ZNF177 (zinc finger protein 177)

Gene

• Entrez ID: 7730
• Gene name: Zinc finger protein 177
• Gene symbol: ZNF177
• Synonyms: PIGX
• Chromosome: 19
• Chromosome location: 19p13.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT708539	hsa-miR-345-3p	HITS-CLIP	19536157
MIRT708538	hsa-miR-4732-3p	HITS-CLIP	19536157
MIRT708537	hsa-miR-125a-5p	HITS-CLIP	19536157
MIRT708536	hsa-miR-125b-5p	HITS-CLIP	19536157
MIRT708535	hsa-miR-4319	HITS-CLIP	19536157
MIRT708534	hsa-miR-4324	HITS-CLIP	19536157
MIRT708533	hsa-miR-4329	HITS-CLIP	19536157
MIRT708532	hsa-miR-4524a-3p	HITS-CLIP	19536157
MIRT708531	hsa-miR-670-5p	HITS-CLIP	19536157
MIRT708530	hsa-miR-4755-5p	HITS-CLIP	19536157
MIRT708529	hsa-miR-5006-3p	HITS-CLIP	19536157
MIRT708528	hsa-miR-4446-5p	HITS-CLIP	19536157
MIRT708539	hsa-miR-345-3p	HITS-CLIP	19536157
MIRT708538	hsa-miR-4732-3p	HITS-CLIP	19536157
MIRT708537	hsa-miR-125a-5p	HITS-CLIP	19536157
MIRT708536	hsa-miR-125b-5p	HITS-CLIP	19536157
MIRT708535	hsa-miR-4319	HITS-CLIP	19536157
MIRT708534	hsa-miR-4324	HITS-CLIP	19536157
MIRT708533	hsa-miR-4329	HITS-CLIP	19536157
MIRT708532	hsa-miR-4524a-3p	HITS-CLIP	19536157
MIRT708531	hsa-miR-670-5p	HITS-CLIP	19536157
MIRT708530	hsa-miR-4755-5p	HITS-CLIP	19536157
MIRT708529	hsa-miR-5006-3p	HITS-CLIP	19536157
MIRT708528	hsa-miR-4446-5p	HITS-CLIP	19536157
MIRT1517136	hsa-miR-3938	CLIP-seq
MIRT1517137	hsa-miR-556-5p	CLIP-seq
MIRT1517138	hsa-miR-587	CLIP-seq
MIRT1517139	hsa-miR-103b	CLIP-seq
MIRT1517140	hsa-miR-1262	CLIP-seq
MIRT1517141	hsa-miR-3143	CLIP-seq
MIRT1517142	hsa-miR-320e	CLIP-seq
MIRT1517143	hsa-miR-4701-3p	CLIP-seq
MIRT1517144	hsa-miR-4729	CLIP-seq
MIRT1517145	hsa-miR-543	CLIP-seq
MIRT1517146	hsa-miR-548a-3p	CLIP-seq
MIRT1517147	hsa-miR-548e	CLIP-seq
MIRT1517148	hsa-miR-548f	CLIP-seq
MIRT1517149	hsa-miR-548g	CLIP-seq
MIRT1517150	hsa-miR-570	CLIP-seq
MIRT2668101	hsa-miR-101	CLIP-seq
MIRT1517139	hsa-miR-103b	CLIP-seq
MIRT2668102	hsa-miR-198	CLIP-seq
MIRT2668103	hsa-miR-2355-3p	CLIP-seq
MIRT2668104	hsa-miR-3064-3p	CLIP-seq
MIRT1517141	hsa-miR-3143	CLIP-seq
MIRT2668105	hsa-miR-3147	CLIP-seq
MIRT2668106	hsa-miR-338-3p	CLIP-seq
MIRT2668107	hsa-miR-34a	CLIP-seq
MIRT2668108	hsa-miR-34c-5p	CLIP-seq
MIRT2668109	hsa-miR-3671	CLIP-seq
MIRT2668110	hsa-miR-4259	CLIP-seq
MIRT2668111	hsa-miR-4302	CLIP-seq
MIRT2668112	hsa-miR-4464	CLIP-seq
MIRT2668113	hsa-miR-449a	CLIP-seq
MIRT2668114	hsa-miR-449b	CLIP-seq
MIRT2668115	hsa-miR-4530	CLIP-seq
MIRT2668116	hsa-miR-4640-5p	CLIP-seq
MIRT2668117	hsa-miR-4646-3p	CLIP-seq
MIRT2668118	hsa-miR-4697-3p	CLIP-seq
MIRT2668119	hsa-miR-4704-3p	CLIP-seq
MIRT2668120	hsa-miR-4717-3p	CLIP-seq
MIRT2668121	hsa-miR-4726-5p	CLIP-seq
MIRT1517144	hsa-miR-4729	CLIP-seq
MIRT2668122	hsa-miR-4748	CLIP-seq
MIRT2668123	hsa-miR-4762-5p	CLIP-seq
MIRT2668124	hsa-miR-4775	CLIP-seq
MIRT2668125	hsa-miR-499-3p	CLIP-seq
MIRT2668126	hsa-miR-499a-3p	CLIP-seq
MIRT2668127	hsa-miR-520a-5p	CLIP-seq
MIRT2668128	hsa-miR-525-5p	CLIP-seq
MIRT1517145	hsa-miR-543	CLIP-seq
MIRT2668129	hsa-miR-548ac	CLIP-seq
MIRT2668130	hsa-miR-548ae	CLIP-seq
MIRT2668131	hsa-miR-548aj	CLIP-seq
MIRT2668132	hsa-miR-548am	CLIP-seq
MIRT2668133	hsa-miR-548d-3p	CLIP-seq
MIRT2668134	hsa-miR-548x	CLIP-seq
MIRT2668135	hsa-miR-548z	CLIP-seq
MIRT2668136	hsa-miR-571	CLIP-seq
MIRT2668137	hsa-miR-590-3p	CLIP-seq
MIRT2668138	hsa-miR-607	CLIP-seq
MIRT2668107	hsa-miR-34a	CLIP-seq
MIRT2668108	hsa-miR-34c-5p	CLIP-seq
MIRT2668113	hsa-miR-449a	CLIP-seq
MIRT2668114	hsa-miR-449b	CLIP-seq
MIRT2668120	hsa-miR-4717-3p	CLIP-seq
MIRT2668124	hsa-miR-4775	CLIP-seq
MIRT2668137	hsa-miR-590-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IBA	21873635
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA	21873635
GO:0005515	Function	Protein binding	IPI	25416956
GO:0005634	Component	Nucleus	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0046872	Function	Metal ion binding	IEA
GO:0072562	Component	Blood microparticle	HDA	22516433
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

Other IDs

• MIM: 601276
• HGNC: 12966
• e!Ensembl: ENSG00000188629

Protein

• UniProt ID: Q13360
• Protein name: Zinc finger protein 177
• Protein function: May be involved in transcriptional regulation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01352	KRAB	13 → 54	KRAB box	Family
  PF13465	zf-H2C2_2	298 → 323		Domain
  PF00096	zf-C2H2	340 → 362	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	368 → 390	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	396 → 418	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	424 → 446	Zinc finger, C2H2 type	Domain
  PF13912	zf-C2H2_6	452 → 477		Domain

• Sequence:

  MAAGWLTTWSQNSVTFQEVAVDFSQEEWALLDPAQKNLYKDVMLENFRNLASVGYQLCRH
  SLISKVDQEQLKTDERGILQGDCADWETQLKPKDTIAMQNIPGGKTSNGINTAENQPGEH
  SLECNHCGKFRKNTRFICTRYCKGEKCYKYIKYSKVFNHPSTLRSHVSIHIGEKTLEFTD
  CRKAFNQESSLRKHLRTPTGQKFQEYEQCDMSFSLHSSCSVREQIPTGEKGDECSDYGKI
  SPLSVHTKTGSVEEGLECNEHEKTFTDPLSLQNCVRTHSGEMPYECSDCGKAFIFQSSLK
  KHMRSHTGEKPYECDHCGKSFSQSSHLNVHKRTHTGEKPYDCKECGKAFTVPSSLQKHVR
  THTGEKPYECSDCGKAFIDQSSLKKHTRSHTGEKPYECNQCGKSFSTGSYLIVHKRTHTG
  EKTYECKECGKAFRNSSCLRVHVRTHTGEKPYKCIQCEKAFSTSTNLIMHKRIHNGQKLH
  E

• Sequence length: 481

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Gastric cancer	Hereditary Diffuse Gastric Cancer	rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802, rs28933369, rs121912469, rs80358011, rs397507262, rs80359439, rs397507333, rs80359543, rs80358831, rs80359596, rs80358920, rs80358972, rs80359659, rs397507404, rs397514661, rs80359516, rs200495564, rs80358419, rs80359274, rs80359283, rs80358427, rs80358428, rs80358435, rs81002805, rs397507660, rs397507663, rs80359391, rs80359443, rs81002797, rs80359466, rs397507752, rs80359484, rs80359603, rs397507954, rs80359058, rs80359071, rs397507981, rs80359121, rs80357086, rs80357064, rs397508936, rs80357695, rs80357661, rs397509035, rs80357544, rs80357577, rs80357881, rs80357296, rs80356923, rs80356866, rs80357504, rs80357390, rs80357239, rs80358099, rs397509284, rs80357258, rs199474738, rs199474747, rs587779204, rs63750439, rs267608076, rs587779246, rs63749999, rs267608078, rs63751327, rs267607719, rs267607734, rs63750706, rs63751711, rs587779047, rs587779075, rs267607949, rs63750633, rs63750803, rs63751618, rs267608154, rs200640585, rs80358018, rs80357857, rs80357882, rs180177103, rs587779815, rs587779865, rs587779872, rs587780059, rs121912666, rs587780088, rs587780104, rs200432447, rs180177100, rs587780226, rs587780784, rs587776416, rs587781276, rs587781629, rs587781694, rs587781727, rs587781730, rs587781807, rs587781894, rs587781948, rs121913344, rs587782292, rs587782350, rs587782558, rs587782719, rs587782885, rs587783057, rs730881833, rs730881411, rs730881336, rs139770721, rs730881869, rs730881633, rs730882007, rs786203115, rs765123255, rs1553333738, rs762083530, rs786202800, rs17174393, rs55996097, rs750621215, rs786203451, rs747604569, rs764389018, rs786204433, rs786204862, rs772821016, rs779582317, rs863225406, rs193922343, rs759965045, rs63749919, rs760228510, rs746481984, rs762307622, rs876659736, rs876660933, rs747727055, rs1450394308, rs876658348, rs876658431, rs876659326, rs876660444, rs730881369, rs878853865, rs753862052, rs587780024, rs138941496, rs886040739, rs886040744, rs886040347, rs878854957, rs886040123, rs398122662, rs886040942, rs1057517104, rs1057516320, rs1057516683, rs879254046, rs1057517253, rs587781927, rs985033810, rs1057519989, rs775464903, rs374230313, rs758304323, rs1060501599, rs758081262, rs1060500126, rs1060502734, rs587776408, rs1060501695, rs1114167816, rs1114167596, rs1114167667, rs1555460315, rs1135402788, rs1554086196, rs730881919, rs773356478, rs769237459, rs1553653158, rs587782087, rs1555107263, rs1555119940, rs1403784434, rs1342519012, rs751710099, rs1553616361, rs1553619721, rs1270783041, rs775036118, rs1555288557, rs1555460548, rs1555461154, rs1298667185, rs1553622218, rs63751101, rs1349928568, rs771936821, rs1021662947, rs1555921011, rs81002831, rs1555124506, rs1555574803, rs1060502716, rs1555605362, rs747057367, rs1565385010, rs1567554500, rs1567516230, rs1558644995, rs1555591308, rs778306619, rs1566231194, rs1603328466, rs1570406302, rs1586108714, rs768362387, rs1597713777, rs1060502926, rs1597867185, rs1591517571, rs1591663236, rs1593903006, rs1555284779, rs1597096243, rs45459799, rs1597360340, rs587781905, rs864622481, rs1601753141, rs1966858562, rs1966967065, rs1967016153, rs1967113484, rs2080473458, rs1591387978, rs1224428422, rs1597747184, rs2082309297, rs2051929740, rs147542208	16367923

Unknown
Disease name	Disease term	dbSNP ID	References
Stomach neoplasms	Malignant neoplasm of stomach, Stomach Neoplasms		16367923