MAPKAPK3 (MAPK activated protein kinase 3)

Gene

• Entrez ID: 7867
• Gene name: MAPK activated protein kinase 3
• Gene symbol: MAPKAPK3
• Synonyms: 3PK, MAPKAP-K3, MAPKAP3, MAPKAPK-3, MDPT3, MK-3, MK3
• Chromosome: 3
• Chromosome location: 3p21.2
• Summary: This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an int

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs886037913	T>C	Pathogenic	Missense variant, intron variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022623	hsa-miR-124-3p	Microarray	18668037
MIRT1131494	hsa-miR-1179	CLIP-seq
MIRT1131495	hsa-miR-1266	CLIP-seq
MIRT1131496	hsa-miR-1291	CLIP-seq
MIRT1131497	hsa-miR-1321	CLIP-seq
MIRT1131498	hsa-miR-1827	CLIP-seq
MIRT1131499	hsa-miR-214	CLIP-seq
MIRT1131500	hsa-miR-2682	CLIP-seq
MIRT1131501	hsa-miR-27a	CLIP-seq
MIRT1131502	hsa-miR-27b	CLIP-seq
MIRT1131503	hsa-miR-3065-3p	CLIP-seq
MIRT1131504	hsa-miR-3126-3p	CLIP-seq
MIRT1131505	hsa-miR-3127-5p	CLIP-seq
MIRT1131506	hsa-miR-3136-3p	CLIP-seq
MIRT1131507	hsa-miR-3173-3p	CLIP-seq
MIRT1131508	hsa-miR-3173-5p	CLIP-seq
MIRT1131509	hsa-miR-338-3p	CLIP-seq
MIRT1131510	hsa-miR-3612	CLIP-seq
MIRT1131511	hsa-miR-3619-5p	CLIP-seq
MIRT1131512	hsa-miR-3677-5p	CLIP-seq
MIRT1131513	hsa-miR-3918	CLIP-seq
MIRT1131514	hsa-miR-4269	CLIP-seq
MIRT1131515	hsa-miR-4270	CLIP-seq
MIRT1131516	hsa-miR-4310	CLIP-seq
MIRT1131517	hsa-miR-4441	CLIP-seq
MIRT1131518	hsa-miR-4495	CLIP-seq
MIRT1131519	hsa-miR-449c	CLIP-seq
MIRT1131520	hsa-miR-4514	CLIP-seq
MIRT1131521	hsa-miR-4518	CLIP-seq
MIRT1131522	hsa-miR-4530	CLIP-seq
MIRT1131523	hsa-miR-4660	CLIP-seq
MIRT1131524	hsa-miR-4690-5p	CLIP-seq
MIRT1131525	hsa-miR-4692	CLIP-seq
MIRT1131526	hsa-miR-4739	CLIP-seq
MIRT1131527	hsa-miR-4742-5p	CLIP-seq
MIRT1131528	hsa-miR-4747-3p	CLIP-seq
MIRT1131529	hsa-miR-4756-5p	CLIP-seq
MIRT1131530	hsa-miR-4764-5p	CLIP-seq
MIRT1131531	hsa-miR-4782-5p	CLIP-seq
MIRT1131532	hsa-miR-512-5p	CLIP-seq
MIRT1131533	hsa-miR-513a-5p	CLIP-seq
MIRT1131534	hsa-miR-548aa	CLIP-seq
MIRT1131535	hsa-miR-556-3p	CLIP-seq
MIRT1131536	hsa-miR-650	CLIP-seq
MIRT1131537	hsa-miR-761	CLIP-seq
MIRT1131538	hsa-miR-940	CLIP-seq
MIRT2037448	hsa-miR-150	CLIP-seq
MIRT2037449	hsa-miR-377	CLIP-seq
MIRT2037450	hsa-miR-4691-3p	CLIP-seq
MIRT2037451	hsa-miR-4731-3p	CLIP-seq
MIRT2037452	hsa-miR-4801	CLIP-seq
MIRT1131532	hsa-miR-512-5p	CLIP-seq
MIRT2037453	hsa-miR-550b	CLIP-seq
MIRT2267365	hsa-miR-128	CLIP-seq
MIRT1131501	hsa-miR-27a	CLIP-seq
MIRT1131502	hsa-miR-27b	CLIP-seq
MIRT1131503	hsa-miR-3065-3p	CLIP-seq
MIRT2267366	hsa-miR-3140-3p	CLIP-seq
MIRT2267367	hsa-miR-3929	CLIP-seq
MIRT1131514	hsa-miR-4269	CLIP-seq
MIRT2267368	hsa-miR-4419b	CLIP-seq
MIRT2267369	hsa-miR-4478	CLIP-seq
MIRT2267370	hsa-miR-4492	CLIP-seq
MIRT2267371	hsa-miR-4498	CLIP-seq
MIRT1131520	hsa-miR-4514	CLIP-seq
MIRT2267372	hsa-miR-4640-5p	CLIP-seq
MIRT2267373	hsa-miR-4676-5p	CLIP-seq
MIRT1131525	hsa-miR-4692	CLIP-seq
MIRT2267374	hsa-miR-4726-5p	CLIP-seq
MIRT1131527	hsa-miR-4742-5p	CLIP-seq
MIRT1131532	hsa-miR-512-5p	CLIP-seq
MIRT2267375	hsa-miR-575	CLIP-seq
MIRT2267376	hsa-miR-762	CLIP-seq
MIRT2390611	hsa-miR-4281	CLIP-seq
MIRT1131520	hsa-miR-4514	CLIP-seq
MIRT1131525	hsa-miR-4692	CLIP-seq
MIRT2037448	hsa-miR-150	CLIP-seq
MIRT2567152	hsa-miR-186	CLIP-seq
MIRT2567153	hsa-miR-1912	CLIP-seq
MIRT2567154	hsa-miR-3133	CLIP-seq
MIRT2567155	hsa-miR-3194-3p	CLIP-seq
MIRT2567156	hsa-miR-3651	CLIP-seq
MIRT2037449	hsa-miR-377	CLIP-seq
MIRT2567157	hsa-miR-3943	CLIP-seq
MIRT2567158	hsa-miR-4311	CLIP-seq
MIRT2567159	hsa-miR-4323	CLIP-seq
MIRT2567160	hsa-miR-4506	CLIP-seq
MIRT2567161	hsa-miR-4662a-3p	CLIP-seq
MIRT2037450	hsa-miR-4691-3p	CLIP-seq
MIRT2037451	hsa-miR-4731-3p	CLIP-seq
MIRT2567162	hsa-miR-4747-5p	CLIP-seq
MIRT2567163	hsa-miR-4786-3p	CLIP-seq
MIRT2037452	hsa-miR-4801	CLIP-seq
MIRT2567164	hsa-miR-569	CLIP-seq
MIRT2567165	hsa-miR-671-5p	CLIP-seq
MIRT2567166	hsa-miR-767-3p	CLIP-seq
MIRT2567167	hsa-miR-769-5p	CLIP-seq
MIRT2037448	hsa-miR-150	CLIP-seq
MIRT2567152	hsa-miR-186	CLIP-seq
MIRT2567153	hsa-miR-1912	CLIP-seq
MIRT2684601	hsa-miR-296-3p	CLIP-seq
MIRT2567154	hsa-miR-3133	CLIP-seq
MIRT2684602	hsa-miR-3184	CLIP-seq
MIRT2567155	hsa-miR-3194-3p	CLIP-seq
MIRT2037449	hsa-miR-377	CLIP-seq
MIRT2684603	hsa-miR-423-5p	CLIP-seq
MIRT2567158	hsa-miR-4311	CLIP-seq
MIRT2567160	hsa-miR-4506	CLIP-seq
MIRT2267373	hsa-miR-4676-5p	CLIP-seq
MIRT2684604	hsa-miR-4685-5p	CLIP-seq
MIRT2037450	hsa-miR-4691-3p	CLIP-seq
MIRT2037451	hsa-miR-4731-3p	CLIP-seq
MIRT2567162	hsa-miR-4747-5p	CLIP-seq
MIRT2567163	hsa-miR-4786-3p	CLIP-seq
MIRT2037452	hsa-miR-4801	CLIP-seq
MIRT2567164	hsa-miR-569	CLIP-seq
MIRT2267375	hsa-miR-575	CLIP-seq
MIRT2684605	hsa-miR-601	CLIP-seq
MIRT2567165	hsa-miR-671-5p	CLIP-seq
MIRT2567166	hsa-miR-767-3p	CLIP-seq
MIRT2567167	hsa-miR-769-5p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
CREB5	Activation	21132541

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	IEA
GO:0000187	Process	Activation of MAPK activity	TAS
GO:0002224	Process	Toll-like receptor signaling pathway	IBA	21873635
GO:0002224	Process	Toll-like receptor signaling pathway	ISS
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	8774846, 15850461
GO:0004683	Function	Calmodulin-dependent protein kinase activity	IBA	21873635
GO:0004708	Function	MAP kinase kinase activity	TAS	10781029
GO:0005515	Function	Protein binding	IPI	8774846, 21575178, 21988832, 23455922, 23487458, 23602568, 25241761, 25852190, 26496610, 28514442, 31515488, 31980649
GO:0005516	Function	Calmodulin binding	IBA	21873635
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	TAS	8626550
GO:0009931	Function	Calcium-dependent protein serine/threonine kinase activity	IBA	21873635
GO:0018105	Process	Peptidyl-serine phosphorylation	IBA	21873635
GO:0018105	Process	Peptidyl-serine phosphorylation	IDA	15850461
GO:0032496	Process	Response to lipopolysaccharide	ISS
GO:0034097	Process	Response to cytokine	IBA	21873635
GO:0034097	Process	Response to cytokine	IDA	8774846
GO:0035556	Process	Intracellular signal transduction	IBA	21873635
GO:0044351	Process	Macropinocytosis	ISS
GO:0046777	Process	Protein autophosphorylation	IBA	21873635
GO:0048010	Process	Vascular endothelial growth factor receptor signaling pathway	TAS
GO:0051019	Function	Mitogen-activated protein kinase binding	IBA	21873635
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0106311	Function	Protein threonine kinase activity	IEA

Other IDs

• MIM: 602130
• HGNC: 6888
• e!Ensembl: ENSG00000114738

Protein

• UniProt ID: Q16644
• Protein name: MAP kinase-activated protein kinase 3 (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAP-K3) (MAPKAPK-3) (MK-3) (EC 2.7.11.1) (Chromosome 3p kinase) (3pK)
• Protein function: Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAP
• PDB: 3FHR, 3FXW, 3R1N, 3SHE, 7NRB
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	44 → 304	Protein kinase domain	Domain

• Sequence:

  MDGETAEEQGGPVPPPVAPGGPGLGGAPGGRREPKKYAVTDDYQLSKQVLGLGVNGKVLE
  CFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMEC
  MEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKD
  AVLKLTDFGFAKETTQNALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFP
  PFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMN
  HPWINQSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSALATMRVDYDQVKIKDLKTSNNR
  LLNKRRKKQAGSSSASQGCNNQ

• Sequence length: 382

Pathways

KEGG:

MAPK signaling pathway
VEGF signaling pathway

Reactome:

p38MAPK events
Oxidative Stress Induced Senescence
VEGFA-VEGFR2 Pathway
activated TAK1 mediates p38 MAPK activation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Macular dystrophy, patterned	Macular Dystrophy, Butterfly-Shaped Pigmentary, 2, MACULAR DYSTROPHY, PATTERNED, 3, Martinique crinkled retinal pigment epitheliopathy	rs121918563, rs61755789, rs61755792, rs61748429, rs672601326, rs61755786, rs61755771, rs61755781, rs61755801, rs61755802, rs61755803, rs869320696, rs869320697, rs886037913, rs121918567, rs1582759785, rs1582764697, rs1203908646, rs1582764600	26744326
Glioblastoma	Glioblastoma Multiforme	rs121913500, rs886042842, rs1555138291, rs1558518449, rs1567176006, rs1558650888
Patterned dystrophy of retinal pigment epithelium	Patterned dystrophy of retinal pigment epithelium	rs61755806, rs121918563, rs61755793, rs61755798, rs61755771, rs61755783, rs61755781, rs61755814, rs281865373, rs121918567, rs986748364, rs369507460, rs61755810, rs1799988458, rs61755813, rs779414078
Rod-cone dystrophy	Rod-Cone Dystrophy	rs267606641, rs199476133, rs193302849, rs777668842, rs775518991, rs752300607, rs142759730, rs756225251, rs536742386, rs1588830568, rs778907433

Unknown
Disease name	Disease term	dbSNP ID	References
Anetoderma	Atrophoderma maculatum