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BTG2 (BTG anti-proliferation factor 2)
Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7832
Gene nameGene Name - the full gene name approved by the HGNC.
BTG anti-proliferation factor 2
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
BTG2
SynonymsGene synonyms aliases
APRO1, PC3, TIS21
ChromosomeChromosome number
1
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q32.1
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein is involved in the regulation of the G1/S transition of the cell cycle
miRNAmiRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
miRTarBase ID miRNA Experiments Reference
MIRT002416 hsa-miR-21-5p semi-qRT-PCR, GFP reporter assay, Western blot 19546886
MIRT002416 hsa-miR-21-5p semi-qRT-PCR, GFP reporter assay, Western blot 19546886
MIRT002416 hsa-miR-21-5p Luciferase reporter assay 19546886
MIRT002416 hsa-miR-21-5p Review 20026422
MIRT025795 hsa-miR-7-5p Sequencing 20371350
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Transcription factor Regulation Reference
AR Repression 16281084
ESR1 Repression 19117054
FOXM1 Activation 19615363
NFKB1 Unknown 17363596
PHB2 Repression 19117054
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0003714 Function Transcription corepressor activity IEA
GO:0005515 Function Protein binding IPI 9712883, 11136725, 18337750, 21172304, 25416956, 32296183
GO:0005634 Component Nucleus IBA 21873635
GO:0005737 Component Cytoplasm IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM
HGNC
e!Ensembl
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P78543
Protein name Protein BTG2 (BTG family member 2) (NGF-inducible anti-proliferative protein PC3)
Protein function Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNO
PDB 3DJU , 3E9V
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07742 BTG
9 → 122
BTG family
 Family
Sequence
Sequence length 158
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
 
KEGG
  
Reactome
  RNA degradation   TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Associated diseases
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Unknown
Disease name Disease term dbSNP ID References
Liver carcinoma Liver carcinoma 18393292

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