ZNF175 (zinc finger protein 175)

Gene

• Entrez ID: 7728
• Gene name: Zinc finger protein 175
• Gene symbol: ZNF175
• Synonyms: OTK18
• Chromosome: 19
• Chromosome location: 19q13.41

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT004203	hsa-miR-197-3p	Microarray	16822819
MIRT016079	hsa-miR-374b-5p	Sequencing	20371350
MIRT017746	hsa-miR-335-5p	Microarray	18185580
MIRT611980	hsa-miR-8485	HITS-CLIP	23824327
MIRT611979	hsa-miR-603	HITS-CLIP	23824327
MIRT611978	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT611977	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT611975	hsa-miR-1229-3p	HITS-CLIP	23824327
MIRT611974	hsa-miR-302c-5p	HITS-CLIP	23824327
MIRT611980	hsa-miR-8485	HITS-CLIP	23824327
MIRT611979	hsa-miR-603	HITS-CLIP	23824327
MIRT611978	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT611977	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT611976	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT621072	hsa-miR-629-5p	HITS-CLIP	23824327
MIRT611975	hsa-miR-1229-3p	HITS-CLIP	23824327
MIRT611974	hsa-miR-302c-5p	HITS-CLIP	23824327
MIRT649714	hsa-miR-7161-3p	HITS-CLIP	23824327
MIRT649713	hsa-miR-3168	HITS-CLIP	23824327
MIRT649712	hsa-miR-148b-5p	HITS-CLIP	23824327
MIRT649711	hsa-miR-6874-3p	HITS-CLIP	23824327
MIRT649710	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT649709	hsa-miR-146a-3p	HITS-CLIP	23824327
MIRT649708	hsa-miR-301a-5p	HITS-CLIP	23824327
MIRT649707	hsa-miR-301b-5p	HITS-CLIP	23824327
MIRT649706	hsa-miR-3921	HITS-CLIP	23824327
MIRT649705	hsa-miR-4653-5p	HITS-CLIP	23824327
MIRT649704	hsa-miR-1199-5p	HITS-CLIP	23824327
MIRT649703	hsa-miR-6751-3p	HITS-CLIP	23824327
MIRT649702	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT649701	hsa-miR-2117	HITS-CLIP	23824327
MIRT649700	hsa-miR-513a-5p	HITS-CLIP	23824327
MIRT649699	hsa-miR-27a-3p	HITS-CLIP	23824327
MIRT649698	hsa-miR-27b-3p	HITS-CLIP	23824327
MIRT649697	hsa-miR-3191-5p	HITS-CLIP	23824327
MIRT649696	hsa-miR-4303	HITS-CLIP	23824327
MIRT649695	hsa-miR-6807-5p	HITS-CLIP	23824327
MIRT649694	hsa-miR-5096	HITS-CLIP	23824327
MIRT649693	hsa-miR-5195-3p	HITS-CLIP	23824327
MIRT611980	hsa-miR-8485	HITS-CLIP	23824327
MIRT611978	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT611975	hsa-miR-1229-3p	HITS-CLIP	23824327
MIRT611980	hsa-miR-8485	HITS-CLIP	23824327
MIRT611978	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT611976	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT621072	hsa-miR-629-5p	HITS-CLIP	23824327
MIRT611975	hsa-miR-1229-3p	HITS-CLIP	23824327
MIRT611980	hsa-miR-8485	HITS-CLIP	23824327
MIRT611978	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT611976	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT611975	hsa-miR-1229-3p	HITS-CLIP	23824327
MIRT611980	hsa-miR-8485	HITS-CLIP	23824327
MIRT611979	hsa-miR-603	HITS-CLIP	23824327
MIRT611978	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT611977	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT611976	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT611975	hsa-miR-1229-3p	HITS-CLIP	23824327
MIRT611974	hsa-miR-302c-5p	HITS-CLIP	23824327
MIRT611980	hsa-miR-8485	HITS-CLIP	23824327
MIRT611979	hsa-miR-603	HITS-CLIP	23824327
MIRT611978	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT611977	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT611976	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT621072	hsa-miR-629-5p	HITS-CLIP	23824327
MIRT611975	hsa-miR-1229-3p	HITS-CLIP	23824327
MIRT611974	hsa-miR-302c-5p	HITS-CLIP	23824327
MIRT611980	hsa-miR-8485	HITS-CLIP	23824327
MIRT611979	hsa-miR-603	HITS-CLIP	23824327
MIRT611978	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT611977	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT611976	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT611975	hsa-miR-1229-3p	HITS-CLIP	23824327
MIRT611974	hsa-miR-302c-5p	HITS-CLIP	23824327
MIRT611980	hsa-miR-8485	HITS-CLIP	23824327
MIRT611979	hsa-miR-603	HITS-CLIP	23824327
MIRT611978	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT611977	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT611976	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT611975	hsa-miR-1229-3p	HITS-CLIP	23824327
MIRT611974	hsa-miR-302c-5p	HITS-CLIP	23824327
MIRT611980	hsa-miR-8485	HITS-CLIP	23824327
MIRT611979	hsa-miR-603	HITS-CLIP	23824327
MIRT611978	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT611977	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT611976	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT611975	hsa-miR-1229-3p	HITS-CLIP	23824327
MIRT611974	hsa-miR-302c-5p	HITS-CLIP	23824327
MIRT611980	hsa-miR-8485	HITS-CLIP	23824327
MIRT611979	hsa-miR-603	HITS-CLIP	23824327
MIRT611978	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT611977	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT611976	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT611975	hsa-miR-1229-3p	HITS-CLIP	23824327
MIRT611974	hsa-miR-302c-5p	HITS-CLIP	23824327
MIRT611980	hsa-miR-8485	HITS-CLIP	23824327
MIRT611979	hsa-miR-603	HITS-CLIP	23824327
MIRT611978	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT611977	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT611975	hsa-miR-1229-3p	HITS-CLIP	23824327
MIRT611974	hsa-miR-302c-5p	HITS-CLIP	23824327
MIRT611980	hsa-miR-8485	HITS-CLIP	23824327
MIRT611979	hsa-miR-603	HITS-CLIP	23824327
MIRT611978	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT611977	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT611976	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT621072	hsa-miR-629-5p	HITS-CLIP	23824327
MIRT611975	hsa-miR-1229-3p	HITS-CLIP	23824327
MIRT611974	hsa-miR-302c-5p	HITS-CLIP	23824327
MIRT649714	hsa-miR-7161-3p	HITS-CLIP	23824327
MIRT649713	hsa-miR-3168	HITS-CLIP	23824327
MIRT649712	hsa-miR-148b-5p	HITS-CLIP	23824327
MIRT649711	hsa-miR-6874-3p	HITS-CLIP	23824327
MIRT649710	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT649709	hsa-miR-146a-3p	HITS-CLIP	23824327
MIRT649708	hsa-miR-301a-5p	HITS-CLIP	23824327
MIRT649707	hsa-miR-301b-5p	HITS-CLIP	23824327
MIRT649706	hsa-miR-3921	HITS-CLIP	23824327
MIRT649705	hsa-miR-4653-5p	HITS-CLIP	23824327
MIRT649704	hsa-miR-1199-5p	HITS-CLIP	23824327
MIRT649703	hsa-miR-6751-3p	HITS-CLIP	23824327
MIRT649702	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT649701	hsa-miR-2117	HITS-CLIP	23824327
MIRT649700	hsa-miR-513a-5p	HITS-CLIP	23824327
MIRT649699	hsa-miR-27a-3p	HITS-CLIP	23824327
MIRT649698	hsa-miR-27b-3p	HITS-CLIP	23824327
MIRT649697	hsa-miR-3191-5p	HITS-CLIP	23824327
MIRT649696	hsa-miR-4303	HITS-CLIP	23824327
MIRT649695	hsa-miR-6807-5p	HITS-CLIP	23824327
MIRT649694	hsa-miR-5096	HITS-CLIP	23824327
MIRT649693	hsa-miR-5195-3p	HITS-CLIP	23824327
MIRT611980	hsa-miR-8485	HITS-CLIP	23824327
MIRT611978	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT611975	hsa-miR-1229-3p	HITS-CLIP	23824327
MIRT611980	hsa-miR-8485	HITS-CLIP	23824327
MIRT611978	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT611976	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT621072	hsa-miR-629-5p	HITS-CLIP	23824327
MIRT611975	hsa-miR-1229-3p	HITS-CLIP	23824327
MIRT611980	hsa-miR-8485	HITS-CLIP	23824327
MIRT611978	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT611976	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT611975	hsa-miR-1229-3p	HITS-CLIP	23824327
MIRT611980	hsa-miR-8485	HITS-CLIP	23824327
MIRT611979	hsa-miR-603	HITS-CLIP	23824327
MIRT611978	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT611977	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT611976	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT611975	hsa-miR-1229-3p	HITS-CLIP	23824327
MIRT611974	hsa-miR-302c-5p	HITS-CLIP	23824327
MIRT611980	hsa-miR-8485	HITS-CLIP	23824327
MIRT611979	hsa-miR-603	HITS-CLIP	23824327
MIRT611978	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT611977	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT611976	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT621072	hsa-miR-629-5p	HITS-CLIP	23824327
MIRT611975	hsa-miR-1229-3p	HITS-CLIP	23824327
MIRT611974	hsa-miR-302c-5p	HITS-CLIP	23824327
MIRT611980	hsa-miR-8485	HITS-CLIP	23824327
MIRT611979	hsa-miR-603	HITS-CLIP	23824327
MIRT611978	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT611977	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT611976	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT611975	hsa-miR-1229-3p	HITS-CLIP	23824327
MIRT611974	hsa-miR-302c-5p	HITS-CLIP	23824327
MIRT611980	hsa-miR-8485	HITS-CLIP	23824327
MIRT611979	hsa-miR-603	HITS-CLIP	23824327
MIRT611978	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT611977	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT611976	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT611975	hsa-miR-1229-3p	HITS-CLIP	23824327
MIRT611974	hsa-miR-302c-5p	HITS-CLIP	23824327
MIRT611980	hsa-miR-8485	HITS-CLIP	23824327
MIRT611979	hsa-miR-603	HITS-CLIP	23824327
MIRT611978	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT611977	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT611976	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT611975	hsa-miR-1229-3p	HITS-CLIP	23824327
MIRT611974	hsa-miR-302c-5p	HITS-CLIP	23824327
MIRT611980	hsa-miR-8485	HITS-CLIP	23824327
MIRT611979	hsa-miR-603	HITS-CLIP	23824327
MIRT611978	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT611977	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT611976	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT611975	hsa-miR-1229-3p	HITS-CLIP	23824327
MIRT611974	hsa-miR-302c-5p	HITS-CLIP	23824327
MIRT1517126	hsa-miR-2054	CLIP-seq
MIRT1517127	hsa-miR-3200-5p	CLIP-seq
MIRT1517128	hsa-miR-3607-3p	CLIP-seq
MIRT1517129	hsa-miR-3686	CLIP-seq
MIRT1517130	hsa-miR-4517	CLIP-seq
MIRT1517131	hsa-miR-4698	CLIP-seq
MIRT1517132	hsa-miR-4762-3p	CLIP-seq
MIRT1517133	hsa-miR-4766-5p	CLIP-seq
MIRT1517134	hsa-miR-548c-3p	CLIP-seq
MIRT1517135	hsa-miR-574-3p	CLIP-seq
MIRT2156130	hsa-miR-302f	CLIP-seq
MIRT2156131	hsa-miR-3157-3p	CLIP-seq
MIRT1517128	hsa-miR-3607-3p	CLIP-seq
MIRT1517129	hsa-miR-3686	CLIP-seq
MIRT2156132	hsa-miR-4290	CLIP-seq
MIRT2156133	hsa-miR-4452	CLIP-seq
MIRT1517135	hsa-miR-574-3p	CLIP-seq
MIRT2156134	hsa-miR-874	CLIP-seq
MIRT2375685	hsa-miR-1271	CLIP-seq
MIRT2375686	hsa-miR-185	CLIP-seq
MIRT2375687	hsa-miR-216a	CLIP-seq
MIRT2375688	hsa-miR-2467-5p	CLIP-seq
MIRT2156130	hsa-miR-302f	CLIP-seq
MIRT2375689	hsa-miR-30a	CLIP-seq
MIRT2375690	hsa-miR-30b	CLIP-seq
MIRT2375691	hsa-miR-30c	CLIP-seq
MIRT2375692	hsa-miR-30d	CLIP-seq
MIRT2375693	hsa-miR-30e	CLIP-seq
MIRT1517128	hsa-miR-3607-3p	CLIP-seq
MIRT1517129	hsa-miR-3686	CLIP-seq
MIRT2375694	hsa-miR-4284	CLIP-seq
MIRT2375695	hsa-miR-4306	CLIP-seq
MIRT2375696	hsa-miR-4528	CLIP-seq
MIRT2375697	hsa-miR-4644	CLIP-seq
MIRT2375698	hsa-miR-4768-5p	CLIP-seq
MIRT2375699	hsa-miR-4802-5p	CLIP-seq
MIRT2375700	hsa-miR-510	CLIP-seq
MIRT2375701	hsa-miR-512-5p	CLIP-seq
MIRT2375702	hsa-miR-544	CLIP-seq
MIRT2375703	hsa-miR-550b	CLIP-seq
MIRT2375704	hsa-miR-944	CLIP-seq
MIRT2375705	hsa-miR-96	CLIP-seq
MIRT2668092	hsa-miR-1253	CLIP-seq
MIRT2668093	hsa-miR-3545-3p	CLIP-seq
MIRT2668094	hsa-miR-3684	CLIP-seq
MIRT2668095	hsa-miR-4251	CLIP-seq
MIRT2668096	hsa-miR-4329	CLIP-seq
MIRT2668097	hsa-miR-4680-5p	CLIP-seq
MIRT2668098	hsa-miR-4699-5p	CLIP-seq
MIRT2668099	hsa-miR-4738-3p	CLIP-seq
MIRT1517135	hsa-miR-574-3p	CLIP-seq
MIRT2668100	hsa-miR-618	CLIP-seq
MIRT2668092	hsa-miR-1253	CLIP-seq
MIRT2668094	hsa-miR-3684	CLIP-seq
MIRT2668095	hsa-miR-4251	CLIP-seq
MIRT2668096	hsa-miR-4329	CLIP-seq
MIRT2668098	hsa-miR-4699-5p	CLIP-seq
MIRT1517135	hsa-miR-574-3p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
FOXD3	Unknown	19034670
YY1	Activation	19034670

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	17170456
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	17170456
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	17170456
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	17170456
GO:0003700	Function	DNA-binding transcription factor activity	TAS	8838321
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IDA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0045111	Component	Intermediate filament cytoskeleton	IDA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	17170456
GO:0046872	Function	Metal ion binding	IEA
GO:0051607	Process	Defense response to virus	IEA

Other IDs

• MIM: 601139
• HGNC: 12964
• e!Ensembl: ENSG00000105497

Protein

• UniProt ID: Q9Y473
• Protein name: Zinc finger protein 175 (Zinc finger protein OTK18)
• Protein function: Down-regulates the expression of several chemokine receptors. Interferes with HIV-1 replication by suppressing Tat-induced viral LTR promoter activity.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01352	KRAB	26 → 67	KRAB box	Family
  PF00096	zf-C2H2	335 → 357	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	363 → 385	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	391 → 413	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	419 → 441	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	447 → 469	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	475 → 497	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	503 → 525	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	531 → 553	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	559 → 581	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	587 → 609	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	615 → 637	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	643 → 665	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	671 → 693	Zinc finger, C2H2 type	Domain

• Sequence:

  MPADVNLSQKPQVLGPEKQDGSCEASVSFEDVTVDFSREEWQQLDPAQRCLYRDVMLELY
  SHLFAVGYHIPNPEVIFRMLKEKEPRVEEAEVSHQRCQEREFGLEIPQKEISKKASFQKD
  MVGEFTRDGSWCSILEELRLDADRTKKDEQNQIQPMSHSAFFNKKTLNTESNCEYKDPGK
  MIRTRPHLASSQKQPQKCCLFTESLKLNLEVNGQNESNDTEQLDDVVGSGQLFSHSSSDA
  CSKNIHTGETFCKGNQCRKVCGHKQSLKQHQIHTQKKPDGCSECGGSFTQKSHLFAQQRI
  HSVGNLHECGKCGKAFMPQLKLSVYLTDHTGDIPCICKECGKVFIQRSELLTHQKTHTRK
  KPYKCHDCGKAFFQMLSLFRHQRTHSREKLYECSECGKGFSQNSTLIIHQKIHTGERQYA
  CSECGKAFTQKSTLSLHQRIHSGQKSYVCIECGQAFIQKAHLIVHQRSHTGEKPYQCHNC
  GKSFISKSQLDIHHRIHTGEKPYECSDCGKTFTQKSHLNIHQKIHTGERHHVCSECGKAF
  NQKSILSMHQRIHTGEKPYKCSECGKAFTSKSQFKEHQRIHTGEKPYVCTECGKAFNGRS
  NFHKHQITHTRERPFVCYKCGKAFVQKSELITHQRTHMGEKPYECLDCGKSFSKKPQLKV
  HQRIHTGERPYVCSECGKAFNNRSNFNKHQTTHTRDKSYKCSYSVKGFTKQ

• Sequence length: 711

Pathways

Reactome:

Generic Transcription Pathway

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Rheumatoid arthritis	Rheumatoid Arthritis	rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212	22491018