223, rs2062994512, rs373701249, rs1600471396, rs1600501018, rs1600504088, rs1600514073, rs748436953, rs765723607, rs758170522, rs1561785045, rs1357591960, rs1591609136, rs1596891223, rs1579370234, rs2047850664, rs1579109565, rs1870202051, rs1574887674, rs778229060, rs1572531281, rs1570622663, rs1573501865, rs1576086299, rs1576164991, rs1574907198, rs1576656734, rs1554121438, rs1581995425, rs1581996813, rs1582001015, rs1588324025, rs1591371152, rs1590008294, rs1590956245, rs1590028691, rs1591606580, rs1591611001, rs1591612317, rs1591612370, rs763436882, rs997044541, rs1595897117, rs747706524, rs1579377990, rs1201878175, rs1894051550, rs1572531730, rs1579576029, rs1577017863, rs752545577, rs1582461267, rs1589460606, rs1588727276, rs1598620094, rs1599368323, rs1600082188, rs1601319352, rs1598226304, rs2076013475, rs2076017638, rs1600596180, rs1554121932, rs1680676671, rs1570607996, rs1382444181, rs1570640673, rs1574994308, rs1596667777, rs1602226289, rs1595629181, rs1595609005, rs1227643933, rs1572705473, rs1570621899, rs1722830922, rs1575094649, rs1417035592, rs1581997098, rs1589457762, rs1598211790, rs758726258, rs1601071971, rs863224922, rs1586692481, rs1586692548, rs1586692551, rs1580988074, rs1594129609, rs1588732344, rs1579368865, rs1586660389, rs1586660370, rs1586660338, rs1586657848, rs1586660381, rs1791701214, rs752676391, rs1680673822, rs758098717, rs1726676630, rs762288077, rs1759964009, rs1760905766, rs1761021165, rs1554121934, rs2055849544, rs1049773, rs587784300, rs1861628072, rs1761241410, rs1064797322, rs1948652423, rs2059194330, rs1777174302, rs2054280202, rs2081190512, rs772665884, rs1400164869, rs1861593395, rs1760897843, rs1761087122, rs1388355040, rs2068797192, rs1777175608, rs376898131
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	29610475
Vesicoureteral reflux	Vesico-Ureteral Reflux	rs587777684, rs148731211

Unknown
Disease name	Disease term	dbSNP ID	References
16p13.2 deletion syndrome	CHROMOSOME 16p13.2 DELETION SYNDROME, 16p13.2 microdeletion syndrome		26365382
Anxiety disorder	Anxiety
Urinary bladder cancer	Malignant neoplasm of urinary bladder		26039340
Bladder neoplasm	Bladder Neoplasm		26039340
Bowel incontinence	Fecal Incontinence
Dyscognitive seizures	Complex partial seizure with impairment of consciousness
Macrodontia	Macrodontia
Optic neuropathy	Optic Neuropathy
Prostatic neoplasms	Prostatic Neoplasms		29610475
Sleep apnea	Sleep Apnea Syndromes
Strabismus	Strabismus